Faculty profile

Mathieu Laplante

ResearcherMedicineUniversité Laval

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université Laval directory, so their courses may be missing. Find their university profile.

Mathieu Laplante

Researcher

Medicine

Health Sciences

Université Laval

Quebec City, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
22 publications in the last five years, latest in 2026.
Senior (last) author on 6 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (5 CIHR, 3 NSERC), most recently in 2024.
Supervised 1 trainee who won CIHR awards, most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Adipogenesis Obesity Human Liver Mouse Atherosclerosis Bile Acids Cholesterol

Latest papers

Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging.
Aging · 2026
Proanthocyanidin-Rich Cranberry Extract Lowers Glycemia in Established Obesity by Delaying Glucose Absorption.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease.
The Journal of clinical endocrinology and metabolism · 2026

All 72 publications

Latest funding

Exploring the biology of HSDL2 in health and disease
CIHR · 2024 · Nominated PI
$906,525
Exploring the Role of EMPRD on Metabolic Regulation
CIHR · 2023 · Supervisor
$1,500
Conférence Signalisation Québec 2022
CIHR · 2022 · Co-investigator
$10,000

All 10 grants and awards

72 publications.

Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging.

Labrada BL, Kumar A, Kolnohuz A, Pineault M, Bellmann K, Schwab M, Gagné A, Laplante M, Morissette MC, Marette A

Aging2026

DOI: 10.18632/aging.206413 PMID: 42669491

Proanthocyanidin-Rich Cranberry Extract Lowers Glycemia in Established Obesity by Delaying Glucose Absorption.

Beji S, Mouchiroud M, Tribouillard L, Efole B, Perazza L, Favereaux L, Poirier A, Idris W, Gélinas Y, Varin TV, Rovère C, Anhê FF, Picard F, Laplante M, Marette A, Michaud A, Caron A

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

DOI: 10.1096/fj.202601382r PMID: 42328893

Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease.

Gobeil É, Bourgault J, Gagnon E, Samson N, Ruel LJ, Côté V, Mitchell PL, Gotti C, Roux-Dalvai F, Droit A, Bossé Y, Mathieu P, Lajeunesse-Trempe F, Vohl MC, Caron A, Tchernof A, Thériault S, Laplante M, Arsenault BJ

The Journal of clinical endocrinology and metabolism2026

DOI: 10.1210/clinem/dgag043 PMID: 41635218

An Itch Receptor Drives Melanoma.

Gour N, Atakkatan A, Akbarzadeh M, Yong HM, Magesh A, Wu Z, Joo H, Chhabra Y, Peng J, Weeraratna A, Laplante M, Lajoie S, Dong X

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.06.01.729383 PMID: 42282710

Thermoregulatory adaptations to cold in C3H/HeJ mice are independent of ADRB3 signaling.

Beji S, Mouchiroud M, Gélinas Y, Laplante M, Michaud A, Caron A

Scientific reports2026

DOI: 10.1038/s41598-026-38538-z PMID: 41663555

The mTOR signaling pathway regulates key steps of mammary gland organoid genesis in a temporal manner.

Lacouture A, Sylla MS, Germain L, Fréville L, Lafront C, Weidmann C, Jobin C, Laplante M, Huot MÉ, Lambert JP, Audet-Walsh É

Scientific reports2026

DOI: 10.1038/s41598-026-37825-z PMID: 41617815

Generation and characterization of a Cre-inducible ZNF768 overexpression mouse model.

Poirier A, Tribouillard L, Kordahi M, Gélinas Y, Roy J, Beaulieu MJ, Orain M, Blanchet MR, Joubert P, Laplante M

Scientific reports2025Senior author

DOI: 10.1038/s41598-025-03110-8 PMID: 40473701

ZNF768 loss amplifies p53 action and reduces lung tumorigenesis in mice.

Poirier A, Utecht T, Villot R, Gélinas Y, Mouchiroud M, Kordahi M, Kolnohuz A, Pasteur C, Roy J, Beaulieu MJ, Orain M, Samson N, Blanchet MR, Joubert P, Laplante M

Oncogene2025Senior author

DOI: 10.1038/s41388-025-03352-w PMID: 40133474

Computational analysis of whole slide images predicts PD-L1 expression and progression-free survival in immunotherapy-treated non-small cell lung cancer patients.

Dia AK, Kolnohuz A, Yolchuyeva S, Tonneau M, Lamaze F, Orain M, Gagné A, Blais F, Coulombe F, Malo J, Belkaid W, Elkrief A, Williamson D, Routy B, Joubert P, Laplante M, Bilodeau S, Manem VS

Journal of translational medicine2025

DOI: 10.1186/s12967-025-06487-2 PMID: 40329352

ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression.

Prifti DK, Lauzier A, Garand C, Calvo E, Devillers R, Roy S, Dos Santos A, Descombes L, Trudel B, Laplante M, Bordeleau F, Elowe S

The Journal of cell biology2025

DOI: 10.1083/jcb.202311194 PMID: 39903211

Exploring the biology of HSDL2 in health and disease

Nominated PICIHR2024Project Grant

Principal investigators: Laplante, Mathieu

Keywords: Atherosclerosis; Bile Acids; Cholesterol; Circulating Lipids; Hsdl2; Human; Liver; Mouse

$906,525

Exploring the Role of EMPRD on Metabolic Regulation

SupervisorCIHR2023CIHR-ICRH Travel Awards - General pool

Principal investigators: Al Dow, Manal

Keywords: Dysfunctional White Adipose Tissue

$1,500

Conférence Signalisation Québec 2022

Co-investigatorCIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Hussein, Samer M

Keywords: Biochimie Fondamentale; Biologie De La Cellule; Chromatine; Développement; Environnement Cellulaire; Identification De Cibles Thérapeutiques; Immunité Et Infection; Kinases Et Phosphatases; Métabolisme; Signalisation Intracellulaire

$10,000

Exploring the biology of the hepatokine TSK in health and disease.

Nominated PICIHR2022Project Grant

Principal investigators: Laplante, Mathieu

Keywords: Cardiovascular Disease; Cell Culture; Crispr/Cas9 Screen; Hepatokine; Human; Liver; Molecular Biology; Mouse; Nafld; Physiology

$791,776

Towards a better understanding of the molecular mechanisms regulating liver metabolism in response to fasting

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Laplante, Mathieu

$198,000

Transcriptional control of brown preadipocyte commitment by PITX2

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Laplante, Mathieu

$32,000

Defining the role of DEPTOR in the regulation of brown adipose tissue development/function and evaluation of its impact on systemic metabolism.

Nominated PICIHR2019Project Grant

Principal investigators: Laplante, Mathieu

Keywords: Adipogenesis; Brown Adipose Tissue; Cell Signaling; Lipid Metabolism; Obesity

$757,350

Molecular mechanisms of adipose tissue development

Nominated PICIHR2016Project Grant

Principal investigators: Laplante, Mathieu

Keywords: Adipocyte; Adipogenesis; Adipose Tissue Development; Obesity

$696,150

Implication of DEPTOR in the regulation of glucose/lipid homeostasis

Nominated PICIHR2012Operating Grant

Principal investigators: Laplante, Mathieu

Keywords: Adipogenesis; Glucocorticoids; Glucose And Lipid Homeostasis; Insulin Resistance; Insulin Signaling; Liver Metabolism; Metabolic Diseases; Mtor Signaling; Obesity; Transgenic Mouse Models

$570,184

Characterization of the molecular mechanisms regulating DEPTOR expression/localization in response to stress and identification of novel cellular functions of this protein.

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Laplante, Mathieu

$180,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Mathieu Laplante

Research

Latest papers

Latest funding

Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging.

Proanthocyanidin-Rich Cranberry Extract Lowers Glycemia in Established Obesity by Delaying Glucose Absorption.

Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease.

An Itch Receptor Drives Melanoma.

Thermoregulatory adaptations to cold in C3H/HeJ mice are independent of ADRB3 signaling.

The mTOR signaling pathway regulates key steps of mammary gland organoid genesis in a temporal manner.

Generation and characterization of a Cre-inducible ZNF768 overexpression mouse model.

ZNF768 loss amplifies p53 action and reduces lung tumorigenesis in mice.

Computational analysis of whole slide images predicts PD-L1 expression and progression-free survival in immunotherapy-treated non-small cell lung cancer patients.

ARHGEF17/TEM4 regulates the cell cycle through control of G1 progression.

Exploring the biology of HSDL2 in health and disease

Exploring the Role of EMPRD on Metabolic Regulation

Conférence Signalisation Québec 2022

Exploring the biology of the hepatokine TSK in health and disease.

Towards a better understanding of the molecular mechanisms regulating liver metabolism in response to fasting

Transcriptional control of brown preadipocyte commitment by PITX2

Defining the role of DEPTOR in the regulation of brown adipose tissue development/function and evaluation of its impact on systemic metabolism.

Molecular mechanisms of adipose tissue development

Implication of DEPTOR in the regulation of glucose/lipid homeostasis

Characterization of the molecular mechanisms regulating DEPTOR expression/localization in response to stress and identification of novel cellular functions of this protein.

Frequent collaborators

Alexandre Caron

Denis Richard

Philippe Joubert

Steve Bilodeau

Sabine Elowe

Pierre-Gilles Blanchard

David Marsolais

Olivier Barbier

Nathalie Perreault

Mathieu Morissette

Patrick Mathieu

Jacques Couet

Nicole Beauchemin

Przemyslaw Sapieha

Yannick Doyon

Jean-Sébastien Joyal

Nathalie Labrecque

Sylvain Moineau

Ivan Topisirovic

Luca Pellegrini

Guillaume Lettre