Faculty profile

Serge Gauthier

ResearcherNeurology and NeurosurgeryMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Serge Gauthier

Researcher

Neurology and Neurosurgery

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
118 publications in the last five years, latest in 2026.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 4 research grants (4 CIHR), most recently in 2016.
Supervised 1 trainee who won CIHR awards, most recently in 2012.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

305

Publications

390

Citations

h-index

152

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Dementia Quality Of Life Therapy Big Data Cognitive Decline Imaging Longitudinal Cohorts Phenotyping

Latest papers

Ventricular enlargement is associated with early Alzheimer's disease pathophysiology.
Brain communications · 2026
Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease.
The journal of prevention of Alzheimer's disease · 2026
Functional network phenotypes of mild behavioural impairment: cognitive effects moderated by amyloid.
Alzheimer's research & therapy · 2026

All 305 publications

Latest funding

Integrating Multi-Omics, Multi-Modal Neuroimaging and Artificial Intelligence for Biologically-defined Staging and Stratification in the Alzheimer's Disease spectrum
CIHR · 2020 · Co-investigator
$745,876
Individualized prognosis and prediction of cognitive decline in cognitively normal individuals at risk of AD and in individuals with mild cognitive impairment
CIHR · 2019 · Co-investigator
$948,600
Individualized prognosis and prediction of cognitive decline in cognitively normal individuals at risk of AD
CIHR · 2018 · Co-investigator
$100,000

All 18 grants and awards

From the 150 most recent of 305 publications.

Ventricular enlargement is associated with early Alzheimer's disease pathophysiology.

Hosseini SA, Aumont E, Rahmouni N, Woo MS, Macedo AC, Hall B, Trudel L, Chan T, Fernandez Arias J, Wang YT, Servaes S, Therriault J, Zheng Y, Socualaya KQ, Bezgin G, Tissot C, Oliva-Lopez D, Hopewell R, Hsiao CH, Saleh C, Stevenson J, Lussier F, Wu L, Chu M, Chawla S, Fonov V, Massarweh G, Iturria-Medina Y, Soucy JP, Rudko DA, Gauthier S, Karikari T, Benedet AL, Ashton NJ, Zetterberg H, Montembeault M, Vitali P, Blennow K, Collins DL, Klostranec J, Pascoal TA, Rosa-Neto P

Brain communications2026

DOI: 10.1093/braincomms/fcag066 PMID: 41853044

Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease.

Wischik CM, Stefanacci R, Bentham P, Gauthier S, Zetterberg H, Wilcock GK, Froelich L, Burns A, MacSweeney E, Ballard C, Yu JT, Choon TS, Asvatourian V, Muehlemann N, Priel J, Kook K, Sullivan T, Downie D, Miller S, Pringle C, Storey JMD, Baddeley T, Harrington CR, Penny LK, Arastoo M, Staff R, Sandu AL, Shiells H, Lo S, Nazlee N, Evans E, Hull C, Schelter BO

The journal of prevention of Alzheimer's disease2026

DOI: 10.1016/j.tjpad.2026.100480 PMID: 41570392

Functional network phenotypes of mild behavioural impairment: cognitive effects moderated by amyloid.

Ng KP, Chong JSX, Lussier F, Therriault J, Rahmouni N, Savard M, Stevenson J, Pascoal T, Gauthier S, Rosa-Neto P, Zhou JH

Alzheimer's research & therapy2026

DOI: 10.1186/s13195-026-01980-2 PMID: 41668114

Choroidal-ventricular system abnormalities are linked to amyloid-β aggregation in Alzheimer's disease.

Hosseini SA, Aumont E, Rahmouni N, Woo MS, Macedo AC, Hall B, Chan T, Therriault J, Trudel L, Zheng Y, Bezgin G, Lebrun A, Arias JF, Socualaya KQ, Tissot C, Servaes S, Wang YT, Oliva-Lopez D, Mitchell S, Hopewell R, Hsiao CH, Saleh C, Stevenson J, Lussier F, Wu L, Chu M, Chawla S, Fonov V, Massarweh G, Medina YI, Soucy JP, Provost K, Rudko DA, Karikari T, Benedet AL, Ashton NJ, Zetterberg H, Montembeault M, Vitali P, Blennow K, Gauthier S, Collins DL, Klostranec J, Pascoal TA, Rosa-Neto P

Alzheimer's & dementia : the journal of the Alzheimer's Association2026

DOI: 10.1002/alz.71205 PMID: 41738400

Hippocampal Atrophy on Magnetic Resonance Imaging as a Surrogate Marker for Clinical Benefit and Neurodegeneration in Early Symptomatic Alzheimer's Disease: Synthesis of Evidence from Observational and Interventional Trials.

Abushakra S, Doraiswamy PM, Hey JA, Tosun D, Barkhof F, Barakos J, Petrella J, Kesslak JP, Power A, Sabbagh M, Porsteinsson A, Cohen S, Gauthier S, Ritchie C, Watson D, McSweeney E, Boada M, Liang E, Bracoud L, McLaine R, Flint S, Schaefer JF, Yu J, Bray M, Hendrix S, Dickson S, Durrant A, Albayrak A, Tolar M

CNS drugs2026

DOI: 10.1007/s40263-025-01251-y PMID: 41324786

Optimized atlas for early tau-PET staging via native space segmentations.

Aumont E, Hall BJ, Chan T, Trudel L, Bezgin G, Hosseini SA, Therriault J, Macedo AC, Fernández Arias J, Rahmouni N, Servaes S, Vitali P, Stevenson J, Fonov V, Montembeault M, Klostranec J, Iturria-Medina Y, Gauthier S, Rosa-Neto P, Alzheimer’s Disease Neuroimaging Initiative

Neurobiology of aging2026

DOI: 10.1016/j.neurobiolaging.2025.11.002 PMID: 41237676

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease.

Ferrari-Souza JP, Povala G, Rahmouni N, Bellaver B, Ferreira PCL, De Bastiani MA, Leffa DT, Lussier FZ, Aguzzoli CS, Brum WS, Carello-Collar G, Borelli WV, Therriault J, Macedo AC, Servaes S, Stevenson J, Pola I, Gauthier S, Souza DO, Schilling LP, Lourenco MV, Triana-Baltzer G, Kolb HC, Benedet AL, Ashton NJ, Tudorascu DL, Zetterberg H, Blennow K, Johnson SC, Pascoal TA, Rosa-Neto P, Zimmer ER

Nature neuroscience2026

DOI: 10.1038/s41593-025-02103-0 PMID: 41198899

Opportunities to treat specific populations with repurposed drugs.

Gauthier S

The journal of prevention of Alzheimer's disease2026First author

DOI: 10.1016/j.tjpad.2026.100671 PMID: 42731301

Clinical-biological Alzheimer's disease stage concordance: insights from cohorts and autopsy data.

Trudel L, Therriault J, Macedo AC, Hosseini SA, Fernandez-Arias J, Chan T, Rahmouni N, Bezgin G, Tissot C, Woo MS, Aumont É, Zheng Y, Hall B, Oliva-Lopez D, Mitchell SW, Hopewell R, Hsiao CH, Toga AW, Braskie MN, Meeker KL, Soucy JP, Guiot MC, Gauthier S, Vitali P, O'Bryant SE, Pascoal TA, Rosa-Neto P

Brain : a journal of neurology2026

DOI: 10.1093/brain/awag018 PMID: 41556545

Associations between REM sleep EEG slowing and brain cholinergic denervation in aging and Mild Cognitive Impairment.

André C, Bédard MA, Daneault V, Wickens R, Fliaguine O, Soucy JP, Gauthier S, Lorrain D, Bastien C, Hudon C, Marchi NA, Montplaisir J, Gosselin N, Carrier J

Molecular psychiatry2026

DOI: 10.1038/s41380-026-03635-y PMID: 42120556

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Serge Gauthier

Research

Latest papers

Latest funding

Ventricular enlargement is associated with early Alzheimer's disease pathophysiology.

Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer's disease.

Functional network phenotypes of mild behavioural impairment: cognitive effects moderated by amyloid.

Choroidal-ventricular system abnormalities are linked to amyloid-&#x3b2; aggregation in Alzheimer's disease.

Hippocampal Atrophy on Magnetic Resonance Imaging as a Surrogate Marker for Clinical Benefit and Neurodegeneration in Early Symptomatic Alzheimer's Disease: Synthesis of Evidence from Observational and Interventional Trials.

Optimized atlas for early tau-PET staging via native space segmentations.

Microglia modulate A&#x3b2;-dependent astrocyte reactivity in Alzheimer's disease.

Opportunities to treat specific populations with repurposed drugs.

Clinical-biological Alzheimer's disease stage concordance: insights from cohorts and autopsy data.

Associations between REM sleep EEG slowing and brain cholinergic denervation in aging and Mild Cognitive Impairment.

Frequent collaborators

Serge Gauthier

Pedro Rosa-Neto

Jean-Paul Soucy

Zahinoor Ismail

Mario Masellis

Sylvie Belleville

Sylvie Belleville

Judes Poirier

Maxime Montembeault

Yasser Iturria Medina

Howard Chertkow

Marie-Jeanne Kergoat

Paramita Saha Chaudhuri

Marie-Jeanne Kergoat

Soham Rej

Isabelle Vedel

Julie Ottoy

Nathan Herrmann

Jianping Jia

Simon Ducharme

Simon Duchesne

Howard Chertkow

Jacques Montplaisir

Linda Lee

Bojana Stefanovic

Linda Lee

Moshe Szyf

Nadia Gosselin

Nicole Anderson

Mukul Sharma

Katherine Zukotynski

Debra Morgan

Ging-Yuek Hsiung

Howard Bergman

Margaret Fahnestock

Peter ST GEORGE-HYSLOP

Christopher Patterson

Sheena Ghodasara

Cheryl Wellington

Sven Joubert

Choroidal-ventricular system abnormalities are linked to amyloid-β aggregation in Alzheimer's disease.

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease.