Vincent Poitout, Université de Montréal

Research

Pancreatic Beta Cell Type 2 Diabetes Islet Of Langerhans Glucose Homeostasis Insulin Secretion G Protein-Coupled Receptors Puberty Growth Factors

Latest papers

Staying Functional Through Connection and Adaptation: When Islets Inspire Islet Biologists.
Diabetes · 2026 · senior author
The role of the beta cell in type 2 diabetes: new findings from the last 5 years.
Diabetologia · 2025 · senior author
Free fatty acid receptor 4 agonists stimulate insulin secretion via different mechanisms in mouse versus human islets.
bioRxiv : the preprint server for biology · 2025 · senior author

All 62 publications

Latest funding

Boston Ithaca Islet Club 2025
CIHR · 2024 · Co-investigator
$15,000
The role of RGS9 in pancreatic islet function
NSERC · 2022 · Principal investigator
$165,000
Beta-cell adaptation to puberty and type 2 diabetes risk
CIHR · 2021 · Nominated PI
$753,525

All 13 grants and awards

62 publications.

01

Staying Functional Through Connection and Adaptation: When Islets Inspire Islet Biologists.

Dhawan S, Hughes J, Matveyenko AV, Poitout V

Diabetes2026Senior author

DOI: 10.2337/dbi25-0036 PMID: 41700931

02

The role of the beta cell in type 2 diabetes: new findings from the last 5 years.

Yau B, Ghislain J, Kebede MA, Hughes J, Poitout V

Diabetologia2025Senior author

DOI: 10.1007/s00125-025-06499-z PMID: 40768044

03

Free fatty acid receptor 4 agonists stimulate insulin secretion via different mechanisms in mouse versus human islets.

Reininger L, Rehman M, Bouabcha A, Ferragne S, Tremblay C, Ethier M, Kimple ME, Ghislain J, Huising MO, Poitout V

bioRxiv : the preprint server for biology2025Senior author

DOI: 10.1101/2025.08.15.670586 PMID: 40894772

04

100 years of glucagon anniversary.

Cantley J, Poitout V, Hull-Meichle RL

The Journal of endocrinology2023

DOI: 10.1530/joe-23-0138 PMID: 37194667

05

Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells.

Lacombe J, Guo K, Bonneau J, Faubert D, Gioanni F, Vivoli A, Muir SM, Hezzaz S, Poitout V, Ferron M

Cell reports2023

DOI: 10.1016/j.celrep.2023.112500 PMID: 37171959

06

Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid-Induced Rat β-Cell Proliferation.

Vivoli A, Ghislain J, Filali-Mouhim A, Angeles ZE, Castell AL, Sladek R, Poitout V

Diabetes2023Senior author

DOI: 10.2337/db22-0121 PMID: 36191509

07

β Cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood.

Castell AL, Goubault C, Ethier M, Fergusson G, Tremblay C, Baltz M, Dal Soglio D, Ghislain J, Poitout V

JCI insight2022Senior author

DOI: 10.1172/jci.insight.160854 PMID: 36107617

08

Very-Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation.

Castell AL, Vivoli A, Tippetts TS, Frayne IR, Angeles ZE, Moullé VS, Campbell SA, Ruiz M, Ghislain J, Des Rosiers C, Holland WL, Summers SA, Poitout V

Diabetes2022Senior author

DOI: 10.2337/db21-0640 PMID: 35287172

09

The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice.

Jouvet N, Bouyakdan K, Campbell SA, Baldwin C, Townsend SE, Gannon MA, Poitout V, Alquier T, Estall JL

Diabetes2021

DOI: 10.2337/db21-0147 PMID: 34610983

10

Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans.

Maachi H, Ghislain J, Tremblay C, Poitout V

Scientific reports2021Senior author

DOI: 10.1038/s41598-021-90643-3 PMID: 34050242

Boston Ithaca Islet Club 2025

Co-investigatorCIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Lim, Gareth E

Keywords: Alpha-Cells; Beta-Cells; Diabetes; Islets; Pancreas

$15,000

The role of RGS9 in pancreatic islet function

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Poitout, Vincent

$165,000

Beta-cell adaptation to puberty and type 2 diabetes risk

Nominated PICIHR2021Project Grant

Principal investigators: Poitout, Vincent

Keywords: Islet Of Langerhans; Pancreatic Beta Cell; Puberty; Type 2 Diabetes

$753,525

Discovery of novel targets and pathways for diabetes remission

Principal investigatorCIHR2020Team Grant: Diabetes Mechanisms and Translational Solutions - LOI - General

Principal investigators: Mcinnes, Natalia; Gerstein, Hertzel C; Pigeyre, Marie; Poitout, Vincent; Steinberg, Gregory R

Keywords: Remission; Type 2 Diabetes

$10,000

Role and therapeutic potential of RGS16 in pancreatic beta cells.

Nominated PICIHR2016Project Grant

Principal investigators: Poitout, Vincent

Keywords: Beta-Cell Proliferation; G Protein-Coupled Receptors; Glucose Homeostasis; Insulin Secretion; Islet Of Langerhans; Pancreatic Beta-Cell

$634,950

HB-EGF as a central regulator of pancreatic beta-cell proliferation.

Nominated PICIHR2016Project Grant

Principal investigators: Poitout, Vincent

Keywords: G Protein-Coupled Receptors; Growth Factors; Islets Of Langerhans; Pancreatic Beta Cell; Proliferation; Type 2 Diabetes

$669,375

The role of GPR120 in glucose homeostasis.

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Poitout, Vincent

$246,000

The role of RGS16 in pancreatic beta-cell function

Nominated PICIHR2015Operating Grant

Principal investigators: Poitout, Vincent

Keywords: Beta-Cell Biology; G-Protein Coupled Receptors; Glucose Homeostasis; Insulin Secretion

$100,000

Effects of Type 2 Diabetes (T2D) on drug disposition and CYP450 activities; a special look at extra-hepatic metabolism.

Co-investigatorCIHR2013Operating Grant

Principal investigators: Michaud, Véronique

Keywords: Cytochromes P450; Drug Analysis; Drug Metabolism; Lc-Ms/Ms; Molecular Biology; Pharmacogenetics; Pharmacokinetics; Phenotype; Type 2 Diabetes

$507,268

CANADA RESEARCH CHAIRHOLDER - Tier 1 / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA - Niveau 1

Nominated PICIHR2012Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Poitout, Vincent

Keywords: Crc

$1,400,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Nutrition
Medicine
Diagnostic Radiology
Engineering Physics
Radiology and Nuclear Medicine
Mechanical Engineering
Diagnostic Radiology and Nuclear Medicine
Other

Co-authors at Université de Montréal, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Michel Bouvier

Biochimie et médecine moléculaire

1 shared papers, latest 2015

Gilles Soulez

Radiology and Nuclear Medicine

1 shared papers, latest 2013

Dominique Trudel

Engineering Physics

1 shared papers, latest 2015

Gilles Soulez

Diagnostic Radiology and Nuclear Medicine

1 shared papers, latest 2013

An Tang

Diagnostic Radiology

1 shared papers, latest 2013

Gilles Soulez

Mechanical Engineering

1 shared papers, latest 2013

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2022

Subject: Prospective PhD student: Pancreatic Beta Cell Dear Professor Poitout, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Staying Functional Through Connection and Adaptation: When Islets Inspire Islet Biologists." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "The role of RGS9 in pancreatic islet function" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Vincent Poitout

Research

Latest papers

Latest funding

Staying Functional Through Connection and Adaptation: When Islets Inspire Islet Biologists.

The role of the beta cell in type 2 diabetes: new findings from the last 5 years.

Free fatty acid receptor 4 agonists stimulate insulin secretion via different mechanisms in mouse versus human islets.

100 years of glucagon anniversary.

Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells.

Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid-Induced Rat β-Cell Proliferation.

β Cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood.

Very-Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation.

The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice.

Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans.

Boston Ithaca Islet Club 2025

The role of RGS9 in pancreatic islet function

Beta-cell adaptation to puberty and type 2 diabetes risk

Discovery of novel targets and pathways for diabetes remission

Role and therapeutic potential of RGS16 in pancreatic beta cells.

HB-EGF as a central regulator of pancreatic beta-cell proliferation.

The role of GPR120 in glucose homeostasis.

The role of RGS16 in pancreatic beta-cell function

Effects of Type 2 Diabetes (T2D) on drug disposition and CYP450 activities; a special look at extra-hepatic metabolism.

CANADA RESEARCH CHAIRHOLDER - Tier 1 / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA - Niveau 1

Frequent collaborators

Thierry Alquier

Marc Prentki

Michel Bouvier

Gilles Soulez

Christine Des Rosiers

Dominique Trudel

Dominique Trudel

Matthieu Ruiz

Mathieu Ferron

Stephanie Fulton

Robert Sladek

Stephanie Fulton

Gilles Soulez

An Tang

Gilles Soulez

Vincent Poitout

Research

Latest papers

Latest funding

Staying Functional Through Connection and Adaptation: When Islets Inspire Islet Biologists.

The role of the beta cell in type 2 diabetes: new findings from the last 5 years.

Free fatty acid receptor 4 agonists stimulate insulin secretion via different mechanisms in mouse versus human islets.

100 years of glucagon anniversary.

Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in &#x3b2; cells.

Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid-Induced Rat &#x3b2;-Cell Proliferation.

&#x3b2; Cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood.

Very-Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat &#x3b2;-Cell Proliferation.

The Tetracycline-Controlled Transactivator (Tet-On/Off) System in &#x3b2;-Cells Reduces Insulin Expression and Secretion in Mice.

Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans.

The role of RGS9 in pancreatic islet function

The role of GPR120 in glucose homeostasis.

Frequent collaborators

Thierry Alquier

Marc Prentki

Michel Bouvier

Gilles Soulez

Christine Des Rosiers

Dominique Trudel

Dominique Trudel

Matthieu Ruiz

Mathieu Ferron

Stephanie Fulton

Robert Sladek

Stephanie Fulton

Gilles Soulez

An Tang

Gilles Soulez

Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells.

Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid-Induced Rat β-Cell Proliferation.

β Cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood.

Very-Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation.

The Tetracycline-Controlled Transactivator (Tet-On/Off) System in β-Cells Reduces Insulin Expression and Secretion in Mice.