John Laffey, University of Toronto

Research

Acute Lung Injury Acute Respiratory Distress Syndrome Macrophage Pneumonia Repair Sepsis Stem Cells Ventilation Induced Lung Injury

Latest papers

The authors reply.
Critical care medicine · 2020
Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19
Journal of the American Medical Association (JAMA) · 2020
Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study.
Critical care medicine · 2019

All 7 publications

Latest funding

EXtubation related complications - an international observational study To Understand impact and BEst practices - the EXTUBE study
CIHR · 2023 · Co-investigator
$1,033,515
Mechanisms and Therapies of ARDS
CIHR · 2014 · Co-investigator
$2,588,884
Cell based therapies for Acute Respiratory Distress Syndrome: Using mechanistic insights to optimize therapeutic potential
CIHR · 2013 · Nominated PI
$655,641

All 3 grants and awards

7 publications.

01

The authors reply.

Pham T, Laffey J, Bellani G, Brochard L, van Haren F

Critical care medicine2020

DOI: 10.1097/ccm.0000000000004302 PMID: 32301785

02

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19

Angus DC, Derde L, Al-Beidh F, Annane D, Arabi Y, Beane A, van Bentum-Puijk W, Berry L, Bhimani Z, Bonten M

Journal of the American Medical Association (JAMA)2020827 citations

DOI: 10.1001/jama.2020.17022

03

Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study.

van Haren F, Pham T, Brochard L, Bellani G, Laffey J, Dres M, Fan E, Goligher EC, Heunks L, Lynch J, Wrigge H, McAuley D, Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) Investigators

Critical care medicine2019

DOI: 10.1097/ccm.0000000000003519 PMID: 30379668

04

The Randomized Educational Acute Respiratory Distress Syndrome Diagnosis Study: A Trial to Improve the Radiographic Diagnosis of Acute Respiratory Distress Syndrome.

Goddard SL, Rubenfeld GD, Manoharan V, Dev SP, Laffey J, Bellani G, Pham T, Fan E

Critical care medicine2018

DOI: 10.1097/ccm.0000000000003000 PMID: 29438110

05

Etiologies, diagnostic work-up and outcomes of acute respiratory distress syndrome with no common risk factor: a prospective multicenter study.

de Prost N, Pham T, Carteaux G, Mekontso Dessap A, Brun-Buisson C, Fan E, Bellani G, Laffey J, Mercat A, Brochard L, Maître B, LUNG SAFE investigators, ESICM trials group, REVA network

Annals of intensive care2017

DOI: 10.1186/s13613-017-0281-6 PMID: 28631088

06

Incidence of Acute Respiratory Distress Syndrome--Reply.

Bellani G, Pham T, Laffey J, LUNG-SAFE Investigators, ESICM Trials Group

JAMA2016Senior author

DOI: 10.1001/jama.2016.6471 PMID: 27434453

07

Mechanical Stress and the Induction of Lung Fibrosis via the Midkine Signaling Pathway.

Zhang R, Pan Y, Fanelli V, Wu S, Luo AA, Islam D, Han B, Mao P, Ghazarian M, Zeng W, Spieth PM, Wang D, Khang J, Mo H, Liu X, Uhlig S, Liu M, Laffey J, Slutsky AS, Li Y, Zhang H

American journal of respiratory and critical care medicine2015

DOI: 10.1164/rccm.201412-2326oc PMID: 25945397

EXtubation related complications - an international observational study To Understand impact and BEst practices - the EXTUBE study

Co-investigatorCIHR2023Project Grant

Principal investigators: Parotto, Matteo; Adhikari, Neill K; Law, John A; Sklar, Michael C; Tsang, Jennifer L; Wijeysundera, Duminda N

Keywords: Airway Management; Anesthesia; Complications; Critical Care; Epidemiology; Extubation; Global; Patient Safety; Point Prevalence; Prospective Cohort

$1,033,515

Mechanisms and Therapies of ARDS

Co-investigatorCIHR2014Foundation Grant

Principal investigators: Zhang, Haibo; Slutsky, Arthur S

Keywords: Bone-Marrow-Derived Mesenchymal Stromal Cells (Msc); Cytokines; Endotoxin; Icam-1; Lung Injury; Lung Mechanics; Mechanical Ventilation; Mechanotransduction; Neutrophil Peptides; Sepsis

$2,588,884

Cell based therapies for Acute Respiratory Distress Syndrome: Using mechanistic insights to optimize therapeutic potential

Nominated PICIHR2013Operating Grant

Principal investigators: Laffey, John G

Keywords: Acute Lung Injury; Acute Respiratory Distress Syndrome; Macrophage; Pneumonia; Repair; Sepsis; Stem Cells; Ventilation Induced Lung Injury

$655,641

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Critical Care Medicine
Anesthesia
Internal Medicine
Department of Medicine
Medicine
Médecine interne
General Internal Medicine
Other

Applying for

Paper to mention

Subject: Prospective PhD student: Acute Lung Injury Dear Professor Laffey, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The authors reply." (2020), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]