Michel Lebel, Université Laval

Research

Aging Chemical Chaperones Endoplasmic Reticulum Inflammation Knockout Mice Liver Non-Alcoholic Fatty Liver Disease Oxidative Stress

Latest papers

Association of vitamin D status with immune-associated serum protein pathways in overweight French-Canadian adults with hyperinsulinaemia in the Quebec City metropolitan area, Canada.
The British journal of nutrition · 2026
Dairy Product Intake Alters the Correlations between Circulating Bile Acids and Short-Chain Fatty Acids with the Bacterial Taxa <italic>Roseburia</italic>, <italic>Faecalibacterium</italic>, <italic>Flavonifractor</italic>, and Verrucomicrobia.
Lifestyle genomics · 2026
Sex and organ specific proteomic responses to vitamin C deficiency in the brain, heart, liver, and spleen of Gulo-/- mice.
PloS one · 2024 · senior author

All 44 publications

Latest funding

Oxidative stress in the endoplasmic reticulum and its impact on liver inflammation in an aging mouse model
CIHR · 2020 · Nominated PI
$650,250
Molecular aging: Mouse molecular models for Werner syndrome.
CIHR · 2011 · Nominated PI
$760,795
Identification of microRNAs important for the lifespan of animal models for the premature aging Werner syndrome.
CIHR · 2010 · Nominated PI
$50,000

All 5 grants and awards

44 publications.

01

Association of vitamin D status with immune-associated serum protein pathways in overweight French-Canadian adults with hyperinsulinaemia in the Quebec City metropolitan area, Canada.

Mahdavi A, Lebel M, Rudkowska I

The British journal of nutrition2026

DOI: 10.1017/s0007114526108009 PMID: 42444165

02

Dairy Product Intake Alters the Correlations between Circulating Bile Acids and Short-Chain Fatty Acids with the Bacterial Taxa <italic>Roseburia</italic>, <italic>Faecalibacterium</italic>, <italic>Flavonifractor</italic>, and Verrucomicrobia.

Mahdavi A, Greffard K, Trottier J, Barbier O, Bilodeau JF, Lebel M, Rudkowska I

Lifestyle genomics2026

DOI: 10.1159/000550224 PMID: 41442422

03

Sex and organ specific proteomic responses to vitamin C deficiency in the brain, heart, liver, and spleen of Gulo-/- mice.

Aumailley L, Lebel M

PloS one2024Senior author

DOI: 10.1371/journal.pone.0311857 PMID: 39388511

04

Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model.

Aumailley L, Dubois MJ, Marette A, Lebel M

Aging2024Senior author

DOI: 10.18632/aging.205866 PMID: 38795389

05

Combined transcriptomics and proteomics unveil the impact of vitamin C in modulating specific protein abundance in the mouse liver.

Aumailley L, Bodein A, Adjibade P, Leclercq M, Bourassa S, Droit A, Mazroui R, Lebel M

Biological research2024Senior author

DOI: 10.1186/s40659-024-00509-x PMID: 38735981

06

Predictive model for vitamin C levels in hyperinsulinemic individuals based on age, sex, waist circumference, low-density lipoprotein, and immune-associated serum proteins.

Mahdavi A, Leclercq M, Droit A, Rudkowska I, Lebel M

The Journal of nutritional biochemistry2024Senior author

DOI: 10.1016/j.jnutbio.2023.109538 PMID: 38030046

07

Ascorbate deficiency increases progression of shigellosis in guinea pigs and mice infection models.

Skerniskyte J, Mulet C, André AC, Anderson MC, Injarabian L, Buck A, Prade VM, Sansonetti PJ, Reibel-Foisset S, Walch AK, Lebel M, Lykkesfeldt J, Marteyn BS

Gut microbes2023

DOI: 10.1080/19490976.2023.2271597 PMID: 37876025

08

Dairy Intake Modifies the Level of the Bile Acid Precursor and Its Correlation with Serum Proteins Associated with Cholesterol Clearance in Subjects with Hyperinsulinemia.

Mahdavi A, Trottier J, Barbier O, Lebel M, Rudkowska I

Nutrients2023

DOI: 10.3390/nu15224707 PMID: 38004101

09

Vitamin C modulates the levels of several proteins of the mitochondrial complex III and its activity in the mouse liver.

Aumailley L, Bourassa S, Gotti C, Droit A, Lebel M

Redox biology2022Senior author

DOI: 10.1016/j.redox.2022.102491 PMID: 36179436

10

Vitamin C Differentially Impacts the Serum Proteome Profile in Female and Male Mice.

Aumailley L, Bourassa S, Gotti C, Droit A, Lebel M

Journal of proteome research2021Senior author

DOI: 10.1021/acs.jproteome.1c00542 PMID: 34643398

Oxidative stress in the endoplasmic reticulum and its impact on liver inflammation in an aging mouse model

Nominated PICIHR2020Project Grant

Principal investigators: Lebel, Michel

Keywords: Aging; Chemical Chaperones; Endoplasmic Reticulum; Inflammation; Knockout Mice; Liver; Non-Alcoholic Fatty Liver Disease; Oxidative Stress; Unfolded Protein Response; Werner Syndrome

$650,250

Molecular aging: Mouse molecular models for Werner syndrome.

Nominated PICIHR2011Operating Grant

Principal investigators: Lebel, Michel

Keywords: Aging; Dna Repair; Dna Replication; Genomic Instability; Metabolism; Mouse Model Of Aging; Oxidative Stress; Senescence; Transcription; Werner Syndrome

$760,795

Identification of microRNAs important for the lifespan of animal models for the premature aging Werner syndrome.

Nominated PICIHR2010Catalyst Grant: Pilot Projects in Aging - Biological & Clinical Aspects of Aging

Principal investigators: Lebel, Michel

Keywords: Healthspan; Lifespan; Mouse Model; Premature Aging; Reactive Oxygen Species; Werner Syndrome; Worm Model (C. Elegans)

$50,000

Understanding the molecular role of the Werner syndrome gene product in preventing aging disorders in the general population.

Nominated PICIHR2008Emerging Team Grant: From Genes to Proteins, Cells, Tissues and Patients - LOI

Principal investigators: Lebel, Michel; Guillemette, Chantal; Masson, Jean-Yves; Poirier, Guy G; Thorin, Eric

Keywords: Dna And Protein Arrays; Dna Stability; Molecular Biology Of Aging; Mouse Model For Aging Disorders; Oxidative Stress; Werner Syndrome

Analysis of fragile sites in the genome of aging Werner syndrome mice.

Principal investigatorNSERC2004Discovery Grants Program - Individual

Principal investigators: Lebel, Michel

$125,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Microbiologie et immunologie
Chemical Engineering
Medicine
Molecular Medicine
Other

Co-authors at Université Laval, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Arnaud Droit

Microbiologie et immunologie

5 shared papers, latest 2024

Étienne Audet-Walsh

Molecular Medicine

1 shared papers, latest 2010

Gerald Batist

Chemical Engineering

1 shared papers, latest 2015

Rachid Mazroui

Faculty

1 shared papers, latest 2024

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2020

Subject: Prospective PhD student: Aging Dear Professor Lebel, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Association of vitamin D status with immune-associated serum protein pathways in overweight French-Canadian adults with hyperinsulinaemia in the Quebec City metropolitan area, Canada." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Oxidative stress in the endoplasmic reticulum and its impact on liver inflammation in an aging mouse model" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Michel Lebel

Research

Latest papers

Latest funding

Association of vitamin D status with immune-associated serum protein pathways in overweight French-Canadian adults with hyperinsulinaemia in the Quebec City metropolitan area, Canada.

Dairy Product Intake Alters the Correlations between Circulating Bile Acids and Short-Chain Fatty Acids with the Bacterial Taxa <italic>Roseburia</italic>, <italic>Faecalibacterium</italic>, <italic>Flavonifractor</italic>, and Verrucomicrobia.

Sex and organ specific proteomic responses to vitamin C deficiency in the brain, heart, liver, and spleen of Gulo-/- mice.

Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model.

Combined transcriptomics and proteomics unveil the impact of vitamin C in modulating specific protein abundance in the mouse liver.

Predictive model for vitamin C levels in hyperinsulinemic individuals based on age, sex, waist circumference, low-density lipoprotein, and immune-associated serum proteins.

Ascorbate deficiency increases progression of shigellosis in guinea pigs and mice infection models.

Dairy Intake Modifies the Level of the Bile Acid Precursor and Its Correlation with Serum Proteins Associated with Cholesterol Clearance in Subjects with Hyperinsulinemia.

Vitamin C modulates the levels of several proteins of the mitochondrial complex III and its activity in the mouse liver.

Vitamin C Differentially Impacts the Serum Proteome Profile in Female and Male Mice.

Oxidative stress in the endoplasmic reticulum and its impact on liver inflammation in an aging mouse model

Molecular aging: Mouse molecular models for Werner syndrome.

Identification of microRNAs important for the lifespan of animal models for the premature aging Werner syndrome.

Understanding the molecular role of the Werner syndrome gene product in preventing aging disorders in the general population.

Analysis of fragile sites in the genome of aging Werner syndrome mice.

Frequent collaborators

Arnaud Droit

Iwona Rudkowska

Jean-Yves Masson

Olivier Barbier

Gerald Batist

Étienne Audet-Walsh

Gerald Batist

Patrick Laprise

Rachid Mazroui