Faculty profile

Jean-Philippe Lambert

ResearcherMolecular MedicineUniversité Laval

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université Laval directory, so their courses may be missing. Find their university profile.

Jean-Philippe Lambert

Researcher

Molecular Medicine

Health Sciences

Université Laval

Quebec City, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
25 publications in the last five years, latest in 2026.
Senior (last) author on 4 recent papers, a sign of leading a research group.
Principal investigator on 7 research grants (4 CIHR, 3 NSERC), most recently in 2024.
Supervised 1 trainee who won CIHR awards, most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

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Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Acetyl Lysine Bromodomain Chromatin Remodeler Epigenetic Proteomics Swi/Snf Complex Brd2 Cell Signaling

Latest papers

Protocol for dissecting the aggregation-prone protein interactome with optogenetic-induced aggregation and biotin labeling proximity assay.
STAR protocols · 2026
The mTOR signaling pathway regulates key steps of mammary gland organoid genesis in a temporal manner.
Scientific reports · 2026
Bromodomain proteins IBD1 and IBD2 link histone acetylation to SWR1- and INO80-mediated H2A.Z regulation in Tetrahymena.
Epigenetics & chromatin · 2025

All 46 publications

Latest funding

Regulation of BRD2 phosphorylation and Its role in melanoma progression
CIHR · 2024 · Nominated PI
$1,193,400
Chromatin structure and function as a readout of physical interactions
NSERC · 2024 · Principal investigator
$41,000
Impact de la modulation des niveaux d'acétyl-CoA sur l'activité de régulateurs épigénétiques
CIHR · 2023 · Supervisor
$105,000

All 11 grants and awards

46 publications.

Protocol for dissecting the aggregation-prone protein interactome with optogenetic-induced aggregation and biotin labeling proximity assay.

Teixeira M, Musiol D, Lambert JP, Oueslati A

STAR protocols2026

DOI: 10.1016/j.xpro.2025.104303 PMID: 41456280

The mTOR signaling pathway regulates key steps of mammary gland organoid genesis in a temporal manner.

Lacouture A, Sylla MS, Germain L, Fréville L, Lafront C, Weidmann C, Jobin C, Laplante M, Huot MÉ, Lambert JP, Audet-Walsh É

Scientific reports2026

DOI: 10.1038/s41598-026-37825-z PMID: 41617815

Bromodomain proteins IBD1 and IBD2 link histone acetylation to SWR1- and INO80-mediated H2A.Z regulation in Tetrahymena.

Garg J, Saettone A, Nabeel-Shah S, Dang S, Khalid AH, Loehr J, Petrova A, Burns JD, Karabatsos P, Shibin S, Wahab S, Taverna SD, Greenblatt JF, Lambert JP, Fillingham J

Epigenetics & chromatin2025

DOI: 10.1186/s13072-025-00614-5 PMID: 40764940

Combining light-induced aggregation and biotin proximity labeling implicates endolysosomal proteins in early α-synuclein oligomerization.

Teixeira M, Sheta R, Musiol D, Ranjakasoa V, Loehr J, Lambert JP, Oueslati A

iScience2025

DOI: 10.1016/j.isci.2025.112823 PMID: 40612512

Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response.

Jain K, Kougnassoukou Tchara PE, Khan A, Mengistalem AB, Holland AP, Bowman CN, Marunde MR, Engel TA, Popova IK, Cooke SW, Krajewski K, Keogh MC, Lambert JP, Strahl BD

Nucleic acids research2025

DOI: 10.1093/nar/gkaf666 PMID: 40671529

Coupling Proximity Biotinylation with Genomic Targeting to Characterize Locus-Specific Changes in Chromatin Environments.

Kougnassoukou Tchara PE, Loehr J, Lambert JP

Journal of proteome research2025Senior author

DOI: 10.1021/acs.jproteome.4c00931 PMID: 40054857

Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response.

Jain K, Kougnassoukou Tchara PE, Mengistalem AB, Holland AP, Bowman CN, Marunde MR, Popova IK, Cooke SW, Krajewski K, Keogh MC, Lambert JP, Strahl BD

bioRxiv : the preprint server for biology2024

DOI: 10.1101/2024.11.20.623956 PMID: 39605374

Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex.

Yang Z, Mameri A, Cattoglio C, Lachance C, Florez Ariza AJ, Luo J, Humbert J, Sudarshan D, Banerjea A, Galloy M, Fradet-Turcotte A, Lambert JP, Ranish JA, Côté J, Nogales E

Science (New York, N.Y.)2024

DOI: 10.1126/science.adl5816 PMID: 39088653

ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers.

Zhang Y, Xie G, Lee JE, Zandian M, Sudarshan D, Estavoyer B, Benz C, Viita T, Asgaritarghi G, Lachance C, Messmer C, Simonetti L, Sinha VK, Lambert JP, Chen YW, Wang SP, Ivarsson Y, Affar EB, Côté J, Ge K, Kutateladze TG

Nature communications2024

DOI: 10.1038/s41467-024-49391-x PMID: 38849395

DNA damage remodels the MITF interactome to increase melanoma genomic instability.

Binet R, Lambert JP, Tomkova M, Tischfield S, Baggiolini A, Picaud S, Sarkar S, Louphrasitthiphol P, Dias D, Carreira S, Humphrey TC, Fillipakopoulos P, White R, Goding CR

Genes & development2024

DOI: 10.1101/gad.350740.123 PMID: 38316520

Regulation of BRD2 phosphorylation and Its role in melanoma progression

Nominated PICIHR2024Project Grant

Principal investigators: Lambert, Jean-Philippe; Roux, Philippe

Keywords: Brd2; Cell Signaling; Chromatin; Melanoma; Phosphorylation; Protein Kinases; Transcription Regulation

$1,193,400

Chromatin structure and function as a readout of physical interactions

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: Lambert, Jean-Philippe

Keywords: liquid-liquid phase separation; proteomics; mass spectrometry; crosslinking mass spectrometry; proximity biotinylation; transcription regulation; chromatin

$41,000

Impact de la modulation des niveaux d'acétyl-CoA sur l'activité de régulateurs épigénétiques

SupervisorCIHR2023Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Linteau, Naomie

Keywords: Acétyl-Coa; Acétylation; Bromodomaines; Cancer; Métabolisme; Protéomique; Épigénétique

$105,000

TBC1D9: therapeutic target of the aggressiveness of triple negative breast cancer

Co-investigatorCIHR2022Project Grant - PA: Breast Cancer Research

Principal investigators: Durocher, Francine

Keywords: Biomarker; Breast Cancer; Tbc1 Domain Family Member 9; Tbc1d9; Therapeutic Target; Treatment Option; Triple Negative Breast Cancer

$100,000

Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada

Co-investigatorCIHR2021Op Grant: Emerging COVID-19 Research Gaps & Priorities - Post COVID-19 condition

Principal investigators: Agharazii, Mohsen; Goupil, Remi

Keywords: Blood Clot; Covid-19; Endothelial Dysfunction; Insulin Resistance; Kidney Function; Vascular Stiffness

$347,260

COVID19 persistent symptomatology: an investigation of the metabolomic and proteomic underpinning

Principal investigatorCIHR2021Op Grant: Emerging COVID-19 Research Gaps & Priorities - Post COVID-19 condition

Principal investigators: Corbeil, Jacques; Lambert, Jean-Philippe

Keywords: Chronic Symptoms; Covid19; Machine Learning; Metabolomic; Proteomic

$394,000

Tetrahymena thermophila - a evolutionary divergent model to uncover novel mode of transcriptional regulation

Principal investigatorNSERC2021Alliance Grants

Principal investigators: Lambert, Jean-Philippe

$135,000

Elucidation of bromodomain functions within SWI/SNF complexes

Nominated PICIHR2019PRIZE - Project Grant - PA: Prize: Early Career Investigator in Cancer

Principal investigators: Lambert, Jean-Philippe

Keywords: Acetyl Lysine; Bromodomain; Chromatin Remodeler; Epigenetic; Proteomics; Swi/Snf Complex

$25,000

Elucidation of bromodomain functions within SWI/SNF complexes

Nominated PICIHR2019Project Grant

Principal investigators: Lambert, Jean-Philippe

Keywords: Acetyl Lysine; Bromodomain; Chromatin Remodeler; Epigenetic; Proteomics; Swi/Snf Complex

$860,625

High throughput analysis of protein interactions and modifications using peptide arrays

Co-investigatorNSERC2019Research Tools and Instruments

Principal investigators: Bisson, Nicolas

$146,864

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Jean-Philippe Lambert

Research

Latest papers

Latest funding

Protocol for dissecting the aggregation-prone protein interactome with optogenetic-induced aggregation and biotin labeling proximity assay.

The mTOR signaling pathway regulates key steps of mammary gland organoid genesis in a temporal manner.

Bromodomain proteins IBD1 and IBD2 link histone acetylation to SWR1- and INO80-mediated H2A.Z regulation in Tetrahymena.

Combining light-induced aggregation and biotin proximity labeling implicates endolysosomal proteins in early &#x3b1;-synuclein oligomerization.

Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response.

Coupling Proximity Biotinylation with Genomic Targeting to Characterize Locus-Specific Changes in Chromatin Environments.

Histone H3 N-terminal recognition by the PHD finger of PHRF1 is required for proper DNA damage response.

Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex.

ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers.

DNA damage remodels the MITF interactome to increase melanoma genomic instability.

Regulation of BRD2 phosphorylation and Its role in melanoma progression

Chromatin structure and function as a readout of physical interactions

Impact de la modulation des niveaux d'acétyl-CoA sur l'activité de régulateurs épigénétiques

TBC1D9: therapeutic target of the aggressiveness of triple negative breast cancer

Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada

COVID19 persistent symptomatology: an investigation of the metabolomic and proteomic underpinning

Tetrahymena thermophila - a evolutionary divergent model to uncover novel mode of transcriptional regulation

Elucidation of bromodomain functions within SWI/SNF complexes

Elucidation of bromodomain functions within SWI/SNF complexes

High throughput analysis of protein interactions and modifications using peptide arrays

Frequent collaborators

Anne-Claude Gingras

Nicolas Bisson

Ji-Young Youn

Zhaolei Zhang

Laurence Pelletier

Brian Raught

Rachid Mazroui

Mikko Taipale

Arnaud Droit

Abid Oueslati

Paul Toren

Yannick Doyon

Francine Durocher

Caroline Diorio

Jacques Corbeil

Sabine Elowe

Samer Hussein

Amina Zoubeidi

Étienne Audet-Walsh

Martin Pelletier

Jack Greenblatt

Donald Poirier

Steve Bilodeau

Combining light-induced aggregation and biotin proximity labeling implicates endolysosomal proteins in early α-synuclein oligomerization.