Sylvie Girard, Université de Montréal

Research

Inflammation Endothelial Activation Immune Cells Preeclampsia Pregnancy Preterm Birth Transcriptomics

Latest papers

Placental ferroptosis and impaired fetal growth in symptomatic and asymptomatic SARS-CoV-2 infections.
Clinical science (London, England : 1979) · 2026
Adverse neonatal outcomes are associated with a sex-specific placental inflammatory profile†.
Biology of reproduction · 2025 · senior author
Corrigendum to "Identification of divergent placental profiles in clinically distinct pregnancy complications revealed by the transcriptome" [Placenta 154 (2024): 184-192 / PMID: 39042974].
Placenta · 2025 · senior author

All 29 publications

Latest funding

Maternal immune cells mediated endothelial activation in preeclampsia
CIHR · 2020 · Nominated PI
$818,550
Integrated view of the preterm birth syndrome
CIHR · 2017 · Nominated PI
$75,000
Mechanism of action of HMGB1 in trophoblast differentiation
NSERC · 2016 · Principal investigator
$185,291

All 4 grants and awards

29 publications.

01

Placental ferroptosis and impaired fetal growth in symptomatic and asymptomatic SARS-CoV-2 infections.

Cariaco Y, Nik-Akhtar A, Brien ME, Menzies K, Girard S, Bainbridge S

Clinical science (London, England : 1979)2026

DOI: 10.1042/cs20257407 PMID: 41885260

02

Adverse neonatal outcomes are associated with a sex-specific placental inflammatory profile†.

Couture C, Brien ME, Piché J, Cervantes E, Luu TM, Girard S

Biology of reproduction2025Senior author

DOI: 10.1093/biolre/ioaf158 PMID: 40679433

03

Corrigendum to "Identification of divergent placental profiles in clinically distinct pregnancy complications revealed by the transcriptome" [Placenta 154 (2024): 184-192 / PMID: 39042974].

Couture C, Caron M, St-Onge P, Brien ME, Sinnett D, Soglio DD, Girard S

Placenta2025Senior author

DOI: 10.1016/j.placenta.2025.05.012 PMID: 40554110

04

Circulating Immune Cells from Early- and Late-onset Pre-eclampsia Displays Distinct Profiles with Differential Impact on Endothelial Activation.

Bernier E, Couture C, Borchers A, Brien ME, Graham CH, Girard S

Journal of immunology (Baltimore, Md. : 1950)2024Senior author

DOI: 10.4049/jimmunol.2400196 PMID: 39302114

05

Identification of divergent placental profiles in clinically distinct pregnancy complications revealed by the transcriptome.

Couture C, Caron M, St-Onge P, Brien ME, Sinnett D, Dal Soglio D, Girard S

Placenta2024Senior author

DOI: 10.1016/j.placenta.2024.07.008 PMID: 39042974

06

Maternal Innate Immune Reprogramming After Complicated Pregnancy.

Lodge-Tulloch NA, Paré JF, Couture C, Bernier E, Cotechini T, Girard S, Graham CH

American journal of reproductive immunology (New York, N.Y. : 1989)2024

DOI: 10.1111/aji.13908 PMID: 39119763

07

Predictive biomarkers and initial analysis of maternal immune alterations in postpartum preeclampsia reveal an immune-driven pathology.

Couture C, Brien ME, Rechtzigel J, Ling S, Ledezma-Soto C, Duran Bishop G, Boufaied I, Dal Soglio D, Rey E, McGraw S, Graham CH, Girard S

Frontiers in immunology2024Senior author

DOI: 10.3389/fimmu.2024.1380629 PMID: 38745664

08

Pregnant individuals with uncomplicated pregnancies display pro-inflammatory immune changes when exposed to the COVID-19 pandemic.

Bernier E, Brien ME, Girard S

American journal of reproductive immunology (New York, N.Y. : 1989)2024Senior author

DOI: 10.1111/aji.13828 PMID: 38374807

09

Placenta analysis of Hofbauer cell profile according to the class of antiretroviral therapy used during pregnancy in people living with HIV.

Hindle S, Brien MÈ, Pelletier F, Giguère F, Trudel MJ, Dal Soglio D, Kakkar F, Soudeyns H, Girard S, Boucoiran I

Placenta2023

DOI: 10.1016/j.placenta.2023.06.003 PMID: 37364521

10

Proinflammatory changes in the maternal circulation, maternal-fetal interface, and placental transcriptome in preterm birth.

Couture C, Brien ME, Boufaied I, Duval C, Soglio DD, Enninga EAL, Cox B, Girard S

American journal of obstetrics and gynecology2023Senior author

DOI: 10.1016/j.ajog.2022.08.035 PMID: 36027951

Maternal immune cells mediated endothelial activation in preeclampsia

Nominated PICIHR2020Project Grant

Principal investigators: Girard, Sylvie

Keywords: Endothelial Activation; Immune Cells; Inflammation; Preeclampsia

$818,550

Integrated view of the preterm birth syndrome

Nominated PICIHR2017Operating Grant: ECI grants in Maternal, Reproductive, Child & Youth Health

Principal investigators: Girard, Sylvie

Keywords: Inflammation; Pregnancy; Preterm Birth; Transcriptomics

$75,000

Mechanism of action of HMGB1 in trophoblast differentiation

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Girard, Sylvie

$185,291

Diagnostic and Treament of Inflammation During Pregnancy

Nominated PICIHR2015Operating Grant: SickKids-CIHR-IHDCYH New Investigator Grants

Principal investigators: Girard, Sylvie

Keywords: Inflammation

$300,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Pediatrics
Obstétrique et gynécologie
Microbiologie et immunologie
Interdisciplinary Health Sciences
Pharmacologie - Physiologie
Pathology and Laboratory Medicine
Biochemistry, Microbiology and Immunology
Other

Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Isabelle Boucoiran

Obstétrique et gynécologie

4 shared papers, latest 2023

Dina El Demellawy

Pathology and Laboratory Medicine

2 shared papers, latest 2022

Daniel Sinnett

Pharmacologie - Physiologie

2 shared papers, latest 2025

Hugo Soudeyns

Microbiologie et immunologie

2 shared papers, latest 2023

Keir Menzies

Interdisciplinary Health Sciences

1 shared papers, latest 2026

Tiziana Cotechini

Biomedical and Molecular Sciences

1 shared papers, latest 2024

Abolfazl Nik-Akhtar

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2026

Serge McGraw

Obstétrique et gynécologie

1 shared papers, latest 2024

Shannon Bainbridge

Interdisciplinary Health Sciences

1 shared papers, latest 2026

Brian Cox

Department of Physiology

1 shared papers, latest 2023

Normand Lapointe

Microbiologie et immunologie

1 shared papers, latest 2019

Helen Trottier

Médecine sociale et préventive

1 shared papers, latest 2019

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2020

Subject: Prospective PhD student: Inflammation Dear Professor Girard, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Placental ferroptosis and impaired fetal growth in symptomatic and asymptomatic SARS-CoV-2 infections." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Maternal immune cells mediated endothelial activation in preeclampsia" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Sylvie Girard

Research

Latest papers

Latest funding

Placental ferroptosis and impaired fetal growth in symptomatic and asymptomatic SARS-CoV-2 infections.

Adverse neonatal outcomes are associated with a sex-specific placental inflammatory profile†.

Corrigendum to "Identification of divergent placental profiles in clinically distinct pregnancy complications revealed by the transcriptome" [Placenta 154 (2024): 184-192 / PMID: 39042974].

Circulating Immune Cells from Early- and Late-onset Pre-eclampsia Displays Distinct Profiles with Differential Impact on Endothelial Activation.

Identification of divergent placental profiles in clinically distinct pregnancy complications revealed by the transcriptome.

Maternal Innate Immune Reprogramming After Complicated Pregnancy.

Predictive biomarkers and initial analysis of maternal immune alterations in postpartum preeclampsia reveal an immune-driven pathology.

Pregnant individuals with uncomplicated pregnancies display pro-inflammatory immune changes when exposed to the COVID-19 pandemic.

Placenta analysis of Hofbauer cell profile according to the class of antiretroviral therapy used during pregnancy in people living with HIV.

Proinflammatory changes in the maternal circulation, maternal-fetal interface, and placental transcriptome in preterm birth.

Maternal immune cells mediated endothelial activation in preeclampsia

Integrated view of the preterm birth syndrome

Mechanism of action of HMGB1 in trophoblast differentiation

Diagnostic and Treament of Inflammation During Pregnancy

Frequent collaborators

Isabelle Boucoiran

Sylvain Chemtob

Dina El Demellawy

Daniel Sinnett

Hugo Soudeyns

Fatima Kakkar

Guillaume Sebire

Keir Menzies

Tiziana Cotechini

Abolfazl Nik-Akhtar

Serge McGraw

Sasha Bernatsky

Shannon Bainbridge

Brian Cox

Yves Giguere

Jean-Sébastien Joyal

Normand Lapointe

Sasha Bernatsky

William Lubell

Jean-Claude Forest

Helen Trottier

Sylvie Girard

Research

Latest papers

Latest funding

Placental ferroptosis and impaired fetal growth in symptomatic and asymptomatic SARS-CoV-2 infections.

Adverse neonatal outcomes are associated with a sex-specific placental inflammatory profile&#x2020;.

Corrigendum to "Identification of divergent placental profiles in clinically distinct pregnancy complications revealed by the transcriptome" [Placenta 154 (2024): 184-192 / PMID: 39042974].

Circulating Immune Cells from Early- and Late-onset Pre-eclampsia Displays Distinct Profiles with Differential Impact on Endothelial Activation.

Identification of divergent placental profiles in clinically distinct pregnancy complications revealed by the transcriptome.

Maternal Innate Immune Reprogramming After Complicated Pregnancy.

Predictive biomarkers and initial analysis of maternal immune alterations in postpartum preeclampsia reveal an immune-driven pathology.

Pregnant individuals with uncomplicated pregnancies display pro-inflammatory immune changes when exposed to the COVID-19 pandemic.

Placenta analysis of Hofbauer cell profile according to the class of antiretroviral therapy used during pregnancy in people living with HIV.

Proinflammatory changes in the maternal circulation, maternal-fetal interface, and placental transcriptome in preterm birth.

Maternal immune cells mediated endothelial activation in preeclampsia

Integrated view of the preterm birth syndrome

Mechanism of action of HMGB1 in trophoblast differentiation

Diagnostic and Treament of Inflammation During Pregnancy

Frequent collaborators

Isabelle Boucoiran

Sylvain Chemtob

Dina El Demellawy

Daniel Sinnett

Hugo Soudeyns

Fatima Kakkar

Guillaume Sebire

Keir Menzies

Tiziana Cotechini

Abolfazl Nik-Akhtar

Serge McGraw

Sasha Bernatsky

Shannon Bainbridge

Brian Cox

Yves Giguere

Jean-Sébastien Joyal

Normand Lapointe

Sasha Bernatsky

William Lubell

Jean-Claude Forest

Helen Trottier

Adverse neonatal outcomes are associated with a sex-specific placental inflammatory profile†.