Faculty profile

Jacek Majewski

ResearcherHuman GeneticsMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Jacek Majewski

Researcher

Human Genetics

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
34 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (4 CIHR, 1 NSERC, 1 SSHRC), most recently in 2022.
Supervised 6 trainees who won CIHR awards, most recently in 2020.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

217

Publications

2,377

Citations

h-index

143

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Genomics Cancer Dna Methylation Epigenetics Histone Modifications Animal Models Genetic Disease Genome Editing

Latest papers

H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs.
Nature genetics · 2026
Report of two patients with variants in FOXL2 and KASH5 and review of gestational trophoblastic neoplasia after recurrent moles.
Journal of assisted reproduction and genetics · 2026
Lessons learned from the exome sequencing of nine cases of infertility and the way forward.
Reproductive biomedicine online · 2026

All 217 publications

Latest funding

Mechanisms and Role of DNA Methylation in X-chromosome Inactivation
NSERC · 2022 · Principal investigator
$120,000
HIT-GLIO – Targeting tumour-host interactions in paediatric malignant gliomas to reinvigorate immunity and improve radio- and immunotherapy efficacy
SSHRC · 2022 · Principal investigator
$187,500
Investigating interdependencies between epigenetic modifications: towards combinatorial epigenetic cancer therapeutics
CIHR · 2022 · Nominated PI
$845,326

All 19 grants and awards

From the 150 most recent of 217 publications.

H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs.

Krug B, Hu B, Chen H, Negrón-Lomas C, Chen X, El Mouatani A, Gretarsson KH, Ptack A, Deshmukh S, Kabir N, Jawhar W, Andrade AF, Jabbour E, Harutyunyan AS, Wang X, Taylor R, Lee JJY, Hulswit M, Faury D, Russo C, Xu X, Yang J, Baguette A, Dahl NA, Weil AG, Ellezam B, Dali R, Blanchette M, Wilson K, Garcia BA, Soni RK, Gallo M, Taylor MD, Kleinman CL, Majewski J, Jabado N, Lu C

Nature genetics2026

DOI: 10.1038/s41588-026-02586-y PMID: 42151415

Report of two patients with variants in FOXL2 and KASH5 and review of gestational trophoblastic neoplasia after recurrent moles.

Saharan A, Hemida R, Lefebvre M, Bareke E, Carile V, Abdalla E, Majewski J, Slim R

Journal of assisted reproduction and genetics2026

DOI: 10.1007/s10815-026-03984-1 PMID: 42503564

Lessons learned from the exome sequencing of nine cases of infertility and the way forward.

Broojeni JV, Elmahdy M, Mitchell S, Rezaei M, Saharan A, Elhady G, Safwat S, Bareke E, Abdelrazek I, Xu C, Li L, Buckett W, Ao A, Miron P, Majewski J, Abdalla E, Slim R

Reproductive biomedicine online2026

DOI: 10.1016/j.rbmo.2025.105359 PMID: 41932285

NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers.

Jeong J, Hausmann S, Dong H, Szczepski K, Flores NM, Garcia Gonzalez A, Shi L, Lu X, Lempiäinen J, Jakab M, Zeng L, Chasan T, Bareke E, Dong R, Carlson E, Padilla R, Husmann D, Thompson J, Shipman GA, Zahn E, Barnes CA, Khan LF, Albertorio-Sáez LM, Brill E, Kumary VUS, Marunde MR, Maryanski DN, Szany CC, Venters BJ, Windham CL, Nowakowski ME, Czaban I, Jaremko M, Keogh MC, Le K, Soth MJ, Garcia BA, Jaremko Ł, Majewski J, Mazur PK, Gozani O

Nature2026

DOI: 10.1038/s41586-025-09299-y PMID: 40770093

Cellular reprogramming of H3K27M pediatric high-grade glioma to neuron-like state.

Uthamacumaran A, Horth C, Bareke E, Gravel M, Majewski J

Acta neuropathologica communications2025Senior author

DOI: 10.1186/s40478-025-02185-8 PMID: 41469740

H3K36 Methylation as a Guardian of Epigenome Integrity.

Padilla R, Shipman GA, Horth C, Gravel M, Bareke E, Majewski J

Nature communications2025Senior author

DOI: 10.1038/s41467-025-66365-9 PMID: 41381501

The mitotic STAG3-cohesin complex shapes male germline nucleome.

Nagano M, Hu B, Ogata K, Umemura F, Ishikura Y, Suzuki S, Katsifis CC, Yoshinaga M, Litos G, Nagasaka K, Tang W, Nosaka Y, Sasada H, Wang H, Kondo D, Katou Y, Mizuta K, Yabuta Y, Ohta H, de Luna Vitorino FN, Arima H, Ichikawa T, Gabriele M, Majewski J, Garcia BA, Takeuchi O, Yoshida S, Hansen AS, Peters JM, Ishihama Y, Saitou M

Nature structural & molecular biology2025

DOI: 10.1038/s41594-025-01647-w PMID: 40855131

Two Novel Protein-Truncating Variants in NLRP2 and Their Functional Impacts on the Subcortical Maternal Complex.

Yalcin Z, Gao Z, Abdelrazek IM, Bareke E, Majewski J, Abdalla E, Tan SL, Li L, Slim R

Clinical genetics2025

DOI: 10.1111/cge.14718 PMID: 39905760

Using multiple modalities to confirm diagnosis in patients with suspected peroxisome biogenesis disorders.

Cheung ACT, Di Pietro E, Argyriou C, Bareke E, D'Souza Y, Puri RD, Muhammed Shabeer P, Ganetzky R, Goldstein A, Vanderver A, Mohan S, Majewski J, Yergeau C, Braverman N

Molecular genetics and metabolism2025

DOI: 10.1016/j.ymgme.2025.109080 PMID: 40112482

ChIPbinner: an R package for analyzing broad histone marks binned in uniform windows from ChIP-Seq or CUT&RUN/TAG data.

Padilla R, Bareke E, Hu B, Majewski J

BMC bioinformatics2025Senior author

DOI: 10.1186/s12859-025-06103-6 PMID: 40128719

Mechanisms and Role of DNA Methylation in X-chromosome Inactivation

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Majewski, Jacek

$120,000

HIT-GLIO – Targeting tumour-host interactions in paediatric malignant gliomas to reinvigorate immunity and improve radio- and immunotherapy efficacy

Principal investigatorSSHRC2022New Frontiers in Research Fund - Global Platforms

Principal investigators: Majewski, Jacek

Keywords: Paeditric Glioma; Tumor microenvironment; Immune therapy; Genomics; Bioinformatics; Epigenetics

$187,500

Investigating interdependencies between epigenetic modifications: towards combinatorial epigenetic cancer therapeutics

Nominated PICIHR2022Project Grant

Principal investigators: Majewski, Jacek A

Keywords: Cancer; Dna Methylation; Epigenetics; Genomics; Histone Modifications

$845,326

The role of spliceosome proteins in disease and development

Co-investigatorCIHR2022Project Grant

Principal investigators: Jerome-Majewska, Loydie A

Keywords: Congenital Malformations; Craniofacial Development; Mfdm; Mouse Models; Nager; Splicing

$749,700

Resolving the cis-regulatory role of the histone post-translational modification H3K36me2 in driving tumorigenesis

SupervisorCIHR2020Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Hu, Bo

Keywords: Chromatin Conformation Capture; Cis-Regulation; Dna Methylation; Enhancer; Epigenetics; H3k36me2; Histone Modifications; Nuclear Architecture; Oncohistones; Tumorigenesis

$105,000

Tackling Childhood Brain Cancer at the root to improve survival and quality of life

Co-investigatorCIHR2017Genomics and Personalized Health -Large-Scale Applied Genomics Res Projects

Principal investigators: Jabado, Nada

Keywords: Epigenetically Deregulated Cancers

$2,650,000

Splicing Defects in Human Hereditary Disease

Nominated PICIHR2015Operating Grant

Principal investigators: Majewski, Jacek A

Keywords: Animal Models; Genetic Disease; Genome Editing; Genomics; Rna Sequencing

$528,504

Inherited susceptibility to cancer: from gene discovery to mechanisms to clinical applications

Co-investigatorCIHR2015Foundation Grant

Principal investigators: Foulkes, William D

Keywords: Dicer1; Founder Mutations; Genetic Predisposition; Hereditary Cancer; Multiple Primary Tumors; Rare Tumours

$2,533,600

ICS IG 2014 Computational Biology Undergraduate Summer Student Health Research award - Analysis of RNA-sequencing data.

SupervisorCIHR2014Undergraduate: Summer Studentship Award - Institute Community Support

Principal investigators: Osmond, Matthew

Keywords: Graphic Interface

$5,000

Identifying the genetic causes of ataxias using Next-generation sequencing (NGS) methods.

SupervisorCIHR2014CIHR Fellowship

Principal investigators: Tetreault, Martine

Keywords: Ataxia; Gene Identification; Human Genetics; Mri Anomalies; Neurodegenerative Disorder; Next-Generation Sequencing; Whole-Exome Sequencing

$135,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Jacek Majewski

Research

Latest papers

Latest funding

H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs.

Report of two patients with variants in FOXL2 and KASH5 and review of gestational trophoblastic neoplasia after recurrent moles.

Lessons learned from the exome sequencing of nine cases of infertility and the way forward.

NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers.

Cellular reprogramming of H3K27M pediatric high-grade glioma to neuron-like state.

H3K36 Methylation as a Guardian of Epigenome Integrity.

The mitotic STAG3-cohesin complex shapes male germline nucleome.

Two Novel Protein-Truncating Variants in NLRP2 and Their Functional Impacts on the Subcortical Maternal Complex.

Using multiple modalities to confirm diagnosis in patients with suspected peroxisome biogenesis disorders.

ChIPbinner: an R package for analyzing broad histone marks binned in uniform windows from ChIP-Seq or CUT&RUN/TAG data.

Mechanisms and Role of DNA Methylation in X-chromosome Inactivation

HIT-GLIO – Targeting tumour-host interactions in paediatric malignant gliomas to reinvigorate immunity and improve radio- and immunotherapy efficacy

Frequent collaborators

Nada Jabado

Rima Slim

Taila Hartley

Tomi Pastinen

Bernard Brais

Frank Rauch

Mark Lathrop

Jason Karamchandani

Jason Karamchandani

Mathieu Blanchette

Jean Michaud

Mark Basik

Adam Fleming

David Grynspan

Roberta La Piana

Guillaume Bourque

Nancy Braverman

Philippe Gros

Pierre Moffatt

Myriam Srour

Myriam Srour

Pranesh Chakraborty

Marco Gallo

David Langlais

Mark Tarnopolsky

Catalin Mihalcioiu

Annie Huang

Yasser Riazalhosseini

François Rousseau

Peter Siegel

Peter Humphreys

Gelareh Zadeh

Eva Tomiak

Jana Feberova

Daniel Schramek

Karine Khatchadourian

Simon Gravel

Malgorzata Nowaczyk

Peter Roughley

Frank Sicheri