Faculty profile

Patrick Laprise

ResearcherUniversité Laval

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université Laval directory, so their courses may be missing. Find their university profile.

Patrick Laprise

Researcher

Health Sciences

Université Laval

Quebec City, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
4 publications in the last five years, latest in 2026.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 7 research grants (4 CIHR, 3 NSERC), most recently in 2022.
Supervised 1 trainee who won CIHR awards, most recently in 2010.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Breast Cancer Cancer Progression Cell Culture Cell Signalling Epithelial-Mesenchymal Transition Invasion Oligomerization Patient-Derived Xenograft

Latest papers

Girdin controls the pace of 3D tracheal cell intercalation by coupling adherens junctions to the actin cytoskeleton in Drosophila.
Development (Cambridge, England) · 2026
EGFR Phosphorylates and Associates with EFNB1 to Regulate Cell Adhesion to Fibronectin.
Molecular & cellular proteomics : MCP · 2025
The polarity protein Yurt associates with the plasma membrane via basic and hydrophobic motifs embedded in its FERM domain.
Journal of cell science · 2024 · senior author

All 21 publications

Latest funding

Role and regulation of EPB41L5 in cancer-promoting cellular processes
CIHR · 2022 · Nominated PI
$986,850
Molecular mechanisms defining the size of biological tubes in vivo
NSERC · 2020 · Principal investigator
$216,000
Versatile and quantitative analysis of macromolecules
NSERC · 2017 · Principal investigator
$148,239

All 9 grants and awards

21 publications.

Girdin controls the pace of 3D tracheal cell intercalation by coupling adherens junctions to the actin cytoskeleton in Drosophila.

Carvalho S, Laprise P, Guichet A, Brodu V

Development (Cambridge, England)2026

DOI: 10.1242/dev.205073 PMID: 41537258

EGFR Phosphorylates and Associates with EFNB1 to Regulate Cell Adhesion to Fibronectin.

Osornio-Hernández AI, Chartier FJM, Schuehle TL, Banerjee SL, Elowe S, Laprise P, Freywald A, Laurin M, Bisson N

Molecular & cellular proteomics : MCP2025

DOI: 10.1016/j.mcpro.2025.101027 PMID: 40619000

The polarity protein Yurt associates with the plasma membrane via basic and hydrophobic motifs embedded in its FERM domain.

Gamblin CL, Alende C, Corriveau F, Jetté A, Parent-Prévost F, Biehler C, Majeau N, Laurin M, Laprise P

Journal of cell science2024Senior author

DOI: 10.1242/jcs.261691 PMID: 38682269

EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks.

Banerjee SL, Lessard F, Chartier FJM, Jacquet K, Osornio-Hernandez AI, Teyssier V, Ghani K, Lavoie N, Lavoie JN, Caruso M, Laprise P, Elowe S, Lambert JP, Bisson N

Cell reports2022

DOI: 10.1016/j.celrep.2022.111031 PMID: 35793621

Pak1 and PP2A antagonize aPKC function to support cortical tension induced by the Crumbs-Yurt complex.

Biehler C, Rothenberg KE, Jette A, Gaude HM, Fernandez-Gonzalez R, Laprise P

eLife2021Senior author

DOI: 10.7554/elife.67999 PMID: 34212861

Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death.

Dziengelewski C, Rodrigue MA, Caillier A, Jacquet K, Boulanger MC, Bergeman J, Fuchs M, Lambert H, Laprise P, Richard DE, Bordeleau F, Huot MÉ, Lavoie JN

The Journal of cell biology2020

DOI: 10.1083/jcb.201805122 PMID: 32328642

Girdin is a component of the lateral polarity protein network restricting cell dissemination.

Biehler C, Wang LT, Sévigny M, Jetté A, Gamblin CL, Catterall R, Houssin E, McCaffrey L, Laprise P

PLoS genetics2020Senior author

DOI: 10.1371/journal.pgen.1008674 PMID: 32196494

A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2.

Dubois EL, Guitton-Sert L, Béliveau M, Parmar K, Chagraoui J, Vignard J, Pauty J, Caron MC, Coulombe Y, Buisson R, Jacquet K, Gamblin C, Gao Y, Laprise P, Lebel M, Sauvageau G, D d'Andrea A, Masson JY

Nucleic acids research2019

DOI: 10.1093/nar/gkz514 PMID: 31219578

Oligomerization of the FERM-FA protein Yurt controls epithelial cell polarity.

Gamblin CL, Parent-Prévost F, Jacquet K, Biehler C, Jetté A, Laprise P

The Journal of cell biology2018Senior author

DOI: 10.1083/jcb.201803099 PMID: 30082297

Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks.

Dionne U, Chartier FJM, López de Los Santos Y, Lavoie N, Bernard DN, Banerjee SL, Otis F, Jacquet K, Tremblay MG, Jain M, Bourassa S, Gish GD, Gagné JP, Poirier GG, Laprise P, Voyer N, Landry CR, Doucet N, Bisson N

Molecular cell2018

DOI: 10.1016/j.molcel.2018.05.013 PMID: 29910111

Role and regulation of EPB41L5 in cancer-promoting cellular processes

Nominated PICIHR2022Project Grant

Principal investigators: Laprise, Patrick

Keywords: Breast Cancer; Cancer Progression; Cell Culture; Cell Signalling; Epithelial-Mesenchymal Transition; Invasion; Oligomerization; Patient-Derived Xenograft; Protein Expression In Tumours; Protein-Protein Interactions

$986,850

Molecular mechanisms defining the size of biological tubes in vivo

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Laprise, Patrick

$216,000

Versatile and quantitative analysis of macromolecules

Principal investigatorNSERC2017Research Tools and Instruments

Principal investigators: Laprise, Patrick

$148,239

4D Confocal Imaging of Endogenous Proteins Tagged by CRISPR/Cas9 Genome Editing

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Moss, Thomas

$148,943

Molecular mechanisms orchestrating epithelial cell polarity

Nominated PICIHR2015Operating Grant

Principal investigators: Laprise, Patrick

Keywords: Apkc; Biochemistry; Cancer; Crumbs; Drosophila Melanogaster; Epithelial Cell Physiology; Epithelial Cell Polarity; Epithelial Tissue Morphogenesis; Retinal Dystrophies; Yurt

$712,935

Epithelial tissue morphogenesis in metazoans

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Laprise, Patrick

$190,000

Signalisation Québec 2014

Nominated PICIHR2013Dissemination Events - Priority Announcement: Cancer Research

Principal investigators: Laprise, Patrick

Keywords: Biologie Du Cancer; Identification De Cibles Thérapeutiques En Oncologie; Signalisation Intracellulaire

$25,000

Role of CRB3 in Wnt signaling regulation and colon cancer

SupervisorCIHR2010CIHR Fellowship

Principal investigators: Chartier, François

Keywords: Biochemistry; Cell Signaling; Colon Cancer; Epithelial Cell Polarity; Epithelium; Tumorigenesis; Wnt Pathway

$112,500

Molecular mechanisms orchestrating epithelial cell polarity

Nominated PICIHR2009Operating Grant

Principal investigators: Laprise, Patrick

Keywords: Breast Cancer; Colon Cancer; Epithelium; Intestine; Morphology; Polarity

$706,884

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Patrick Laprise

Research

Latest papers

Latest funding

Girdin controls the pace of 3D tracheal cell intercalation by coupling adherens junctions to the actin cytoskeleton in Drosophila.

EGFR Phosphorylates and Associates with EFNB1 to Regulate Cell Adhesion to Fibronectin.

The polarity protein Yurt associates with the plasma membrane via basic and hydrophobic motifs embedded in its FERM domain.

EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks.

Pak1 and PP2A antagonize aPKC function to support cortical tension induced by the Crumbs-Yurt complex.

Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death.

Girdin is a component of the lateral polarity protein network restricting cell dissemination.

A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2.

Oligomerization of the FERM-FA protein Yurt controls epithelial cell polarity.

Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks.

Role and regulation of EPB41L5 in cancer-promoting cellular processes

Molecular mechanisms defining the size of biological tubes in vivo

Versatile and quantitative analysis of macromolecules

4D Confocal Imaging of Endogenous Proteins Tagged by CRISPR/Cas9 Genome Editing

Molecular mechanisms orchestrating epithelial cell polarity

Epithelial tissue morphogenesis in metazoans

Signalisation Québec 2014

Role of CRB3 in Wnt signaling regulation and colon cancer

Molecular mechanisms orchestrating epithelial cell polarity

Frequent collaborators

Nicolas Bisson

Sabine Elowe

Jean-Yves Masson

Rachid Mazroui

Luke McCaffrey

Rodrigo Fernandez-Gonzalez

Jean-Philippe Lambert

Michel Lebel

Marc-Étienne Huot

Ulrich Tepass

Andrew Freywald

Manuel Caruso