Faculty profile

Sagi Abelson

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Associate ProfessorDepartment of Molecular GeneticsUniversity of Toronto

Sagi Abelson

Associate Professor

Department of Molecular Genetics

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
14 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 1 research grant (1 CIHR), most recently in 2022.
Supervisor on 1 trainee award (1 CIHR), most recently in 2024.

These signals come from public records, including federal and provincial funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

721

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Latest papers

Response to Immune Checkpoint Blockade Is Enhanced in the Presence of Hematopoietic TET2 Inactivation.
Cancer research · 2026
Blood-based epigenetic instability linked to human aging and disease.
Nature communications · 2026 · senior author
The adverse prognostic impact of HMGCLL1 gene variants can be abrogated by frontline second-generation tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia
Leukemia · 2026

All 20 publications

Latest funding

Extracellular Vesicle-Derived Biomarkers for Early Leukaemia Detection and Monitoring Exercise-Based Risk Reduction
CIHR · 2025 · Co-investigator
$1,988,650
A highly sensitive, multi-omics framework for relapse risk prediction in acute myeloid leukemia
CIHR · 2024 · Supervisor
$120,000
Phenotypic and Functional Characterization of Relapse-Fated Cells Present at Diagnosis in AML leading to improved therapeutic targeting and monitoring
CIHR · 2023 · Co-investigator
$1,051,875

All 5 grants and awards

20 publications.

Response to Immune Checkpoint Blockade Is Enhanced in the Presence of Hematopoietic TET2 Inactivation.

Rondeau V, Bansal S, Buttigieg MM, Zeng AGX, Chan DY, Chan-Seng-Yue M, Jin L, McLeod J, Kates M, Donato E, Stelmach P, Vlasschaert C, Yang Y, Gupta A, Genta S, Sanz-Garcia E, Shlush L, Ribeiro M, Butler MO, Abelson S, Minden MD, Saibil SD, Chan SM, Rauh MJ, Trumpp A, Dick JE, Vanner RJ

Cancer research20267 citations

DOI: 10.1158/0008-5472.can-24-3329 PMID: 41218172

Blood-based epigenetic instability linked to human aging and disease.

Basrai S, Nofech-Mozes I, Detroja R, Scolari FL, Bakhtiari M, Arruda A, Murphy T, Bratman SV, Chan SM, Minden MD, Sook Ahn J, Kim DDH, Kridel R, Billia F, Abelson S

Nature communications20261 citationsSenior authorOpen Access

DOI: 10.1038/s41467-026-69430-z PMID: 41690920

The adverse prognostic impact of HMGCLL1 gene variants can be abrogated by frontline second-generation tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia

María Agustina Perusini, Katia Pagnano, Carolina Pavlovsky, Daniela Žáčková, Jiří Mayer, Beatriz Moiraghi, Ana Inés Varela, Michele Bianchini, Ana Beatriz Pascoal Lopes, G. M. Duarte, C. de Souza, Ivana Ježíšková, Anežka Kvetková, Tomáš Jurček, Hye Won Lee, Myung Hee Chang, Jessie J.F. Medeiros, Sagi Abelson, Dennis Dong Hwan Kim

Leukemia2026

DOI: 10.1038/s41375-026-02921-6 PMID: 41912912

A novel H2A-A127 variant is associated with human cancer and enhances tumor-related phenotypes in Drosophila melanogaster models.

AlHajj Hassan Z, Dakik H, Arreba-Tutusaus P, Frey F, Mantash S, Mitchell A, Boileau M, Abelson S, Kleit M, Hayek Z, Awada J, El Darzi R, Eppert K, Shirinian M

Frontiers in oncology2026Open Access

DOI: 10.3389/fonc.2026.1814908 PMID: 42516136

Association Between Clonal Hematopoiesis and Cardiometabolic Disease: A Systematic Review and Meta-Analysis.

D'Mello B, Sheth N, Orchanian-Cheff A, Soave D, Abelson S, Woo M, Ke C

JACC. CardioOncology2026Open Access

DOI: 10.1016/j.jaccao.2026.04.005 PMID: 42307149

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

Joana Araújo, Elvin Wagenblast, Véronique Voisin, Jessica L. McLeod, Olga I. Gan, Suraj Bansal, Liqing Jin, Amanda Mitchell, Blaise Gratton, Sarah K. Cutting, Andrea Arruda, Monica Doedens, Anthea Travas, Dennis Dong Hwan Kim, José‐Mario Capo‐Chichi, Sagi Abelson, Mark David Minden, Jean C. Y. Wang, Manuel Sobrinho Simões, Perpétua Pinto‐do‐Ó, Eric R. Lechman, John Edgar Dick

Blood202511 citationsOpen Access

DOI: 10.1182/blood.2024025886 PMID: 39841016

Chronic TNF in the aging microenvironment exacerbates Tet2 loss-of-function myeloid expansion

Quin C, DeJong EN, McNaughton AJM, Buttigieg MM, Basrai S, Abelson S, Larché MJ, Rauh MJ, Bowdish DME

Blood advances202426 citationsOpen Access

DOI: 10.1182/bloodadvances.2023011833

Mutations in myeloid transcription factors and activated signaling genes predict chronic myeloid leukemia outcomes.

Perusini MA, Žáčková D, Kim T, Pagnano K, Pavlovsky C, Ježíšková I, Kvetková A, Jurček T, Kim J, Yoo Y, Yi S, Lee H, Kim KH, Chang M, Capo-Chichi JM, Medeiros JJF, Arruda A, Minden M, Zhang Z, Abelson S, Mayer J, Hwan Kim DD

Blood advances202415 citationsOpen Access

DOI: 10.1182/bloodadvances.2023012127 PMID: 38447114

Clonal haematopoiesis is associated with major adverse cardiovascular events in patients with hypertrophic cardiomyopathy.

Scolari FL, Brahmbhatt D, Abelson S, Lee D, Kim RH, Pedarzadeh A, Sakhnini A, Adler A, Chan RH, Dick JE, Rakowski H, Billia F

European journal of heart failure202413 citationsOpen Access

DOI: 10.1002/ejhf.3408 PMID: 39091134

Pan-cancer classification of single cells in the tumour microenvironment.

Nofech-Mozes I, Soave D, Awadalla P, Abelson S

Nature communications202384 citationsSenior authorOpen Access

DOI: 10.1038/s41467-023-37353-8 PMID: 36959212

Extracellular Vesicle-Derived Biomarkers for Early Leukaemia Detection and Monitoring Exercise-Based Risk Reduction

Co-investigatorCIHR2025Team Grant: Bringing Biology to Cancer Prevention - Tech, Tools and Methods

Principal investigators: Abraham, Sheela A; Chan, Edmond Y; De Felice, Fernanda G; Koushik, Anita; McGlory, Christopher; Tyryshkin, Kathrin

Keywords: Exercise; Extracellular Vesicles; Leukaemia; Liquid Biomarkers; Mitochondria

$1,988,650

A highly sensitive, multi-omics framework for relapse risk prediction in acute myeloid leukemia

SupervisorCIHR2024Doctoral Research Award - PA - Bioinformatics and Computational Biology

Principal investigators: Basrai, Salman

Keywords: Acute Myeloid Leukemia; Biomarker Discovery; Epigenetics; Genomics; Machine Learning; Multi-Omics; Relapse Prediction

$120,000

Phenotypic and Functional Characterization of Relapse-Fated Cells Present at Diagnosis in AML leading to improved therapeutic targeting and monitoring

Co-investigatorCIHR2023Project Grant

Principal investigators: Dick, John E

Keywords: Acute Myeloid Leukemia; Biomarker Development; Early Detection And Monitoring; Leukemic Stem Cells; Pharmacogenomics; Relapse-Origin; Therapeutic Targeting; Xenograft Functional Validation

$1,051,875

Preparing for the Recovery from the Effects of the PAndemic on cancer control using Real-world Evidence in Canada (PREPARE-Canada)

Principal investigatorCIHR2022Project Grant

Principal investigators: Awadalla, Philip; Abelson, Sagi; Alvi, Riaz; Bhatti, Parveen; broet, philippe; Dummer, Trevor J; Kirsh, Victoria; Mclaughlin, John R; Shen-Tu, Grace; Sweeney, Ellen; Turner, Donna C; Urquhart, Robin L

Keywords: Biomarkers; Cancer; Covid-19; Early Detection; Modeling; Screening

$1,147,500

Evaluating the additional efficacy of metabolic surgery vs optimal medical therapy in type 2 diabetes and cardiovascular disease

Co-investigatorCIHR2020Team Grant: DM/TS - Geroscience, Diabetes and Cardiometabolic Disease

Principal investigators: Farkouh, Michael E; Dash, Satya; Poirier, Paul; Woo, Minna N

Keywords: Cardiovascular Disease; Obesity; Type 2 Diabetes

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Sagi Abelson

Research

Latest papers

Latest funding

Response to Immune Checkpoint Blockade Is Enhanced in the Presence of Hematopoietic TET2 Inactivation.

Blood-based epigenetic instability linked to human aging and disease.

The adverse prognostic impact of HMGCLL1 gene variants can be abrogated by frontline second-generation tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia

A novel H2A-A127 variant is associated with human cancer and enhances tumor-related phenotypes in Drosophila melanogaster models.

Association Between Clonal Hematopoiesis and Cardiometabolic Disease: A Systematic Review and Meta-Analysis.

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

Chronic TNF in the aging microenvironment exacerbates Tet2 loss-of-function myeloid expansion

Mutations in myeloid transcription factors and activated signaling genes predict chronic myeloid leukemia outcomes.

Clonal haematopoiesis is associated with major adverse cardiovascular events in patients with hypertrophic cardiomyopathy.

Pan-cancer classification of single cells in the tumour microenvironment.

Extracellular Vesicle-Derived Biomarkers for Early Leukaemia Detection and Monitoring Exercise-Based Risk Reduction

A highly sensitive, multi-omics framework for relapse risk prediction in acute myeloid leukemia

Phenotypic and Functional Characterization of Relapse-Fated Cells Present at Diagnosis in AML leading to improved therapeutic targeting and monitoring

Preparing for the Recovery from the Effects of the PAndemic on cancer control using Real-world Evidence in Canada (PREPARE-Canada)

Evaluating the additional efficacy of metabolic surgery vs optimal medical therapy in type 2 diabetes and cardiovascular disease

Frequent collaborators

John Dick

Mark Minden

Filio Billia

Steven Chan

Philip Awadalla

Sajid Marhon

Daniel de Carvalho

José-Mario Capo-Chichi

Scott Bratman

Jean Wang

Catherine O'Brien

Michael Rauh

Patrick Lawler

Trevor Pugh

Robert Kridel

Marco Buttigieg

Maria Perusini

David Soave

Dennis Kim

Stephen Wright

Patrick Shannon