Faculty profile
Shane Harding
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Read how they describe their research on their University of Toronto profile.
Latest papers
Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33.
Cancer cell · 2025
In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor-microenvironment interactions.
Nature genetics · 2024
Opposing Roles of Type I Interferons in Cancer Immunity.
Annual review of pathology · 2021
Latest funding
- $600,000
Canada Research Chair - Tier 2
CIHR · 2025 · Nominated PI
- $120,000
Characterizing the interactome of DSB-induced transcriptional silencing and its role in DNA repair
CIHR · 2025 · Supervisor
- $1,082,475
Pattern recognition receptors drive a networked cellular signaling system during cancer therapy
CIHR · 2024 · Nominated PI
4 publications.
Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33.
Lamorte S, Quevedo R, Jin R, Neufeld L, Liu ZQ, Ciudad MT, Lukhele S, Bruce J, Mishra S, Zhang X, Saeed ZK, Berman H, Philpott DJ, Girardin SE, Harding S, Munn DH, Mak TW, Karlsson MCI, Brooks DG, McGaha TL
In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor-microenvironment interactions.
Su P, Liu Y, Chen T, Xue Y, Zeng Y, Zhu G, Chen S, Teng M, Ci X, Guo M, He MY, Hao J, Chu V, Xu W, Wang S, Mehdipour P, Xu X, Marhon SA, Soares F, Pham NA, Wu BX, Her PH, Feng S, Alshamlan N, Khalil M, Krishnan R, Yu F, Chen C, Burrows F, Hakem R, Lupien M, Harding S, Lok BH, O'Brien C, Berlin A, De Carvalho DD, Brooks DG, Schramek D, Tsao MS, He HH
Opposing Roles of Type I Interferons in Cancer Immunity.
Boukhaled GM, Harding S, Brooks DG
Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.
Li L, Halaby MJ, Hakem A, Cardoso R, El Ghamrasni S, Harding S, Chan N, Bristow R, Sanchez O, Durocher D, Hakem R
Canada Research Chair - Tier 2
Principal investigators: Harding, Shane M
Keywords: Crc
Characterizing the interactome of DSB-induced transcriptional silencing and its role in DNA repair
Principal investigators: Deane, Madeline J
Keywords: Cancer; Chromatin Organization; Dna Damage; Dna Repair; Transcription
Pattern recognition receptors drive a networked cellular signaling system during cancer therapy
Principal investigators: Harding, Shane M
Keywords: Cytokine Signalling; Dna Damage; Epigenetic Therapy; Pattern Recognition Receptors
Micronuclei as integrators of cellular DNA damage responses
Principal investigators: Harding, Shane M
Keywords: Cell Cycle; Chromosome Mis-Segregation; Dna Damage
Micronuclei as integrators of cellular DNA damage responses
Principal investigators: Harding, Shane M
Keywords: Cell Cycle; Cgas-Sting; Chromosome Mis-Segregation; Cytokine Signalling; Dna Damage; Dna Repair; Dna Replication; Micronuclei; Radiobiology
Micronuclei as integrators of cellular DNA damage responses
Principal investigators: Harding, Shane M
Keywords: Cell Cycle; Cgas-Sting; Chromatin; Chromosome Mis-Segregation; Cytokine Signalling; Dna Damage; Dna Repair; Micronuclei; Oncogenic Stress; Radiobiology
The Terry Fox New Frontiers Program Project Grant in Mammary OMICs: Intercepting Breast Cancer Early to Improve Outcomes
Principal investigators: Khokha, Rama; Harding, Shane M; Kislinger, Thomas
Keywords: Biospecimen Repository; Breast Cancer Prevention; Cancer Precursors; Cell Vulnerabilities; Early Interception; High-Risk Patients; Lineage-Rooted Distinctions; Mammary Heterogeneity; Multimodal Omics; Targeted Drugs
Redox homeostasis in pancreatic cancer - molecular mechanisms and combined modalities
Principal investigators: Koritzinsky, Marianne
Keywords: Biomarkers; Dna Damage Response; Immune Therapy; Pancreatic Cancer; Radiotherapy; Redox Homeostasis; Tumor Microenvironment
Molecular directives for cGAS recognition of DNA damage-induced micronuclei.
Principal investigators: MacDonald, Kate
Keywords: Cancer Biology; Cell Biology; Cell Culture; Cgas; Dna Damage; Flow Cytometry; Mass Spectrometry; Micronuclei; Viral Pattern Recognition Receptors; Whole-Genome Sequencing
Shedding light on SBRT: functional optical coherence tomography and MR imaging for in vivo monitoring of high-dose few-fractions radiotherapy of pancreatic cancer
Principal investigators: Vitkin, I. Alex
Keywords: (High) Radiation Doses; Functional Imaging; Image Analysis / Quantification; Magnetic Resonance Imaging (Mri); Microvasculature; Optical Coherence Tomography (Oct); Optical In-Vivo Imaging; Personalized Medicine; Radiotherapy For Pancreatic Cancer; Treatment Monitoring And Feedback
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Lunenfeld-Tanenbaum Research Institute
- Department of Medical Biophysics
- Radiation Oncology/Medical Physics
- Surgery and Cancer
- Medical Biophysics
- Department of Laboratory Medicine and Pathobiology
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Razqallah Hakem
Faculty
2 shared papers, latest 2024
Alejandro Berlin
Radiation Oncology/Medical Physics
1 shared papers, latest 2024
Mathieu Lupien
Medical Biophysics
1 shared papers, latest 2024
Daniel Durocher
Lunenfeld-Tanenbaum Research Institute
1 shared papers, latest 2010
Catherine O'Brien
Surgery and Cancer
1 shared papers, latest 2024
Ming-Sound Tsao
Department of Laboratory Medicine and Pathobiology
1 shared papers, latest 2024
Daniel Schramek
Lunenfeld-Tanenbaum Research Institute
1 shared papers, latest 2024
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Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.