Faculty profile

Michael Shum

ResearcherEndocrinology and nephrologyUniversité Laval

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université Laval directory, so their courses may be missing. Find their university profile.

Michael Shum

Researcher

Endocrinology and nephrology

Université Laval

Quebec City, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
3 publications in the last five years, latest in 2024.
Principal investigator on 2 research grants (2 NSERC), most recently in 2021.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Inter-organelle communication Lipid Droplets Lipid metabolism Mitochondria Organelles Proteomics Signal transduction

Latest papers

HSDL2 links nutritional cues to bile acid and cholesterol homeostasis.
Science advances · 2024
Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic-mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer.
Molecular oncology · 2023
Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance.
Molecular metabolism · 2022 · first author

All 9 publications

Latest funding

Understanding mitochondria and lipids droplet interactions in cell biology
NSERC · 2021 · Principal investigator
$120,000
Understanding mitochondria and lipids droplet interactions in cell biology
NSERC · 2021 · Principal investigator
$12,500
Diabetes and Healthy Liver- Unravelling the links between postprandial metabolism in type 2 diabetes and progression of metabolic fatty liver disease.
CIHR · 2021 · Co-investigator
$722,925

All 3 grants and awards

9 publications.

HSDL2 links nutritional cues to bile acid and cholesterol homeostasis.

Samson N, Bosoi CR, Roy C, Turcotte L, Tribouillard L, Mouchiroud M, Berthiaume L, Trottier J, Silva HCG, Guerbette T, Plata-Gómez AB, Besse-Patin A, Montoni A, Ilacqua N, Lamothe J, Citron YR, Gélinas Y, Gobeil S, Zoncu R, Caron A, Morissette M, Pellegrini L, Rochette PJ, Estall JL, Efeyan A, Shum M, Audet-Walsh É, Barbier O, Marette A, Laplante M

Science advances2024

DOI: 10.1126/sciadv.adk9681 PMID: 38820148

Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic-mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer.

Gonthier K, Weidmann C, Berthiaume L, Jobin C, Lacouture A, Lafront C, Harvey M, Neveu B, Loehr J, Bergeron A, Fradet Y, Lacombe L, Riopel J, Latulippe É, Atallah C, Shum M, Lambert JP, Pouliot F, Pelletier M, Audet-Walsh É

Molecular oncology2023

DOI: 10.1002/1878-0261.13441 PMID: 37086156

Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance.

Shum M, Segawa M, Gharakhanian R, Viñuela A, Wortham M, Baghdasarian S, Wolf DM, Sereda SB, Nocito L, Stiles L, Zhou Z, Gutierrez V, Sander M, Shirihai OS, Liesa M

Molecular metabolism2022First author

DOI: 10.1016/j.molmet.2021.101403 PMID: 34823065

Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2.

Chella Krishnan K, Vergnes L, Acín-Pérez R, Stiles L, Shum M, Ma L, Mouisel E, Pan C, Moore TM, Péterfy M, Romanoski CE, Reue K, Björkegren JLM, Laakso M, Liesa M, Lusis AJ

Nature metabolism2021

DOI: 10.1038/s42255-021-00481-w PMID: 34697471

Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells.

Shum M, Houde VP, Bellemare V, Junges Moreira R, Bellmann K, St-Pierre P, Viollet B, Foretz M, Marette A

The Journal of biological chemistry2019First author

DOI: 10.1074/jbc.ra119.008488 PMID: 31243102

AMPK in skeletal muscle function and metabolism.

Kjøbsted R, Hingst JR, Fentz J, Foretz M, Sanz MN, Pehmøller C, Shum M, Marette A, Mounier R, Treebak JT, Wojtaszewski JFP, Viollet B, Lantier L

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

DOI: 10.1096/fj.201700442r PMID: 29242278

Loss of hepatic DEPTOR alters the metabolic transition to fasting.

Caron A, Mouchiroud M, Gautier N, Labbé SM, Villot R, Turcotte L, Secco B, Lamoureux G, Shum M, Gélinas Y, Marette A, Richard D, Sabatini DM, Laplante M

Molecular metabolism2017

DOI: 10.1016/j.molmet.2017.02.005 PMID: 28462079

Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice.

Shum M, Bellmann K, St-Pierre P, Marette A

Diabetologia2016First author

DOI: 10.1007/s00125-015-3839-6 PMID: 26733005

Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism.

Smadja-Lamère N, Shum M, Déléris P, Roux PP, Abe J, Marette A

The Journal of biological chemistry2013

DOI: 10.1074/jbc.m113.474148 PMID: 24036112

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Michael Shum

Research

Latest papers

Latest funding

HSDL2 links nutritional cues to bile acid and cholesterol homeostasis.

Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic-mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer.

Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance.

Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2.

Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells.

AMPK in skeletal muscle function and metabolism.

Loss of hepatic DEPTOR alters the metabolic transition to fasting.

Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice.

Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism.

Understanding mitochondria and lipids droplet interactions in cell biology

Understanding mitochondria and lipids droplet interactions in cell biology

Diabetes and Healthy Liver- Unravelling the links between postprandial metabolism in type 2 diabetes and progression of metabolic fatty liver disease.

Frequent collaborators

Mathieu Laplante

Alexandre Caron

Martin Pelletier

Mathieu Morissette

Jean-Philippe Lambert

Denis Richard

Olivier Barbier