Faculty profile

Connie Eaves

ResearcherTerry Fox LaboratoryUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses and email address may be missing. Find their university profile.

Connie Eaves

Researcher

Terry Fox Laboratory

Health Sciences

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
No publications since 2021.
Principal investigator on 2 research grants (2 CIHR), most recently in 2017.
Supervised 12 trainees who won CIHR awards, most recently in 2016.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Crs Bioinformatics Core Pathogenic Pathways Disease Progression Epigenomics And Genomics Flow Cytometry Genetic Engineering Human Leukemia Models

Latest papers

A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML.
Blood · 2021
UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells.
Molecular therapy. Methods & clinical development · 2018
RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1.
Stem cell reports · 2015

All 22 publications

Latest funding

Clonal interactions in myeloid malignancy
CIHR · 2022 · Co-investigator
$1,025,100
Elucidating the mitotic mechanisms that are needed for alveologenesis in the pregnant mammary gland and are likely to be disturbed in pregnancy-associated breast cancer.
CIHR · 2022 · Co-investigator
$100,000
Dissecting aging associated epigenetic contributions to breast cancer
CIHR · 2020 · Co-investigator
$1,059,525

All 29 grants and awards

22 publications.

A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML.

Chen BR, Deshpande A, Barbosa K, Kleppe M, Lei X, Yeddula N, Vela PS, Campos AR, Wechsler-Reya RJ, Bagchi A, Meshinchi S, Eaves C, Jeremias I, Haferlach T, Frank DA, Ronai Z, Chanda S, Armstrong SA, Adams PD, Levine RL, Deshpande AJ

Blood2021

DOI: 10.1182/blood.2020009023 PMID: 33690798

UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells.

Ngom M, Imren S, Maetzig T, Adair JE, Knapp DJHF, Chagraoui J, Fares I, Bordeleau ME, Sauvageau G, Leboulch P, Eaves C, Humphries RK

Molecular therapy. Methods & clinical development2018

DOI: 10.1016/j.omtm.2018.06.009 PMID: 30101153

RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1.

Joshi PA, Waterhouse PD, Kannan N, Narala S, Fang H, Di Grappa MA, Jackson HW, Penninger JM, Eaves C, Khokha R

Stem cell reports2015

DOI: 10.1016/j.stemcr.2015.05.012 PMID: 26095608

A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.

Burleigh A, McKinney S, Brimhall J, Yap D, Eirew P, Poon S, Ng V, Wan A, Prentice L, Annab L, Barrett JC, Caldas C, Eaves C, Aparicio S

Breast cancer research : BCR2015

DOI: 10.1186/s13058-014-0510-y PMID: 25572802

The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction.

Kannan N, Huda N, Tu L, Droumeva R, Aubert G, Chavez E, Brinkman RR, Lansdorp P, Emerman J, Abe S, Eaves C, Gilley D

Stem cell reports2013

DOI: 10.1016/j.stemcr.2013.04.003 PMID: 24052939

NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.

Giambra V, Jenkins CR, Wang H, Lam SH, Shevchuk OO, Nemirovsky O, Wai C, Gusscott S, Chiang MY, Aster JC, Humphries RK, Eaves C, Weng AP

Nature medicine2012

DOI: 10.1038/nm.2960 PMID: 23086478

A fond farewell to Ernest A. McCulloch--a beacon who inspired generations of scientists and framed the foundation of modern stem cell biology.

Eaves C, Eaves A

Experimental hematology2011First author

DOI: 10.1016/j.exphem.2011.02.012 PMID: 21682007

Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex

Heuser M, Yun H, Berg T, Yung E, Argiropoulos B, Kuchenbauer F, Park G, Hamwi I, Palmqvist L, Lai CK

Cancer Cell201187 citations

DOI: 10.1016/j.ccr.2011.06.020

Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate.

Jiang X, Forrest D, Nicolini F, Turhan A, Guilhot J, Yip C, Holyoake T, Jorgensen H, Lambie K, Saw KM, Pang E, Vukovic R, Lehn P, Ringrose A, Yu M, Brinkman RR, Smith C, Eaves A, Eaves C

Blood2010Senior author

DOI: 10.1182/blood-2009-05-222471 PMID: 20574046

Reduction in multi-lineage and erythroid progenitors distinguishes myelodysplastic syndromes from non-malignant cytopenias.

Vercauteren SM, Bashashati A, Wu D, Brinkman RR, Eaves C, Eaves A, Karsan A

Leukemia research2009

DOI: 10.1016/j.leukres.2009.03.019 PMID: 19414193

Clonal interactions in myeloid malignancy

Co-investigatorCIHR2022Project Grant

Principal investigators: Karsan, Aly

Keywords: Clonal Interactions; Clonal Tracking; H2s; Leukemia; Leukemic Stem Cells; Oxidative Phosphorylation; Single Cell Sequencing; Ubiquitylation

$1,025,100

Elucidating the mitotic mechanisms that are needed for alveologenesis in the pregnant mammary gland and are likely to be disturbed in pregnancy-associated breast cancer.

Co-investigatorCIHR2022Project Grant - PA: Breast Cancer Research

Principal investigators: Maxwell, Christopher A

Keywords: Alveologenesis; Asymmetric Cell Division; Brca1; Cytokinesis; Hereditary Breast Cancer; Involution; Mitosis; Oriented Cell Division; Pregnancy-Associated Breast Cancer

$100,000

Dissecting aging associated epigenetic contributions to breast cancer

Co-investigatorCIHR2020Project Grant

Principal investigators: Hirst, Martin

Keywords: Aging; Breast Cancer; Experimental Model; Human Mammary Gland; Preneoplastic Changes; Xenografts

$1,059,525

Understanding mutagenic replication-transcription conflicts in cancer-initiation

Co-investigatorCIHR2018Project Grant

Principal investigators: Stirling, Peter C

Keywords: Cancer Susceptibility; Dna Damage; Dna Repair; Dna Replication; R-Loops; Replication Stress; Transcription; Tumour Suppressor Genes

$845,326

Role of autophagy in a de novo model of human breast cancer genesis from purified primary normal cells.

Nominated PICIHR2017CIHR - ICR / Cancer Research Society Partnership - Research Grants

Principal investigators: Eaves, Connie J

Keywords: Crs

$60,000

Identification of early epigenomic changes produced by oncogenic mutant KRAS in transduced normal human mammary cells

SupervisorCIHR2016Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Tan, Susanna Shu Xia

Keywords: Breast Cancer; Breast Cancer Modelling; Epigenomics; Mammary Epithelium; Mammary Stem Cell; Oncogene; Sequencing; Tumourigenesis

$105,000

Role of Proliferative Activity in Human Hematopoietic Stem Cell Aging and Leukemogenesis

SupervisorCIHR2016Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Hammond, Colin A

Keywords: Cellular Aging; Cellular Proliferation; Dna Methylation; Hematopoietic Stem Cells; Leukemia

$105,000

Centre for Epigenome Mapping Technologies (CEMT)

Co-investigatorCIHR2016CEEHRC Phase II: Platform Centres Renewal

Principal investigators: Hirst, Martin; Jones, Steven; Marra, Marco A

Keywords: Bioinformatics; Cancer; Data Visualisation; Epigenetics; Epigenomics; Technology Development

$3,932,500

Developing new therapeutic strategies for AML (Acute Myeloid Leukemia)

Co-investigatorCIHR2016Foundation Grant

Principal investigators: Schimmer, Aaron D

Keywords: Drug Development; Leukemia; Metabolism; Mitochondria; Translational Research

$3,333,379

Effect of perturbed c-MYC expression on chronic myeloid leukemia disease progression.

SupervisorCIHR2015Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Bulaeva, Elizaveta

Keywords: Acute Leukemia; C-Myc; Cancer Stem Cell; Chronic Myeloid Leukemia; Dna Barcoding Technology; Flow And Mass Cytometry; Human Hematopoietic Stem Cell; Lentiviral Transduction; Leukemia Modelling; Oncogene

$105,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Connie Eaves

Research

Latest papers

Latest funding

A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML.

UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells.

RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1.

A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.

The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction.

NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.

A fond farewell to Ernest A. McCulloch--a beacon who inspired generations of scientists and framed the foundation of modern stem cell biology.

Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex

Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate.

Reduction in multi-lineage and erythroid progenitors distinguishes myelodysplastic syndromes from non-malignant cytopenias.

Clonal interactions in myeloid malignancy

Elucidating the mitotic mechanisms that are needed for alveologenesis in the pregnant mammary gland and are likely to be disturbed in pregnancy-associated breast cancer.

Dissecting aging associated epigenetic contributions to breast cancer

Understanding mutagenic replication-transcription conflicts in cancer-initiation

Role of autophagy in a de novo model of human breast cancer genesis from purified primary normal cells.

Identification of early epigenomic changes produced by oncogenic mutant KRAS in transduced normal human mammary cells

Role of Proliferative Activity in Human Hematopoietic Stem Cell Aging and Leukemogenesis

Centre for Epigenome Mapping Technologies (CEMT)

Developing new therapeutic strategies for AML (Acute Myeloid Leukemia)

Effect of perturbed c-MYC expression on chronic myeloid leukemia disease progression.

Frequent collaborators

Xiaoyan Jiang

Marco Marra

Samuel Aparicio

Martin Hirst

Aly Karsan

Steven Jones

Calvin Yip

James Thomson

Emily Pang

Peter Lansdorp

Ali Bashashati

Rama Khokha

Tobias Berg

Ryan Brinkman

Connie Eaves

Research

Latest papers

Latest funding

A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML.

UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells.

RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1.

A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.

The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction.

NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-&#x3b8; and reactive oxygen species.

A fond farewell to Ernest A. McCulloch--a beacon who inspired generations of scientists and framed the foundation of modern stem cell biology.

Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex

Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate.

Reduction in multi-lineage and erythroid progenitors distinguishes myelodysplastic syndromes from non-malignant cytopenias.

Frequent collaborators

Xiaoyan Jiang

Marco Marra

Samuel Aparicio

Martin Hirst

Aly Karsan

Steven Jones

Calvin Yip

James Thomson

Emily Pang

Peter Lansdorp

Ali Bashashati

Rama Khokha

Tobias Berg

Ryan Brinkman

NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.