Faculty profile

Derek Bowie

ResearcherPharmacology and TherapeuticsMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Derek Bowie

Researcher

Pharmacology and Therapeutics

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
15 publications in the last five years, latest in 2026.
Senior (last) author on 7 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (7 CIHR), most recently in 2023.
Supervised 6 trainees who won CIHR awards, most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Signals and details

Research

Electrophysiology Fragile X Syndrome Ionotropic Glutamate Receptor Ampa Receptor Cerebellum Neuronal Nitric Oxide Synthase Nmda Receptor Gaba-A Receptor

Latest papers

The AMPA receptor life cycle: assembly, regulation and synaptic diversity.
Nature reviews. Neuroscience · 2026 · first author
Splicing, RNA editing, and auxiliary subunits shaped AMPA receptor function through coordinated evolution.
Trends in neurosciences · 2026 · first author
GluA2-containing AMPA receptors form a continuum of Ca2+-permeable channels.
Nature · 2025 · senior author

All 57 publications

Latest funding

Unravelling the impact of AMPA receptor missense mutations in neurodevelopmental disorders
CIHR · 2025 · Supervisor
$140,000
AMPA receptor missense mutations in neurodevelopmental disorders
CIHR · 2024 · Supervisor
$6,000
Unraveling the functional impact of AMPA receptor missense mutations in neurodevelopmental disorders
CIHR · 2023 · Nominated PI
$1,127,111

All 14 grants and awards

57 publications.

The AMPA receptor life cycle: assembly, regulation and synaptic diversity.

Bowie D, Wang XT, Miguez-Cabello F, Perozzo AM

Nature reviews. Neuroscience2026First author

DOI: 10.1038/s41583-026-01055-z PMID: 42286176

Splicing, RNA editing, and auxiliary subunits shaped AMPA receptor function through coordinated evolution.

Bowie D

Trends in neurosciences2026First author

DOI: 10.1016/j.tins.2026.01.006 PMID: 41794641

GluA2-containing AMPA receptors form a continuum of Ca2+-permeable channels.

Miguez-Cabello F, Wang XT, Yan Y, Brake N, Alexander RPD, Perozzo AM, Khadra A, Bowie D

Nature2025Senior author

DOI: 10.1038/s41586-025-08736-2 PMID: 40108453

Evolution of iGluR ligand specificity, polyamine regulation, and ion selectivity inferred from a placozoan epsilon receptor

Singh A, Zhorov BS, Yanez-Guerra LA, Aleotti A, Koens CC, Yanartas CD, Song Y, Miguez Cabello FJ, Bowie D, Senatore A

Communications Biology20254 citations

DOI: 10.1038/s42003-025-08402-3

Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5).

Buschbom-Helmke S, Wang P, Alcaide A, Miguez-Cabello F, Carta M, Viotti JS, Nielsen B, Mulle C, Bowie D, Jørgensen FS, Pickering DS, Bunch L

Journal of medicinal chemistry2024

DOI: 10.1021/acs.jmedchem.4c01311 PMID: 39133077

Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538.

Bay Y, Cabello FJM, Koens CC, Frantsen SM, Pickering DS, Frydenvang K, Francotte P, Pirotte B, Kristensen AS, Bowie D, Kastrup JS

Journal of structural biology2024

DOI: 10.1016/j.jsb.2024.108113 PMID: 39079583

The open gate of the AMPA receptor forms a Ca2+ binding site critical in regulating ion transport.

Nakagawa T, Wang XT, Miguez-Cabello FJ, Bowie D

Nature structural & molecular biology2024Senior author

DOI: 10.1038/s41594-024-01228-3 PMID: 38409505

Recovery from desensitization in GluA2 AMPA receptors is affected by a single mutation in the N-terminal domain interface.

Larsen AH, Perozzo AM, Biggin PC, Bowie D, Kastrup JS

The Journal of biological chemistry2024

DOI: 10.1016/j.jbc.2024.105717 PMID: 38311178

GSG1L-containing AMPA receptor complexes are defined by their spatiotemporal expression, native interactome and allosteric sites.

Perozzo AM, Schwenk J, Kamalova A, Nakagawa T, Fakler B, Bowie D

Nature communications2023Senior author

DOI: 10.1038/s41467-023-42517-7 PMID: 37884493

Alternative Splicing of the Flip/Flop Cassette and TARP Auxiliary Subunits Engage in a Privileged Relationship That Fine-Tunes AMPA Receptor Gating.

Perozzo AM, Brown PMGE, Bowie D

The Journal of neuroscience : the official journal of the Society for Neuroscience2023Senior author

DOI: 10.1523/jneurosci.2293-22.2023 PMID: 36931708

Unravelling the impact of AMPA receptor missense mutations in neurodevelopmental disorders

SupervisorCIHR2025Canada Postdoctoral Research Award (CPRA) program

Principal investigators: Wang, Xin-Tong

Keywords: Ampa Receptors; Cryogenic Electron Microscopy (Cryo-Em); Electrophysiology; Glutamatergic Neurotransmission; Intellectual Disability; Ion Channel Biophysics; Missense Mutations; Modal Gating Behavior; Neurodevelopmental Disorders; Structure

$140,000

AMPA receptor missense mutations in neurodevelopmental disorders

SupervisorCIHR2024Undergraduate Student Research Awards (USRA)

Principal investigators: Charles, Roberto

Keywords: Ampa Receptor Missense Mutations; Neurodevelopmental Disorders

$6,000