Faculty profile
Nica Borradaile
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Research
Read how they describe their research on their Western University profile.
Latest papers
On-Chip Microfluidic Production of Sonosensitizer-Loaded Liposomes for Sonodynamic Therapy of Hepatocellular Carcinoma.
ACS pharmacology & translational science · 2026
The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells.
Cell and tissue research · 2025
SARS-CoV-2 Nucleocapsid Protein Does Not Induce Inflammation in Endothelial Cells or Monocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
Latest funding
- $125,000
A New Enabling Technology to Manufacture CAR-T Cells for Personalized Cell Therapy
SSHRC · 2024 · Co-investigator
- $150,000
Microscale thermophoresis for assessing diverse molecular interactions.
NSERC · 2020 · Co-investigator
- $156,000
Elongation factor 1A1 and the regulation of protein synthesis and cytoskeleton dynamics during lipid-induced stress
NSERC · 2017 · Principal investigator
9 publications.
On-Chip Microfluidic Production of Sonosensitizer-Loaded Liposomes for Sonodynamic Therapy of Hepatocellular Carcinoma.
Luo W, Zahid AA, Chakraborty A, Huang J, Kelly JJ, Borradaile N, Ronald JA, Paul A
The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells.
Schuurman M, Wilson RB, Borradaile N, Wang R
SARS-CoV-2 Nucleocapsid Protein Does Not Induce Inflammation in Endothelial Cells or Monocytes.
Tufail M, Lu X, Barr SD, Borradaile N, Feng Q
Long-Term Administration of Antioxidant N-Acetyl-L-Cysteine Impacts Beta Cell Oxidative Stress, Insulin Secretion, and Intracellular Signaling Pathways in Aging Mice.
Schuurman M, Nguyen J, Wilson RB, Barillaro M, Wallace M, Borradaile N, Wang R
Cell Membrane-Derived Nanoparticles as Biomimetic Nanotherapeutics to Alleviate Fatty Liver Disease.
Zahid AA, Chakraborty A, Shamiya Y, Wilson RB, Borradaile N, Paul A
N-acetyl-L-cysteine treatment reduces beta-cell oxidative stress and pancreatic stellate cell activity in a high fat diet-induced diabetic mouse model.
Schuurman M, Wallace M, Sahi G, Barillaro M, Zhang S, Rahman M, Sawyez C, Borradaile N, Wang R
Differential and Synergistic Effects of Low Birth Weight and Western Diet on Skeletal Muscle Vasculature, Mitochondrial Lipid Metabolism and Insulin Signaling in Male Guinea Pigs.
Dunlop K, Sarr O, Stachura N, Zhao L, Nygard K, Thompson JA, Hadway J, Richardson BS, Bureau Y, Borradaile N, Lee TY, Regnault TRH
Nuclear receptors regulate lipid metabolism and oxidative stress markers in chondrocytes.
Ratneswaran A, Sun MM, Dupuis H, Sawyez C, Borradaile N, Beier F
Lipidomic approach provides new clues toward solving the mystery of accelerated atherosclerosis in diabetes.
Borradaile N, Le Goff W
A New Enabling Technology to Manufacture CAR-T Cells for Personalized Cell Therapy
Principal investigators: Paul, Arghya
Microscale thermophoresis for assessing diverse molecular interactions.
Principal investigators: Stathopulos, Peter
Elongation factor 1A1 and the regulation of protein synthesis and cytoskeleton dynamics during lipid-induced stress
Principal investigators: Borradaile, Nica
Roles of elongation factor 1A1 in the progression of nonalcoholic fatty liver disease
Principal investigators: Borradaile, Nica M
Keywords: Cell Biology; Hepatic Stellate Cells; Hepatocytes; Lipids; Lipotoxicity; Liver; Metabolism; Mice; Nonalcoholic Fatty Liver Disease; Obesity
Roles of elongation factor 1A-1 in apolipoprotein B metabolism and the pathogenesis of nonalcoholic fatty liver disease
Principal investigators: Borradaile, Nica M
Keywords: Apolipoprotein B; Cellular Stress; Lipid; Liver; Nonalcoholic Fatty Liver Disease; Obesity; Type 2 Diabetes
Roles of elongation factor 1A-1 in apolipoprotein B metabolism and the pathogenesis of nonalcoholic fatty liver disease
Principal investigators: Borradaile, Nica M
Keywords: Apolipoprotein B; Cellular Stress; Lipid; Liver; Nonalcoholic Fatty Liver Disease; Obesity; Type 2 Diabetes
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Physiology and Pharmacology
- Chemical and Biochemical Engineering
- Biochemistry
Co-authors at Western University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Rennian Wang
Physiology and Pharmacology
3 shared papers, latest 2025
Arghya Paul
Chemical and Biochemical Engineering
2 shared papers, latest 2026
Ting-Yim Lee
Biochemistry
1 shared papers, latest 2021
Frank Beier
Physiology and Pharmacology
1 shared papers, latest 2017
Qingping Feng
Physiology and Pharmacology
1 shared papers, latest 2025
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