Benoit Laurent, Université de Sherbrooke

Research

Aging Brain Choroid Plexus Inflammation Alternative Splicing Cell Differentiation Chromatin Demethylases

Latest papers

Brain DHA increases in APOE3, but not in APOE4 mice, despite robust brain EPA increase during LPC n-3 supplementation in both genotypes.
The Journal of nutritional biochemistry · 2026
Age-related molecular and functional remodeling of the choroid plexus in the gray mouse lemur.
PloS one · 2026
Short-term docosahexaenoic acid rich diet prevents cognitive deficits in human apolipoprotein E epsilon 4-targeted replacement mice.
Prostaglandins, leukotrienes, and essential fatty acids · 2026

All 31 publications

Latest funding

Decoding and challenging choroid plexus inflammation in the aging brain
CIHR · 2024 · Nominated PI
$1,071,000
The choroid plexus is the effector of omega-3 fatty acids to support the brain during aging.
CIHR · 2024 · Co-investigator
$1,235,475
Boosting stem cell engraftment and differentiation with engineered biomaterials bearing cell adhesion peptides
NSERC · 2024 · Principal investigator
$75,000

All 5 grants and awards

31 publications.

01

Brain DHA increases in APOE3, but not in APOE4 mice, despite robust brain EPA increase during LPC n-3 supplementation in both genotypes.

Andriambelo B, Vachon A, Dansereau MA, Dumais É, Flamand N, Laurent B, Plourde M

The Journal of nutritional biochemistry2026

DOI: 10.1016/j.jnutbio.2026.110376 PMID: 41962782

02

Age-related molecular and functional remodeling of the choroid plexus in the gray mouse lemur.

Amiot F, Etchebest A, Andriambelo B, St-Germain J, Avino M, Plourde M, Laurent B, Pifferi F

PloS one2026

DOI: 10.1371/journal.pone.0357233 PMID: 42672073

03

Short-term docosahexaenoic acid rich diet prevents cognitive deficits in human apolipoprotein E epsilon 4-targeted replacement mice.

Raffoul R, Lopez JA, Vachon A, Laurent B, Plourde M

Prostaglandins, leukotrienes, and essential fatty acids2026

DOI: 10.1016/j.plefa.2026.102730 PMID: 41806661

04

Antiretroviral raltegravir, a selective human immunodeficiency virus type 1 integrase inhibitor, shows anti-Alzheimer's potential against amyloid-beta1-42-induced neurodegeneration.

Alami M, Berrougui H, Boumezough K, Salih I, Sadki K, Laurent B, van Tellingen O, Bunt T, Khalil A, Fulop T

Mechanisms of ageing and development2026

DOI: 10.1016/j.mad.2026.112161 PMID: 41707918

05

Unmasking the hidden catalyst: How infections trigger Alzheimer's disease.

Fulop T, Cohen AA, Frost EH, Lévesque S, Khalil A, Rodrigues S, Desroches M, Alami M, Berrougui H, Ramassamy C, Hirokawa K, Witkowski JM, Laurent B

Journal of Alzheimer's disease : JAD2026Senior author

DOI: 10.1177/13872877251415571 PMID: 41593034

06

Proof-of-principle of NF1 gene therapy in plexiform neurofibroma xenograft mouse models.

Hewa Bostanthirige D, Plante C, Caron M, Gascon S, Lévesque M, Poirier C, Deschenes M, Sabo Vatasescu JP, Chabot B, Geha S, Laurent B, Brosseau JP

Communications biology2026

DOI: 10.1038/s42003-026-09695-8 PMID: 41680443

07

The Lipidome of the Lateral Ventricle Choroid Plexus Exhibits Sex-Specific Changes Across Aging.

Loupiac G, Andriambelo B, Avila-Lopez J, Vachon A, Avino M, Ahumada JR, Miard S, Picard F, Qiu Y, Kurland IJ, Laurent B, Plourde M

Journal of neurochemistry2025

DOI: 10.1111/jnc.70329 PMID: 41432428

08

No winners or losers: clinical chemistry-based biological aging metrics perform similarly across cohorts and health outcomes.

Provost G, Tanner K, Legault V, Ferrucci L, Bandinelli S, Fried LP, Belsky DW, Laurent B, Cohen AA

The journals of gerontology. Series A, Biological sciences and medical sciences2025

DOI: 10.1093/gerona/glaf179 PMID: 40796170

09

Translational traffic jam in aging brains.

Dionne O, Laurent B

Science (New York, N.Y.)2025Senior author

DOI: 10.1126/science.adz4995 PMID: 40743358

10

CyKILR splice variants: A double-edged sword in non-small cell lung cancer.

Khan MR, Laurent B

Molecular therapy. Nucleic acids2025Senior author

DOI: 10.1016/j.omtn.2025.102538 PMID: 40291375

Decoding and challenging choroid plexus inflammation in the aging brain

Nominated PICIHR2024Project Grant

Principal investigators: Laurent, Benoit

Keywords: Aging; Brain; Choroid Plexus; Inflammation

$1,071,000

The choroid plexus is the effector of omega-3 fatty acids to support the brain during aging.

Co-investigatorCIHR2024Project Grant

Principal investigators: Plourde, Mélanie

Keywords: Adeno-Associated Virus; Aging; Choroid Plexus; Inflammatory Mediators; Lipid Transporters; Lipidomics; Neurogenesis; Omega-3 Fatty Acids

$1,235,475

Boosting stem cell engraftment and differentiation with engineered biomaterials bearing cell adhesion peptides

Principal investigatorNSERC2024Discovery Horizons

Principal investigators: Laurent, Benoit

Keywords: stem cells; regeneration; adhesion peptides; cell differentiation; computational biology; biomaterials; material sciences; bioengineering; kinematics; neurosurgery

$75,000

Identification de biomarqueurs de réponse thérapeutique chez le syndrome du X fragile

SupervisorCIHR2021Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Dionne, Olivier

Keywords: Biochimie; Biologie Cellulaire Et Moléculaire; Cellules Souches Pluripotentes Induites; Déficience Intellectuelle; Microscopie Confocale; Protéomique; Recherche Translationelle; Syndrome Du X Fragile; Transcriptomique; Troubles Du Spectre Autistique

$105,000

RNA splicing and epigenetics in tuning the fate of neurons

Nominated PICIHR2019Project Grant

Principal investigators: Laurent, Benoit

Keywords: Alternative Splicing; Cell Differentiation; Chromatin; Demethylases; Dna Repetitive Elements; Epigenetics; Neurons; Rna Biology; Transcription Factors

$711,450

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochimie et génomique fonctionnelle
Médecine
Biochemistry
Pédiatrie
Microbiologie et d'infectiologie
Medicine

Co-authors at Université de Sherbrooke, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Tamàs Fulop

Pédiatrie

7 shared papers, latest 2026

Abdelouahed Khalil

Médecine

6 shared papers, latest 2026

Jean-Philippe Brosseau

Biochimie et génomique fonctionnelle

2 shared papers, latest 2026

Xavier Roucou

Biochemistry

2 shared papers, latest 2023

Benoit Chabot

Microbiologie et d'infectiologie

1 shared papers, latest 2026

Guylain Boissonneault

Biochemistry

1 shared papers, latest 2023

Nicolas Flamand

Médecine

1 shared papers, latest 2026

Pedro Geraldes

Medicine

1 shared papers, latest 2022

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Aging Dear Professor Laurent, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Brain DHA increases in APOE3, but not in APOE4 mice, despite robust brain EPA increase during LPC n-3 supplementation in both genotypes." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Decoding and challenging choroid plexus inflammation in the aging brain" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]