Faculty profile

Aly Karsan

ResearcherGenome Sciences CentreUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses and email address may be missing. Find their university profile.

Aly Karsan

Researcher

Genome Sciences Centre

Health Sciences

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
47 publications in the last five years, latest in 2026.
Senior (last) author on 16 recent papers, a sign of leading a research group.
Principal investigator on 13 research grants (12 CIHR, 1 NSERC), most recently in 2025.
Supervised 11 trainees who won CIHR awards, most recently in 2020.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

172

Publications

216

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Hematopoietic Stem Cells Xenografts Inflammaging Microrna Nf-Kappab Sash1 Endothelial-To-Hematopoietic Transition Hemogenic Endothelium

Latest papers

LySeqST: a targeted sequencing assay for robust genomic classification of diffuse large B-cell lymphoma.
Blood advances · 2026
Initial leukemic epigenomic state determines hypomethylating agent response.
Nature communications · 2026 · senior author
Heterogeneous survival outcomes in molecularly defined acute myeloid leukemia with myelodysplasia-related changes.
Blood neoplasia · 2026

All 172 publications

Latest funding

Hematopoietic stem cell aging
CIHR · 2025 · Nominated PI
$1,086,300
Clonal interactions in myeloid malignancy
CIHR · 2022 · Nominated PI
$1,025,100
Role of SASH1 in generation of hematopoietic stem cells
CIHR · 2022 · Nominated PI
$948,600

All 29 grants and awards

From the 150 most recent of 172 publications.

LySeqST: a targeted sequencing assay for robust genomic classification of diffuse large B-cell lymphoma.

Hilton LK, Gillis S, Y-Moayyed F, Bridgers J, Alduaij W, Jiang A, Ben-Neriah S, Collinge B, Wong JCH, Boyle M, Meissner B, Slack GW, Farinha P, Craig JW, Gerrie AS, Villa D, Savage KJ, Sehn LH, Karsan A, Wright GW, Staudt LM, Morin RD, Steidl C, Scott DW

Blood advances2026

DOI: 10.1182/bloodadvances.2026020105 PMID: 41985007

Initial leukemic epigenomic state determines hypomethylating agent response.

Gopal A, Tam D, Mey F, Lin D, May C, Jiang J, Bridgers J, Caswell B, O'Neill K, Vizeacoumar FS, MacAuley M, Haniak E, Craddock C, Vyas P, Malcovati L, Buckstein R, Moksa M, Hirst M, Vizeacoumar FJ, Medvedev N, Heuser M, Stubbins RJ, Deng Y, Karsan A

Nature communications2026Senior author

DOI: 10.1038/s41467-026-73334-3 PMID: 42173855

Heterogeneous survival outcomes in molecularly defined acute myeloid leukemia with myelodysplasia-related changes.

Chornenki N, Fadul A, Supan A, Abou Mourad Y, Cherniawsky H, Chung S, Forrest D, Lad D, Karsan A, Kuchenbauer F, McGinnis E, Nantel S, Narayanan S, Nevill T, Rodrigo J, Roy C, Song K, Toze C, White J, Sanford D, Stubbins RJ

Blood neoplasia2026

DOI: 10.1016/j.bneo.2026.100198 PMID: 41798677

Clonal Hematopoiesis after 177Lu-PSMA-617 Radioligand Therapy in Prostate Cancer.

Munzur AD, Herberts C, Kwan EM, Emmett L, Sandhu S, Buteau JP, Iravani A, Joshua AM, Francis RJ, Lee ST, Scott AM, Martin AJ, Stockler MR, Zhang AY, Williams SG, Bernales CQ, Donnellan G, Koudjanian M, Parekh K, Bacon JVW, Karsan A, Azad AA, Davis ID, Hofman MS, Wyatt AW

Clinical cancer research : an official journal of the American Association for Cancer Research2026

DOI: 10.1158/1078-0432.ccr-25-4001 PMID: 41649873

How does AI perform compared to human expert panels in medical Delphi studies? A pilot study through the lens of pathology.

Pantanowitz J, Manko CD, Majewski J, Berbís MA, Farris AB, Karsan A, Bychkov A, Luna A, Williams B, Delahunt B, Eloy C, McClintock DS, Hollemans E, Tuthill JM, Van der Laak J, Cheng JY, Lennerz JK, Sinard JH, Aneiros-Fernandez J, Calderaro J, Iczkowski KA, Egevad L, Kriegsmann M, Herrmann MD, Salama ME, Del Moral RG, Sirintrapun SJ, Vrbin C, Pantanowitz L, Shen J, Rashidi H

Journal of pathology informatics2026

DOI: 10.1016/j.jpi.2026.100661 PMID: 42164630

EpiATLAS - a reference for human epigenomic research.

International Human Epigenome Consortium, Manz Q, Bilenky M, Hecker D, Aggarwal N, Arcila-Galvis JE, Ashrafiyan S, Baumgarten N, Ardakani FB, Branco Lins PR, Breeze CE, Brownlee D, Bujold D, Chapman AR, Chow SH, Dincer TU, Dupras C, Frosi G, Fu J, Gérard D, Hauduc A, Hyacinthe J, Jaroszewicz A, Li R, Mangan RJ, Mikulasova A, Moghul I, Needhamsen M, Palmour N, Pacheco MP, Quon J, Raby J, Reynolds A, Rumpf L, Salhab A, Shi CH, Sinkkonen L, Tanigawa Y, Tanner RM, Vu H, White F, Aw JTM, Badii S, Bowlby R, Boyle M, Brown C, Chand D, Calingo M, Cao Q, Carles A, Caron M, Carreira M, Cheng ASL, Cheng CCY, Cheng D, Cheng Y, Cheung MF, Choe G, Chuah E, Dali R, Deng A, Gakkhar S, Gut M, He A, Heath SC, Ho V, Intan AG, Ito CY, Jiang Q, Kluiver JL, Lee J, Lee S, Leung Z, Li I, Lorzadeh A, McKerricher D, Mishra N, Mungall K, Nagai LAE, Ngubo M, Palmquist D, Pang J, Park V, Plettner P, Puri A, Redensek A, Sharafian Z, Simon MM, Steif J, Su E, Tam SKM, Tam SST, Van den Berg A, Wong R, Wong T, Wu JKH, Zhu A, Kwan T, Moksa M, Aherne ST, Aparicio S, Arima T, Chung HR, Costello JF, Eaves CJ, Fisher SJ, Gut IG, Harrison PW, Horsthemke B, Ilsley GR, Jagodic M, Karsan A, Lavoie PM, Leung D, Libbrecht MW, Manke T, Marra MA, Meuleman W, Müller F, Nakato R, Okae H, Rico D, Rosenstiel P, Sasaki H, Sauter T, Schreiber S, Scott DW, Stanford WL, Steidl C, Stunnenberg HG, Suyama M, Tran F, Ushijima T, Weng AP, Wiseman SM, Wu AR, Yip KY, Yip S, Beck S, Bourque G, Ernst J, Jacques PÉ, Joly Y, Kellis M, List M, Perkins TJ, Schulz MH, Walter J, Hirst M

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.06.22.729579 PMID: 42395464

Patient and population impacts of multigene panel and pembrolizumab coverage in metastatic melanoma.

Weymann D, Krebs E, Pollard S, McPhail M, Bosdet I, Yip S, Weppler AM, Karsan A, Anderson H, Bubela T, Law MR, Kesselheim AS, Regier DA

Journal of the National Cancer Institute2026

DOI: 10.1093/jnci/djaf307 PMID: 41206749

Loss of FBXO11 establishes a stem cell program in acute myeloid leukemia by dysregulating LONP1.

Kincross H, Mo YA, Wang X, Chang L, Duns G, Mey F, Jiang J, Zhu Z, Isak N, Kwan H, Lau TT, Docking TR, Garg P, Tran J, Colborne S, Cheng SG, Huang S, Gharaee N, Willie E, Parker JD, Bridgers J, Wood D, Klein Geltink RI, Morin GB, Karsan A

The Journal of clinical investigation2026Senior author

DOI: 10.1172/jci181943 PMID: 41289019

Validation of a Modular Gene Expression Assay for Risk Stratification and Subtyping Lymphomas.

Sabatini PJB, Bridgers J, Huang S, Zhang T, Sheen C, Stockley T, Kridel R, Bosdet I, Marra MA, Steidl C, Scott DW, Karsan A

The Journal of molecular diagnostics : JMD2026Senior author

DOI: 10.1016/j.jmoldx.2025.09.004 PMID: 41077189

Predisposition to hematopoietic malignancies by deleterious germline CHEK2 variants.

Stubbins RJ, Arnovitz S, Vagher J, Asom A, Perpich M, Pies M, Akpan IJ, Chew E, Bridgers J, Karsan A, Rodgers C, Koppayi A, Basdag H, Drazer MW, Das S, Cheng J, Osman AEG, Godley LA

Leukemia2025

DOI: 10.1038/s41375-025-02635-1 PMID: 40335619

Hematopoietic stem cell aging

Nominated PICIHR2025Project Grant

Principal investigators: Karsan, Aly

Keywords: Clonal Hematopoiesis; Hematopoietic Stem Cells; Inflammaging; Microrna; Mutations; Nf-Kappab; Xenografts

$1,086,300

Clonal interactions in myeloid malignancy

Nominated PICIHR2022Project Grant

Principal investigators: Karsan, Aly

Keywords: Clonal Interactions; Clonal Tracking; H2s; Leukemia; Leukemic Stem Cells; Oxidative Phosphorylation; Single Cell Sequencing; Ubiquitylation

$1,025,100

Role of SASH1 in generation of hematopoietic stem cells

Nominated PICIHR2022Project Grant

Principal investigators: Karsan, Aly

Keywords: Endothelial-To-Hematopoietic Transition; Hematopoietic Stem Cells; Hemogenic Endothelium; Mouse Models; Sash1; Single Cell Rna-Seq

$948,600

Canada Research Chair - Tier 1

Nominated PICIHR2021Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Karsan, Aly

Keywords: Crc

$1,400,000

Understanding the mechanisms of primary 5-Azacytidine resistance in the treatment of MDS

SupervisorCIHR2020Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Gopal, Aparna

Keywords: Drug Resistance; Epigenetics; Flow Cytometry; Leukemic Stem Cell State; Myelodysplastic Syndrome

$105,000

Vascular differentiation

Nominated PICIHR2019Project Grant

Principal investigators: Karsan, Aly

Keywords: Endothelial-To-Hematopoietic Transition; Hematopoiesis; Hemogenic Endothelium; Meis 1; Transcription Factors; Vascular Development; Vascular Endothelium

$910,350

Precision Medicine for Myeloid Malignancies with 5-Azacitidine

SupervisorCIHR2019Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Stubbins, Ryan J

Keywords: Acute Myeloid Leukemia; Cancer; Chemotherapy; Hematology; Myelodysplastic Syndrome; Precision Medicine

$105,000

Early detection of cancer in high-risk patients through profiling of circulating tumour DNA

Co-investigatorCIHR2018Project Grant

Principal investigators: Pugh, Trevor J; Kim, Raymond; Pollett, Aaron

Keywords: Circulating Tumour Dna; Epigenetics; Genomics; Hereditary Cancer Syndrome

$1,977,525

Hematopoietic stem cell aging

Nominated PICIHR2018Project Grant

Principal investigators: Karsan, Aly

Keywords: Gene-Targeted Mice; Hematopoietic Stem Cells; Inflammaging; Inflammatory Cytokines; Microrna; Nf-Kappab

$914,175

Preference analyses and development of an e-health app facilitating communication of test results for hereditary cancer syndromes

Co-investigatorCIHR2017Catalyst Grant: Personalized Health Catalyst Grants

Principal investigators: Regier, Dean A

Keywords: Discrete Choice Experiment; Hereditary Cancer Syndromes; Precision Medicine; Shared Decision Making

$200,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Aly Karsan

Research

Latest papers

Latest funding

LySeqST: a targeted sequencing assay for robust genomic classification of diffuse large B-cell lymphoma.

Initial leukemic epigenomic state determines hypomethylating agent response.

Heterogeneous survival outcomes in molecularly defined acute myeloid leukemia with myelodysplasia-related changes.

Clonal Hematopoiesis after 177Lu-PSMA-617 Radioligand Therapy in Prostate Cancer.

How does AI perform compared to human expert panels in medical Delphi studies? A pilot study through the lens of pathology.

EpiATLAS - a reference for human epigenomic research.

Patient and population impacts of multigene panel and pembrolizumab coverage in metastatic melanoma.

Loss of FBXO11 establishes a stem cell program in acute myeloid leukemia by dysregulating LONP1.

Validation of a Modular Gene Expression Assay for Risk Stratification and Subtyping Lymphomas.

Predisposition to hematopoietic malignancies by deleterious germline CHEK2 variants.

Frequent collaborators

Christian Steidl

Martin Hirst

Marco Marra

Robert Kridel

Andrew Minchinton

Mark Basik

Dean Regier

Aaron Pollett

Yvonne Bombard

Inanc Birol

John Kuruvilla

Lesa Dawson

Ming-Sound Tsao

Guy Rouleau

Steven Jones

Tracy Stockley

Gerald Batist

Kasmintan Schrader

David Huntsman

Jordan Lerner-Ellis

Gerald Batist

Jean-claude Cutz

Connie Eaves

Tobias Berg

Andrea Eisen

Brian Leber

Ron Carter

Elizabeth McCready

John Waye