Faculty profile

Jean-Yves Masson

ResearcherUniversité Laval

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université Laval directory, so their courses may be missing. Find their university profile.

Jean-Yves Masson

Researcher

Health Sciences

Université Laval

Quebec City, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
35 publications in the last five years, latest in 2026.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 15 research grants (12 CIHR, 3 NSERC), most recently in 2024.
Supervisor on 2 trainee awards (2 CIHR), most recently in 2013.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

127

Publications

158

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Homologous Recombination Dna Repair Double-Strand Breaks Brca1/Brca2/Palb2 Genome Stability Dna Double-Strand Break Repair Dna Resection Dna Strand Invasion

Latest papers

Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses
Cell reports · 2026
Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.
Cell reports. Medicine · 2026
ZIPPing the gaps: A new class of zinc finger proteins orchestrates the DNA damage response.
DNA repair · 2026

All 127 publications

Latest funding

Roles of the tumor suppressor PALB2 at the intersection of DNA repair and synthetic lethal strategies in cancer
CIHR · 2024 · Nominated PI
$1,143,676
Defining and targeting the eraser functions of Poly(ADP-ribose) Glycohydrolase (PARG) in PAR-DNA hybrids and DNA double-strand break repair
CIHR · 2024 · Nominated PI
$1,273,725
Characterization of novel breast cancer susceptibility genes through large-scale targeted sequencing and functional assays.
CIHR · 2023 · Co-investigator
$1,093,950

All 25 grants and awards

127 publications.

Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses

Cui S, Batenburg NL, Coulombe Y, Arumugam A, Walker JR, Sheida SV, Bielinsky A-K, Wahl MC, Masson J-Y, Zhu X-D

Cell reports20263 citations

DOI: 10.1016/j.celrep.2026.117051

Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.

Le BV, Vekariya U, Toma MM, Nieborowska-Skorska M, Caron MC, Gozdecka M, Haydar Z, Walsh M, Ghosh J, Vaughan-Williams E, Podszywalow-Bartnicka P, Kukuyan AM, Ziolkowska S, Atkins J, Hadzijusufovic E, Chandramouly G, Nejati R, Piwocka K, Pomerantz R, Vassiliou GS, Huntly BJP, Valent P, Wasik M, Bellacosa A, Masson JY, Gupta GP, Challen GA, Skorski T

Cell reports. Medicine2026

DOI: 10.1016/j.xcrm.2026.102687 PMID: 41850232

ZIPPing the gaps: A new class of zinc finger proteins orchestrates the DNA damage response.

Nonfoux L, Gagné JP, Kang BG, Kang SU, Hendzel MJ, Dawson TM, Dawson VL, Masson JY, Poirier GG

DNA repair2026

DOI: 10.1016/j.dnarep.2026.103960 PMID: 42762747

Targeting DHODH reveals a metabolic vulnerability in AR-positive and AR-negative prostate cancer cells via pyrimidine synthesis and metabolic crosstalk with the TCA and urea cycles.

Labroy M, Paré MO, Berthiaume L, Thomas M, Jobin C, Veilleux A, Pelletier M, Pouliot F, Masson JY, Audet-Walsh É

Molecular metabolism2026

DOI: 10.1016/j.molmet.2025.102316 PMID: 41506347

The Genetic and Molecular Analyses of Rare Candidate Germline BRIP1/FANCJ Variants Implicated in Hereditary Breast and Ovarian Cancers.

Alenezi WM, Milano L, Fierheller CT, Serruya C, Revil T, Oros KK, Bruce JP, Spiegelman D, Pugh T, Mes-Masson AM, Provencher D, Foulkes WD, El Haffaf Z, Rouleau G, Bouchard L, Greenwood CMT, Ragoussis J, Masson JY, Tonin PN

International journal of molecular sciences2026

DOI: 10.3390/ijms27021037 PMID: 41596682

The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses

Cui S, Batenburg NL, Coulombe Y, Arumugam A, Walker JR, Sheida SV, Bielinsky A-K, Wahl MC, Masson J-Y, Zhu X-D

2025

DOI: 10.1101/2025.07.24.666583

Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline PALB2 sequence variants.

Richardson ME, Bishop MFH, Holdren MA, de la Hoya M, Spurdle AB, Tavtigian SV, Brannan T, Young CC, Zec L, Hiraki S, Turnbull C, Tischkowitz M, Bernstein KA, Masson JY, McNulty SM, Pesaran T, Monteiro AN, Walker LC, Foulkes WD, Couch FJ

American journal of human genetics2025

DOI: 10.1016/j.ajhg.2025.08.020 PMID: 40967221

Pathogenic variants in MAEA disrupt DNA replication fork stability and are associated with developmental abnormalities in humans.

Zeinali E, Mashayekhi F, Farraj RA, Hasanni T, Caron MC, Coulombe Y, Fitieh A, Glover JNM, Masson JY, Ismail IH

Science advances2025

DOI: 10.1126/sciadv.adv0381 PMID: 40880485

Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress.

Galloy M, Blondeau A, Vion É, Kim D, Bakker CA, Gaggioli V, Thomas M, Lavoie ÉG, Marois I, Delgado Monterroso AD, Masson JY, Taneja N, Miller KM, Maréchal A, Fradet-Turcotte A

Molecular cell2025

DOI: 10.1016/j.molcel.2025.07.013 PMID: 40812313

PALB2 and 53BP1 govern post-resection homologous recombination DNA repair.

Wang Y, Coulombe Y, Yueh WT, Conway GD, Milano L, Glass DJ, Thomas M, Rodrigue A, Nacson J, Lu D, Bernhardy AJ, Betsch RG, Russo AI, Elfar GA, Cai KQ, Testa JR, Andrake M, Dunbrack R, Gupta GP, Xia B, Dray E, Masson JY, Johnson N

Molecular cell2025

DOI: 10.1016/j.molcel.2025.07.003 PMID: 40749686

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Jean-Yves Masson

Research

Latest papers

Latest funding

Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses

Pol&#x3b8; activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.

ZIPPing the gaps: A new class of zinc finger proteins orchestrates the DNA damage response.

Targeting DHODH reveals a metabolic vulnerability in AR-positive and AR-negative prostate cancer cells via pyrimidine synthesis and metabolic crosstalk with the TCA and urea cycles.

The Genetic and Molecular Analyses of Rare Candidate Germline BRIP1/FANCJ Variants Implicated in Hereditary Breast and Ovarian Cancers.

The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses

Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline PALB2 sequence variants.

Pathogenic variants in MAEA disrupt DNA replication fork stability and are associated with developmental abnormalities in humans.

Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress.

PALB2 and 53BP1 govern post-resection homologous recombination DNA repair.

Versatile and quantitative analysis of macromolecules

4D Confocal Imaging of Endogenous Proteins Tagged by CRISPR/Cas9 Genome Editing

Frequent collaborators

Graham Dellaire

Jacques Simard

Anne-Marie Mes-Masson

Xu-dong Zhu

Alexandre Orthwein

Michel Lebel

Luigi Bouchard

Marc Ouellette

Guy Sauvageau

Luigi Bouchard

Philip Hieter

Patrick Laprise

Guy Rouleau

Anne-Claude Gingras

Steve Bilodeau

Alain Nepveu

Morag Park

Razqallah Hakem

Jacek Majewski

Alain Veilleux

Aisha Lofters

Sylvain Moineau

Michael Wolfson

Aisha Lofters

Hugo Wurtele

Steven Narod

Roseline Godbout

David Dyment

Andrea Eisen

Cheryl Arrowsmith

Anne Junker

Andrea Eisen

Mathieu Laplante

Frank Sicheri

Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.