Faculty profile

Leigh Murphy

ResearcherManitoba Institute of Cell BiologyUniversity of Manitoba

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Manitoba directory, so their courses may be missing. Find their university profile.

Leigh Murphy

Researcher

Manitoba Institute of Cell Biology

Health Sciences

University of Manitoba

Winnipeg, Manitoba, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
5 publications in the last five years, latest in 2025.
Principal investigator on 2 research grants (2 CIHR), most recently in 2015.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Biochemistry Biomarker Breast Cancer Cell Biology Estrogen Receptor Immunohistochemistry Kinase Molecular Endocrinology

Latest papers

Federated Deep Learning Enables Cancer Subtyping by Proteomics.
Cancer discovery · 2025
Obesity-associated changes in molecular biology of primary breast cancer.
Nature communications · 2023
Development and validation of a prognostic 15-gene signature for stratifying HER2+/ER+ breast cancer.
Computational and structural biotechnology journal · 2023

All 20 publications

Latest funding

Beyond the Estrogen Receptor: involvement of kinases in estrogen signaling in normal and malignant human breast epithelial cells
CIHR · 2015 · Nominated PI
$100,000
Beyond the estrogen receptor: Involvement of kinases in estrogen dependence and independence in human breast cancer
CIHR · 2009 · Nominated PI
$729,830

All 2 grants and awards

20 publications.

Federated Deep Learning Enables Cancer Subtyping by Proteomics.

Cai Z, Boys EL, Noor Z, Aref AT, Xavier D, Lucas N, Williams SG, Koh JMS, Poulos RC, Wu Y, Dausmann M, MacKenzie KL, Aguilar-Mahecha A, Armengol C, Barranco MM, Basik M, Bowman ED, Clifton-Bligh R, Connolly EA, Cooper WA, Dalal B, DeFazio A, Filipits M, Flynn PJ, Graham JD, George J, Gill AJ, Gnant M, Habib R, Harris CC, Harvey K, Horvath LG, Jackson C, Kohonen-Corish MRJ, Lim E, Liu JJ, Long GV, Lord RV, Mann GJ, McCaughan GW, Morgan L, Murphy L, Nagabushan S, Nagrial A, Navinés J, Panizza BJ, Samra JS, Scolyer RA, Souglakos J, Swarbrick A, Thomas D, Balleine RL, Hains PG, Robinson PJ, Zhong Q, Reddel RR

Cancer discovery2025

DOI: 10.1158/2159-8290.cd-24-1488 PMID: 40488620

Obesity-associated changes in molecular biology of primary breast cancer.

Nguyen HL, Geukens T, Maetens M, Aparicio S, Bassez A, Borg A, Brock J, Broeks A, Caldas C, Cardoso F, De Schepper M, Delorenzi M, Drukker CA, Glas AM, Green AR, Isnaldi E, Eyfjörð J, Khout H, Knappskog S, Krishnamurthy S, Lakhani SR, Langerod A, Martens JWM, McCart Reed AE, Murphy L, Naulaerts S, Nik-Zainal S, Nevelsteen I, Neven P, Piccart M, Poncet C, Punie K, Purdie C, Rakha EA, Richardson A, Rutgers E, Vincent-Salomon A, Simpson PT, Schmidt MK, Sotiriou C, Span PN, Tan KTB, Thompson A, Tommasi S, Van Baelen K, Van de Vijver M, Van Laere S, Van't Veer L, Viale G, Viari A, Vos H, Witteveen AT, Wildiers H, Floris G, Garg AD, Smeets A, Lambrechts D, Biganzoli E, Richard F, Desmedt C

Nature communications2023

DOI: 10.1038/s41467-023-39996-z PMID: 37479706

Development and validation of a prognostic 15-gene signature for stratifying HER2+/ER+ breast cancer.

Liu Q, Huang S, Desautels D, McManus KJ, Murphy L, Hu P

Computational and structural biotechnology journal2023

DOI: 10.1016/j.csbj.2023.05.002 PMID: 37216014

Data-driven identification of plasma metabolite clusters and metabolites of interest for potential detection of early-stage non-small cell lung cancer cases versus cancer-free controls.

Kim JO, Balshaw R, Trevena C, Banerji S, Murphy L, Dawe D, Tan L, Srinathan S, Buduhan G, Kidane B, Qing G, Domaratzki M, Aliani M

Cancer & metabolism2022

DOI: 10.1186/s40170-022-00294-9 PMID: 36224630

Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance.

Wang H, Wang Q, Cai G, Duan Z, Nugent Z, Huang J, Zheng J, Borowsky AD, Li JJ, Liu P, Kung HJ, Murphy L, Chen HW, Wang J

Acta pharmaceutica Sinica. B2022

DOI: 10.1016/j.apsb.2021.10.015 PMID: 35847493

Computational Prediction of the Pathogenic Status of Cancer-Specific Somatic Variants.

Feizi N, Liu Q, Murphy L, Hu P

Frontiers in genetics2021

DOI: 10.3389/fgene.2021.805656 PMID: 35116056

DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation.

Batra RN, Lifshitz A, Vidakovic AT, Chin SF, Sati-Batra A, Sammut SJ, Provenzano E, Ali HR, Dariush A, Bruna A, Murphy L, Purushotham A, Ellis I, Green A, Garrett-Bakelman FE, Mason C, Melnick A, Aparicio SAJR, Rueda OM, Tanay A, Caldas C

Nature communications2021

DOI: 10.1038/s41467-021-25661-w PMID: 34518533

Comparative metabolomics studies of blood collected in streck and heparin tubes from lung cancer patients.

Goldberg E, Ievari-Shariati S, Kidane B, Kim J, Banerji S, Qing G, Srinathan S, Murphy L, Aliani M

PloS one2021

DOI: 10.1371/journal.pone.0249648 PMID: 33891605

Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups.

Rueda OM, Sammut SJ, Seoane JA, Chin SF, Caswell-Jin JL, Callari M, Batra R, Pereira B, Bruna A, Ali HR, Provenzano E, Liu B, Parisien M, Gillett C, McKinney S, Green AR, Murphy L, Purushotham A, Ellis IO, Pharoah PD, Rueda C, Aparicio S, Caldas C, Curtis C

Nature2019

DOI: 10.1038/s41586-019-1007-8 PMID: 30867590

Claudin 1 Is Highly Upregulated by PKC in MCF7 Human Breast Cancer Cells and Correlates Positively with PKCε in Patient Biopsies.

Blanchard AA, Ma X, Wang N, Hombach-Klonisch S, Penner C, Ozturk A, Klonisch T, Pitz M, Murphy L, Leygue E, Myal Y

Translational oncology2019

DOI: 10.1016/j.tranon.2018.12.011 PMID: 30658316

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Leigh Murphy

Research

Latest papers

Latest funding

Federated Deep Learning Enables Cancer Subtyping by Proteomics.

Obesity-associated changes in molecular biology of primary breast cancer.

Development and validation of a prognostic 15-gene signature for stratifying HER2+/ER+ breast cancer.

Data-driven identification of plasma metabolite clusters and metabolites of interest for potential detection of early-stage non-small cell lung cancer cases versus cancer-free controls.

Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance.

Computational Prediction of the Pathogenic Status of Cancer-Specific Somatic Variants.

DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation.

Comparative metabolomics studies of blood collected in streck and heparin tubes from lung cancer patients.

Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups.

Claudin 1 Is Highly Upregulated by PKC in MCF7 Human Breast Cancer Cells and Correlates Positively with PKCε in Patient Biopsies.

Beyond the Estrogen Receptor: involvement of kinases in estrogen signaling in normal and malignant human breast epithelial cells

Beyond the estrogen receptor: Involvement of kinases in estrogen dependence and independence in human breast cancer

Frequent collaborators

Yvonne Myal

Samuel Aparicio

Marshall Pitz

Thomas Klonisch

Sabine Hombach-Klonisch

Michel Aliani

Pingzhao Hu

Mark Basik

Julian Kim

David Dawe

Michelle Lobchuk

Sohrab Shah

Leigh Murphy

Research

Latest papers

Latest funding

Federated Deep Learning Enables Cancer Subtyping by Proteomics.

Obesity-associated changes in molecular biology of primary breast cancer.

Development and validation of a prognostic 15-gene signature for stratifying HER2+/ER+&#xa0;breast cancer.

Data-driven identification of plasma metabolite clusters and metabolites of interest for potential detection of early-stage non-small cell lung cancer cases versus cancer-free controls.

Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance.

Computational Prediction of the Pathogenic Status of Cancer-Specific Somatic Variants.

DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation.

Comparative metabolomics studies of blood collected in streck and heparin tubes from lung cancer patients.

Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups.

Claudin 1 Is Highly Upregulated by PKC in MCF7 Human Breast Cancer Cells and Correlates Positively with PKC&#x3b5; in Patient Biopsies.

Beyond the Estrogen Receptor: involvement of kinases in estrogen signaling in normal and malignant human breast epithelial cells

Beyond the estrogen receptor: Involvement of kinases in estrogen dependence and independence in human breast cancer

Frequent collaborators

Yvonne Myal

Samuel Aparicio

Marshall Pitz

Thomas Klonisch

Sabine Hombach-Klonisch

Michel Aliani

Pingzhao Hu

Mark Basik

Julian Kim

David Dawe

Michelle Lobchuk

Sohrab Shah

Development and validation of a prognostic 15-gene signature for stratifying HER2+/ER+ breast cancer.

Claudin 1 Is Highly Upregulated by PKC in MCF7 Human Breast Cancer Cells and Correlates Positively with PKCε in Patient Biopsies.