Faculty profile
Madeline Hayes
Back to facultyThis profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.
Research
Latest papers
Modeling human brain tumors in flies, worms, and zebrafish: From proof of principle to novel therapeutic targets.
Neuro-oncology · 2021
ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease.
Nature communications · 2014 · first author
Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/β-catenin-dependent cell fate decisions during vertebrate development.
Development (Cambridge, England) · 2013 · first author
Latest funding
- $1,044,225
Mechanisms of Metastatic Rhabdomyosarcoma
CIHR · 2025 · Nominated PI
- $120,000
Defining the Role of Patient-Specific CHEK2 Genetic Variants in High-Risk Neuroblastoma
CIHR · 2025 · Supervisor
- $12,500
In vivo cell dynamics along the muscle differentiation hierarchy
NSERC · 2023 · Principal investigator
5 publications.
Modeling human brain tumors in flies, worms, and zebrafish: From proof of principle to novel therapeutic targets.
Shahzad U, Taccone MS, Kumar SA, Okura H, Krumholtz S, Ishida J, Mine C, Gouveia K, Edgar J, Smith C, Hayes M, Huang X, Derry WB, Taylor MD, Rutka JT
ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease.
Hayes M, Gao X, Yu LX, Paria N, Henkelman RM, Wise CA, Ciruna B
Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/β-catenin-dependent cell fate decisions during vertebrate development.
Hayes M, Naito M, Daulat A, Angers S, Ciruna B
Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function.
Persaud A, Alberts P, Hayes M, Guettler S, Clarke I, Sicheri F, Dirks P, Ciruna B, Rotin D
Depletion of plasma membrane PtdIns(4,5)P2 reveals essential roles for phosphoinositides in flagellar biogenesis.
Wei HC, Rollins J, Fabian L, Hayes M, Polevoy G, Bazinet C, Brill JA
Mechanisms of Metastatic Rhabdomyosarcoma
Principal investigators: Hayes, Madeline
Keywords: Drug Resistance; In Vivo Drug Discovery; Metastasis; Pediatric Cancer; Relapse; Rhabdomyosarcoma; Zebrafish
Defining the Role of Patient-Specific CHEK2 Genetic Variants in High-Risk Neuroblastoma
Principal investigators: Xiong, Xueting
Keywords: Dna Damage; Immunofluorescence; Neuroblastoma; Precision Medicine; Rna Sequencing; Targeted Inhibitors; Treatment Resistance; Zebrafish
In vivo cell dynamics along the muscle differentiation hierarchy
Principal investigators: Hayes, Madeline
In vivo cell dynamics along the muscle differentiation hierarchy
Principal investigators: Hayes, Madeline
Keywords: muscle stem cells; self-renewal; differentiation; zebrafish; live imaging; microenvironment; cell fate specification
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Frank Sicheri and Daniela Rotin: 3 shared papers
- Brian Ciruna and Madeline Hayes: 3 shared papers
- Frank Sicheri and Stephane Angers: 2 shared papers
- Stephane Angers and Xi Huang: 2 shared papers
- Frank Sicheri and Brian Ciruna: 1 shared paper
- Frank Sicheri and Madeline Hayes: 1 shared paper
- Stephane Angers and Brian Ciruna: 1 shared paper
- Stephane Angers and Madeline Hayes: 1 shared paper
- Daniela Rotin and Brian Ciruna: 1 shared paper
- Daniela Rotin and Madeline Hayes: 1 shared paper
- Brian Ciruna and Xi Huang: 1 shared paper
- Xi Huang and Madeline Hayes: 1 shared paper
- Developmental and Stem Cell Biology
- Department of Biochemistry
- Lunenfeld-Tanenbaum Research Institute
- Terrence Donnelly Centre for Cellular and Biomolecular Research
- Developmental & Stem Cell Biology
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Brian Ciruna
Developmental and Stem Cell Biology
3 shared papers, latest 2014
Frank Sicheri
Lunenfeld-Tanenbaum Research Institute
1 shared papers, latest 2011
Stephane Angers
Terrence Donnelly Centre for Cellular and Biomolecular Research
1 shared papers, latest 2013
Daniela Rotin
Department of Biochemistry
1 shared papers, latest 2011
Xi Huang
Developmental & Stem Cell Biology
1 shared papers, latest 2021
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