Faculty profile
Nabil Seidah
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Research
Latest papers
PCSK9 in metabolism and diseases.
Metabolism: clinical and experimental · 2025
PCSK9 is not secreted from mature differentiated intestinal cells.
Journal of lipid research · 2021
Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases.
BMC cancer · 2005
Latest funding
- $1,224,000
The unique and complementary functions of PCSK7 and PCSK9 in cardiometabolic health and disease
CIHR · 2023 · Nominated PI
- $1,400,000
CRC Tier 1
CIHR · 2016 · Nominated PI
- $3,761,408
The proprotein convertases and their partners in health and disease
CIHR · 2015 · Nominated PI
5 publications.
PCSK9 in metabolism and diseases.
Ajoolabady A, Pratico D, Mazidi M, Davies IG, Lip GYH, Seidah N, Libby P, Kroemer G, Ren J
PCSK9 is not secreted from mature differentiated intestinal cells.
Moreau F, Thédrez A, Garçon D, Ayer A, Sotin T, Dijk W, Blanchard C, Chadeuf G, Arnaud L, Croyal M, Van Landeghem L, Touvron M, Prieur X, Roubtsova A, Seidah N, Prat A, Cariou B, Le May C
Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases.
Tzimas GN, Chevet E, Jenna S, Nguyên DT, Khatib AM, Marcus V, Zhang Y, Chrétien M, Seidah N, Metrakos P
Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases.
Siegfried G, Basak A, Prichett-Pejic W, Scamuffa N, Ma L, Benjannet S, Veinot JP, Calvo F, Seidah N, Khatib AM
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2.
Costa-Mattioli M, Gobert D, Harding H, Herdy B, Azzi M, Bruno M, Bidinosti M, Ben Mamou C, Marcinkiewicz E, Yoshida M, Imataka H, Cuello AC, Seidah N, Sossin W, Lacaille JC, Ron D, Nader K, Sonenberg N
The unique and complementary functions of PCSK7 and PCSK9 in cardiometabolic health and disease
Principal investigators: Seidah, Nabil G
Keywords: Cholesterol; Familial Hypercholesterolemia,; Fatty Liver; Fibrosis; Hepatocytes; Inflammation; Nafld; Proprotein Convertase Pcsk7; Proprotein Convertase Pcsk9; Triglycerides
CRC Tier 1
Principal investigators: Seidah, Nabil G
Keywords: Crc
The proprotein convertases and their partners in health and disease
Principal investigators: Seidah, Nabil G
Keywords: Apoa5; Enzymology & Biochemistry; Gene Expression & Regulation; Hdl & Triglycerides; Hypercholesterolemia/Inflammation/Neuropathology; Knockout & Transgenic Mice; Ldl; Lipoprotein Metabolism & Atherosclerosis; Lp(A); Lpl; Microarrays & Mass Spectrometry; Mirnas; Molecular & Cellular Biology; Pc7; Pcsk9; Physiological & Pathological Functions; Proprotein Convertases; Proteomics; Sdldl
The sex/tissue-specific regulation of the LDLR in absence of PCSK9 activity and its clinical relevance
Principal investigators: Seidah, Nabil G; Prat, Annik
Keywords: Enzymology & Biochemistry; Females Versus Males; Gene Expression & Regulation; Genetically Modified Mice; Hypercholesterolemia/Inflammation; Inflammation; Ldl & Ldlr; Lipoprotein Metabolism & Atherosclerosis; Molecular & Cellular Biology Of Ldlr E2-Regulation; Pcsk9 Ko Mice
How does substrate cleavage by the proprotein convertases impact on physiology and pathology?
Principal investigators: Seidah, Nabil G
Keywords: Cellular Growth And Extracellular Matrix; Enzymology And Biochemistry; Furin; Knockout Mice; Molecular And Cell Biology; Mutagenesis; Neuroendocrine Functions Of Anxiety And Depression; Pace4 And Pc7; Physiology And Biosynthesis; Proprotein Convertases Pc5/6; Stress And Adrenal Function; Substrate Identification And Mass Spectrometry
Validation of PCSK9 single domain antibodies in cholesterol regulation in humanized mice
Principal investigators: Seidah, Nabil G
Keywords: Atherosclerosis; Cholesterol; Hypercholesterolemia; Ldlr; Low Density Lipoprotein; Mouse Models; Nanobodies; Pcsk9; Single Domain Antibodies; Statins
PCSK9 and Cardiovascular Disease
Principal investigators: Seidah, Nabil G
Keywords: Autosomal Dominant Hypercholesterolemia; Cardiovascular Disease; Cholesterol And Lipid Metabolism; Familial Hypercholesterolemia; Molecular And Cellular Biology; Mouse Models; Next Generation Sequencing; Proprotein Convertase Pcsk9; Proteomics And Genomics; Structure-Function
CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA
Principal investigators: Seidah, Nabil G
Keywords: Crc
PCSK9: Functions and mechanisms of action in liver and adipocytes
Principal investigators: Seidah, Nabil G
Keywords: Cell Biology; Cholesterol And Fatty Acids; Mechanisms And Physiology; Mouse Knockout And Transgenic Models; Proteases; Stucture-Function
The roles of PCSK9 and SKI-1 in Hepatitis C infection
Principal investigators: Seidah, Nabil G; Labonté, Patrick
Keywords: Enzymes; Hcv Receptors; Hepatitis C Infection; Lipoprotein Receptor (Ldlr); Proprotein Convertase; Subtilisin-Like Serine Proteinases
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Laboratory of Biochemical Neuroendocrinology
- Biochemical Neuroendocrinology
- Neurosciences
- Psychology
- Biochemistry
- Neurology and Neurosurgery
- Other
Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Jean-Claude Lacaille
Neurosciences
1 shared papers, latest 2005
Wayne Sossin
Neurology and Neurosurgery
1 shared papers, latest 2005
Annik Prat
Biochemical Neuroendocrinology
1 shared papers, latest 2021
Peter Metrakos
Faculty
1 shared papers, latest 2005
Karim Nader
Psychology
1 shared papers, latest 2005
Nahum Sonenberg
Biochemistry
1 shared papers, latest 2005
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