Faculty profile

Frank Beier

ResearcherPhysiology and PharmacologyWestern University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Western University directory, so their courses may be missing. Find their university profile.

Frank Beier

Researcher

Physiology and Pharmacology

Health Sciences

Western University

London, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
15 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 12 research grants (11 CIHR, 1 NSERC), most recently in 2022.
Supervisor on 17 trainee awards (17 CIHR), most recently in 2018.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

110

Publications

219

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Cartilage Osteoarthritis Bone Synovium Crc Osteoporosis Aging Animal Model

Latest papers

Acute TGFα drives OA-associated transcriptional and metabolic remodelling in primary chondrocytes.
Osteoarthritis and cartilage open · 2026 · senior author
Human pannexin mutations and their implications in erosive osteoarthritis.
Proceedings of the National Academy of Sciences of the United States of America · 2026
Severe osteoarthritis in aged PANX3 knockout mice: implications for a novel primary osteoarthritis model.
JBMR plus · 2025

All 110 publications

Latest funding

Bioreactor suite to study mechanical loading in skeletal tissues & biomaterials
NSERC · 2022 · Co-investigator
$149,767
The role of Pannexin 3 in aging-associated osteoarthritis
CIHR · 2022 · Nominated PI
$100,000
Disease-modifying effects of osteotomy and exercise for knee osteoarthritis
CIHR · 2021 · Co-investigator
$845,326

All 41 grants and awards

110 publications.

Acute TGFα drives OA-associated transcriptional and metabolic remodelling in primary chondrocytes.

White EL, Day EA, Appleton CT, Grol MW, Beier F

Osteoarthritis and cartilage open2026Senior author

DOI: 10.1016/j.ocarto.2026.100873 PMID: 42756972

Human pannexin mutations and their implications in erosive osteoarthritis.

Tang J, Lu J, Johnston D, Hoshijima K, Wakefield B, Bai D, Stathopulos PB, Thompson RJ, Lohman AW, Jurynec MJ, Beier F, Penuela S

Proceedings of the National Academy of Sciences of the United States of America2026

DOI: 10.1073/pnas.2535302123 PMID: 42127103

Severe osteoarthritis in aged PANX3 knockout mice: implications for a novel primary osteoarthritis model.

Wakefield B, Tang J, Balanta-Melo J, Hutchinson JL, Kanji R, Herold G, O'Donnell BL, Brooks C, Kiser P, Grol MW, Séguin CA, Plotkin LI, Beier F, Penuela S

JBMR plus2025

DOI: 10.1093/jbmrpl/ziaf057 PMID: 40386290

Changes and associations between synovial fluid and magnetic resonance imaging markers of osteoarthritis after high tibial osteotomy.

Schulz JM, Birmingham TB, Philpott HT, Appleton CT, Atkinson HF, Giffin JR, Beier F

Arthritis research & therapy2024Senior author

DOI: 10.1186/s13075-024-03409-3 PMID: 39390512

Pannexin 3 deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running.

Wakefield B, Tang J, Hutchinson JL, Kanji R, Brooks C, Grol MW, Séguin CA, Penuela S, Beier F

Journal of orthopaedic research : official publication of the Orthopaedic Research Society2024Senior author

DOI: 10.1002/jor.25830 PMID: 38499500

Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress.

Wolpe AG, Luse MA, Baryiames C, Schug WJ, Wolpe JB, Johnstone SR, Dunaway LS, Juśkiewicz ZJ, Loeb SA, Askew Page HR, Chen YL, Sabapathy V, Pavelec CM, Wakefield B, Cifuentes-Pagano E, Artamonov MV, Somlyo AV, Straub AC, Sharma R, Beier F, Barrett EJ, Leitinger N, Pagano PJ, Sonkusare SK, Redemann S, Columbus L, Penuela S, Isakson BE

Science signaling2024

DOI: 10.1126/scisignal.adg2622 PMID: 38289985

GPx1 promotes hypertrophic differentiation of chondrocytes through modulation of akt signaling in a non-monotonic manner.

Mi S, Zhang J, Sun M, Huo X, Lv Y, Beier F, Lu S, Yan J

Experimental cell research2023

DOI: 10.1016/j.yexcr.2023.113824 PMID: 37890608

Comparative histopathological analysis of age-associated intervertebral disc degeneration in CD-1 and C57BL/6 mice: Anatomical and sex-based differences.

Hutchinson JL, Veras MA, Serjeant ME, McCann MR, Kelly AL, Quinonez D, Beier F, Séguin CA

JOR spine2023

DOI: 10.1002/jsp2.1298 PMID: 38156059

Anabolic phenotype in cartilage-specific mitogen-inducible gene-6 knockout mice is independent of transforming growth factor-α.

Hadzic E, To B, Pest MA, Qin L, Beier F

Osteoarthritis and cartilage open2023Senior author

DOI: 10.1016/j.ocarto.2023.100387 PMID: 37547183

Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression.

Chan B, Glogauer M, Wang Y, Wrana J, Chan K, Beier F, Bali S, Hinz B, Parreno J, Ashraf S, Kandel R

Science advances2023

DOI: 10.1126/sciadv.adf1130 PMID: 37540756

Bioreactor suite to study mechanical loading in skeletal tissues & biomaterials

Co-investigatorNSERC2022Research Tools and Instruments

Principal investigators: Seguin, Cheryle

$149,767

The role of Pannexin 3 in aging-associated osteoarthritis

Nominated PICIHR2022Project Grant

Principal investigators: Beier, Frank; Penuela, Silvia

Keywords: Aging; Animal Model; Bone; Cartilage; Ko Mice; Obesity; Osteoarthritis; Pannexin; Patient Samples; Synovium

$100,000

Disease-modifying effects of osteotomy and exercise for knee osteoarthritis

Co-investigatorCIHR2021Project Grant

Principal investigators: Birmingham, Trevor B; Appleton, Thomas C; Giffin, James R

Keywords: Articular Cartilage; Gait Biomechanics; High Tibial Osteotomy; Inflammation; Knee; Orthopaedics; Osteoarthritis Progression; Pain And Fuunction; Physical Therapy; Therapeutic Exercise

$845,326

Targeting the Protease Activated Receptor (PAR) - Transient Receptor Potential Vanilloid-4 (TRPV4) signalling axis in osteoarthritis.

Co-investigatorCIHR2021Project Grant

Principal investigators: Ramachandran, Rithwik

Keywords: Animal Models; Inflammation; Mechanosensitive Ion Channels; Osteoarthritis; Pain; Proteinase Activated Receptors; Proteolytic Enzymes; Synovial Fluids; Therapeutic Targets; Trpv4

$711,450

The role of PGC1alpha in osteoarthritis

Nominated PICIHR2021Project Grant

Principal investigators: Beier, Frank

Keywords: Bone; Cartilage; Gene Expression; Metabolism; Mitochondria; Mouse Model; Osteoarthritis; Pgc1alpha; Synovium

$745,875

Canada Research Chair - Tier 1

Nominated PICIHR2020Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Beier, Frank

Keywords: Crc

$1,400,000

Intra-articular Delivery of PPAR-delta Inhibitors for the Treatment of Post-traumatic Osteoarthritis

Co-investigatorCIHR2019Project Grant - PA: Arthritis

Principal investigators: Gillies, Elizabeth R

Keywords: Drug Delivery; Hydrogel; Osteoarthritis; Stimuli-Responsive

$100,000

Regulation of Pannexin-3 by Rac1 in mouse cartilage

SupervisorCIHR2018Undergraduate: Summer Studentship Award - Institute Community Support

Principal investigators: Shao, Ziyi

Keywords: Chonrocytes; Mice; Osteoarthritis; Pannexin3; Rac1; Regulation

$5,000

The role of Panx3 in Osteoarthritis

SupervisorCIHR2017Undergraduate: Summer Studentship Award - Institute Community Support

Principal investigators: Shao, Ziyi

Keywords: Aging; Musculoskeletal; Osteoarthritis; Panx3

$5,000

Workshop on Early Knee Osteoarthritis: Novel biomarkers, Diagnostics, Therapeutics and Clinical Cohorts for Early Detection and Intervention

Co-investigatorCIHR2016Planning and Dissemination Grant - Institute Community Support

Principal investigators: Kapoor, Mohit

Keywords: Biomarkers; Computational Biology; Drug Discovery; Epidemiology; Knee; Oa Clinical Cohort; Oa Diagnostics; Oa Therapeutic Targets; Osteoarthritis

$9,916

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Frank Beier

Research

Latest papers

Latest funding

Acute TGF&#x3b1; drives OA-associated transcriptional and metabolic remodelling in primary chondrocytes.

Human pannexin mutations and their implications in erosive osteoarthritis.

Severe osteoarthritis in aged PANX3 knockout mice: implications for a novel primary osteoarthritis model.

Changes and associations between synovial fluid and magnetic resonance imaging markers of osteoarthritis after high tibial osteotomy.

Pannexin 3 deletion in mice results in knee osteoarthritis and intervertebral disc degeneration after forced treadmill running.

Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress.

GPx1 promotes hypertrophic differentiation of chondrocytes through modulation of akt signaling in a non-monotonic manner.

Comparative histopathological analysis of age-associated intervertebral disc degeneration in CD-1 and C57BL/6 mice: Anatomical and sex-based differences.

Anabolic phenotype in cartilage-specific mitogen-inducible gene-6 knockout mice is independent of transforming growth factor-&#x3b1;.

Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression.

Bioreactor suite to study mechanical loading in skeletal tissues & biomaterials

Frequent collaborators

Silvia Penuela

Qingping Feng

Andrew Leask

Lauren Flynn

Robert Gros

Nica Borradaile

Donglin Bai

Amin Rizkalla

Ting-Yim Lee

Subrata Chakrabarti

Mamadou Diop

Mark Darling

Keith St Lawrence

Patti Kiser

Amira Klip

Jeffrey Wrana

Dianne Bryant

Baraa Al-Khazraji

James Lorne Henry

Michael Glogauer

Monzur Murshed

Roman Krawetz

Boris Hinz

Rita Kandel

Acute TGFα drives OA-associated transcriptional and metabolic remodelling in primary chondrocytes.

Anabolic phenotype in cartilage-specific mitogen-inducible gene-6 knockout mice is independent of transforming growth factor-α.