Faculty profile

Razqallah Hakem

ResearcherUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Razqallah Hakem

Researcher

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
17 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (5 CIHR), most recently in 2022.
Supervisor on 2 trainee awards (2 CIHR), most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

Search on Google Scholar

Find them onX · LinkedIn · Bluesky · YouTube

Signals and details

Research

Brca1 Breast Cancer Cancer Mechanisms Biological Processes Biochemistry Cancer Vulnerabilities Dna Repair Ovarian Cancer

Latest papers

Adipocyte caspase-8 but not RIPK3 promotes adiposity.
Cell death discovery · 2026
Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt.
Scientific reports · 2026
CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer.
Molecular cancer therapeutics · 2026

All 45 publications

Latest funding

Investigating the mechanism of arginine methyltransferase PRMT1 in regulating mRNA splicing and as a therapeutic target against small cell lung cancer
CIHR · 2024 · Co-investigator
$948,600
Deciphering the tubulin code underlying nuclear envelope-mediated DNA double-strand break repair to target breast cancer
CIHR · 2024 · Supervisor
$120,000
FAAP24 safeguards genome integrity against transcription-replication conflicts in BRCA1-deficient breast cancer
CIHR · 2022 · Supervisor
$135,000

All 10 grants and awards

45 publications.

Adipocyte caspase-8 but not RIPK3 promotes adiposity.

Chan CK, Aslam R, Yang F, Panesar A, Hakem A, Hakem R, Gaisano HY, Winer DA, Luk CT

Cell death discovery2026

DOI: 10.1038/s41420-026-03201-z PMID: 42337230

Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt.

Ghebreselassie M, Park YJ, Nakib D, Dodington D, Patel P, Won S, Hakem A, Hakem R, MacParland S, Woo M

Scientific reports2026

DOI: 10.1038/s41598-026-39581-6 PMID: 41781465

CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer.

Patel UA, Shi MY, Kazan JM, Nixon KCJ, Ran X, Nair SN, Huang O, Song L, Aparnathi MK, He MY, Bakhtiari M, Krishnan R, Hessenow RK, Philip V, Ketela T, Jendrossek V, Hakem R, He HH, Kridel R, Lok BH

Molecular cancer therapeutics2026

DOI: 10.1158/1535-7163.mct-24-0861 PMID: 40899441

PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents.

Aparnathi MK, Ul Haq S, St-Germain J, Nixon KCJ, Walton J, Song L, Majeed S, Patel PS, Subramaniam R, Philip V, Marcellus R, Barsyte-Lovejoy D, Al-Awar R, Hakem R, Arrowsmith CH, Ailles L, Raught B, Lok BH

Neoplasia (New York, N.Y.)2025

DOI: 10.1016/j.neo.2025.101176 PMID: 40413955

Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment.

Espín R, Medina-Jover F, Sigüenza-Andrade J, Farran-Matas S, Mateo F, Figueras A, Sanz RT, Vicent GP, Shabbir A, Ruiz-Auladell L, Racionero-Andrés E, García I, Baiges A, Franco-Luzón L, Martínez-Tebar A, Pardo-Cea MA, Martínez-Iniesta M, Wang XC, Cuyàs E, Menendez JA, Lopez-Cerda M, Muñoz P, Richaud I, Raya A, Fabregat I, Villanueva A, Serrat X, Cerón J, Alemany M, Guix I, Herencia-Ropero A, Serra V, Krishnan R, Mekhail K, Hakem R, Bruna J, Barcellos-Hoff MH, Viñals F, Aytes Á, Pujana MA

NAR cancer2025

DOI: 10.1093/narcan/zcaf007 PMID: 40061566

Nucleolar Pol II interactome reveals TBPL1, PAF1, and Pol I at intergenic rDNA drive rRNA biogenesis.

Khosraviani N, Yerlici VT, St-Germain J, Hou YY, Cao SB, Ghali C, Bokros M, Krishnan R, Hakem R, Lee S, Raught B, Mekhail K

Nature communications2024

DOI: 10.1038/s41467-024-54002-w PMID: 39505901

Protocol for machine-learning-based 3D image analysis of nuclear envelope tubules in cultured cells.

Hundal A, Urman D, Stanic M, Hakem R, Mekhail K

STAR protocols2024

DOI: 10.1016/j.xpro.2024.103214 PMID: 39088324

In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor-microenvironment interactions.

Su P, Liu Y, Chen T, Xue Y, Zeng Y, Zhu G, Chen S, Teng M, Ci X, Guo M, He MY, Hao J, Chu V, Xu W, Wang S, Mehdipour P, Xu X, Marhon SA, Soares F, Pham NA, Wu BX, Her PH, Feng S, Alshamlan N, Khalil M, Krishnan R, Yu F, Chen C, Burrows F, Hakem R, Lupien M, Harding S, Lok BH, O'Brien C, Berlin A, De Carvalho DD, Brooks DG, Schramek D, Tsao MS, He HH

Nature genetics2024

DOI: 10.1038/s41588-024-01874-9 PMID: 39227744

DNA double-strand break-capturing nuclear envelope tubules drive DNA repair.

Shokrollahi M, Stanic M, Hundal A, Chan JNY, Urman D, Jordan CA, Hakem A, Espin R, Hao J, Krishnan R, Maass PG, Dickson BC, Hande MP, Pujana MA, Hakem R, Mekhail K

Nature structural & molecular biology2024

DOI: 10.1038/s41594-024-01286-7 PMID: 38632359

A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity.

Sellars E, Savguira M, Wu J, Cancelliere S, Jen M, Krishnan R, Hakem A, Barsyte-Lovejoy D, Hakem R, Narod SA, Kotsopoulos J, Salmena L

iScience2024

DOI: 10.1016/j.isci.2024.110180 PMID: 38993666

Something wrong or missing on this profile? Suggest a correction

Razqallah Hakem

Research

Latest papers

Latest funding

Adipocyte caspase-8 but not RIPK3 promotes adiposity.

Paradoxical oncogenic effects of hepatic Brca1 through modulating Bhmt.

CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer.

PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents.

Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment.

Nucleolar Pol II interactome reveals TBPL1, PAF1, and Pol I at intergenic rDNA drive rRNA biogenesis.

Protocol for machine-learning-based 3D image analysis of nuclear envelope tubules in cultured cells.

In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor-microenvironment interactions.

DNA double-strand break-capturing nuclear envelope tubules drive DNA repair.

A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity.

Frequent collaborators

Leonardo Salmena

Karim Mekhail

Brian Raught

Minna Woo

Daniel Schramek

Shane Harding

Dalia Barsyte-Lovejoy

Ming-Sound Tsao

Andrea Jurisicova

Cheryl Arrowsmith

Igor Jurisica

Daniel Durocher

Sonya MacParland

Benjamin Haibe-Kains

Alejandro Berlin

Elias Orouji

Moulay Alaoui-Jamali

Robert Kridel

Paul Boutros

Mathieu Lupien

Peter Cheung

Jean-Yves Masson

Thomas Kislinger

Linda Penn

Stefan Hofer

Catherine O'Brien

Laurie Ailles

Rama Khokha

Joanne Kotsopoulos