Faculty profile

Charles Boone

ResearcherDonnelly CentreUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Charles Boone

Researcher

Donnelly Centre

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
52 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 14 research grants (10 CIHR, 4 NSERC), most recently in 2025.
Supervised 2 trainees who won CIHR awards, most recently in 2013.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

188

Publications

752

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Functional Genomics Genetic Networks Chemical Genomics Yeast Genetics Bioactive Compounds Computational Biology Network Biology Molecular Genetics

Latest papers

The 2025 Westlake Autumn Symposium for AI Proteomics and Virtual Cell.
Genomics, proteomics & bioinformatics · 2026
The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation.
bioRxiv : the preprint server for biology · 2026
The novel antifungal agent NPD2560 perturbs the Rho1-centered signaling network to induce a cell wall integrity response.
Microbiology spectrum · 2026

All 188 publications

Latest funding

Mapping human genetic disease modifiers and biology from biobanks
CIHR · 2026 · Co-investigator
$1,304,326
Chemical genomics for annotating gene and bioactive compound function in yeast and human cells
CIHR · 2025 · Nominated PI
$1,216,350
Mapping a reference genetic interaction network for a human cell
CIHR · 2021 · Nominated PI
$1,495,575

All 22 grants and awards

From the 150 most recent of 188 publications.

The 2025 Westlake Autumn Symposium for AI Proteomics and Virtual Cell.

Sun 孙瑞 R, Aebersold R, Xiao 肖琦 Q, Mann M, Zhou 周岩 Y, Heck AJR, Wang 王瑛睿 Y, Völker U, Cai 蔡雪 X, Boone C, Zhou 周梓卓 Z, Li 李明 M, Dong 董振 Z, Andrews B, Wang 王帅尧 S, Schacherer J, Jimenez CR, Wollscheid B, Yue 岳靓 L, Collins BC, Jiang 蒋恒 H, Wang 王栋 D, Qian 钱鎏佳 L, Yue 岳家兴 JX, Sun 孙莹莹 Y, Nice E, Zhang 张晓帆 X, Perez-Riverol Y, A 阿俊 J, Sander C, Hermjakob H, Bittremieux W, Goh WWB, Gao 高歌 G, Zhou 周沛劼 P, Sun 孙思琦 S, Wen 温翰 H, Xu 许梓妍 Z, Guo 郭天南 T

Genomics, proteomics & bioinformatics2026

DOI: 10.1093/gpbjnl/qzag022 PMID: 41795813

The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation.

Chen L, Thompson K, Kamal M, Sihuta K, Topalidou I, Burns AR, Farshour NH, Cooke B, Knox J, Jiang Y, Qasser MA, Shuteriqi E, Usaj M, Ching J, Flaget A, Costanzo M, Tan G, Lacoste J, Lautens M, Andrews B, Boone C, Taipale M, Lehrbach NJ, Roy PJ

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.07.10.737828 PMID: 42523351

The novel antifungal agent NPD2560 perturbs the Rho1-centered signaling network to induce a cell wall integrity response.

Liu W, Sekiguchi H, Li SC, Vega Isuhuaylas LA, Yamanaka D, Itto-Nakama K, Noda Y, Boone C, Yashiroda Y, Ohya Y

Microbiology spectrum2026

DOI: 10.1128/spectrum.03630-25 PMID: 42233670

Towards the construction of a virtual yeast.

Qian L, Zhou Z, Zhou P, Dong Z, Zhang X, Dai Z, Gao Z, Sun S, Roy KR, Wang S, Zamboni N, Boone C, Costanzo M, Li J, Liti G, Yue JX, Ralser M, Williams E, Zampieri M, Jiang H, Wu T, Wang Y, Li F, Schacherer J, Sun R, Li Z, Deng Y, Chen Y, Xie Z, Lou H, Wang X, Xie L, Wen H, Chen L, Lei K, Rosenberger G, Cai X, Wang Y, Xiao Q, Shen H, Liu G, Ma L, Andrews B, Lu H, Piatkevich K, Zhu Y, Bai L, Cai Y, Chen Y, E W, Gao G, He F, Chen L, Li SZ, Ma H, Qiao L, Steinmetz LM, Tang L, Tang T, Zhang X, Yang J, Yang Y, Yu K, Zeng J, Zheng Y, Zhou B, Guo T

Nature2026

DOI: 10.1038/s41586-026-10574-9 PMID: 42387167

Orobas: A computational approach for scoring and analysis of quantitative chemical-genetic interactions from CRISPR-Cas9 screens.

Hassan AZ, Zhang X, Ward HN, Billmann M, Bajjali S, Brown KR, Bhojoo U, Chan K, Lin K, Costanzo M, Andrews B, Boone C, Moffat J, Myers CL

STAR protocols2026

DOI: 10.1016/j.xpro.2026.104594 PMID: 42213768

Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.

Billmann M, Costanzo M, Zhang X, Hassan AZ, Rahman M, Brown KR, Chan KS, Tong AHY, Pons C, Ward HN, Ross C, van Leeuwen J, Aregger M, Lawson KA, Mair B, Roth AF, Sen NE, Forster DT, Tan G, Mero P, Masud SN, Lee Y, Aguilera-Uribe M, Ušaj M, Almeida SMT, Aulakh K, Bhojoo U, Birkadze S, Budijono N, Cai X, Caumanns JJ, Chalmers JJ, Chandrashekhar M, Chang D, Climie R, Dasgupta K, Drazic A, Echenique JIR, Gacesa R, Farias AG, Habsid A, Horecka I, Kantautas K, Ji F, Kim DK, Lee SY, Liang W, Lim HJ, Lin K, Lu X, Maier M, Nami B, Nixon A, Mikolajewicz N, Mokhtaridoost M, Nedyalkova L, Rohde T, Rodrigues MS, Soste M, Schultz E, Wang W, Seetharaman A, Shuteriqi E, Sizova O, Taylor DT, Tereshchenko M, Tieu D, Turowec J, Ubhi T, Varland S, Wang KE, Wang ZY, Wei J, Xiao YX, Maass PG, Reversade B, Brown GW, Cravatt BF, Dixon SJ, Wyatt HDM, Röst HL, Roth FP, Xia T, Bader GD, Loewith R, Davis NG, Andrews B, Myers CL, Moffat J, Boone C

Cell2026Senior author

DOI: 10.1016/j.cell.2026.03.044 PMID: 42049019

Population-scale chemical response revealed by a barcoded yeast collection.

Dutta A, Garin M, Loegler V, Brach G, Friedrich A, Yoshimura M, Hirano H, Osada H, Boone C, Yashiroda Y, Hou J, Schacherer J

Nature communications2026

DOI: 10.1038/s41467-026-73532-z PMID: 42209485

Role of Pbr1, a putative oxidoreductase, in the ER quality control and folding of yeast Fks1 glucan synthase.

Obara K, Okada H, Tan G, Ohnuki S, Suzuki G, Ohtake H, Kubo K, Ghanegolmohammadi F, Ishizaka S, Yashiroda Y, Okita A, Mishiro-Sato E, Suzuki K, Tamura Y, Ashine R, Ikeda Y, Kamura T, van Leeuwen J, Andrews B, Bi E, Noda NN, Boone C, Ohya Y

Proceedings of the National Academy of Sciences of the United States of America2026

DOI: 10.1073/pnas.2612792123 PMID: 42441850

Expanding TheCellMap.org to visualize a genome-scale genetic interaction network for a human cell line.

Horecka I, Ušaj M, Masinas MPD, Ward HN, Zhang X, Hassan AZ, Billmann M, Röst HL, Myers CL, Costanzo M, Andrews B, Boone C

bioRxiv : the preprint server for biology2026Senior author

DOI: 10.64898/2026.03.16.712129 PMID: 41890115

HTD1265 Disrupts GimC-Dependent Cellular Processes in Saccharomyces cerevisiae.

Itto-Nakama K, Hosoyamada N, Ohnuki S, Shirai F, Mukaiyama M, Hirano H, Osada H, Boone C, Usui T, Yashiroda Y, Ohya Y

Pathogens (Basel, Switzerland)2026

DOI: 10.3390/pathogens15020185 PMID: 41754437

Mapping human genetic disease modifiers and biology from biobanks

Co-investigatorCIHR2026Project Grant

Principal investigators: Bader, Gary D

Keywords: Bioinformatics; Computational Biology; Genetics; Genomics; Human Genetics; Statistical Genetics; Statistics

$1,304,326

Chemical genomics for annotating gene and bioactive compound function in yeast and human cells

Nominated PICIHR2025Project Grant

Principal investigators: Boone, Charles M

Keywords: Bioactive Compounds; Chemical Genomics; Functional Genomics

$1,216,350

Mapping a reference genetic interaction network for a human cell

Nominated PICIHR2021Project Grant

Principal investigators: Boone, Charles M

Keywords: Computational Biology; Functional Genomics; Genetic Networks; Network Biology

$1,495,575

A platform for live-cell time-lapse imaging

Co-investigatorNSERC2018Research Tools and Instruments

Principal investigators: Brown, Grant

$147,925

Systematic Genetic Analysis with Conditional Estradiol-Regulated Gene Expression Alleles in Yeast

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Boone, Charles

$38,000

Genome-scale discovery and classification of functional genetic elements that drive cancer cell proliferation with ultracomplex CRISPR-Cas libraries

Co-investigatorCIHR2015Operating Grant

Principal investigators: Moffat, Jason

Keywords: Cancer Gene; Cell Lines; Cell Signaling; Crispr-Cas; Essential Genes; Functional Genomics; Lentivirus; Pooled Screen; Systems Biology

$891,656

Principles of Global Genetic Interaction Networks

Nominated PICIHR2014Foundation Grant

Principal investigators: Boone, Charles M

Keywords: Chemical Genomics; Functional Genomics; Genetic Networks; Molecular Genetics; Yeast

$5,962,958

Large-scale analysis of complex genetic suppression networks

Nominated PICIHR2013Operating Grant

Principal investigators: Boone, Charles M

Keywords: Complex Genetic Disease; Complex Traits; Functional Genomics; Genetic Interactions; Suppression; Yeast Genetics

$1,360,048

Large-scale identification of suppressors of human disease genes in yeast

SupervisorCIHR2013CIHR Fellowship

Principal investigators: van Leeuwen, Jolanda

Keywords: Genetic Diseases; Genetic Suppression; Next-Generation Sequencing; Synthetic Genetic Array Mapping; Yeast Genetics

$135,000

Gene duplication and functional divergence: using systematic genetics to link genotype to phenotype

Co-investigatorCIHR2013Operating Grant

Principal investigators: Andrews, Brenda J

Keywords: Complex Genetic Disease; Complex Genetics; Computational Biology; Gene Duplication; Genetic Networks; Genome Evolution; Yeast Genetics

$1,220,864

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Charles Boone

Research

Latest papers

Latest funding

The 2025 Westlake Autumn Symposium for AI Proteomics and Virtual Cell.

The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation.

The novel antifungal agent NPD2560 perturbs the Rho1-centered signaling network to induce a cell wall integrity response.

Towards the construction of a virtual yeast.

Orobas: A computational approach for scoring and analysis of quantitative chemical-genetic interactions from CRISPR-Cas9 screens.

Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.

Population-scale chemical response revealed by a barcoded yeast collection.

Role of Pbr1, a putative oxidoreductase, in the ER quality control and folding of yeast Fks1 glucan synthase.

Expanding TheCellMap.org to visualize a genome-scale genetic interaction network for a human cell line.

HTD1265 Disrupts GimC-Dependent Cellular Processes in Saccharomyces cerevisiae.

A platform for live-cell time-lapse imaging

Systematic Genetic Analysis with Conditional Estradiol-Regulated Gene Expression Alleles in Yeast

Frequent collaborators

Brenda Andrews

Jason Moffat

Anne-Claude Gingras

Zhaolei Zhang

Elena Kuzmin

Brian Raught

Andrew Emili

Alan Moses

Igor Stagljar

Ji-Young Youn

Gerard Wright

Daniel Durocher

Leah Cowen

Quaid Morris

Wei Wang

Alexei Savchenko

David Hess

Ahmed Aman

Alexei Savchenko

Mohan Babu

Michael Brudno

Amy Caudy

Michel Roberge

Cameron Currie

Laurence Pelletier

Robert Rottapel

Mei Zhen

Jack Greenblatt

Frank Sicheri