Faculty profile

Reina Bendayan

Back to faculty

ProfessorPharmaceutical SciencesUniversity of Toronto

Reina Bendayan

Professor

Pharmaceutical Sciences

Leslie Dan Faculty of Pharmacy

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
17 publications in the last five years, latest in 2026.
Senior (last) author on 15 recent papers, a sign of leading a research group.
Principal investigator on 9 research grants (6 CIHR, 3 NSERC), most recently in 2023.
Supervisor on 5 trainee awards (5 CIHR), most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Education

Pharm.D., Clinical Pharmacy
Diploma, Hospital Pharmacy Residency
Bachelor's Pharmacy

Profiles and links

University Profile Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Protein trafficking in cell biology Virology Molecular neuroscience Neuroinflammation

Latest papers

Therapeutic potential of a novel PPARγ agonist in a mouse model of HIV-associated neurocognitive impairment.
Brain, behavior, and immunity · 2026 · senior author
Protective effects of pyrroloquinoline quinone in CNS disorders.
The Journal of nutritional biochemistry · 2026 · senior author
Bictegravir decreases expression of system L-amino acid transporters and inhibits leucine uptake activity in a human placental cell line.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025

All 86 publications

Latest funding

Investigating the in utero toxicity of Anti-HIV drugs across Placental-Fetal Barriers
CIHR · 2024 · Supervisor
$120,000
Flow Cytometer for Advanced Cell marker Analysis
NSERC · 2023 · Principal investigator
$150,000
Delivery of Antiretroviral Drugs across Placental-Fetal Barriers: Relevance to in Utero Drug Toxicity
CIHR · 2023 · Nominated PI
$960,076

All 18 grants and awards

86 publications.

Therapeutic potential of a novel PPARγ agonist in a mouse model of HIV-associated neurocognitive impairment.

Titus C, Hoque MT, Bonin R, Bendayan R

Brain, behavior, and immunity2026Senior author

DOI: 10.1016/j.bbi.2026.106981 PMID: 42648454

Protective effects of pyrroloquinoline quinone in CNS disorders.

Aboulhassane S, Sangha V, Bendayan R

The Journal of nutritional biochemistry2026Senior author

DOI: 10.1016/j.jnutbio.2025.110178 PMID: 41237996

Bictegravir decreases expression of system L-amino acid transporters and inhibits leucine uptake activity in a human placental cell line.

Rasna RS, Dunk CE, Hoque MT, Bendayan R, Serghides L

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2025

DOI: 10.1016/j.biopha.2025.118291 PMID: 40570710

Neuroprotective role of pyrroloquinoline quinone in folate deficiency-induced blood-brain barrier disruption.

Aboulhassane S, Sangha V, Hoque MT, Bendayan R

Fluids and barriers of the CNS2025Senior author

DOI: 10.1186/s12987-025-00689-y PMID: 40696390

Dolutegravir Inhibits Autophagy In Vitro in a Mouse Blood-Brain Barrier Model.

Huang C, Qu QR, Bendayan R

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2025Senior author

DOI: 10.1096/fj.202500568rr PMID: 40540247

Dolutegravir induces endoplasmic reticulum stress at the blood-brain barrier.

Huang C, Qu QR, Hoque MT, Bendayan R

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2025Senior author

DOI: 10.1096/fj.202402677rr PMID: 39985305

Regulation of folate transport at the mouse arachnoid barrier.

Sangha V, Aboulhassane S, Bendayan R

Fluids and barriers of the CNS2024Senior author

DOI: 10.1186/s12987-024-00566-0 PMID: 39192328

Antiretroviral drug dolutegravir induces inflammation at the mouse brain barriers.

Huang C, Hoque MT, Qu QR, Henderson J, Bendayan R

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2024Senior author

DOI: 10.1096/fj.202400558r PMID: 38982638

Low-dose daily folic acid (400 μg) supplementation does not affect regulation of folate transporters found present throughout the terminal ileum and colon of humans: a randomized clinical trial.

Farrell CC, Khanna S, Hoque MT, Plaga A, Basset N, Syed I, Biouss G, Aufreiter S, Marcon N, Bendayan R, Kim YI, O'Connor DL

The American journal of clinical nutrition2024

DOI: 10.1016/j.ajcnut.2023.12.018 PMID: 38157986

PPAR agonists for the treatment of neuroinflammatory diseases.

Titus C, Hoque MT, Bendayan R

Trends in pharmacological sciences2024Senior author

DOI: 10.1016/j.tips.2023.11.004 PMID: 38065777

Investigating the in utero toxicity of Anti-HIV drugs across Placental-Fetal Barriers

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Bennett, Teresa M

Keywords: Antiretroviral Drugs; Drug Transporters And Metabolic Enzymes; Fetal Health; Folate Deficiency; Hiv; In Utero Toxicities; Neural Tube Defects; Placenta; Preterm Birth

$120,000

Flow Cytometer for Advanced Cell marker Analysis

Principal investigatorNSERC2023Research Tools and Instruments

Principal investigators: Bendayan, Reina

$150,000

Delivery of Antiretroviral Drugs across Placental-Fetal Barriers: Relevance to in Utero Drug Toxicity

Nominated PICIHR2023Project Grant

Principal investigators: Bendayan, Reina; Serghides, Lena

Keywords: Drug Metabolic Enzymes; Drug Transporters; Fetal Drug Efficacy; Fetal Drug Toxicity; Hiv Drugs-Pharmacokinetics; Hiv Infection; Placenta- Fetal Drug Delivery; Placental-Fetal Barriers; Pregnancy; Sex Differences

$960,076

Predicting the Optimal Clinical Dosing Regimen for Promising COVID-19 Drugs

SupervisorCIHR2022Canada Graduate Scholarships - Michael Smith Foreign Study Supplements

Principal investigators: Nwabufo, Chukwunonso K

Keywords: Covid 19; Drug; Regimen

$6,000

HIV antiretrovirals and placenta dysfunction - identifying the mechanisms leading to poor fetal growth

Co-investigatorCIHR2021Project Grant

Principal investigators: Serghides, Lena

Keywords: Angiogenic; Antiretroviral Therapy; Birth Outcomes; Hiv; Metabolic Function; Mouse Model; Placenta; Placenta Explant; Pregnancy

$925,650

Improving the Clinical Efficacy and Safety Profile of Repurposed COVID-19 Drugs

SupervisorCIHR2021Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Nwabufo, Chukwunonso K

Keywords: Chronic Obstructive Pulmonary Disease; Coronavirus Disease 2019; Covid-19-Associated Neurocognitive Dysfunction; Disease - Drug Interactions; Drug - Drug Interactions; Drug Metabolism And Disposition; Drug Metabolizing Enzymes; Membrane-Associated Drug Transporters; Physiologically-Based Pharmacokinetic Modeling; Repurposed Drugs

$105,000

Regulatory Mechanisms of Folate Transporters by Transcription Factors in the Brain

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Bendayan, Reina

$132,000

Novel Pharmacological Approaches for the Treatment of HIV-Associated Neurological Complications

Nominated PICIHR2020Project Grant

Principal investigators: Bendayan, Reina

Keywords: Animal Behavioural Studies; Brain Inflammatory Markers; Ecohiv Mouse Model; Hiv Neurocognitive Disorders (Hand); Hiv-1 Infection; Hiv-Associated Brain Inflammation; Peroxisome Proliferator-Activated Receptors (Ppars); Pharmacokinetic Studies; Pharmacological Treatment Of Hand; Ppar Gamma Novel Agonists

$673,200

Does fetal sex influence in utero HIV antiretroviral toxicity?

Principal investigatorCIHR2017Catalyst Grant: Sex as a Variable in Biomedical Research

Principal investigators: Serghides, Lena; Bendayan, Reina

Keywords: Drug Disposition; Drug Transporters; Fetal Brain; Hiv Antiretrovirals; In Utero Exposure; Metabolic Enzymes; Pregnancy

$150,000

Development of the next generation ultrasound therapy

Co-investigatorCIHR2016Foundation Grant

Principal investigators: Hynynen, Kullervo H

Keywords: Bioeffects; Image Guided Interventions; Therapy; Ultrasound

$2,273,295

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

Something wrong or missing on this profile? Suggest a correction

Reina Bendayan

Research

Latest papers

Latest funding

Therapeutic potential of a novel PPAR&#x3b3; agonist in a mouse model of HIV-associated neurocognitive impairment.

Protective effects of pyrroloquinoline quinone in CNS disorders.

Bictegravir decreases expression of system L-amino acid transporters and inhibits leucine uptake activity in a human placental cell line.

Neuroprotective role of pyrroloquinoline quinone in folate deficiency-induced blood-brain barrier disruption.

Dolutegravir Inhibits Autophagy In&#xa0;Vitro in a Mouse Blood-Brain Barrier Model.

Dolutegravir induces endoplasmic reticulum stress at the blood-brain barrier.

Regulation of folate transport at the mouse arachnoid barrier.

Antiretroviral drug dolutegravir induces inflammation at the mouse brain barriers.

Low-dose daily folic acid (400 &#x3bc;g) supplementation does not affect regulation of folate transporters found present throughout the terminal ileum and colon of humans: a randomized clinical trial.

PPAR agonists for the treatment of neuroinflammatory diseases.

Flow Cytometer for Advanced Cell marker Analysis

Regulatory Mechanisms of Folate Transporters by Transcription Factors in the Brain

Frequent collaborators

Jean-Pierre Routy

Lena Serghides

Christine Allen

Rupert Kaul

Mohammad-Ali Jenabian

Jeffrey Henderson

Mohammad-Ali Jenabian

Kullervo Hynynen

Nicolas Chomont

Young-In Kim

Sharon Walmsley

Mohammad-Ali Jenabian

Nicolas Chomont

Robert Bonin

Samira Mubareka

John F Valliant

Petronela Ancuta

Jean-Pierre Routy

Therapeutic potential of a novel PPARγ agonist in a mouse model of HIV-associated neurocognitive impairment.

Dolutegravir Inhibits Autophagy In Vitro in a Mouse Blood-Brain Barrier Model.

Low-dose daily folic acid (400 μg) supplementation does not affect regulation of folate transporters found present throughout the terminal ileum and colon of humans: a randomized clinical trial.