Faculty profile

Stephane Angers

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ProfessorTerrence Donnelly Centre for Cellular and Biomolecular ResearchUniversity of Toronto

Stephane Angers

Professor

Terrence Donnelly Centre for Cellular and Biomolecular Research

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Scholar ORCID

Supervision signals

Professors usually supervise graduate students in their department's programs.
47 publications in the last five years, latest in 2026.
Senior (last) author on 12 recent papers, a sign of leading a research group.
Principal investigator on 11 research grants (10 CIHR, 1 NSERC), most recently in 2026.
Supervisor on 1 trainee award (1 CIHR), most recently in 2021.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

144

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Education

Profiles and links

University Profile Personal Website Google Scholar iDORCID

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Wnt Crispr Glioblastoma Synthetic Antibodies Functional Genomics Targeted Therapy Antibody Blood Brain

Latest papers

Glioblastoma stem cell growth requires DOT1L-MED23 control of enhancer accessibility.
Cell reports · 2026
A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increasing PDGFB signaling.
bioRxiv : the preprint server for biology · 2026
The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding "ZZ" domain.
Genetics · 2026

All 99 publications

Latest funding

Restoring Endothelial Barrier Function in Cerebral Cavernous Malformations (CCM) with an FZD4-LRP6 Wnt Surrogate.
CIHR · 2026 · Nominated PI
$1,021,276
Functional Genomic Characterization of Glioblastoma Stem Cell state determinants
CIHR · 2026 · Nominated PI
$1,021,276
Dissecting the determinants and dynamics of cellular states promoting glioma evolution
CIHR · 2022 · Co-investigator
$1,040,400

All 16 grants and awards

99 publications.

Glioblastoma stem cell growth requires DOT1L-MED23 control of enhancer accessibility.

Assaf S, Bozek DA, Heemskerk K, Banks A, MacLeod G, Bahia RK, Cutts E, Johnston MJ, Cseh O, Angers S, Nikolic A, Gallo M, Luchman HA, Weiss S

Cell reports2026

DOI: 10.1016/j.celrep.2026.117647 PMID: 42397736

A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increasing PDGFB signaling.

Levey J, Howe M, Douglas K, Odame E, Rajvansh N, Jo HN, Zhang L, Chung C, Roehrich H, Seshagiri S, Angers S, Chen Z, Junge HJ

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.03.13.711629 PMID: 41890033

The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding "ZZ" domain.

Low TCH, Luo H, Weerasooriya C, Wang Z, Lin S, Karaiskakis A, Angers S, Smibert CA, Lipshitz HD

Genetics2026

DOI: 10.1093/genetics/iyaf241 PMID: 41206465

Epigenetic maintenance of the injury response state in glioblastoma stem cells.

Molaei F, MacLeod G, Haider S, Tiffany A, Oteng FM, Berman JM, Skirzynska A, Shoichet MS, Schramek D, Dirks PB, Angers S

Neuro-oncology advances2026Senior author

DOI: 10.1093/noajnl/vdag002 PMID: 41756760

Clarifying Frizzled 2 function in development through genetically validated mouse models.

Michalski MN, Diegel CR, Zhong ZA, Marshall ME, Foxa Wiartalla GE, Stevens PD, Suino-Powell K, Blazer LL, Adams JJ, Melcher K, Sidhu SS, Angers S, Williams BO

Disease models & mechanisms2026

DOI: 10.1242/dmm.052410 PMID: 42290195

Wnt Pathway Agonism as a Therapeutic Strategy for Retinal Vascular Diseases: A Narrative Review of Evidence to Date.

Angers S, Wykoff CC, Antonetti DA, Junge HJ, Nudleman E, Nagiel A, Schlottmann PG, D'Amico DJ, Prenner J, Guyer DR, Miller CG, Baker K, Stephens P, Henry E, Rekers H, Adamis AP, Ng YSE

Ophthalmology and therapy2026First author

DOI: 10.1007/s40123-026-01476-0 PMID: 42593649

Wnt-dependent Frizzled clustering is required for Dishevelled phosphorylation but insufficient for β-catenin stabilization.

Moldaver S, Thibeault PE, Robitaille M, Au A, Lin S, MacLeod G, Junge HJ, Gammons MV, Yip CM, Angers S

Science signaling2026Senior author

DOI: 10.1126/scisignal.aec0204 PMID: 41945658

PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites

Yadav M, AlQazzaz MA, Ciamponi FE, Ho JC, Maron MI, Sababi AM, MacLeod G, Ahmadi M, Bullivant G, Tano V

Nucleic Acids Research (NAR)20254 citations

DOI: 10.1093/nar/gkaf347

Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation

Chidiac R, Yang A, Kubarakos E, Mikolajewicz N, Han H, Almeida MP, Thibeault PE, Lin S, MacLeod G, Gratton J-P

Stem Cell Reports20253 citationsSenior author

DOI: 10.1016/j.stemcr.2024.102391

mRNA decay pre-complex assembly drives timely cell-state transitions during differentiation.

Komori H, Rastogi G, Bugay JP, Luo H, Lin S, Angers S, Smibert CA, Lipshitz HD, Lee CY

Cell reports2025

DOI: 10.1016/j.celrep.2024.115138 PMID: 39739530

Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Stephane Angers

Research

Latest papers

Latest funding

Glioblastoma stem cell growth requires DOT1L-MED23 control of enhancer accessibility.

A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increasing PDGFB signaling.

The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding "ZZ" domain.

Epigenetic maintenance of the injury response state in glioblastoma stem cells.

Clarifying Frizzled 2 function in development through genetically validated mouse models.

Wnt Pathway Agonism as a Therapeutic Strategy for Retinal Vascular Diseases: A Narrative Review of Evidence to Date.

Wnt-dependent Frizzled clustering is required for Dishevelled phosphorylation but insufficient for &#x3b2;-catenin stabilization.

PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites

Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation

mRNA decay pre-complex assembly drives timely cell-state transitions during differentiation.

Frequent collaborators

Jason Moffat

Mathieu Lupien

Samuel Weiss

Daniel Schramek

Chi-Chung Hui

Mark Bernstein

Sylvain Meloche

Daniel Durocher

Anne-Claude Gingras

Mohan Babu

Igor Stagljar

Igor Jurisica

Ali Salahpour

Sachdev Sidhu

Benjamin Haibe-Kains

Sunit Das

Jean-Philippe Gratton

Ivan Topisirovic

Xi Huang

Vijay Ramaswamy

Frank Sicheri

Sheila Singh

Ray Truant

Hong Han

Uri Tabori

Wnt-dependent Frizzled clustering is required for Dishevelled phosphorylation but insufficient for β-catenin stabilization.