Faculty profile

Constantin Polychronakos

ResearcherPediatricsMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Constantin Polychronakos

Researcher

Pediatrics

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
16 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (5 CIHR), most recently in 2019.
Supervised 1 trainee who won CIHR awards, most recently in 2010.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Diabetes Clonal Expansion Autoimmunity Celiac Disease Post-Zygotic Mutations T-Lymphocytes Type 1 Diabetes Dominant

Latest papers

Machine learning in prediction and classification of type 1 diabetes.
Nature genetics · 2026 · senior author
What Proportion of Antibody-Negative Type 1 Diabetes Cases Have a Nonautoimmune Etiology? A Genetics-Based Estimate.
Diabetes · 2026 · senior author
Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes.
Diabetologia · 2026

All 84 publications

Latest funding

Canadian Population Screening for Risk of Type 1 Diabetes Research Consortium
CIHR · 2023 · Co-investigator
$5,999,552
Driver somatic mutations in autoimmunity
CIHR · 2019 · Nominated PI
$1,132,200
Precision diagnostics in childhood diabetes; therapeutic implications
CIHR · 2018 · Nominated PI
$1,086,301

All 10 grants and awards

84 publications.

Machine learning in prediction and classification of type 1 diabetes.

Li Y, Polychronakos C

Nature genetics2026Senior author

DOI: 10.1038/s41588-026-02571-5 PMID: 42062539

What Proportion of Antibody-Negative Type 1 Diabetes Cases Have a Nonautoimmune Etiology? A Genetics-Based Estimate.

Nicodemo JL, Makri A, Polychronakos C

Diabetes2026Senior author

DOI: 10.2337/db25-1110 PMID: 42635517

Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes.

Jumentier B, Qu HQ, Lu T, Liu K, Kleinbrink EL, Klein K, Belbellaj W, Gamache I, Ferrat L, Butler-Laporte G, Li Y, Hakonarson H, Wu W, Polychronakos C, Greenwood CMT, Manousaki D

Diabetologia2026

DOI: 10.1007/s00125-026-06706-5 PMID: 41795035

Metabolome-wide Mendelian randomisation reveals causal links between circulating metabolites and type 1 diabetes.

Jumentier B, Gamache I, Michalek DA, Chen WM, Onengut-Gumuscu S, Rich SS, Polychronakos C, Manousaki D

EBioMedicine2025

DOI: 10.1016/j.ebiom.2025.105807 PMID: 40561777

Investigating TSHR gene variants in consanguineous families: novel insights into variable expression in familial congenital hypothyroidism.

Nadeali Z, Mohammadi-Zaniani Z, Biglari S, Molavi N, Zardoui K, Mirfendereski S, Hashemipour M, Tabatabaiefar MA, Polychronakos C

Frontiers in endocrinology2025Senior author

DOI: 10.3389/fendo.2025.1559281 PMID: 40391015

Non-syndromic WFS1 mutations are not a rare cause of diabetes in Pakistan.

Rafique I, Mir A, Popovic N, Vanpoperinghe A, Nadeem Saqib MA, Fawwad A, Basit A, Naeem M, Polychronakos C, Makri A

Diabetes research and clinical practice2025

DOI: 10.1016/j.diabres.2025.112361 PMID: 40617298

Population-based prevalence of self-reported pediatric diabetes and screening for undiagnosed type 2 diabetes in Chinese children in years 2017-2019, a cross-sectional study.

Wu W, Zhang JW, Li Y, Huang K, Chen RM, Maimaiti M, Luo JS, Chen SK, Wu D, Zhu M, Wang CL, Su Z, Liang Y, Yao H, Wei HY, Zheng RX, Du HW, Luo FH, Li P, Wang E, Polychronakos C, Fu JF

The Lancet regional health. Western Pacific2024

DOI: 10.1016/j.lanwpc.2024.101206 PMID: 39324120

Parsing the spectrum of allelic architectures in diabetes.

Li Y, Polychronakos C

Nature genetics2024Senior author

DOI: 10.1038/s41588-024-01950-0 PMID: 39402157

Clinical application of immune repertoire sequencing in solid organ transplant.

Wong P, Cina DP, Sherwood KR, Fenninger F, Sapir-Pichhadze R, Polychronakos C, Lan J, Keown PA

Frontiers in immunology2023

DOI: 10.3389/fimmu.2023.1100479 PMID: 36865546

Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator.

Cardinale CJ, Chang X, Wei Z, Qu HQ, Bradfield JP, Polychronakos C, Hakonarson H

Frontiers in immunology2023

DOI: 10.3389/fimmu.2023.1101488 PMID: 36817429

Canadian Population Screening for Risk of Type 1 Diabetes Research Consortium

Co-investigatorCIHR2023Team Grant: CIHR-JDRF Type 1 Diabetes Screening Research Consortium

Principal investigators: Wherrett, Diane K; Delorme, Sasha; Chakraborty, Pranesh K; Hayeems, Robin Z; Kastner, Monika; L'Espérance, Audrey; Manousaki, Despoina; Marwaha, Ashish K; McGavock, Jonathan M; Pow, Conrad; Senior, Peter A; Tsui, Albert K; Verchere, Bruce C; Witteman, Holly M

Keywords: Autoantibodies; Consortium; Diabetic Ketoacidosis; Genetic Risk Score; Metabolic Monitoring; Population; Screening; Type 1 Diabetes

$5,999,552

Driver somatic mutations in autoimmunity

Nominated PICIHR2019Project Grant

Principal investigators: Polychronakos, Constantin

Keywords: Autoimmunity; Celiac Disease; Clonal Expansion; Post-Zygotic Mutations; T-Lymphocytes; Type 1 Diabetes

$1,132,200

Precision diagnostics in childhood diabetes; therapeutic implications

Nominated PICIHR2018Project Grant

Principal investigators: Polychronakos, Constantin

Keywords: Diabetes; Dominant; Exome; Mendelian; Mody; Monogenic; Neonatal; Recessive

$1,086,301

Antigen-specific functional properties and molecular profiling of autoreactive T-cells in individuals at risk for type 1 diabetes.

Co-investigatorCIHR2016Project Grant

Principal investigators: Piccirillo, Ciriaco A

Keywords: Antigen-Specific; Autoreactive Tcr Sequences; Biomarkers; Epigenetics; Immune Regulation; Regulatory T Cells; T Cells; Type 1 Diabetes (Recent-Onset)

$1,957,120

A genome-wide search for exonic variants affecting translational efficiency

Nominated PICIHR2016Project Grant

Principal investigators: Polychronakos, Constantin

Keywords: Complex Trait; Diabetes; Genetic Variation; Genome-Wide Associatin; Mass Spectrometry; Polysomes; Protein Quantification; Proteomics; Ribosomes; Translation

$798,904

Molecular alterations in type 1 diabetes

Nominated PICIHR2014Operating Grant

Principal investigators: Polychronakos, Constantin

Keywords: Blood Cells; Clonal Expansion; Comparative Genomic Hybridisation; Diabetes; Lymph Nodes; Lymphocytes; Microarrays; Molecular Alterations; Personalised Medicine; Proliferation

$369,478

The Role of Rare and Somatic Variants in Ageing-Related Disease

SupervisorCIHR2010Institute of Genetics Clinical Investigatorship Award

Principal investigators: Richards, Brent

Keywords: Ageing; Epigenetic Modification; Genetic Epidemiology; Genomics; Osteoporosis; Rare Base Pair Variation; Somatic Mutation

$280,000

From population-based gene identification studies to molecular biology: a genetic epidemiology training program

Principal investigatorCIHR2009Training Grant in Genetic Epidemiology - Letter of Intent

Principal investigators: Infante-Rivard, Claire; Labbe, Aurelie; Polychronakos, Constantin; Richards, Brent; Sladek, Robert G

Keywords: Bioinformatics; Gene Characterization; Gene Identification; Genetic Epidemiology; Methods In Genetic Epidemiology; Molecular Biology

CIHR Training Program in Integrative Approaches to Human Health

Co-investigatorCIHR2008Training Grant

Principal investigators: Hallett, Michael T

Keywords: Bioinformatics; Cancer; Complex Diseases; Computational Biology; Genomics; Imaging; Mathematical Modelling; Orphan Diseases; Proteomics; Quantitative Biology; Systems Biology

$1,766,127

Genetic Epidemiology of Osteoporotic Fractures; From Susceptibility Genes to Susceptible Populations

Co-investigatorCIHR2008Operating Grant

Principal investigators: Richards, Brent

Keywords: Aging; Fracture; Genetic Epidemiology; Human Genetics; Osteoporosis

$273,698

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Constantin Polychronakos

Research

Latest papers

Latest funding

Machine learning in prediction and classification of type 1 diabetes.

What Proportion of Antibody-Negative Type 1 Diabetes Cases Have a Nonautoimmune Etiology? A Genetics-Based Estimate.

Development and validation of a trans-ancestry polygenic risk score for type 1 diabetes.

Metabolome-wide Mendelian randomisation reveals causal links between circulating metabolites and type 1 diabetes.

Investigating TSHR gene variants in consanguineous families: novel insights into variable expression in familial congenital hypothyroidism.

Non-syndromic WFS1 mutations are not a rare cause of diabetes in Pakistan.

Population-based prevalence of self-reported pediatric diabetes and screening for undiagnosed type 2 diabetes in Chinese children in years 2017-2019, a cross-sectional study.

Parsing the spectrum of allelic architectures in diabetes.

Clinical application of immune repertoire sequencing in solid organ transplant.

Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator.

Frequent collaborators

Despoina Manousaki

Tomi Pastinen

Ruth Sapir-Pichhadze

Michael Pollak

Jacek Majewski

Robert Sladek

Nada Jabado

Cynthia Goodyer

Laurent Legault

Meranda Nakhla

Jo Knight

Laurent Legault

Meranda Nakhla

Martin Olivier

Steven Paraskevas

Roberta La Piana

James Lan

Nadine Taleb

Eriskay Liston

Daniela Pohl

Bernard Brais

Jerry Pelletier

Elsa Rossignol

Alan Peterson

Martin Olivier

Elin Grundberg

Ciriaco Piccirillo

Marc Prentki