Xiang-Jiao Yang, McGill University

Research

Brain Development Chip-Seq Chromatin Regulation Developmental Disorder Epigenetic Regulation Histone Acetylation Mouse Models Rna-Seq

Latest papers

Efficient and Fast Site-Directed Mutagenesis via Partially or Completely Overlapping Primer Pairs.
Bio-protocol · 2026 · senior author
CRISPR-Cas9-producing probiotic bacteria for editing NOX2/gp91phox and treating inflammatory bowel disease.
Cell reports. Medicine · 2026
Efficiency and Fidelity of Site-Directed Mutagenesis with Complementary Primer Pairs.
Cells · 2026 · senior author

All 68 publications

Latest funding

Roles of lysine acetyltransferase 6 complexes in cerebral development and neurodevelopmental disorders
CIHR · 2023 · Nominated PI
$948,600
Molecular, cellular, and physiological response to DNA damage, genotoxic stress, and cell death across living systems: RadSource RS-2000 X-ray irradiator
NSERC · 2023 · Co-investigator
$150,000
Roles of KAT8 complexes in governing histone acylation and mouse cerebral development
NSERC · 2019 · Principal investigator
$216,000

All 10 grants and awards

68 publications.

01

Efficient and Fast Site-Directed Mutagenesis via Partially or Completely Overlapping Primer Pairs.

Varela-Castillo P, Razavi A, Zhao C, Geng MM, Nour A, Yang XJ

Bio-protocol2026Senior author

DOI: 10.21769/bioprotoc.5792 PMID: 42656820

02

CRISPR-Cas9-producing probiotic bacteria for editing NOX2/gp91phox and treating inflammatory bowel disease.

Zhang C, Li T, Hao H, Wang G, Zhang Y, Huang Y, Chen L, Wang J, Yang XJ, Bi X

Cell reports. Medicine2026

DOI: 10.1016/j.xcrm.2026.102940 PMID: 42497864

03

Efficiency and Fidelity of Site-Directed Mutagenesis with Complementary Primer Pairs.

Varela-Castillo P, Razavi A, Mousavi N, Robinson N, Yang XJ

Cells2026Senior author

DOI: 10.3390/cells15020138 PMID: 41597213

04

Seamless and Highly Efficient Site-directed Mutagenesis for Protein, RNA, and Plasmid Engineering.

Yang XJ

Current protocols2026First author

DOI: 10.1002/cpz1.70303 PMID: 41543491

05

Highly Efficient Site-Specific and Cassette Mutagenesis of Plasmids Harboring GC-Rich Sequences.

Varela-Castillo P, Zhou E, Razavi A, Ebrahimi E, Yang XJ

Cells2025Senior author

DOI: 10.3390/cells14242016 PMID: 41440036

06

P3a site-specific and cassette mutagenesis for seamless protein, RNA and plasmid engineering.

Yang XJ

Genes & cancer2025First author

DOI: 10.18632/genesandcancer.243 PMID: 41221126

07

P3 site-directed mutagenesis: An efficient method based on primer pairs with 3'-overhangs.

Mousavi N, Zhou E, Razavi A, Ebrahimi E, Varela-Castillo P, Yang XJ

The Journal of biological chemistry2025Senior author

DOI: 10.1016/j.jbc.2025.108219 PMID: 39863101

08

Efficient Site-Directed Mutagenesis Mediated by Primer Pairs with 3'-Overhangs.

Mousavi N, Zhou E, Razavi A, Ebrahimi E, Varela-Castillo P, Yang XJ

Current protocols2025Senior author

DOI: 10.1002/cpz1.70104 PMID: 39945594

09

Bromodomain and PHD Finger-Containing Protein 1: From Functions to a Developmental Disorder, Cancer, and Therapeutics.

Razavi A, Varela-Castillo P, Yang XJ

Results and problems in cell differentiation2025Senior author

DOI: 10.1007/978-3-031-91459-1_15 PMID: 40593219

10

Lysine Acetyltransferase 6 Complexes in Neurodevelopmental Disorders and Different Types of Cancer.

Mousavi N, Yang XJ

Results and problems in cell differentiation2025Senior author

DOI: 10.1007/978-3-031-91459-1_14 PMID: 40593218

Roles of lysine acetyltransferase 6 complexes in cerebral development and neurodevelopmental disorders

Nominated PICIHR2023Project Grant

Principal investigators: Yang, Xiang-Jiao

Keywords: Brain Development; Chip-Seq; Chromatin Regulation; Developmental Disorder; Epigenetic Regulation; Histone Acetylation; Mouse Models; Rna-Seq; Transcriptomic Control

$948,600

Molecular, cellular, and physiological response to DNA damage, genotoxic stress, and cell death across living systems: RadSource RS-2000 X-ray irradiator

Co-investigatorNSERC2023Research Tools and Instruments

Principal investigators: Nijnik, Anastasia

$150,000

Roles of KAT8 complexes in governing histone acylation and mouse cerebral development

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Yang, XiangJiao

$216,000

Roles of chromatin regulators in governing histone acylation and mouse development

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Yang, XiangJiao

$32,000

Roles of the chromatin regulator Brpf1 in mouse embryogenesis and hematopoietic stem cells

Nominated PICIHR2015Operating Grant

Principal investigators: Yang, Xiang-Jiao

Keywords: Chromatin Regulator; Gene Regulation; Mouse Development; Mouse Knockout; Stem Cells; Transcriptional Regulation

$692,015

Roles of the sumoylation machinery in regulating pluripoptent stem cells

Principal investigatorNSERC2012Discovery Grants Program - Individual

Principal investigators: Yang, XiangJiao

$170,000

Roles of a kinase-HDAC-MEF2 signaling axis in normal and oncogenic cellular programs

Nominated PICIHR2009Operating Grant

Principal investigators: Yang, Xiang-Jiao

Keywords: Cell Differentiation; Cell Signaling; Chromatin; Epigenetics; Histone Deacetylase; Transcription

$677,385

Role of the epigenetic regulator Bmi1 in mediating the anti-aging effect of parathyroid hormone-related peptide

Nominated PICIHR2009China-Canada Joint Health Research Initiative

Principal investigators: Yang, Xiang-Jiao; Miao, Dengshun

Keywords: Aging; Chromatin; Endocrine Hormone; Epigenetics; Gene Regulation; Stem Cells

$150,000

The CIHR/FRSQ Training Program in Cancer Research at McGill

Co-investigatorCIHR2008Training Grant

Principal investigators: Tremblay, Michel L; Miller, Wilson H

Keywords: Cancer Research; Collaborative; Ethics; Multidisciplinary Program; Scientific Management; Training; Translational Research

$975,000

Roles of a recurrent phospho-sumoyl switch in coordinated transcriptional repression

Principal investigatorNSERC2007Discovery Grants Program - Individual

Principal investigators: Yang, XiangJiao

$150,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Nahum Sonenberg

Biochemistry

2 shared papers, latest 2016

Tommy Alain

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2014

Peter Kannu

Developmental and Stem Cell Biology

1 shared papers, latest 2021

Serge McGraw

Obstétrique et gynécologie

1 shared papers, latest 2019

Guillaume Bourque

Human Genetics

1 shared papers, latest 2016

Gerald Batist

Chemical Engineering

1 shared papers, latest 2006

Anne-Claude Gingras

Department of Molecular Genetics

1 shared papers, latest 2016

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Brain Development Dear Professor Yang, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Efficient and Fast Site-Directed Mutagenesis via Partially or Completely Overlapping Primer Pairs." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Roles of lysine acetyltransferase 6 complexes in cerebral development and neurodevelopmental disorders" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Xiang-Jiao Yang

Research

Latest papers

Latest funding

Efficient and Fast Site-Directed Mutagenesis via Partially or Completely Overlapping Primer Pairs.

CRISPR-Cas9-producing probiotic bacteria for editing NOX2/gp91phox and treating inflammatory bowel disease.

Efficiency and Fidelity of Site-Directed Mutagenesis with Complementary Primer Pairs.

Seamless and Highly Efficient Site-directed Mutagenesis for Protein, RNA, and Plasmid Engineering.

Highly Efficient Site-Specific and Cassette Mutagenesis of Plasmids Harboring GC-Rich Sequences.

P3a site-specific and cassette mutagenesis for seamless protein, RNA and plasmid engineering.

P3 site-directed mutagenesis: An efficient method based on primer pairs with 3'-overhangs.

Efficient Site-Directed Mutagenesis Mediated by Primer Pairs with 3'-Overhangs.

Bromodomain and PHD Finger-Containing Protein 1: From Functions to a Developmental Disorder, Cancer, and Therapeutics.

Lysine Acetyltransferase 6 Complexes in Neurodevelopmental Disorders and Different Types of Cancer.

Roles of lysine acetyltransferase 6 complexes in cerebral development and neurodevelopmental disorders

Molecular, cellular, and physiological response to DNA damage, genotoxic stress, and cell death across living systems: RadSource RS-2000 X-ray irradiator

Roles of KAT8 complexes in governing histone acylation and mouse cerebral development

Roles of chromatin regulators in governing histone acylation and mouse development

Roles of the chromatin regulator Brpf1 in mouse embryogenesis and hematopoietic stem cells

Roles of the sumoylation machinery in regulating pluripoptent stem cells

Roles of a kinase-HDAC-MEF2 signaling axis in normal and oncogenic cellular programs

Role of the epigenetic regulator Bmi1 in mediating the anti-aging effect of parathyroid hormone-related peptide

The CIHR/FRSQ Training Program in Cancer Research at McGill

Roles of a recurrent phospho-sumoyl switch in coordinated transcriptional repression

Frequent collaborators

Morag Park

Morag Park

Yojiro Yamanaka

Arkady Khoutorsky

Nahum Sonenberg

Tommy Alain

Peter Kannu

Serge McGraw

François Bolduc

Guillaume Bourque

Jagdeep Walia

Jean-Jacques Lebrun

Masha Prager-Khoutorsky

Gerald Batist

Jennifer MacKenzie

Alan Peterson

Katherine Siminovitch

Tammie Dewan

Gerald Batist

Anne-Claude Gingras