Faculty profile

Daniel Durocher

ResearcherLunenfeld-Tanenbaum Research InstituteUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Daniel Durocher

Researcher

Lunenfeld-Tanenbaum Research Institute

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
22 publications in the last five years, latest in 2026.
Senior (last) author on 10 recent papers, a sign of leading a research group.
Principal investigator on 12 research grants (12 CIHR), most recently in 2026.
Supervised 7 trainees who won CIHR awards, most recently in 2019.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

105

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Dna Damage Chromatin Dna Repair Ubiquitin Brca1 Dna Double-Strand Breaks Synthetic Lethality Genome Stability

Latest papers

The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.
Nature chemical biology · 2026
Mitotic single-stranded DNA suppression by DDIAS.
Molecular cell · 2026 · senior author
Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.
Communications chemistry · 2026

All 105 publications

Latest funding

Structural biology of a human papillomavirus oncogene complex
CIHR · 2026 · Nominated PI
$1,136,026
Elucidating the causes and consequences of methylcytosine-driven DNA double-strand breaks
CIHR · 2023 · Nominated PI
$1,308,150
Understanding and exploiting the CIP2A-BRCA synthetic lethality
CIHR · 2021 · Nominated PI
$882,046

All 22 grants and awards

105 publications.

The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.

Chana CK, Ben Makhlouf I, Kim J, Yu AJY, Moatti N, Orlicky S, Wong CJ, Baronijan L, Tang X, Mao D, Larsen B, McGary L, Seale B, Mader P, Ceccarelli DF, Barbulescu P, Martin A, Durocher D, Pelletier L, Gingras AC, Sicheri F

Nature chemical biology2026

DOI: 10.1038/s41589-026-02183-4 PMID: 41957281

Mitotic single-stranded DNA suppression by DDIAS.

Xue Y, Rashed FB, Mao DYL, Abe KT, Lin ZY, Krastev DB, Setiaputra D, Hoeg L, Bonnet C, Kumar A, Mavousian A, Maan A, Harvey-Jones E, Pettitt SJ, Tutt ANJ, Lord CJ, Sicheri F, Gingras AC, Durocher D

Molecular cell2026Senior author

DOI: 10.1016/j.molcel.2026.07.034 PMID: 42636809

Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.

Mader P, Liu L, Vallée F, Denis F, Pau V, Mao D, Caldwell L, Chan K, Kurinov I, Mamane Y, Parikh P, Zhang Z, Gallant M, Tyers M, Black WC, Zinda M, Durocher D, Wrana J, Zimmermann M, Sicheri F

Communications chemistry2026

DOI: 10.1038/s42004-026-02100-9 PMID: 42365187

Genome-wide CRISPR screens map synthetic lethal interactions across recurrent cancer driver alterations.

Desjardins J, Bowlan J, Bernier C, Jain S, Goullet de Rugy T, Gallo D, Orcholski ME, Laterreur N, Rajah A, Miller J, Lafontaine J, Bhaskaran V, Li L, Ling A, Leblanc JH, Mathieu MC, Zinda M, Morris SJ, Durocher D, Zimmermann M, Roulston A, Veloso A, Fiore C, Álvarez-Quilón A, Young JTF

Cell reports2026

DOI: 10.1016/j.celrep.2026.117961 PMID: 42726641

Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ.

Bubenik M, Mader P, Orlicky S, Perryman AL, Hamel M, Godbout C, Falgueyret JP, Kurinov I, Wong C, Gingras AC, Mamane Y, Zinda M, Morris SJ, Gallant M, Sfeir A, Black WC, Durocher D, Zimmermann M, Sicheri F

ACS medicinal chemistry letters2026

DOI: 10.1021/acsmedchemlett.5c00643 PMID: 41704370

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response.

Tjeerdsma RB, Ng TF, Roorda M, Bianchi D, Yang S, Bonnet C, VanInsberghe M, Everts M, Bakker FJ, de Boer HR, Moatti N, Hustedt N, Yin JZ, Hoeg L, Leibovitch M, Sicheri F, van Oudenaarden A, de Jong S, van den Berg J, Tanenbaum ME, Brummelkamp TR, Durocher D, van Vugt MATM

Nature communications2025

DOI: 10.1038/s41467-025-66514-0 PMID: 41285872

Author Correction: A substrate binding model for the KEOPS tRNA modifying complex.

Beenstock J, Ona SM, Porat J, Orlicky S, Wan LCK, Ceccarelli DF, Maisonneuve P, Szilard RK, Yin Z, Setiaputra D, Mao DYL, Khan M, Raval S, Schriemer DC, Bayfield MA, Durocher D, Sicheri F

Nature communications2025

DOI: 10.1038/s41467-025-60136-2 PMID: 40404707

Editorial Expression of Concern: 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.

Fradet-Turcotte A, Canny MD, Escribano-Díaz C, Orthwein A, Leung CCY, Huang H, Landry MC, Kitevski-LeBlanc J, Noordermeer SM, Sicheri F, Durocher D

Nature2025Senior author

DOI: 10.1038/s41586-025-08696-7 PMID: 39880959

Retraction Note: A mechanism for the suppression of homologous recombination in G1 cells.

Orthwein A, Noordermeer SM, Wilson MD, Landry S, Enchev RI, Sherker A, Munro M, Pinder J, Salsman J, Dellaire G, Xia B, Peter M, Durocher D

Nature2025Senior author

DOI: 10.1038/s41586-025-08644-5 PMID: 39870925

Author Correction: PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint.

Nakada S, Chen GI, Gingras AC, Durocher D

EMBO reports2025Senior author

DOI: 10.1038/s44319-024-00338-9 PMID: 39810021

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Daniel Durocher

Research

Latest papers

Latest funding

The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.

Mitotic single-stranded DNA suppression by DDIAS.

Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.

Genome-wide CRISPR screens map synthetic lethal interactions across recurrent cancer driver alterations.

Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Pol&#x3b8;.

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response.

Author Correction: A substrate binding model for the KEOPS tRNA modifying complex.

Editorial Expression of Concern: 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.

Retraction Note: A mechanism for the suppression of homologous recombination in G1 cells.

Author Correction: PP4 is a &#x3b3;H2AX phosphatase required for recovery from the DNA damage checkpoint.

Frequent collaborators

Frank Sicheri

Anne-Claude Gingras

Jason Moffat

Laurence Pelletier

Alberto Martin

Lara O'Donnell

Stephane Angers

Graham Dellaire

Razqallah Hakem

David Uehling

Charles Boone

Sachdev Sidhu

Yannick Doyon

Neesha Dhani

Mikko Taipale

Karim Mekhail

Marc Therrien

Faiyaz Notta

Aaron Pollett

Adam Shlien

Shane Harding

Ellen Langille

Dheva Setiaputra

Steven Gallinger

Ahmed Aman

Daniel Schramek

Jean-Yves Masson

Andrea Jurisicova

Fei-Fei Liu

David Hedley

Xu-dong Zhu

Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ.

Author Correction: PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint.