Faculty profile

Serge McGraw

ResearcherObstétrique et gynécologieUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses may be missing. Find their university profile.

Serge McGraw

Researcher

Obstétrique et gynécologie

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
12 publications in the last five years, latest in 2026.
Senior (last) author on 6 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (4 CIHR, 2 NSERC), most recently in 2024.
Supervised 4 trainees who won CIHR awards, most recently in 2026.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

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Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Brain Development Epigenetics Dna Methyltransferase 3a (Dnmt3a)Induced Pluripotent Stem Cells (Ipsc)Mouse Model Polycomb Repressive Complex 2 (Prc2)Cortical Organoids Ipsc Derived Models

Latest papers

Fibroadipogenic progenitor-secreted prostaglandin E2 coordinates stem cell fate via autocrine and paracrine crosstalk in healthy and dystrophic muscle.
Cell death and differentiation · 2026
DNMT3A in cancer: from epigenetic writer to oncogenic driver.
Clinical epigenetics · 2026 · senior author
Heterologous expression of bovine histone H1foo into porcine fibroblasts alters the transcriptome profile but not embryo development following nuclear transfer.
Journal of assisted reproduction and genetics · 2025

All 25 publications

Latest funding

Epigenetic Regulation of Neural Cell Fate by DNMT3A During in vitro Brain Development
CIHR · 2026 · Supervisor
$27,000
The Impact of Pathogenic DNMT3A on Neurodevelopment
CIHR · 2025 · Supervisor
$120,000
Germline DNMT3A loss-of-function alters histone H3K27 methylation and causes neuronal impairments
CIHR · 2024 · Nominated PI
$963,900

All 12 grants and awards

25 publications.

Fibroadipogenic progenitor-secreted prostaglandin E2 coordinates stem cell fate via autocrine and paracrine crosstalk in healthy and dystrophic muscle.

Molina T, Fabre P, Garcia P, Kim TY, Gurlekian Z, Tellier L, Rieger L, Dallaire J, Collette É, Desaulniers R, Greffard K, Pellerito O, McGraw S, Bilodeau JF, Dumont NA

Cell death and differentiation2026

DOI: 10.1038/s41418-026-01762-1 PMID: 42286262

DNMT3A in cancer: from epigenetic writer to oncogenic driver.

Dupas T, Gautreau E, Clavel J, Raynal NJ, McGraw S

Clinical epigenetics2026Senior author

DOI: 10.1186/s13148-026-02127-8 PMID: 41987339

Heterologous expression of bovine histone H1foo into porcine fibroblasts alters the transcriptome profile but not embryo development following nuclear transfer.

de Macedo MP, Glanzner WG, Gutierrez K, Currin L, Rissi VB, Baldassarre H, McGraw S, Bordignon V

Journal of assisted reproduction and genetics2025

DOI: 10.1007/s10815-025-03437-1 PMID: 40025368

Rescuing DNMT1 fails to fully reverse the molecular and functional repercussions of its loss in mouse embryonic stem cells.

Elder E, Lemieux A, Legault LM, Caron M, Bertrand-Lehouillier V, Dupas T, Raynal NJ, Bourque G, Sinnett D, Gévry N, McGraw S

Nucleic acids research2025Senior author

DOI: 10.1093/nar/gkaf130 PMID: 39997223

Sex-specific DNA methylation and gene expression changes in mouse placentas after early preimplantation alcohol exposure.

Legault LM, Dupas T, Breton-Larrivée M, Filion-Bienvenue F, Lemieux A, Langford-Avelar A, McGraw S

Environment international2024Senior author

DOI: 10.1016/j.envint.2024.109014 PMID: 39321537

Predictive biomarkers and initial analysis of maternal immune alterations in postpartum preeclampsia reveal an immune-driven pathology.

Couture C, Brien ME, Rechtzigel J, Ling S, Ledezma-Soto C, Duran Bishop G, Boufaied I, Dal Soglio D, Rey E, McGraw S, Graham CH, Girard S

Frontiers in immunology2024

DOI: 10.3389/fimmu.2024.1380629 PMID: 38745664

An adult patient with Tatton-Brown-Rahman syndrome caused by a novel DNMT3A variant and axonal polyneuropathy.

AlSabah AA, Alsalmi M, Massie R, Bilodeau MC, Campeau PM, McGraw S, D'Agostino MD

American journal of medical genetics. Part A2024

DOI: 10.1002/ajmg.a.63484 PMID: 38041495

Sex-based disparities in DNA methylation and gene expression in late-gestation mouse placentas.

Legault LM, Breton-Larrivée M, Langford-Avelar A, Lemieux A, McGraw S

Biology of sex differences2024Senior author

DOI: 10.1186/s13293-023-00577-w PMID: 38183126

O-GlcNAcylation: the sweet side of epigenetics.

Dupas T, Lauzier B, McGraw S

Epigenetics & chromatin2023Senior author

DOI: 10.1186/s13072-023-00523-5 PMID: 38093337

Repurposing disulfiram, an alcohol-abuse drug, in neuroblastoma causes KAT2A downregulation and in vivo activity with a water/oil emulsion.

Beaudry A, Jacques-Ricard S, Darracq A, Sgarioto N, Garcia A, García TR, Lemieux W, Béland K, Haddad E, Cordeiro P, Duval M, McGraw S, Richer C, Caron M, Marois F, St-Onge P, Sinnett D, Banquy X, Raynal NJ

Scientific reports2023

DOI: 10.1038/s41598-023-43219-2 PMID: 37777587

Epigenetic Regulation of Neural Cell Fate by DNMT3A During in vitro Brain Development

SupervisorCIHR2026CIHR Strategic Master's Award - Bioinformatics, Comput. Biology/Health Data Sci.

Principal investigators: Vaquero, Alicia A

Keywords: Bio-Informatique; Différenciation Cellulaire; Développement Embryonnaire; Marques D'Histones; Mutations Génétiques; Méthylation; Neuroscience; Organoïde; Transcriptomique; Épigénétique

$27,000

The Impact of Pathogenic DNMT3A on Neurodevelopment

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Clavel, Josianne

Keywords: Behavior; Brain Development; Dna Methylation; Dna Methyltransferase 3a (Dnmt3a); Epigenetics; Mouse Model; Mutation; Neurodevelopment; Rare Disease; Transcriptomics

$120,000

Germline DNMT3A loss-of-function alters histone H3K27 methylation and causes neuronal impairments

Nominated PICIHR2024Project Grant

Principal investigators: McGraw, Serge

Keywords: Brain Development; Cortical Organoids; Dna Methyltransferase 3a (Dnmt3a); Epigenetics; Induced Pluripotent Stem Cells (Ipsc); Ipsc Derived Models; Mouse Model; Multiomics; Polycomb Repressive Complex 2 (Prc2)

$963,900

Decoding the role of DNMT1 in the Inherited Dysregulation of Epigenetic Marks using Embryonic Cells

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: McGraw, Serge

Keywords: Bioinformatic Analyses; CUT&RUN-Seq; DNA Methylation; DNMT1 (DNA methyltransferase1); Epigenetic Crosstalk; Epigenetics; Histone Modifications; Mouse Embryonic Stem Cells; Whole Genome DNA Methylation profiling

$70,000

Germline DNMT3A loss-of-function alters PRC2-dependent H3K27me3 deposition and leads to neuronal impairments.

Nominated PICIHR2023Pr. Gr. - PA: Human Development Child and Youth Health - Mid Career Support

Principal investigators: McGraw, Serge

Keywords: Bioinformatics; Brain Development; Dna Methyltransferase 3a (Dnmt3a); Epigenetics; Induced Pluripotent Stem Cells (Ipsc); Mouse Model; Multiomic Approaches; Polycomb Repressive Complex 2 (Prc2)

$100,000

Understanding Esophageal Atresia using Induced Pluripotent Stem Cells

Co-investigatorCIHR2022Project Grant

Principal investigators: Faure, Christophe

Keywords: Children; Congenital Malformation; Esophageal Atresia Tracheoesophageal Fistula; Esophagus-Trachea Development; Foregut; Induced Pluripotent Stem Cells

$864,452

Dissecting the impact of DNA methyltransferase 3A (DNMT3A) mutations on neuronal cell fate specification.

SupervisorCIHR2022Fellowship - PA: Takeda Canada and CIHR Institute of Genetics Rare Diseases

Principal investigators: Dupas, Thomas C

Keywords: Dna Methyltransferase 3a; Epigenetics; Induced Pluripotent Stem Cell (Ipsc); Intellectual Disorders; Sequencing Approaches; Single Cell Rna Sequencing; Tatton-Brown Rahman Syndrome

$67,500

Implication of early embryonic epigenetic dysregulation in fetal alcohol spectrum disorders-associated outcomes

Nominated PICIHR2020Project Grant

Principal investigators: McGraw, Serge

Keywords: Adverse Maternal Exposure; Brain Development; Developmental Origin Of Health And Diseases (Dohad); Dna Methylation; Epigenetics; Fetal Alcohol Spectrum Disorders; Fetal Development; Gabaergic Interneurons; Transcriptomics

$826,200

Defining the consequences associated with early embryonic alcohol exposure and investigate the impact of a nutritional preventive intervention.

SupervisorCIHR2018Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Legault, Lisa-Marie

Keywords: Brain Development And Function; Developmental Origins Of Health And Disease (Dohad); Dna Methylation; Embryonic Development; Fetal Alcohol Spectrum Disorders; Gene Expression; High-Resolution Imaging; Next-Generation Sequencing; Prenatal Alcohol Exposure; Youth Health

$105,000

Stem cell-derived Encapsulated Liver Tissue to treat liver failure without immunosuppression: technology maturation towards clinical translation

Co-investigatorCIHR2018Project Grant

Principal investigators: Paganelli, Massimiliano

Keywords: Commercialization; Liver Failure; Liver Organoids; Product Development; Regenerative Medicine; Stem Cell-Derived Tissues; Technology Transfer

$497,249

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Serge McGraw

Research

Latest papers

Latest funding

Fibroadipogenic progenitor-secreted prostaglandin E2 coordinates stem cell fate via autocrine and paracrine crosstalk in healthy and dystrophic muscle.

DNMT3A in cancer: from epigenetic writer to oncogenic driver.

Heterologous expression of bovine histone H1foo into porcine fibroblasts alters the transcriptome profile but not embryo development following nuclear transfer.

Rescuing DNMT1 fails to fully reverse the molecular and functional repercussions of its loss in mouse embryonic stem cells.

Sex-specific DNA methylation and gene expression changes in mouse placentas after early preimplantation alcohol exposure.

Predictive biomarkers and initial analysis of maternal immune alterations in postpartum preeclampsia reveal an immune-driven pathology.

An adult patient with Tatton-Brown-Rahman syndrome caused by a novel DNMT3A variant and axonal polyneuropathy.

Sex-based disparities in DNA methylation and gene expression in late-gestation mouse placentas.

O-GlcNAcylation: the sweet side of epigenetics.

Repurposing disulfiram, an alcohol-abuse drug, in neuroblastoma causes KAT2A downregulation and in vivo activity with a water/oil emulsion.

Decoding the role of DNMT1 in the Inherited Dysregulation of Epigenetic Marks using Embryonic Cells

Frequent collaborators

Jacquetta Trasler

Guillaume Bourque

Daniel Sinnett

Sarah Kimmins

Sarah Kimmins

Cynthia Gagnon

Elise Duchesne

Cynthia Gagnon

Tamara Cohen

Mathieu Dalvai

Michel Duval

Arnaud Droit

Janusz Rak

Gregor Andelfinger

Xavier Banquy

Xiang-Jiao Yang

Elie Haddad

Sylvie Girard

Nada Jabado

Tomi Pastinen