Faculty profile
Tak Mak
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Research
Latest papers
Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2.
Journal of immunology (Baltimore, Md. : 1950) · 2023
A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.
Science (New York, N.Y.) · 2022
Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion.
Science advances · 2021
Latest funding
- $120,000
Evaluating the Role of Choline Acetyltransferase (ChAT) in T Cell Malignancies
CIHR · 2025 · Supervisor
- $1,147,500
Identification of tumour-reactive gamma delta T cell receptors to treat hematological malignancies.
CIHR · 2024 · Nominated PI
- $20,000
Clonal Hematopoiesis of Indeterminate Potential (CHIP) as a Novel Biomarker and Therapeutic Target for Vulnerable Type 2 Diabetes Populations
CIHR · 2024 · Principal investigator
13 publications.
Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2.
Yu H, Worrall LJ, Berger T, Petric M, Lin BH, Vuckovic M, Robb CS, Le Q, Kenward C, Dai C, Wakeham A, Liu S, Snow B, Tobin C, Budylowski P, Guvenc F, You-Ten A, Haight J, Silvester J, Singh RP, Ahn SK, Sultana A, Poon B, Lam J, Christie-Holmes N, Ostrowski M, Gray-Owen SD, Kubli S, Mak T, Strynadka NCJ, Brunham RC
A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.
Yanchus C, Drucker KL, Kollmeyer TM, Tsai R, Winick-Ng W, Liang M, Malik A, Pawling J, De Lorenzo SB, Ali A, Decker PA, Kosel ML, Panda A, Al-Zahrani KN, Jiang L, Browning JWL, Lowden C, Geuenich M, Hernandez JJ, Gosio JT, Ahmed M, Loganathan SK, Berman J, Trcka D, Michealraj KA, Fortin J, Carson B, Hollingsworth EW, Jacinto S, Mazrooei P, Zhou L, Elia A, Lupien M, He HH, Murphy DJ, Wang L, Abyzov A, Dennis JW, Maass PG, Campbell K, Wilson MD, Lachance DH, Wrensch M, Wiencke J, Mak T, Pennacchio LA, Dickel DE, Visel A, Wrana J, Taylor MD, Zadeh G, Dirks P, Eckel-Passow JE, Attisano L, Pombo A, Ida CM, Kvon EZ, Jenkins RB, Schramek D
Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion.
Zhu C, Dixon KO, Newcomer K, Gu G, Xiao S, Zaghouani S, Schramm MA, Wang C, Zhang H, Goto K, Christian E, Rangachari M, Rosenblatt-Rosen O, Okada H, Mak T, Singer M, Regev A, Kuchroo V
Influence of the microenvironment on modulation of the host response by typhoid toxin.
Martin OCB, Bergonzini A, Lopez Chiloeches M, Paparouna E, Butter D, Theodorou SDP, Haykal MM, Boutet-Robinet E, Tebaldi T, Wakeham A, Rhen M, Gorgoulis VG, Mak T, Pateras IS, Frisan T
Immune Cell Associations with Cancer Risk.
Palomero L, Galván-Femenía I, de Cid R, Espín R, Barnes DR, Cimba, Blommaert E, Gil-Gil M, Falo C, Stradella A, Ouchi D, Roso-Llorach A, Violan C, Peña-Chilet M, Dopazo J, Extremera AI, García-Valero M, Herranz C, Mateo F, Mereu E, Beesley J, Chenevix-Trench G, Roux C, Mak T, Brunet J, Hakem R, Gorrini C, Antoniou AC, Lázaro C, Pujana MA
Amplification of a calcium channel subunit CACNG4 increases breast cancer metastasis.
Kanwar N, Carmine-Simmen K, Nair R, Wang C, Moghadas-Jafari S, Blaser H, Tran-Thanh D, Wang D, Wang P, Wang J, Pasculescu A, Datti A, Mak T, Lewis JD, Done SJ
A Journey in Science: "Not Lost in Translation".
Mak T
The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila.
Chang YJ, Zhou L, Binari R, Manoukian A, Mak T, McNeill H, Stambolic V
Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity.
Gaublomme JT, Yosef N, Lee Y, Gertner RS, Yang LV, Wu C, Pandolfi PP, Mak T, Satija R, Shalek AK, Kuchroo VK, Park H, Regev A
The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes.
Chang YJ, Pownall S, Jensen TE, Mouaaz S, Foltz W, Zhou L, Liadis N, Woo M, Hao Z, Dutt P, Bilan PJ, Klip A, Mak T, Stambolic V
Evaluating the Role of Choline Acetyltransferase (ChAT) in T Cell Malignancies
Principal investigators: Hilal, Arwa
Keywords: Choline Acetyltransferase; Cite Sequencing; Crispr/Cas9; Dna Repair Pathways; Pi3k-Akt Signalling; T Cell Activation; T Cell Acute Lymphoblastic Leukemia; Tumor Suppressor Genes
Identification of tumour-reactive gamma delta T cell receptors to treat hematological malignancies.
Principal investigators: Mak, Tak W
Keywords: Machine Learning-Based Prediction Algorithm; Multiple Myeloma; Single Cell Rna Sequencing; T Cell Receptor; Tcr-T Cell Therapy
Clonal Hematopoiesis of Indeterminate Potential (CHIP) as a Novel Biomarker and Therapeutic Target for Vulnerable Type 2 Diabetes Populations
Principal investigators: Woo, Minna N; Billia, Filio; Ke, Calvin; Lofters, Aisha K; Mak, Tak W
Keywords: Cardiovascular Disease; Clonal Haematopoiesis; East, South And West Asian Populations; Ethnic Minority Populations; Haematopoietic Stem Cells; Type 2 Diabetes
Investigation of Acetylcholine-producing B cells in Liver Regeneration following Partial Hepatectomy or Induction of Metabolic Dysfunction-Associated Steatohepatitis.
Principal investigators: Mak, Tak W
Keywords: Acetylcholine; Acetylcholine Receptors; B Cells; Hepatocytes; Immune Cells; Liver Regeneration; Partial Hepatectomy
Therapeutic targeting of epigenetic regulators in hematological malignancies
Principal investigators: Mak, Tak W
Keywords: Anti-Cancer Therapeutics; Epigenetics; Human Blood Cancers; Idh; Leukemia; Lymphoma; Mouse Models; Tet2
The roles of cholinergic T cells in immunosurveillance and immunotherapy of liver cancer.
Principal investigators: Mak, Tak W
Keywords: Acetycholine; Cholinergic Pathway; Hcc Mouse Model; Immunosurveilance; Liver Cancer; T Cells
Identification of T cell receptors that recognize novel HPV-associated tumor antigens
Principal investigators: St. Paul, Michael
Keywords: Cancer; Human Papilloma Virus; Immunology; Immunotherapy; T Cell Receptor; Tumor Antigens
Cholinergic Control of Immune Responses in Health and Autoimmune Disease: Mechanisms and Novel Therapeutic Opportunities
Principal investigators: Mak, Tak W
Keywords: Acetylcholine (Ach); B Cells; Choline Acetyltransferase (Chat).; Intra-Vital Microscopy; Mouse Models; T Cells; Thymocyte Development
CIHR Gold Leaf Prize for Discovery
Principal investigators: Mak, Tak W
Keywords: Gold Leaf
Identification of novel vulnerabilities and therapeutic strategies for breast cancers with acquired resistance to CDK4/6 inhibitors
Principal investigators: Soria Bretones, Isabel
Keywords: Breast Cancer; Cell Cycle; Crispr/Cas9 Screen; Drug Resistance; Plk4 Inhibitor (Plk4i); Targeted Therapies
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Medicine
- Lunenfeld-Tanenbaum Research Institute
- Medical Biophysics
- Medical Biophysics & Immunology
- Research
- Cell Biology
- Neurosurgery
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Lily Zhou
Faculty
3 shared papers, latest 2022
Vuk Stambolic
Research
2 shared papers, latest 2016
Mathieu Lupien
Medical Biophysics
1 shared papers, latest 2022
Mario Ostrowski
Medicine
1 shared papers, latest 2023
Amira Klip
Cell Biology
1 shared papers, latest 2015
Liliana Attisano
Department of Biochemistry
1 shared papers, latest 2022
Helen McNeill
Samuel Lunenfeld Research Institute
1 shared papers, latest 2016
Gelareh Zadeh
Neurosurgery
1 shared papers, latest 2022
Warren Foltz
Medicine
1 shared papers, latest 2015
Heiko Blaser
Faculty
1 shared papers, latest 2020
Daniel Schramek
Lunenfeld-Tanenbaum Research Institute
1 shared papers, latest 2022
Manu Rangachari
Faculty
1 shared papers, latest 2021
Chiara Gorrini
Faculty
1 shared papers, latest 2020
Kieran Campbell
Faculty
1 shared papers, latest 2022
Jeffrey Wrana
Lunenfeld-Tanenbaum Research Institute
1 shared papers, latest 2022
Minna Woo
Medicine
1 shared papers, latest 2015
Robert Rottapel
Medical Biophysics
1 shared papers, latest 2005
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