Faculty profile

Zhengping Jia

ResearcherUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Zhengping Jia

Researcher

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
12 publications in the last five years, latest in 2025.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 9 research grants (6 CIHR, 3 NSERC), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Electrophysiological Recording Immunostaining Astrocyte Behavior Tests Electrophysiology Genetic Manipulations Glutamate Receptors Imaging

Latest papers

Social memory maintenance relies on social interaction-induced proteolytic products of neuroligin 1.
Signal transduction and targeted therapy · 2025
Endocannabinoids inhibit contextual fear memory generalization via hippocampal GABAergic synaptic transmission.
Proceedings of the National Academy of Sciences of the United States of America · 2025
Neuroligin 1 Regulates Autistic-Like Repetitive Behavior through Modulating the Activity of Striatal D2 Receptor-Expressing Medium Spiny Neurons.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025

All 69 publications

Latest funding

Regulation of neuronal morphology and synapse development by NGPF2 signaling pathway
NSERC · 2023 · Principal investigator
$104,000
Regulation of social memory and synaptic plasticity by astrocytic neuroligin 3
CIHR · 2023 · Nominated PI
$1,093,950
Hormonal modulation of the gut-brain axis in necrotizing enterocolitis
CIHR · 2022 · Co-investigator
$826,200

All 10 grants and awards

69 publications.

Social memory maintenance relies on social interaction-induced proteolytic products of neuroligin 1.

Liu A, Li X, Zhuang M, Ren Q, Zhang J, Lv D, Wu M, Bian X, Zhu C, Yang X, Li M, Wang Y, Jia Z, Xie W

Signal transduction and targeted therapy2025

DOI: 10.1038/s41392-025-02467-6 PMID: 41276544

Endocannabinoids inhibit contextual fear memory generalization via hippocampal GABAergic synaptic transmission.

Ge Q, Zhang J, Huo Q, Yu J, Zheng Q, Qian Z, Wei C, Jiang T, Liu Y, Liu Z, Ren W, Sun Z, Jia Z, Han J

Proceedings of the National Academy of Sciences of the United States of America2025

DOI: 10.1073/pnas.2423974122 PMID: 40763027

Neuroligin 1 Regulates Autistic-Like Repetitive Behavior through Modulating the Activity of Striatal D2 Receptor-Expressing Medium Spiny Neurons.

Lv D, Liu A, Yi Z, Mu M, Wu M, Li X, Cao K, Liu R, Jia Z, Han J, Xie W

Advanced science (Weinheim, Baden-Wurttemberg, Germany)2025

DOI: 10.1002/advs.202410728 PMID: 39661696

Astrocytic neuroligin 3 regulates social memory and synaptic plasticity through adenosine signaling in male mice.

Dang R, Liu A, Zhou Y, Li X, Wu M, Cao K, Meng Y, Zhang H, Gan G, Xie W, Jia Z

Nature communications2024Senior author

DOI: 10.1038/s41467-024-52974-3 PMID: 39366972

An Irak1-Mecp2 tandem duplication mouse model for the study of MECP2 duplication syndrome.

Maino E, Scott O, Rizvi SZ, Chan WS, Visuvanathan S, Zablah YB, Li H, Sengar AS, Salter MW, Jia Z, Rossant J, Cohn RD, Gu B, Ivakine EA

Disease models & mechanisms2024

DOI: 10.1242/dmm.050528 PMID: 38881329

Novel Social Stimulation Ameliorates Memory Deficit in Alzheimer's Disease Model through Activating α-Secretase.

Ren Q, Wang S, Li J, Cao K, Zhuang M, Wu M, Geng J, Jia Z, Xie W, Liu A

The Journal of neuroscience : the official journal of the Society for Neuroscience2024

DOI: 10.1523/jneurosci.1689-23.2024 PMID: 38418221

Universal, label-free, single-molecule visualization of DNA origami nanodevices across biological samples using origamiFISH.

Wang WX, Douglas TR, Zhang H, Bhattacharya A, Rothenbroker M, Tang W, Sun Y, Jia Z, Muffat J, Li Y, Chou LYT

Nature nanotechnology2024

DOI: 10.1038/s41565-023-01449-5 PMID: 37500778

Small-molecule targeting AMPA-mediated excitotoxicity has therapeutic effects in mouse models for multiple sclerosis.

Zhai D, Yan S, Samsom J, Wang L, Su P, Jiang A, Zhang H, Jia Z, Wallach I, Heifets A, Zanato C, Tseng CC, Wong AHC, Greig IR, Liu F

Science advances2023

DOI: 10.1126/sciadv.adj6187 PMID: 38064562

Inhibition of Rac1 in ventral hippocampal excitatory neurons improves social recognition memory and synaptic plasticity.

Zhang H, Ben Zablah Y, Zhang H, Liu A, Gugustea R, Lee D, Luo X, Meng Y, Li S, Zhou C, Xin T, Jia Z

Frontiers in aging neuroscience2022Senior author

DOI: 10.3389/fnagi.2022.914491 PMID: 35936771

The omega-3 hydroxy fatty acid 7(S)-HDHA is a high-affinity PPARα ligand that regulates brain neuronal morphology.

Liu J, Sahin C, Ahmad S, Magomedova L, Zhang M, Jia Z, Metherel AH, Orellana A, Poda G, Bazinet RP, Attisano L, Cummins CL, Peng H, Krause HM

Science signaling2022

DOI: 10.1126/scisignal.abo1857 PMID: 35857636

Regulation of neuronal morphology and synapse development by NGPF2 signaling pathway

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Jia, Zhengping

Keywords: Actin cytoskeleton; Cultured neurons; Dendritic spine; Elelctrophysiology; LIM kinase, Cofilin; Mouse models; Neuronal morphology; Synapse; Synaptic proteins; Synaptogenesis

$104,000

Regulation of social memory and synaptic plasticity by astrocytic neuroligin 3

Nominated PICIHR2023Project Grant

Principal investigators: Jia, Zhengping

Keywords: Astrocyte; Behavior Tests; Electrophysiology; Genetic Manipulations; Glutamate Receptors; Imaging; Ltp; Neuroligin; Social Memory And Impairment; Synapse And Plasticity

$1,093,950

Hormonal modulation of the gut-brain axis in necrotizing enterocolitis

Co-investigatorCIHR2022Project Grant

Principal investigators: Pierro, Agostino

Keywords: Brain Injury; Glp Signaling; Intestinal Injury; Necrotizing Enterocolitis; Neonate; Prematurity

$826,200

Targeting specific domains of AMPA glutamate receptors in synaptic and cognitive impairments in Alzheimer's disease

Nominated PICIHR2019Project Grant

Principal investigators: Jia, Zhengping

Keywords: Alzheimer'S Disease; Animal Models; Behavior Test; Electrophysiological Recording; Glutamate Receptor; Immunostaining; Learning And Memory; Long-Term Depression; Long-Term Potentiation; Receptor Trafficking

$826,200

Canada Research Chair - Tier 1

Nominated PICIHR2018Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Jia, Zhengping

Keywords: Crc

$1,400,000

Molecular and synaptic mechanisms underlying social memory and its impairments in brain disorders: role of PAK signaling

Nominated PICIHR2017Project Grant

Principal investigators: Jia, Zhengping

Keywords: Behavioral Tests; Electrophysiological Recording; Immunostaining; Neurodevelopmental Disorder; Optogenetics; P21-Activated Kinase; Social Recognition Memory; Synaptic Transmission And Plasticity; Transgenic Mice

$979,200

Regulation of mammalian brain development by p21-activated kinase signaling pathways

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Jia, Zhengping

$240,000

Regulation of mammalian brain development by p21-activated kinases

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Jia, Zhengping

$140,000

Role of neuroligin/neurrexin trans-synaptic interaction in pre- and post-synaptic coupling during long-lasting synaptic plasticity

Nominated PICIHR2011China-Canada Joint Health Research Initiative

Principal investigators: Jia, Zhengping; Xie, Wei

Keywords: Biochemical Analysis; Cellular Imaging; Cultured Neurons; Drosophila; Electrophysiology; Hippocampal Slices; Mglur-Dependent Synaptic Plasticity; Neuroligin And Neurexin; Pre- And Post-Synaptic Coupling; Synaptic Transmission And Plasticity

$210,600

Molecular mechanisms coordinating structural and functional synaptic plasticity: role of GluA2/N-cadherin dependent Rho signaling

Nominated PICIHR2011Operating Grant

Principal investigators: Jia, Zhengping

Keywords: Dendritic Spine; Electrophysiology; Excitatory Synaptic Transmission And Plasticity; Genetically Altered Mice; Glutamate Receptors; Imaging; Learning And Memory; Mglur-Ltd; Pharmacological Perturbation; Rho Signaling

$939,720

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Zhengping Jia

Research

Latest papers

Latest funding

Social memory maintenance relies on social interaction-induced proteolytic products of neuroligin 1.

Endocannabinoids inhibit contextual fear memory generalization via hippocampal GABAergic synaptic transmission.

Neuroligin 1 Regulates Autistic-Like Repetitive Behavior through Modulating the Activity of Striatal D2 Receptor-Expressing Medium Spiny Neurons.

Astrocytic neuroligin 3 regulates social memory and synaptic plasticity through adenosine signaling in male mice.

An Irak1-Mecp2 tandem duplication mouse model for the study of MECP2 duplication syndrome.

Novel Social Stimulation Ameliorates Memory Deficit in Alzheimer's Disease Model through Activating &#x3b1;-Secretase.

Universal, label-free, single-molecule visualization of DNA origami nanodevices across biological samples using origamiFISH.

Small-molecule targeting AMPA-mediated excitotoxicity has therapeutic effects in mouse models for multiple sclerosis.

Inhibition of Rac1 in ventral hippocampal excitatory neurons improves social recognition memory and synaptic plasticity.

The omega-3 hydroxy fatty acid 7(S)-HDHA is a high-affinity PPAR&#x3b1; ligand that regulates brain neuronal morphology.

Regulation of neuronal morphology and synapse development by NGPF2 signaling pathway

Regulation of social memory and synaptic plasticity by astrocytic neuroligin 3

Hormonal modulation of the gut-brain axis in necrotizing enterocolitis

Targeting specific domains of AMPA glutamate receptors in synaptic and cognitive impairments in Alzheimer's disease

Canada Research Chair - Tier 1

Molecular and synaptic mechanisms underlying social memory and its impairments in brain disorders: role of PAK signaling

Regulation of mammalian brain development by p21-activated kinase signaling pathways

Regulation of mammalian brain development by p21-activated kinases

Role of neuroligin/neurrexin trans-synaptic interaction in pre- and post-synaptic coupling during long-lasting synaptic plasticity

Molecular mechanisms coordinating structural and functional synaptic plasticity: role of GluA2/N-cadherin dependent Rho signaling

Frequent collaborators

Xiao-Yan Wen

Fang Liu

Jim Hu

Lu-Yang Wang

Arturo Orellana

Armand Keating

Julien Muffat

Yun Li

Hui Peng

Shuzo Sugita

Ren-Ke Li

Liliana Attisano

Janet Rossant

Yu Sun

Li Zhang

Khosrow Adeli

Jose Perez Velazquez

Min Zhuo

Graham Collingridge

Kenichi Okamoto

Anmol Gupta

Maja Tarailo-Graovac

James Ellis

Michael Brudno

Novel Social Stimulation Ameliorates Memory Deficit in Alzheimer's Disease Model through Activating α-Secretase.

The omega-3 hydroxy fatty acid 7(S)-HDHA is a high-affinity PPARα ligand that regulates brain neuronal morphology.