Faculty profile

Olivier Barbier

ResearcherUniversité Laval

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université Laval directory, so their courses may be missing. Find their university profile.

Olivier Barbier

Researcher

Health Sciences

Université Laval

Quebec City, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
25 publications in the last five years, latest in 2026.
Senior (last) author on 5 recent papers, a sign of leading a research group.
Principal investigator on 10 research grants (7 CIHR, 3 NSERC), most recently in 2021.
Supervisor on 1 trainee award (1 CIHR), most recently in 2009.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Beta-Glucuronidase (Gus) Enzymes Bile Acids Detoxification Cholestatic And Autoimmune Liver Diseases Enzymatic Assays Germ-Free Animal Models Mass Spectrometry Microbiome Pharmacological Gus Inhibitors

Latest papers

Differential role for hepatic glucuronidation and sulfonation in controlling the 24S-hydroxycholesterol ability to activate LXR.
Scientific reports · 2026 · senior author
Cold exposure remodels bile acid metabolism in a mouse strain- and tissue-specific manner.
The Biochemical journal · 2026
Dairy Product Intake Alters the Correlations between Circulating Bile Acids and Short-Chain Fatty Acids with the Bacterial Taxa <italic>Roseburia</italic>, <italic>Faecalibacterium</italic>, <italic>Flavonifractor</italic>, and Verrucomicrobia.
Lifestyle genomics · 2026

All 86 publications

Latest funding

Investigating diet-rosuvastatin interactions: a controlled-feeding randomized crossover trial in primary CVD prevention.
CIHR · 2026 · Co-investigator
$952,426
Aminosteroid derivatives as a new class of cholesterol homeostasis disruptors for selective treatment of pancreatic cancer: Mechanistic and translational studies
CIHR · 2022 · Co-investigator
$841,500
Elucidating the differential contribution of sulfonation and glucuronidation in controlling nuclear receptor activity.
NSERC · 2021 · Principal investigator
$200,000

All 16 grants and awards

86 publications.

Differential role for hepatic glucuronidation and sulfonation in controlling the 24S-hydroxycholesterol ability to activate LXR.

Brousseau V, Rettenmeier E, Verreault M, Trottier J, Chen S, Tukey RH, Barbier O

Scientific reports2026Senior author

DOI: 10.1038/s41598-026-61280-5 PMID: 42443275

Cold exposure remodels bile acid metabolism in a mouse strain- and tissue-specific manner.

Beji S, Mouchiroud M, Efole B, Gélinas Y, Verreault M, Trottier J, Michaud A, Barbier O, Caron A

The Biochemical journal2026

DOI: 10.1042/bcj20260006 PMID: 41874275

Dairy Product Intake Alters the Correlations between Circulating Bile Acids and Short-Chain Fatty Acids with the Bacterial Taxa <italic>Roseburia</italic>, <italic>Faecalibacterium</italic>, <italic>Flavonifractor</italic>, and Verrucomicrobia.

Mahdavi A, Greffard K, Trottier J, Barbier O, Bilodeau JF, Lebel M, Rudkowska I

Lifestyle genomics2026

DOI: 10.1159/000550224 PMID: 41442422

Automated quantification of collagen proportionate area correlates with molecular and histological markers of fibrosis in CCl4-treated rats.

Efole B, Mouchiroud M, Dubé A, Allaire A, Labbé SM, Serdjebi C, Barbier O, Caron A

Experimental and molecular pathology2025

DOI: 10.1016/j.yexmp.2025.104996 PMID: 40957315

Loss of hepatic alpha-1b adrenoceptor exacerbates inflammation and stellate cell activation in diet-induced MASLD.

Efole B, Beji S, Mouchiroud M, Gélinas Y, Canivet C, Trottier J, Serdjebi C, Elmquist JK, Deslauriers J, Barbier O, Caron A

American journal of physiology. Gastrointestinal and liver physiology2025

DOI: 10.1152/ajpgi.00143.2025 PMID: 41087030

Plasma and fecal bile acids profiles in metabolic dysfunction-associated steatotic liver disease with advanced fibrosis.

Pradeau M, Beaulieu S, Paquet V, Trottier J, Verreault M, Ferland S, Barbier O, Carreau AM

American journal of physiology. Endocrinology and metabolism2025

DOI: 10.1152/ajpendo.00346.2024 PMID: 40987517

A New Synthetic Analogue of Protectin DX With Enhanced Therapeutic Potential Against Metabolic-Associated Steatotic Liver Disease.

Desmarais F, Maltais R, Sancéau JY, Marcotte B, Guèvremont G, Trottier J, Mitchell PL, Barbier O, Poirier D, Marette A

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

DOI: 10.1096/fj.202502152rrrr PMID: 41139243

Pharmaco-nutraceutical improvement of the response to obeticholic acid with omega-3 polyunsaturated fatty acids.

Lavoie AA, Thérien A, Silva A, Paré E, Ciešlak A, Gagnon W, Desjardins C, Verreault M, Trottier J, Vohl MC, Drouin-Chartier JP, Corbeil J, Caron A, Barbier O

The Biochemical journal2025Senior author

DOI: 10.1042/bcj20253113 PMID: 40699986

Fecal deoxycholic acid associates with diet, intestinal microbes, and total bilirubin in primary sclerosing cholangitis.

Chan C, Lemos M, Finnegan P, Gagnon W, Dean R, Yazdanafar M, Zepeda J, Vohl MC, Trauner M, Korzenik JR, Barbier O, Marco ML, Bowlus CL

JHEP reports : innovation in hepatology2024

DOI: 10.1016/j.jhepr.2024.101188 PMID: 39624235

Rise in plasma bile acids following hypoabsorptive bariatric surgeries predicts beneficial metabolic and homeostatic outcomes in male rats.

Mukorako P, Lavoie AA, Trottier J, Lemoine N, Biertho L, Lebel S, Plamondon J, Tchernof A, St-Pierre DH, Marette A, Barbier O, Richard D

American journal of physiology. Gastrointestinal and liver physiology2024

DOI: 10.1152/ajpgi.00289.2023 PMID: 39404774

Investigating diet-rosuvastatin interactions: a controlled-feeding randomized crossover trial in primary CVD prevention.

Co-investigatorCIHR2026Project Grant

Principal investigators: Drouin-Chartier, Jean-Philippe

Keywords: Cardiovascular Disease Risk; Diet; Statin; Trial

$952,426

Aminosteroid derivatives as a new class of cholesterol homeostasis disruptors for selective treatment of pancreatic cancer: Mechanistic and translational studies

Co-investigatorCIHR2022Project Grant

Principal investigators: Poirier, Donald

Keywords: Cancer Cell; Chemical Synthesis; Chemotherapy; Cholesterol Homeostasis; Drug; Medicinal Chemistry; Pancreatic Cancer; Pharmaceutic; Steroid; Xenograft

$841,500

Elucidating the differential contribution of sulfonation and glucuronidation in controlling nuclear receptor activity.

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Barbier, Olivier

$200,000

The UGT to GUS equilibrium as novel target for the treatment of cholestatic autoimmune liver diseases.

Nominated PICIHR2020Project Grant

Principal investigators: Barbier, Olivier

Keywords: Beta-Glucuronidase (Gus) Enzymes; Bile Acids Detoxification; Cholestatic And Autoimmune Liver Diseases; Enzymatic Assays; Germ-Free Animal Models; Mass Spectrometry; Microbiome; Pharmacological Gus Inhibitors; Pharmacological Ugt Inducers; Udp-Glucuronosyltransferase (Ugt) Enzymes

$960,075

Identifying the biological basis of GWAS hits for plasma triglyceride response to an omega-3 fatty acid supplementation.

Co-investigatorCIHR2019Project Grant

Principal investigators: Vohl, Marie-Claude

Keywords: Functional Studies; Human Clinical Studies; Nutrigenomics; Nutrition; Omega-3 Fatty Acids; Triglycerides

$455,176

Therapeutic potential of obeticholic acid for the treatment of advanced prostate cancer

Nominated PICIHR2016Project Grant

Principal investigators: Barbier, Olivier

Keywords: Advanced Prostate Cancer; Androgen Receptor (Ar); Androgen-Deprivation Therapy; Apoptosis; Cell Cycle Progression; Farnesoid X-Receptor (Fxr); Obeticholic Acid; Tumor Growth; Xenograft Models

$516,036

In Vivo Imaging System

Co-investigatorNSERC2014Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Shah, Girish

$150,000

Interactions between dietary n-3 fatty acids and genetic variations on cardiovascular disease risk factors.

Principal investigatorCIHR2013Catalyst Grant: Environments, Genes and Chronic Disease

Principal investigators: Vohl, Marie-Claude; Barbier, Olivier

Keywords: Association Studies; Gene-Diet Interactions; Metabolomics; Omega-3 Fatty Acids

$100,000

COUPLING METABOLOMIC AND PROTEOMIC APPROACHES IN PROFILING ENDOBIOTICS METABOLISM

Principal investigatorNSERC2012Discovery Grants Program - Group

Principal investigators: Barbier, Olivier

$195,000

Coupling metabolomic and proteomic approaches in profiling endobiotics metabolism

Principal investigatorNSERC2011Discovery Grants Program - Group

Principal investigators: Barbier, Olivier

$30,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2021

Subject: Prospective PhD student: Beta-Glucuronidase (Gus) Enzymes Dear Professor Barbier, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Differential role for hepatic glucuronidation and sulfonation in controlling the 24S-hydroxycholesterol ability to activate LXR." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Elucidating the differential contribution of sulfonation and glucuronidation in controlling nuclear receptor activity." (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Olivier Barbier

Research

Latest papers

Latest funding

Differential role for hepatic glucuronidation and sulfonation in controlling the 24S-hydroxycholesterol ability to activate LXR.

Cold exposure remodels bile acid metabolism in a mouse strain- and tissue-specific manner.

Dairy Product Intake Alters the Correlations between Circulating Bile Acids and Short-Chain Fatty Acids with the Bacterial Taxa <italic>Roseburia</italic>, <italic>Faecalibacterium</italic>, <italic>Flavonifractor</italic>, and Verrucomicrobia.

Automated quantification of collagen proportionate area correlates with molecular and histological markers of fibrosis in CCl4-treated rats.

Loss of hepatic alpha-1b adrenoceptor exacerbates inflammation and stellate cell activation in diet-induced MASLD.

Plasma and fecal bile acids profiles in metabolic dysfunction-associated steatotic liver disease with advanced fibrosis.

A New Synthetic Analogue of Protectin DX With Enhanced Therapeutic Potential Against Metabolic-Associated Steatotic Liver Disease.

Pharmaco-nutraceutical improvement of the response to obeticholic acid with omega-3 polyunsaturated fatty acids.

Fecal deoxycholic acid associates with diet, intestinal microbes, and total bilirubin in primary sclerosing cholangitis.

Rise in plasma bile acids following hypoabsorptive bariatric surgeries predicts beneficial metabolic and homeostatic outcomes in male rats.

Investigating diet-rosuvastatin interactions: a controlled-feeding randomized crossover trial in primary CVD prevention.

Aminosteroid derivatives as a new class of cholesterol homeostasis disruptors for selective treatment of pancreatic cancer: Mechanistic and translational studies

Elucidating the differential contribution of sulfonation and glucuronidation in controlling nuclear receptor activity.

The UGT to GUS equilibrium as novel target for the treatment of cholestatic autoimmune liver diseases.

Identifying the biological basis of GWAS hits for plasma triglyceride response to an omega-3 fatty acid supplementation.

Therapeutic potential of obeticholic acid for the treatment of advanced prostate cancer

In Vivo Imaging System

Interactions between dietary n-3 fatty acids and genetic variations on cardiovascular disease risk factors.

COUPLING METABOLOMIC AND PROTEOMIC APPROACHES IN PROFILING ENDOBIOTICS METABOLISM

Coupling metabolomic and proteomic approaches in profiling endobiotics metabolism

Frequent collaborators

Marie-Claude Vohl

Iwona Rudkowska

Patrick Couture

Simone Lemieux

Jean-Philippe Drouin-Chartier

Alexandre Caron

Mathieu Laplante

Anne Gangloff

Anne-Marie Carreau

Michel Lebel

Philippe Joubert

Chantal Guillemette

Laurent Biertho

Claudia Gagnon

Anne-Sophie Morisset

Nicolas Flamand

Jessica Deslauriers

Xuesen Dong

Denis Richard

Jacques Corbeil

Marc Ouellette

Vincenzo Di Marzo

Mathieu Morissette

Denis Boudreau

Louis Pérusse

Michel Lucas

Emile Levy

Patrick Mathieu

Donald Poirier