Faculty profile

Sylvain Chemtob

ResearcherPediatricsUniversité de Montréal

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses may be missing. Find their university profile.

Sylvain Chemtob

Researcher

Pediatrics

Health Sciences

Université de Montréal

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
25 publications in the last five years, latest in 2026.
Senior (last) author on 12 recent papers, a sign of leading a research group.
Principal investigator on 13 research grants (13 CIHR), most recently in 2024.
Supervisor on 9 trainee awards (9 CIHR), most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Inflammation Medicinal Chemistry Preterm Birth Age-Related Macular Degeneration Organic Synthesis Retina Pharmacology Il-1 Receptor Antagonist

Latest papers

Maternal and Postnatal Effects of Poly I:C-Induced Intrauterine Inflammation and Rytvela, a Non-Competitive IL-1R Antagonist, in the Pregnant Spiny Mouse.
Developmental neurobiology · 2026
The long-term impact of retinopathy of prematurity on retinal function assessed with new patterns of mfERG analysis.
Documenta ophthalmologica. Advances in ophthalmology · 2026
Inter- vs Intramolecular Aldehyde-Alkyne-Amine A3-Reaction in the Solution-Phase Synthesis of a Potent Macrocyclic Azapeptide CD36 Modulator.
The Journal of organic chemistry · 2026

All 99 publications

Latest funding

A Breakthrough Solution to Effectively Prevent Preterm Birth
CIHR · 2024 · Nominated PI
$599,500
Interleukin-1 Receptor Modulating Therapy for Treating Macular Degeneration
CIHR · 2023 · Co-investigator
$516,376
Efficacité d'un antagoniste allostérique d'IL-1R, rytvela, à traiter le travail pré-terme pour prévenir les dommages aux tissus fœtaux liés à la naissance prématurée
CIHR · 2022 · Supervisor
$105,000

All 32 grants and awards

99 publications.

Maternal and Postnatal Effects of Poly I:C-Induced Intrauterine Inflammation and Rytvela, a Non-Competitive IL-1R Antagonist, in the Pregnant Spiny Mouse.

Tran NT, Kamareddine R, Bellofiore N, Olson DM, Chemtob S, Robertson SA, Keelan JA, Ellery SJ

Developmental neurobiology2026

DOI: 10.1002/dneu.70064 PMID: 42755417

The long-term impact of retinopathy of prematurity on retinal function assessed with new patterns of mfERG analysis.

Youn YE, Dorfman AL, Polosa A, Hamel P, Luu TM, Nuyt AM, Chemtob S, Ali SK, Qian CX

Documenta ophthalmologica. Advances in ophthalmology2026

DOI: 10.1007/s10633-026-10096-9 PMID: 42053862

Inter- vs Intramolecular Aldehyde-Alkyne-Amine A3-Reaction in the Solution-Phase Synthesis of a Potent Macrocyclic Azapeptide CD36 Modulator.

Maarouf-Mesli N, Fonseca JC, Harvey SM, Chauhan PS, Mulumba M, Ahsanullah, Selka A, Meneksedag Erol D, Chemtob S, Ong H, Polyak F, Lubell WD

The Journal of organic chemistry2026

DOI: 10.1021/acs.joc.6c00445 PMID: 42049622

Rytvela, an allosteric modulator of the interleukin-1 receptor, prevents preterm birth and neonatal complications in mice while nifedipine is ineffective.

Habelrih T, Ferri B, Loiselle SE, Mauffette-Whyte F, Augustin TL, Côté F, Hou X, Sévigny J, Gallant M, Sawaya K, Di Battista E, Quiniou C, Lubell WD, Olson DM, Chemtob S

Journal of immunology (Baltimore, Md. : 1950)2026Senior author

DOI: 10.1093/jimmun/vkaf341 PMID: 41729165

Hypercholesterolemia Impairs the Expression of Angiogenic MicroRNAs in Extracellular Vesicles Within Ischemic Skeletal Muscles.

Raguema N, Dussault S, Sawaya K, Desjarlais M, Boilard E, Chemtob S, Rivard A

Non-coding RNA2026

DOI: 10.3390/ncrna12010003 PMID: 41718092

Aza-Isotryptophan: Synthesis, Pictet-Spengler Chemistry, Incorporation and Conformational Analysis in Peptides, and Activity in Modulators of the Cluster of Differentiation-36 Receptor.

Wei X, Mulumba M, Chemtob S, Ong H, Lubell WD

Journal of medicinal chemistry2025

DOI: 10.1021/acs.jmedchem.5c01693 PMID: 41151018

A novel modulator of IL-6R prevents inflammation-induced preterm birth and improves newborn outcome.

Côté F, Prairie E, Sierra EM, Quiniou C, Habelrih T, Xu W, Ferri B, Hou X, Lahaie I, Côté N, Loiselle SE, Gobeil L, Sawaya K, Faucher A, Beaulieu A, Delisle S, Simard MP, Mohammad Nezhady MA, Laplante V, Reuben A, Kalaidji SM, Bajon E, Cagnone G, Leimert KB, Gauchat JF, Gaudreau L, Robertson S, Lubell WD, Olson DM, Chemtob S

EMBO molecular medicine2025Senior author

DOI: 10.1038/s44321-025-00257-9 PMID: 40610814

Role of Cellular Senescence in IUGR: Impact on Fetal Morbidity and Development.

Zia A, Sahebdel F, Er-Reguyeg Y, Desjarlais M, Mars JC, Lodygensky GA, Chemtob S

Cells2025Senior author

DOI: 10.3390/cells14141097 PMID: 40710350

Inhibition of interleukin-1 signaling protects against Group B streptococcus-induced preterm birth and fetal loss in mice.

Chin PY, Moldenhauer LM, Lubell WD, Olson DM, Chemtob S, Keelan JA, Robertson SA

Journal of reproductive immunology2025

DOI: 10.1016/j.jri.2025.104520 PMID: 40139077

Interleukin-1 Receptor Antagonists Partially Inhibited Histological Injury but Not Tissue Inflammation in a Sheep Model of Pregnancy.

Takahashi Y, Fee EL, Takahashi T, Usuda H, Ikeda H, Carter SW, Saito Y, Sato S, Mochii N, Chemtob S, Olson DM, Keelan JA, Kumagai Y, Choolani MA, Illanes SE, Saito M, Kemp MW

Reproductive sciences (Thousand Oaks, Calif.)2025

DOI: 10.1007/s43032-024-01781-8 PMID: 39953369

A Breakthrough Solution to Effectively Prevent Preterm Birth

Nominated PICIHR2024Op. Grant: NWHRI: Innovation Fund - Translational Research

Principal investigators: Chemtob, Sylvain; Vinturache, Angela E

Keywords: Il-1 Receptor Antagonist; Inflammation; Interleukin-1; Myometrial Contractions; Pre-Clinical; Preterm Birth; Tocolytics

$599,500

Interleukin-1 Receptor Modulating Therapy for Treating Macular Degeneration

Co-investigatorCIHR2023Project Grant

Principal investigators: Lubell, William D

Keywords: Age-Related Macular Degeneration; Allosteric Modulation; Commercialization; Computational Analysis; Conformational Dynamics; Inflammation; Interleukin-1 Receptor,; Medicinal Chemistry; Opthamology; Peptide Mimicry

$516,376

Efficacité d'un antagoniste allostérique d'IL-1R, rytvela, à traiter le travail pré-terme pour prévenir les dommages aux tissus fœtaux liés à la naissance prématurée

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Habelrih, Tiffany

Keywords: Cytokine; Grossesse; Immunologie; Pharmacologie; Prématurité

$105,000

Rôle de l'Interleukine-6 prénatale dans la genèse de la vasculopathie rétinienne des nouveau-nés

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Côté, France

Keywords: Grossesse; Immunologie; Peptide; Pharmacologie; Prématurité; Rétine; Rétinopathie Du Prématuré

$105,000

Treating Age-Related Macular Degeneration by Mitigating Inflammation, Oxidative Stress, and Lipid Accumulation through CD36 Modulation

Co-investigatorCIHR2022Project Grant

Principal investigators: Lubell, William D

Keywords: Age-Related Macular Degeneration; Azapeptide; Cluster Of Differentiation 36 Receptor (Cd36); Commercialization; Computational Analysis; Conformational Dynamics; Inflammation; Macrophage; Medicinal Chemistry; Opthamology

$833,851

Azacyclopeptide Modulators of Immuno-metabolism to Treat Age-Related Macular Degeneration

Co-investigatorNSERC2019Collaborative Health Research Projects

Principal investigators: Lubell, William

$451,677

Unprecedented role for the novel lactate receptor GPR81 in protecting against age-related macular degeneration.

SupervisorCIHR2019Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Prairie, Élizabeth

Keywords: Amd; Angiogénèse; Choroïde; Chronis Hypoxia; Gpr81; Lactate; Neovascularization; Ophtalmologie; Oxidant Stress; Vision

$105,000

Azacyclopeptide Modulators of Immuno-metabolism to Treat Age-Related Macular Degeneration

Principal investigatorCIHR2018Collaborative Health Research Projects (NSERC partnered)

Principal investigators: Lubell, William D; Chipperton, Paul; Chemtob, Sylvain

Keywords: Age-Related Macular Degeneration; Azacyclopeptide; Cluster Of Differentiation-36 Receptor (Cd36); Inflammation; Macrocyclization; Macrophage; Medicinal Chemistry; Optometry; Organic Synthesis; Peptide Science

$403,623

Canada Research Chair - Tier 1

Nominated PICIHR2017Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Chemtob, Sylvain

Keywords: Crc

$1,400,000

Development of innovative optical technologies for quantitative blood perfusion imaging

Co-investigatorNSERC2016Research Tools and Instruments

Principal investigators: Dehaes, Mathieu

$141,442

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Sylvain Chemtob

Research

Latest papers

Latest funding

Maternal and Postnatal Effects of Poly I:C-Induced Intrauterine Inflammation and Rytvela, a Non-Competitive IL-1R Antagonist, in the Pregnant Spiny Mouse.

The long-term impact of retinopathy of prematurity on retinal function assessed with new patterns of mfERG analysis.

Inter- vs Intramolecular Aldehyde-Alkyne-Amine A3-Reaction in the Solution-Phase Synthesis of a Potent Macrocyclic Azapeptide CD36 Modulator.

Rytvela, an allosteric modulator of the interleukin-1 receptor, prevents preterm birth and neonatal complications in mice while nifedipine is ineffective.

Hypercholesterolemia Impairs the Expression of Angiogenic MicroRNAs in Extracellular Vesicles Within Ischemic Skeletal Muscles.

Aza-Isotryptophan: Synthesis, Pictet-Spengler Chemistry, Incorporation and Conformational Analysis in Peptides, and Activity in Modulators of the Cluster of Differentiation-36 Receptor.

A novel modulator of IL-6R prevents inflammation-induced preterm birth and improves newborn outcome.

Role of Cellular Senescence in IUGR: Impact on Fetal Morbidity and Development.

Inhibition of interleukin-1 signaling protects against Group B streptococcus-induced preterm birth and fetal loss in mice.

Interleukin-1 Receptor Antagonists Partially Inhibited Histological Injury but Not Tissue Inflammation in a Sheep Model of Pregnancy.

Azacyclopeptide Modulators of Immuno-metabolism to Treat Age-Related Macular Degeneration

Development of innovative optical technologies for quantitative blood perfusion imaging

Frequent collaborators

Pierre Lachapelle

Pierre Hardy

Przemyslaw Sapieha

Przemyslaw Sapieha

David Olson

Sylvie Girard

William Lubell

Sophie Tremblay

Adriana Di Polo

Sylvie Lesage

Maria Febbraio

Santiago Costantino

Santiago Costantino

Gregor Andelfinger

Alfredo Ribeiro-Da-Silva

Jean-Sébastien Joyal

Gilles Hickson

Elvire Vaucher

Jaques Belik

Stanley Nattel

Nikolaus Heveker

Alain Rivard