Nicole Leclerc, Université de Montréal

Research

Tau Protein Induced Neurons Ipsc-Derived Neurons Microtubules Neurodegeneration Progressive Supranuclear Palsy Single-Nucleus Rna Seq Transcriptome

Latest papers

Plasma p-tau markers, vascular factors, and cognitive decline in the CIMA-Q cohort.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells.
Molecular neurobiology · 2023 · senior author
Unconventional secretion of tau by VAMP8 impacts its intra- and extracellular cleavage.
Frontiers in cell and developmental biology · 2022 · senior author

All 9 publications

Latest funding

Microtubule alterations in progressive supranuclear palsy
CIHR · 2023 · Nominated PI
$902,700
High performance nucleofection unit for difficult to manipulate cell types
NSERC · 2017 · Co-investigator
$45,743
Mechanisms leading to extracellular and intracellular accumulation of tau in Alzheimer's disease
CIHR · 2017 · Nominated PI
$665,550

All 10 grants and awards

9 publications.

01

Plasma p-tau markers, vascular factors, and cognitive decline in the CIMA-Q cohort.

Cottez RJ, Peyrot C, Denis HL, Tremblay C, Loiselle A, Dallaire-Théroux C, Filali-Mouhim A, Hébert SS, Leclerc N, Blennow K, Zetterberg H, Consortium for the Early Identification of Alzheimer's Disease – Quebec (CIMA‐Q), Kergoat MJ, Calon F, Pichet Binette A

Alzheimer's & dementia : the journal of the Alzheimer's Association2026

DOI: 10.1002/alz.71588 PMID: 42273887

02

Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells.

Levert S, Pilliod J, Aumont É, Armanville S, Tremblay C, Calon F, Leclerc N

Molecular neurobiology2023Senior author

DOI: 10.1007/s12035-022-03121-w PMID: 36399251

03

Unconventional secretion of tau by VAMP8 impacts its intra- and extracellular cleavage.

Pilliod J, Gélinas-Faucher M, Leclerc N

Frontiers in cell and developmental biology2022Senior author

DOI: 10.3389/fcell.2022.912118 PMID: 36313558

04

Similarities and Differences in the Pattern of Tau Hyperphosphorylation in Physiological and Pathological Conditions: Impacts on the Elaboration of Therapies to Prevent Tau Pathology.

Duquette A, Pernègre C, Veilleux Carpentier A, Leclerc N

Frontiers in neurology2020Senior author

DOI: 10.3389/fneur.2020.607680 PMID: 33488502

05

Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion.

Pilliod J, Desjardins A, Pernègre C, Jamann H, Larochelle C, Fon EA, Leclerc N

The Journal of biological chemistry2020Senior author

DOI: 10.1074/jbc.ra120.013553 PMID: 33454017

06

The Consortium for the early identification of Alzheimer's disease-Quebec (CIMA-Q).

Belleville S, LeBlanc AC, Kergoat MJ, Calon F, Gaudreau P, Hébert SS, Hudon C, Leclerc N, Mechawar N, Duchesne S, Gauthier S, Consortium for the Early Identification of Alzheimer's disease-Quebec (CIMA-Q)

Alzheimer's & dementia (Amsterdam, Netherlands)2019

DOI: 10.1016/j.dadm.2019.07.003 PMID: 31788534

07

Tau Secretion: Good and Bad for Neurons.

Pernègre C, Duquette A, Leclerc N

Frontiers in neuroscience2019Senior author

DOI: 10.3389/fnins.2019.00649 PMID: 31293374

08

Rab7A regulates tau secretion.

Rodriguez L, Mohamed NV, Desjardins A, Lippé R, Fon EA, Leclerc N

Journal of neurochemistry2017Senior author

DOI: 10.1111/jnc.13994 PMID: 28222213

09

Interaction of 14-3-3ζ with microtubule-associated protein tau within Alzheimer's disease neurofibrillary tangles.

Qureshi HY, Li T, MacDonald R, Cho CM, Leclerc N, Paudel HK

Biochemistry2013

DOI: 10.1021/bi400442d PMID: 23962087

Microtubule alterations in progressive supranuclear palsy

Nominated PICIHR2023Project Grant

Principal investigators: Leclerc, Nicole

Keywords: Induced Neurons; Ipsc-Derived Neurons; Microtubules; Neurodegeneration; Progressive Supranuclear Palsy; Single-Nucleus Rna Seq; Tau Protein; Transcriptome; Tubulin Isoforms; Tubulin Post-Translational Modifications

$902,700

High performance nucleofection unit for difficult to manipulate cell types

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: VandeVelde, Christine

$45,743

Mechanisms leading to extracellular and intracellular accumulation of tau in Alzheimer's disease

Nominated PICIHR2017Project Grant

Principal investigators: Leclerc, Nicole

Keywords: Aggregation; Alzheimer'S Disease; Bioid; Dendrites; Endosomes; Filamin A; Neuronal Cultures; Protein-Protein Interactions; Secretion; Tau Protein

$665,550

The contribution of extracellular tau to the propagation of neurodegeneration in Alzheimer disease

Nominated PICIHR2011Operating Grant

Principal investigators: Leclerc, Nicole

Keywords: Alzheimer Disease; Fronto-Temporal Dementia; Microtubules; Neurodegeneration; Phosphorylation; Secretion; Tau Proteins

$589,457

The neurobiology of aging and Alzeihmers dissease: walking down the same road?

Co-investigatorCIHR2011Dissemination Events - PA: Neurosciences, Mental Health and Addiction

Principal investigators: Robitaille, Richard

Keywords: Aging; Alzheimer'S Disease; Cell Death; Glial Cells; Stem Cells; Synaptic Plasticity

$20,800

Caméra numérique pour microscope électronique

Co-investigatorNSERC2011Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Descarries, Laurent

$58,203

Nucleofector for gene expression

Co-investigatorNSERC2008Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: DesGroseillers, Luc

$21,500

The role rer/microtubule interaction in the establishment and maintenance of neuronal polarity

Principal investigatorNSERC2007Discovery Grants Program - Individual

Principal investigators: Leclerc, Nicole

$175,000

Phosphorylation of MAP2 and its contribution to dendritic differentiation and plasticity

Principal investigatorNSERC2002Discovery Grants Program - Individual

Principal investigators: Leclerc, Nicole

$175,000

Molecular organization of the acitin cytoskeleton in neurons

Principal investigatorNSERC1998Discovery Grants Program - Individual

Principal investigators: Leclerc, Nicole

$114,125

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Neurosciences
Neurology and Neurosurgery
Psychiatry
Sciences de l'activité physique
Radiology and Nuclear Medicine
Centre de recherche
Other

1 shared papers, latest 2019

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Tau Protein Dear Professor Leclerc, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Plasma p-tau markers, vascular factors, and cognitive decline in the CIMA-Q cohort." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Microtubule alterations in progressive supranuclear palsy" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Nicole Leclerc

Research

Latest papers

Latest funding

Plasma p-tau markers, vascular factors, and cognitive decline in the CIMA-Q cohort.

Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells.

Unconventional secretion of tau by VAMP8 impacts its intra- and extracellular cleavage.

Similarities and Differences in the Pattern of Tau Hyperphosphorylation in Physiological and Pathological Conditions: Impacts on the Elaboration of Therapies to Prevent Tau Pathology.

Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion.

The Consortium for the early identification of Alzheimer's disease-Quebec (CIMA-Q).

Tau Secretion: Good and Bad for Neurons.

Rab7A regulates tau secretion.

Interaction of 14-3-3&#x3b6; with microtubule-associated protein tau within Alzheimer's disease neurofibrillary tangles.

Microtubule alterations in progressive supranuclear palsy

High performance nucleofection unit for difficult to manipulate cell types

Mechanisms leading to extracellular and intracellular accumulation of tau in Alzheimer's disease

The contribution of extracellular tau to the propagation of neurodegeneration in Alzheimer disease

The neurobiology of aging and Alzeihmers dissease: walking down the same road?

Caméra numérique pour microscope électronique

Nucleofector for gene expression

The role rer/microtubule interaction in the establishment and maintenance of neuronal polarity

Phosphorylation of MAP2 and its contribution to dendritic differentiation and plasticity

Molecular organization of the acitin cytoskeleton in neurons

Frequent collaborators

Marie-Jeanne Kergoat

Antoine Duquette

Marie-Jeanne Kergoat

Catherine Larochelle

Pierrette Gaudreau

Simon Duchesne

Pierrette Gaudreau

Sylvie Belleville

Sylvie Belleville

Serge Gauthier

Naguib Mechawar

Serge Gauthier

Interaction of 14-3-3ζ with microtubule-associated protein tau within Alzheimer's disease neurofibrillary tangles.