Rachid Mazroui, Université Laval

Research

Anticancer Drugs Atf4 Ddx3 Eif4e-Eif4g Immunofluorescence Polysomes Assays Protein Synthesis Assays Rna-Binding Proteins

Latest papers

Regulation of Translation of ATF4 mRNA: A Focus on Translation Initiation Factors and RNA-Binding Proteins.
Cells · 2026 · senior author
The RNA Demethylases ALKBH5 and FTO Regulate the Translation of ATF4 mRNA in Sorafenib-Treated Hepatocarcinoma Cells.
Biomolecules · 2024 · senior author
Combined transcriptomics and proteomics unveil the impact of vitamin C in modulating specific protein abundance in the mouse liver.
Biological research · 2024

All 22 publications

Latest funding

Role of the nuclear isoforms of the RNA-binding proteins named FXRP in DNA damage response
NSERC · 2024 · Principal investigator
$41,000
Defining the role of stress granules (SG) in RNA stability and translation.
NSERC · 2020 · Principal investigator
$150,000
Role of eIF4E-4GI translation initiation complexes in stress granules formation and downstream ATF4 expression: implication in cancer cells resistance to anti-cancer drugs-mediated cell death
CIHR · 2016 · Nominated PI
$100,000

All 8 grants and awards

22 publications.

01

Regulation of Translation of ATF4 mRNA: A Focus on Translation Initiation Factors and RNA-Binding Proteins.

Adjibade P, Mazroui R

Cells2026Senior author

DOI: 10.3390/cells15020188 PMID: 41597261

02

The RNA Demethylases ALKBH5 and FTO Regulate the Translation of ATF4 mRNA in Sorafenib-Treated Hepatocarcinoma Cells.

Adjibade P, Di-Marco S, Gallouzi IE, Mazroui R

Biomolecules2024Senior author

DOI: 10.3390/biom14080932 PMID: 39199320

03

Combined transcriptomics and proteomics unveil the impact of vitamin C in modulating specific protein abundance in the mouse liver.

Aumailley L, Bodein A, Adjibade P, Leclercq M, Bourassa S, Droit A, Mazroui R, Lebel M

Biological research2024

DOI: 10.1186/s40659-024-00509-x PMID: 38735981

04

The Identification of Nuclear FMRP Isoform Iso6 Partners.

Ledoux N, Lelong EIJ, Simard A, Hussein S, Adjibade P, Lambert JP, Mazroui R

Cells2023Senior author

DOI: 10.3390/cells12242807 PMID: 38132127

05

Prostate cancer resistance leads to a global deregulation of translation factors and unconventional translation.

Lelong EIJ, Khelifi G, Adjibade P, Joncas FH, Grenier St-Sauveur V, Paquette V, Gris T, Zoubeidi A, Audet-Walsh E, Lambert JP, Toren P, Mazroui R, Hussein SMI

NAR cancer2022

DOI: 10.1093/narcan/zcac034 PMID: 36348939

06

The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans.

Michaud P, Shah VN, Adjibade P, Houle F, Quévillon Huberdeau M, Rioux R, Lavoie-Ouellet C, Gu W, Mazroui R, Simard MJ

PLoS genetics2021

DOI: 10.1371/journal.pgen.1009511 PMID: 33826611

07

Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation.

Adjibade P, Simoneau B, Ledoux N, Gauthier WN, Nkurunziza M, Khandjian EW, Mazroui R

PloS one2020Senior author

DOI: 10.1371/journal.pone.0231894 PMID: 32365111

08

PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation.

Haghandish N, Baldwin RM, Morettin A, Dawit HT, Adhikary H, Masson JY, Mazroui R, Trinkle-Mulcahy L, Côté J

Molecular biology of the cell2019

DOI: 10.1091/mbc.e18-05-0330 PMID: 30699057

09

DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.

Adjibade P, Grenier St-Sauveur V, Bergeman J, Huot ME, Khandjian EW, Mazroui R

Scientific reports2017Senior author

DOI: 10.1038/s41598-017-14262-7 PMID: 29062139

10

Analysis of the translatome in solid tumors using polyribosome profiling/RNA-Seq.

Adjibade P, Grenier St-Sauveur V, Droit A, Khandjian EW, Toren P, Mazroui R

Journal of biological methods2016Senior author

DOI: 10.14440/jbm.2016.151 PMID: 31453221