Faculty profile

Mario Ostrowski

ResearcherMedicineUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Mario Ostrowski

Researcher

Medicine

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
24 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 23 research grants (23 CIHR), most recently in 2025.
Supervisor on 3 trainee awards (3 CIHR), most recently in 2012.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Hiv Tim-3 T Cell Covid-19 Antibody Dependent Enhancement B Cell Reperotire Correlates Of Protection Covid19

Latest papers

Modeling of longitudinal immune profiles reveals distinct immunogenic signatures following five COVID-19 vaccinations among people living with HIV.
Patterns (New York, N.Y.) · 2026
HIV superinfection reveals sequential reservoir reactivation and immune-driven rebound dynamics.
Journal of virology · 2026
5' leader defects drive persistent HIV-1 viremia on long-term ART.
Nature communications · 2026

All 71 publications

Latest funding

Enhancing CD8+T cell clearance of autologous HIV reservoirs
CIHR · 2025 · Nominated PI
$100,000
Combinatorial Design of RNA Vaccines for HIV Broadly Neutrazling Antibody Induction
CIHR · 2025 · Co-investigator
$1,147,500
Enhancing CD8+T cell clearance of autologous HIV reservoirs
CIHR · 2025 · Nominated PI
$615,826

All 40 grants and awards

71 publications.

Modeling of longitudinal immune profiles reveals distinct immunogenic signatures following five COVID-19 vaccinations among people living with HIV.

Korosec CS, Conway JM, Matveev VA, Ostrowski M, Heffernan JM, Ghaemi MS

Patterns (New York, N.Y.)2026

DOI: 10.1016/j.patter.2025.101474 PMID: 42028410

HIV superinfection reveals sequential reservoir reactivation and immune-driven rebound dynamics.

Omondi FH, Shahid A, Kinloch NN, Dong W, Duncan MC, Yaseen F, Barad E, Moran-Garcia N, Cabral da Silva A, Mysak V, Kirkby D, Ostrowski M, Lynch RM, Brumme CJ, Kovacs C, Jones RB, Lee GQ, Brumme ZL

Journal of virology2026

DOI: 10.1128/jvi.00473-26 PMID: 42429629

5' leader defects drive persistent HIV-1 viremia on long-term ART.

Box JR, Camilo-Contreras A, Dragoni F, Yue FY, Matveev V, Foley J, Zhang J, Mok YW, DeSousa M, Lai J, Mulcare Z, Bakewell Z, Poulin S, Chano F, Fortin C, Tremblay C, Blankson JN, Krishnan S, Weld ED, Basseth C, Hamill MM, Hoffmann CJ, Scully EP, Jones JL, Cox AL, El Atrouni W, Sha B, Siliciano JD, Siliciano RF, Reinhard R, Gunst JD, Ostrowski M, Maldarelli F, Kovacs C, Simonetti FR

Nature communications2026

DOI: 10.1038/s41467-026-73475-5 PMID: 42259781

Engineering Komagataella phaffii for secreted and surface-displayed production of SARS-CoV-2 receptor-binding domain and its immunogenicity evaluation.

Dmytruk K, Dmytruk O, Semkiv M, Vasylyshyn R, Fayura L, Gaffke L, Podlacha M, Cyske Z, Pierzynowska K, Budylowski P, Ostrowski M, Wegrzyn G, Sibirny A

Microbial cell factories2026

DOI: 10.1186/s12934-026-03043-5 PMID: 42277856

Vaccination against SARS-CoV-2 provides low-level cross-protection against common cold coronaviruses in mouse and non-human primate animal models.

Naghibosadat M, Babuadze GG, Pei Y, Hurst J, Salvant E, Gaete K, Biondi M, Moloo B, Goldstein A, Avery S, Ma K, Pietraszek A, Wootton SK, Alhaboub A, Martin B, Mubareka S, Corredor J, Sultana A, Adeekoa A, Budylowski P, Ostrowski M, Chao J, Nagy E, Kozak R

Journal of virology2025

DOI: 10.1128/jvi.01390-24 PMID: 39817773

mRNA vaccine-induced SARS-CoV-2 spike-specific IFN-γ and IL-2 T-cell responses are predictive of serological neutralization and are transiently enhanced by pre-existing cross-reactive immunity.

Samaan P, Korosec CS, Budylowski P, Chau SLL, Pasculescu A, Qi F, Delgado-Brand M, Tursun TR, Mailhot G, Dayam RM, Arnold CR, Langlois M-A, Mendoza J, Morningstar T, Law R, Mihelic E, Sheikh-Mohamed S, Cao EY, Paul N, Patel A, de Launay KQ, Boyd JM, Takaoka A, Colwill K, Matveev V, Yue FY, McGeer A, Straus S, Gingras A-C, Heffernen JM, Ostrowski M

Journal of virology2025Senior author

DOI: 10.1128/jvi.01685-24 PMID: 39887249

Rapid In Vivo Screening of Monoclonal Antibody Cocktails Using Hydrodynamic Delivery of DNA-Encoded Modified Antibodies.

Fausther-Bovendo H, Babuadze GG, Ivanciuc T, Kalveram B, Qu Y, Choi J, McGeer A, Ostrowski M, Mubareka S, Patel A, Garofalo RP, Kozak R, Kobinger GP

Biomedicines2025

DOI: 10.3390/biomedicines13030637 PMID: 40149613

A Significant Contribution of the Classical Pathway of Complement in SARS-CoV-2 Neutralization of Convalescent and Vaccinee Sera.

Budylowski P, Chau SLL, Banerjee A, Guvenc F, Samson R, Hu Q, Fiddes L, Seifried L, Chao G, Buchholz M

Journal of Immunology20244 citationsSenior author

DOI: 10.4049/jimmunol.2300320

Comparison of a SARS-CoV-2 mRNA booster immunization containing additional antigens to a spike-based mRNA vaccine against Omicron BA.5 infection in hACE2 mice.

Hurst JR, Naghibosadat M, Budowski P, Liu J, Samaan P, Budiman F, Kurtesi A, Qi F, Menon H, Krishnan R, Abioye J, Gingras AC, Ostrowski M, Orozco NM, Kozak RA

PloS one2024

DOI: 10.1371/journal.pone.0314061 PMID: 39625929

A T cell receptor specific for an HLA-A*03:01-restricted epitope in the endogenous retrovirus ERV-K-Env exhibits limited recognition of its cognate epitope.

Grundy EE, Shaw LC, Wang L, Lee AV, Argueta JC, Powell DJ, Ostrowski M, Jones RB, Cruz CRY, Gordish-Dressman H, Chappell NP, Bollard CM, Chiappinelli KB

Mobile DNA2024

DOI: 10.1186/s13100-024-00333-w PMID: 39385229

Enhancing CD8+T cell clearance of autologous HIV reservoirs

Nominated PICIHR2025Project Grant - Priority Announcement: HIV/AIDS and STBBI

Principal investigators: Ostrowski, Mario A

Keywords: Ceacam1; Checkpoint; Cure; Cytotoxic Cd8 T Cell, Or Ctl; Hiv; Hiv Nef; Hiv Reservoir; T Cell; Tim-3

$100,000

Combinatorial Design of RNA Vaccines for HIV Broadly Neutrazling Antibody Induction

Co-investigatorCIHR2025Project Grant

Principal investigators: Li, Bowen

Keywords: Broadly Neutralizing Antibodies; Circular Rna; Hiv; Infectious Diseases; Lipid Nanoparticle; Rna Vaccines

$1,147,500

Enhancing CD8+T cell clearance of autologous HIV reservoirs

Nominated PICIHR2025Project Grant

Principal investigators: Ostrowski, Mario A

Keywords: Ceacam1; Checkpoint; Cure; Cytotoxic Cd8 T Cell, Or Ctl; Hiv; Hiv Nef; Hiv Reservoir; T Cell; Tim-3

$615,826

CAMP 2.0 An Ongoing Community-based Interdisciplinary Model for Mpox pandemic Preparedness

Co-investigatorCIHR2025Team Grant: Monkeypox Rapid Research Response - Extension

Principal investigators: Tan, Darrell H; Adebajo, Sylvia; Audu, Rosemary; Chan, Adrienne; DAODU, OLUWAFEMI B; Klein, Marina B; Kozak, Robert A; Kwong, Jeffrey C; McGeer, Allison J; Mishra, Sharmistha; Okpokoro, Evaezi; Olufadewa, Isaac I; Walmsley, Sharon L

Keywords: Clinical Trial; Epidemiology; Mathematical Modeling; Prospective Cohort; Vaccine Effectiveness; Veterinary Medecine; Virology

$350,000

Deciphering Long Covid - Investigating Immune Dysfunction and Novel Pathways

Nominated PICIHR2024Project Grant - PA: Pandemic Preparedness and Health Emergencies Research

Principal investigators: Ostrowski, Mario A

Keywords: B Cell; Covid-19; Cytokine; Ebv; Immunity; Long Covid; Sars-Cov-2; T Cell

$100,000

Combinatorial Design of Multiplexed mRNA Vaccines for HIV Broadly Neutralizing Antibody Induction

Co-investigatorCIHR2022Project Grant - Priority Announcement: HIV/AIDS and STBBI

Principal investigators: Li, Bowen

Keywords: Biomaterials; Drug Delivery; Hiv Vaccine; Lipid Nanoparticles; Mrna Vaccine; Nonviral Gene Delivery

$100,000

Canada-Africa Monkeypox Partnership (CAMP): Characterizing transmission dynamics and evaluating medical countermeasures to inform the clinical and public health response to Mpox

Co-investigatorCIHR2022Team Grant: Monkeypox Rapid Research Response

Keywords: Clinical Trial; Epidemiology; Mathematical Modeling; Prospective Cohort; Vaccine Effectiveness; Veterinary Medicine; Virology

$2,000,000

Mathematical mobilization of vaccine development

Co-investigatorSSHRC2021New Frontiers in Research Fund - Exploration

Principal investigators: Heffernan, Jane

Keywords: mathematical immunology mathematical biology vaccine development adaptive immunity immune response vaccine adjuvants sensitivity analysis in-vitro and in-vivo machine learning

$250,000

COVID-19 Variant Network - Towards a comprehensive understanding of adaptive immunity to SARS-CoV-2

Principal investigatorCIHR2021Operating Grant: SARS-CoV-2 variants supplement stream 2

Principal investigators: Watts, Tania H; Ehrhardt, Rudolf A; Gommerman, Jennifer L; Martin, Alberto; Ostrowski, Mario A

Keywords: Antibody Dependent Enhancement; B Cell Reperotire; Correlates Of Protection; Covid19; Immune Memory; Neutralizing Antibody; Rna-Seq; Saliva Iga; T Cell Epitopes; Vaccines

$100,000

COVID-19 Variant Supplement - RIsk of environmental Surface and air Contamination in COVID19 (RISC-COV)

Principal investigatorCIHR2021Operating Grant: SARS-CoV-2 variants supplement stream 1

Principal investigators: McGeer, Allison J; Bryce, Elizabeth; Mubareka, Samira; Ostrowski, Mario A; Wong, Titus

Keywords: Bioaerosol; Clinical And Epidemiologic Characteristics; Covid-19

$49,928

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Mario Ostrowski

Research

Latest papers

Latest funding

Modeling of longitudinal immune profiles reveals distinct immunogenic signatures following five COVID-19 vaccinations among people living with HIV.

HIV superinfection reveals sequential reservoir reactivation and immune-driven rebound dynamics.

5' leader defects drive persistent HIV-1 viremia on long-term ART.

Engineering Komagataella phaffii for secreted and surface-displayed production of SARS-CoV-2 receptor-binding domain and its immunogenicity evaluation.

Vaccination against SARS-CoV-2 provides low-level cross-protection against common cold coronaviruses in mouse and non-human primate animal models.

mRNA vaccine-induced SARS-CoV-2 spike-specific IFN-&#x3b3; and IL-2 T-cell responses are predictive of serological neutralization and are transiently enhanced by pre-existing cross-reactive immunity.

Rapid In Vivo Screening of Monoclonal Antibody Cocktails Using Hydrodynamic Delivery of DNA-Encoded Modified Antibodies.

A Significant Contribution of the Classical Pathway of Complement in SARS-CoV-2 Neutralization of Convalescent and Vaccinee Sera.

Comparison of a SARS-CoV-2 mRNA booster immunization containing additional antigens to a spike-based mRNA vaccine against Omicron BA.5 infection in hACE2 mice.

A T cell receptor specific for an HLA-A*03:01-restricted epitope in the endogenous retrovirus ERV-K-Env exhibits limited recognition of its cognate epitope.

Mathematical mobilization of vaccine development

Frequent collaborators

Rupert Kaul

Samira Mubareka

Jun Liu

Anne-Claude Gingras

Jean-Pierre Routy

Jean-Pierre Routy

Sharon Walmsley

Mohammad-Ali Jenabian

Mohammad-Ali Jenabian

Allison McGeer

Mark Hull

Robert Kozak

Mohammad-Ali Jenabian

Mona Loutfy

Chao Wang

Catharine Chambers

Jennifer Gommerman

Nicolas Chomont

Shari Margolese

Hasina Samji

Hasina Samji

Nicolas Chomont

Janet Raboud

Curtis Cooper

Alberto Martin

Karen Mossman

Sharmistha Mishra

Ron Rosenes

Sonya MacParland

Lena Serghides

Madeleine Durand

James Rini

Igor Stagljar

Wangari Tharao

Jason Brophy

Andrew Doxey

Matthew S Miller

Frank Sicheri

Andrew McArthur

Tak Mak

mRNA vaccine-induced SARS-CoV-2 spike-specific IFN-γ and IL-2 T-cell responses are predictive of serological neutralization and are transiently enhanced by pre-existing cross-reactive immunity.