Research
Read how they describe their research on their University of Toronto profile.
Latest papers
Enantioselective protein affinity selection mass spectrometry (E-ASMS).
Nature communications · 2025
Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space.
bioRxiv : the preprint server for biology · 2025
Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS).
bioRxiv : the preprint server for biology · 2025
Latest funding
- $12,500
Investigation of structure function relationships of HEAT repeat proteins
NSERC · 2024 · Principal investigator
- $46,000
Investigation of structure function relationships of HEAT repeat proteins
NSERC · 2024 · Principal investigator
- $963,900
Macrocyclic Peptides to Uncover Huntington Disease Biology
CIHR · 2024 · Nominated PI
8 publications.
Enantioselective protein affinity selection mass spectrometry (E-ASMS).
Wang X, Sun J, Ahmad S, Yang D, Li F, Chan UH, Zeng H, Simoben CV, Green SR, Silva M, Houliston S, Dong A, Bolotokova A, Gibson E, Kutera M, Ghiabi P, Kondratov I, Matviyuk T, Chuprina A, Mavridi D, Lenz C, Joerger AC, Brown BD, Heath RB, Yue WW, Robbie LK, Beyett TS, Müller S, Knapp S, Owen DR, Harding R, Schapira M, Brown PJ, Santhakumar V, Ackloo S, Arrowsmith CH, Edwards AM, Peng H, Halabelian L
Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space.
Ban F, Ravichandran R, Correy GJ, Herasymenko O, Silva M, Ackloo S, Bolotokova A, Chau I, Gibson E, Harding R, Hutchinson A, Loppnau P, Fraser JS, Schapira M, Cherkasov A, Gentile F
Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS).
Wang X, Sun J, Ahmad S, Yang D, Li F, Chan UH, Zeng H, Simoben CV, Green SR, Silva M, Houliston S, Dong A, Bolotokova A, Gibson E, Kutera M, Ghiabi P, Kondratov I, Matviyuk T, Chuprina A, Mavridi D, Lenz C, Joerger AC, Brown BD, Heath RB, Yue WW, Robbie LK, Beyett TS, Müller S, Knapp S, Harding R, Schapira M, Brown PJ, Santhakumar V, Ackloo S, Arrowsmith CH, Edwards AM, Peng H, Halabelian L
Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.
Szewczyk MM, Ishikawa Y, Organ S, Sakai N, Li F, Halabelian L, Ackloo S, Couzens AL, Eram M, Dilworth D, Fukushi H, Harding R, Dela Seña CC, Sugo T, Hayashi K, McLeod D, Zepeda C, Aman A, Sánchez-Osuna M, Bonneil E, Takagi S, Al-Awar R, Tyers M, Richard S, Takizawa M, Gingras AC, Arrowsmith CH, Vedadi M, Brown PJ, Nara H, Barsyte-Lovejoy D
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.
Szewczyk MM, Ishikawa Y, Organ S, Sakai N, Li F, Halabelian L, Ackloo S, Couzens AL, Eram M, Dilworth D, Fukushi H, Harding R, Dela Seña CC, Sugo T, Hayashi K, McLeod D, Zepeda C, Aman A, Sánchez-Osuna M, Bonneil E, Takagi S, Al-Awar R, Tyers M, Richard S, Takizawa M, Gingras AC, Arrowsmith CH, Vedadi M, Brown PJ, Nara H, Barsyte-Lovejoy D
Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Zhang H, Zhou B, Qin S, Xu J, Harding R, Tempel W, Nayak V, Li Y, Loppnau P, Dou Y, Min J
The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear.
Zhang Q, Wang Z, Hou F, Harding R, Huang X, Dong A, Walker JR, Tong Y
Structural Basis of the Recruitment of Ubiquitin-specific Protease USP15 by Spliceosome Recycling Factor SART3.
Zhang Q, Harding R, Hou F, Dong A, Walker JR, Bteich J, Tong Y
Investigation of structure function relationships of HEAT repeat proteins
Principal investigators: Harding, Rachel
Keywords: protein structure-function; protein interactions; heat repeat; scaffold proteins; macromolecular assemblies; structural biology
Investigation of structure function relationships of HEAT repeat proteins
Principal investigators: Harding, Rachel
Keywords: protein structure-function; protein interactions; heat repeat; scaffold proteins; macromolecular assemblies; structural biology
Macrocyclic Peptides to Uncover Huntington Disease Biology
Principal investigators: Harding, Rachel J
Keywords: Chemical Biology; Huntington'S Disease; Proximity Pharmacology; Structure-Function
A pan-Canadian chemical library to explore uncharted chemistry space for drug discovery
Principal investigators: Schapira, Matthieu
Keywords: Artificial Intelligence; Biophysical Assays; Chemical Library; Chemical Reaction; Chemical Synthesis; Cheminformatics; Drug Discovery; Virtual Screening
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Structural Genomics Consortium
- Department of Molecular Genetics
- Pharmacology and Toxicology
- Medicine/Oncology
- Pharmacologie - Physiologie
- Urologic Sciences
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Matthieu Schapira
Structural Genomics Consortium
3 shared papers, latest 2025
Ahmed Aman
Faculty
2 shared papers, latest 2020
Stéphane Richard
Medicine/Oncology
2 shared papers, latest 2020
Anne-Claude Gingras
Department of Molecular Genetics
2 shared papers, latest 2020
Dalia Barsyte-Lovejoy
Pharmacology and Toxicology
2 shared papers, latest 2020
Hui Peng
Faculty
2 shared papers, latest 2025
Stéphane Richard
Pharmacologie - Physiologie
2 shared papers, latest 2020
Artem Cherkasov
Urologic Sciences
1 shared papers, latest 2025
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Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.