Anmar Khadra, McGill University

Research

Calcium transients Computational modeling Deep neural networks Electron microscopy images Electrophysiology Neural axonal fibers Nonlinear stochastic dynamics Oligodendrocytes and myelin sheath

Latest papers

Extrinsic inputs underscore heterogeneities of ELL pyramidal cell neural activity in awake, behaving weakly electric fish.
The Journal of general physiology · 2026 · senior author
Mechanisms underlying spontaneous and evoked calcium responses in oligodendrocyte precursor cells: A modeling investigation.
PLoS computational biology · 2026 · senior author
Rapid dynamics of dorsal raphe serotonin neurons regulate the strength of visual attention.
Nature communications · 2026

All 52 publications

Latest funding

Unveiling the Intricate Axon-Myelin-Oligodendrocyte Interplay using Computational Modeling
NSERC · 2023 · Principal investigator
$149,062
Dorsal Raphe neuromodulation of visual circuit function, behavior, and ASD
CIHR · 2022 · Co-investigator
$872,100
Controlling cellular and organismal microenvironment using light
NSERC · 2021 · Co-investigator
$150,000

All 7 grants and awards

52 publications.

01

Extrinsic inputs underscore heterogeneities of ELL pyramidal cell neural activity in awake, behaving weakly electric fish.

Akhshi A, Haggard M, Marquez MM, Farjami S, Chacron MJ, Khadra A

The Journal of general physiology2026Senior author

DOI: 10.1085/jgp.202513841 PMID: 42053563

02

Mechanisms underlying spontaneous and evoked calcium responses in oligodendrocyte precursor cells: A modeling investigation.

Lardy M, Wang L, Guerrier C, Cheli VT, Paez PM, Khadra A

PLoS computational biology2026Senior author

DOI: 10.1371/journal.pcbi.1013430 PMID: 42313802

03

Rapid dynamics of dorsal raphe serotonin neurons regulate the strength of visual attention.

Lehnert J, Cha K, Forestell J, Yang K, Ma X, Shariff S, Britt JP, Khadra A, Cook EP, Krishnaswamy A

Nature communications2026

DOI: 10.1038/s41467-026-70658-y PMID: 41851109

04

The geometry of pMHC-coated nanoparticles and T-cell receptor clusters governs the sensitivity-specificity trade-off in T-cell response: a modeling investigation.

Richez L, Khadra A

Immunology and cell biology2026Senior author

DOI: 10.1111/imcb.70082 PMID: 41631395

05

Dendritic interaction of timescales in afterdepolarization potentials and nonmonotonic spike-adding.

Koch NA, Zhao Y, Khadra A

Journal of computational neuroscience2026Senior author

DOI: 10.1007/s10827-025-00917-2 PMID: 41493696

06

In vivo neural activity of electrosensory pyramidal cells: Biophysical characterization and phenomenological modeling.

Akhshi A, Metzen MG, Chacron MJ, Khadra A

PLoS computational biology2025Senior author

DOI: 10.1371/journal.pcbi.1013711 PMID: 41248174

07

Burst firing optimizes invariant coding of natural communication signals by electrosensory neural populations.

Metzen MG, Akhshi A, Bashivan P, Khadra A, Chacron MJ

iScience2025

DOI: 10.1016/j.isci.2025.112399 PMID: 40641556

08

GluA2-containing AMPA receptors form a continuum of Ca2+-permeable channels.

Miguez-Cabello F, Wang XT, Yan Y, Brake N, Alexander RPD, Perozzo AM, Khadra A, Bowie D

Nature2025

DOI: 10.1038/s41586-025-08736-2 PMID: 40108453

09

Contributions of action potentials to scalp EEG: Theory and biophysical simulations.

Brake N, Khadra A

PLoS computational biology2025Senior author

DOI: 10.1371/journal.pcbi.1012794 PMID: 39903777

10

Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics.

Koch NA, Corrigan BW, Feyerabend M, Gulli RA, Jimenez-Sosa MS, Abbass M, Sunstrum JK, Matovic S, Roussy M, Luna R, Mestern SA, Mahmoudian B, Vijayraghavan S, Igarashi H, Pradeepan KS, Assis WJ, Pruszynski JA, Tripathy S, Staiger JF, Gonzalez-Burgos G, Neef A, Treue S, Everling S, Inoue W, Khadra A, Martinez-Trujillo JC

Cell reports2025

DOI: 10.1016/j.celrep.2024.115159 PMID: 39772396

Unveiling the Intricate Axon-Myelin-Oligodendrocyte Interplay using Computational Modeling

Principal investigatorNSERC2023Alliance Grants

Principal investigators: Khadra, Anmar A

Keywords: calcium transients; computational modeling; deep neural networks; electron microscopy images; electrophysiology; neural axonal fibers; nonlinear stochastic dynamics; oligodendrocytes and myelin sheath; signal conduction; signal processing

$149,062

Dorsal Raphe neuromodulation of visual circuit function, behavior, and ASD

Co-investigatorCIHR2022Project Grant

Principal investigators: Krishnaswamy, Arjun S

Keywords: Attention; Autism, Fragile X Syndrome; Dorsal Raphe; Fiber Photometry; In Vivo Two-Photon Imaging; Mice; Molecular-Genetics; Serotonin; Visual System; Visually Guided Behaviors

$872,100

Controlling cellular and organismal microenvironment using light

Co-investigatorNSERC2021Research Tools and Instruments

Principal investigators: Hayer, Arnold

$150,000

Using ASD models to gain insight into serotonergic feedback during perceptual decsion making in mice

SupervisorCIHR2019Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Lehnert, Jonas

Keywords: Asd Mouse Models; Attention; Computational Modelling; Dorsal Raphe; Fiber Photometry; Genetically Encoded Calcium Indicators; Lateral Geniculate Nucleus; Neural Circuits; Optogenetics; Visually Guided Behavior

$105,000

Deciphering the dynamics of physiological systems using quantitative and computational approaches

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Khadra, Anmar

Keywords: Algorithm Design and Machine Learning; Bayesian Inference & computational methods; Biophysics; Cellular Physiology; Complex systems; Computational Neuroscience & neuroelectrophysiology; Mathematical modeling; Nonlinear (stochastic) dynamics; Quantitative biosciences; Quantitative Immunology

$252,000

CREATE in Complex Dynamics: Accelerating discoveries in brain and behaviour

Co-investigatorNSERC2017Collaborative Research and Training Experience

Principal investigators: Palmer, Caroline C

$1,650,000

Computational Models for the Study of Various Immunological and Electrophysiological Systems

Principal investigatorNSERC2013Discovery Grants Program - Individual

Principal investigators: Khadra, Anmar

$192,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Physiology
Psychiatry
Physiology and Pharmacology
Pharmacology and Therapeutics
Physiology / Cell information systems Group Bellini Life Science Complex
Microbiology and Infectious Diseases
Chemistry and Biochemistry
Other

1 shared papers, latest 2024

Luda Diatchenko

Faculty

1 shared papers, latest 2024

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2023

Subject: Prospective PhD student: Calcium transients Dear Professor Khadra, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Extrinsic inputs underscore heterogeneities of ELL pyramidal cell neural activity in awake, behaving weakly electric fish." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Unveiling the Intricate Axon-Myelin-Oligodendrocyte Interplay using Computational Modeling" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]