Faculty profile

Annik Prat

ResearcherBiochemical NeuroendocrinologyUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses and email address may be missing. Find their university profile.

Annik Prat

Researcher

Biochemical Neuroendocrinology

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
7 publications in the last five years, latest in 2025.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 1 research grant (1 CIHR), most recently in 2015.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

161

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Enzymology & Biochemistry Females Versus Males Gene Expression & Regulation Genetically Modified Mice Hypercholesterolemia/Inflammation Inflammation Ldl & Ldlr Lipoprotein Metabolism & Atherosclerosis

Latest papers

Blockade of colon cancer metastasis via single and double silencing of PCSK7/PCSK9: enhanced T cells cytotoxicity in mouse and human.
Journal for immunotherapy of cancer · 2025
Molecular interactions of PCSK9 with an inhibitory nanobody, CAP1 and HLA-C: Functional regulation of LDLR levels.
Molecular metabolism · 2023
Surface LDLR is a major receptor for lipoprotein(a) clearance in male mice lacking PCSK9.
Biochimica et biophysica acta. Molecular and cell biology of lipids · 2023 · senior author

All 51 publications

Latest funding

The proprotein convertases and their partners in health and disease
CIHR · 2015 · Co-investigator
$3,761,408
The sex/tissue-specific regulation of the LDLR in absence of PCSK9 activity and its clinical relevance
CIHR · 2015 · Principal investigator
$150,000
How does substrate cleavage by the proprotein convertases impact on physiology and pathology?
CIHR · 2012 · Co-investigator
$100,000

All 5 grants and awards

51 publications.

Blockade of colon cancer metastasis via single and double silencing of PCSK7/PCSK9: enhanced T cells cytotoxicity in mouse and human.

Porcheron C, Le Devehat M, Roubtsova A, Bayat H, Evagelidis A, Jafarzadeh L, Sachan V, Labrecque N, Fonta Holder A, Susan-Resiga D, Essalmani R, Boudreau G, Prat A, Cusseddu R, Côté JF, Khatib AM, Delisle JS, Seidah NG

Journal for immunotherapy of cancer2025

DOI: 10.1136/jitc-2024-011364 PMID: 40518289

Molecular interactions of PCSK9 with an inhibitory nanobody, CAP1 and HLA-C: Functional regulation of LDLR levels.

Fruchart Gaillard C, Ouadda ABD, Ciccone L, Girard E, Mikaeeli S, Evagelidis A, Le Dévéhat M, Susan-Resiga D, Lajeunesse EC, Nozach H, Ramos OHP, Thureau A, Legrand P, Prat A, Dive V, Seidah NG

Molecular metabolism2023

DOI: 10.1016/j.molmet.2022.101662 PMID: 36566984

Surface LDLR is a major receptor for lipoprotein(a) clearance in male mice lacking PCSK9.

Roubtsova A, Scipione CA, Garçon D, Boffa MB, Seidah NG, Koschinsky ML, Prat A

Biochimica et biophysica acta. Molecular and cell biology of lipids2023Senior author

DOI: 10.1016/j.bbalip.2023.159288 PMID: 36708961

PCSK9 Contributes to the Cholesterol, Glucose, and Insulin2 Homeostasis in Seminiferous Tubules and Maintenance of Immunotolerance in Testis.

Pelletier RM, Layeghkhavidaki H, Seidah NG, Prat A, Vitale ML

Frontiers in cell and developmental biology2022

DOI: 10.3389/fcell.2022.889972 PMID: 35586340

The Multifaceted Biology of PCSK9.

Seidah NG, Prat A

Endocrine reviews2022Senior author

DOI: 10.1210/endrev/bnab035 PMID: 35552680

PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol.

Roubtsova A, Garçon D, Lacoste S, Chamberland A, Marcinkiewicz J, Métivier R, Sotin T, Paquette M, Bernard S, Cariou B, Le May C, Koschinsky ML, Seidah NG, Prat A

Biochimica et biophysica acta. Molecular and cell biology of lipids2022Senior author

DOI: 10.1016/j.bbalip.2022.159217 PMID: 35985474

Sortilin enhances secretion of apolipoprotein(a) through effects on apolipoprotein B secretion and promotes uptake of lipoprotein(a).

Clark JR, Gemin M, Youssef A, Marcovina SM, Prat A, Seidah NG, Hegele RA, Boffa MB, Koschinsky ML

Journal of lipid research2022

DOI: 10.1016/j.jlr.2022.100216 PMID: 35469919

The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury

Lebeau PF, Wassef H, Byun JH, Platko K, Ason B, Jackson S, Dobroff J, Shetterly S, Richards WG, Al-Hashimi AA

Journal of Clinical Investigation202139 citationsOpen Access

DOI: 10.1172/jci128650 PMID: W3098436432

PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs.

Roudaut M, Idriss S, Caillaud A, Girardeau A, Rimbert A, Champon B, David A, Lévêque A, Arnaud L, Pichelin M, Prieur X, Prat A, Seidah NG, Zibara K, Le May C, Cariou B, Si-Tayeb K

Stem cell reports2021

DOI: 10.1016/j.stemcr.2021.10.004 PMID: 34739847

Substantial PCSK9 inactivation in β-cells does not modify glucose homeostasis or insulin secretion in mice.

Peyot ML, Roubtsova A, Lussier R, Chamberland A, Essalmani R, Murthy Madiraju SR, Seidah NG, Prentki M, Prat A

Biochimica et biophysica acta. Molecular and cell biology of lipids2021Senior author

DOI: 10.1016/j.bbalip.2021.158968 PMID: 33992809

The proprotein convertases and their partners in health and disease

Co-investigatorCIHR2015Foundation Grant

Principal investigators: Seidah, Nabil G

Keywords: Apoa5; Enzymology & Biochemistry; Gene Expression & Regulation; Hdl & Triglycerides; Hypercholesterolemia/Inflammation/Neuropathology; Knockout & Transgenic Mice; Ldl; Lipoprotein Metabolism & Atherosclerosis; Lp(A); Lpl; Microarrays & Mass Spectrometry; Mirnas; Molecular & Cellular Biology; Pc7; Pcsk9; Physiological & Pathological Functions; Proprotein Convertases; Proteomics; Sdldl

$3,761,408

The sex/tissue-specific regulation of the LDLR in absence of PCSK9 activity and its clinical relevance

Principal investigatorCIHR2015Catalyst Grant: Sex as a Variable in Biomedical Research

Principal investigators: Seidah, Nabil G; Prat, Annik

Keywords: Enzymology & Biochemistry; Females Versus Males; Gene Expression & Regulation; Genetically Modified Mice; Hypercholesterolemia/Inflammation; Inflammation; Ldl & Ldlr; Lipoprotein Metabolism & Atherosclerosis; Molecular & Cellular Biology Of Ldlr E2-Regulation; Pcsk9 Ko Mice

$150,000

How does substrate cleavage by the proprotein convertases impact on physiology and pathology?

Co-investigatorCIHR2012Operating Grant

Principal investigators: Seidah, Nabil G

Keywords: Cellular Growth And Extracellular Matrix; Enzymology And Biochemistry; Furin; Knockout Mice; Molecular And Cell Biology; Mutagenesis; Neuroendocrine Functions Of Anxiety And Depression; Pace4 And Pc7; Physiology And Biosynthesis; Proprotein Convertases Pc5/6; Stress And Adrenal Function; Substrate Identification And Mass Spectrometry

$100,000

PCSK9 and Cardiovascular Disease

Co-investigatorCIHR2011Team Grant: Chronic Disease Risk and Intervention Strategies - LOI

Principal investigators: Seidah, Nabil G

Keywords: Autosomal Dominant Hypercholesterolemia; Cardiovascular Disease; Cholesterol And Lipid Metabolism; Familial Hypercholesterolemia; Molecular And Cellular Biology; Mouse Models; Next Generation Sequencing; Proprotein Convertase Pcsk9; Proteomics And Genomics; Structure-Function

$10,000

PCSK9: Functions and mechanisms of action in liver and adipocytes

Co-investigatorCIHR2009Operating Grant

Principal investigators: Seidah, Nabil G

Keywords: Cell Biology; Cholesterol And Fatty Acids; Mechanisms And Physiology; Mouse Knockout And Transgenic Models; Proteases; Stucture-Function

$795,892

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Annik Prat

Research

Latest papers

Latest funding

Blockade of colon cancer metastasis via single and double silencing of PCSK7/PCSK9: enhanced T cells cytotoxicity in mouse and human.

Molecular interactions of PCSK9 with an inhibitory nanobody, CAP1 and HLA-C: Functional regulation of LDLR levels.

Surface LDLR is a major receptor for lipoprotein(a) clearance in male mice lacking PCSK9.

PCSK9 Contributes to the Cholesterol, Glucose, and Insulin2 Homeostasis in Seminiferous Tubules and Maintenance of Immunotolerance in Testis.

The Multifaceted Biology of PCSK9.

PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol.

Sortilin enhances secretion of apolipoprotein(a) through effects on apolipoprotein B secretion and promotes uptake of lipoprotein(a).

The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury

PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs.

Substantial PCSK9 inactivation in β-cells does not modify glucose homeostasis or insulin secretion in mice.

The proprotein convertases and their partners in health and disease

The sex/tissue-specific regulation of the LDLR in absence of PCSK9 activity and its clinical relevance

How does substrate cleavage by the proprotein convertases impact on physiology and pathology?

PCSK9 and Cardiovascular Disease

PCSK9: Functions and mechanisms of action in liver and adipocytes

Frequent collaborators

Richard C Austin

Gaétan Mayer

Jacques Genest

Sophie Bernard

Bernardo Trigatti

Guillaume Pare

David Goltzman

Robert Day

Nabil Seidah

Michel Tremblay

Nathalie Labrecque

Michel Tremblay

Dusica Maysinger

Suleiman Igdoura

An Tang

Marc Prentki

Annik Prat

Research

Latest papers

Latest funding

Blockade of colon cancer metastasis via single and double silencing of PCSK7/PCSK9: enhanced T cells cytotoxicity in mouse and human.

Molecular interactions of PCSK9 with an inhibitory nanobody, CAP1 and HLA-C: Functional regulation of LDLR levels.

Surface LDLR is a major receptor for lipoprotein(a) clearance in male mice lacking PCSK9.

PCSK9 Contributes to the Cholesterol, Glucose, and Insulin2 Homeostasis in Seminiferous Tubules and Maintenance of Immunotolerance in Testis.

The Multifaceted Biology of PCSK9.

PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol.

Sortilin enhances secretion of apolipoprotein(a) through effects on apolipoprotein B secretion and promotes uptake of lipoprotein(a).

The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury

PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs.

Substantial PCSK9 inactivation in &#x3b2;-cells does not modify glucose homeostasis or insulin secretion in mice.

The proprotein convertases and their partners in health and disease

The sex/tissue-specific regulation of the LDLR in absence of PCSK9 activity and its clinical relevance

How does substrate cleavage by the proprotein convertases impact on physiology and pathology?

PCSK9 and Cardiovascular Disease

PCSK9: Functions and mechanisms of action in liver and adipocytes

Frequent collaborators

Richard C Austin

Gaétan Mayer

Jacques Genest

Sophie Bernard

Bernardo Trigatti

Guillaume Pare

David Goltzman

Robert Day

Nabil Seidah

Michel Tremblay

Nathalie Labrecque

Michel Tremblay

Dusica Maysinger

Suleiman Igdoura

An Tang

Marc Prentki

Substantial PCSK9 inactivation in β-cells does not modify glucose homeostasis or insulin secretion in mice.