Faculty profile

Sohrab Shah

ResearcherUniversity of British Columbia

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of British Columbia directory, so their courses and email address may be missing. Find their university profile.

Sohrab Shah

Researcher

Health Sciences

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
No publications since 2021.
Principal investigator on 5 research grants (5 CIHR), most recently in 2017.
Supervisor on 2 trainee awards (2 CIHR), most recently in 2014.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Publications

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Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Crc Tumour Evolution Clonal Dynamics Computational Biology Dna Repair Genomic Instability Genomic Signatures Homologous Recombination

Latest papers

Dhaka: variational autoencoder for unmasking tumor heterogeneity from single cell genomic data.
Bioinformatics (Oxford, England) · 2021
Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation.
Communications biology · 2019
Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma.
Nature communications · 2018

All 18 publications

Latest funding

Canada Research Chair - Tier 2
CIHR · 2017 · Nominated PI
$500,000
Targeting the dynamics and genomics of clonal evolution in cancer patients
CIHR · 2015 · Co-investigator
$2,833,460
Chromosome instability and synthetic lethality in yeast and cancer
CIHR · 2015 · Co-investigator
$2,526,307

All 23 grants and awards

18 publications.

Dhaka: variational autoencoder for unmasking tumor heterogeneity from single cell genomic data.

Rashid S, Shah S, Bar-Joseph Z, Pandya R

Bioinformatics (Oxford, England)2021

DOI: 10.1093/bioinformatics/btz095 PMID: 30768159

Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation.

Mazloomian A, Araki S, Ohori M, El-Naggar AM, Yap D, Bashashati A, Nakao S, Sorensen PH, Nakanishi A, Shah S, Aparicio S

Communications biology2019

DOI: 10.1038/s42003-019-0391-9 PMID: 31069274

Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma.

Arthur SE, Jiang A, Grande BM, Alcaide M, Cojocaru R, Rushton CK, Mottok A, Hilton LK, Lat PK, Zhao EY, Culibrk L, Ennishi D, Jessa S, Chong L, Thomas N, Pararajalingam P, Meissner B, Boyle M, Davidson J, Bushell KR, Lai D, Farinha P, Slack GW, Morin GB, Shah S, Sen D, Jones SJM, Mungall AJ, Gascoyne RD, Audas TE, Unrau P, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD

Nature communications2018

DOI: 10.1038/s41467-018-06354-3 PMID: 30275490

The driver landscape of sporadic chordoma.

Tarpey PS, Behjati S, Young MD, Martincorena I, Alexandrov LB, Farndon SJ, Guzzo C, Hardy C, Latimer C, Butler AP, Teague JW, Shlien A, Futreal PA, Shah S, Bashashati A, Jamshidi F, Nielsen TO, Huntsman D, Baumhoer D, Brandner S, Wunder J, Dickson B, Cogswell P, Sommer J, Phillips JJ, Amary MF, Tirabosco R, Pillay N, Yip S, Stratton MR, Flanagan AM, Campbell PJ

Nature communications2017

DOI: 10.1038/s41467-017-01026-0 PMID: 29026114

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.

Funnell T, Tasaki S, Oloumi A, Araki S, Kong E, Yap D, Nakayama Y, Hughes CS, Cheng SG, Tozaki H, Iwatani M, Sasaki S, Ohashi T, Miyazaki T, Morishita N, Morishita D, Ogasawara-Shimizu M, Ohori M, Nakao S, Karashima M, Sano M, Murai A, Nomura T, Uchiyama N, Kawamoto T, Hara R, Nakanishi O, Shumansky K, Rosner J, Wan A, McKinney S, Morin GB, Nakanishi A, Shah S, Toyoshiba H, Aparicio S

Nature communications2017

DOI: 10.1038/s41467-016-0008-7 PMID: 28232751

densityCut: an efficient and versatile topological approach for automatic clustering of biological data.

Ding J, Shah S, Condon A

Bioinformatics (Oxford, England)2016

DOI: 10.1093/bioinformatics/btw227 PMID: 27153661

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.

Pereira B, Chin SF, Rueda OM, Vollan HK, Provenzano E, Bardwell HA, Pugh M, Jones L, Russell R, Sammut SJ, Tsui DW, Liu B, Dawson SJ, Abraham J, Northen H, Peden JF, Mukherjee A, Turashvili G, Green AR, McKinney S, Oloumi A, Shah S, Rosenfeld N, Murphy L, Bentley DR, Ellis IO, Purushotham A, Pinder SE, Børresen-Dale AL, Earl HM, Pharoah PD, Ross MT, Aparicio S, Caldas C

Nature communications2016

DOI: 10.1038/ncomms11479 PMID: 27161491

Divergent clonal selection dominates medulloblastoma at recurrence.

Morrissy AS, Garzia L, Shih DJ, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FM, Ramaswamy V, Lindsay PE, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, Li Y, Mayoh C, Thiessen N, Mercier E, Mungall KL, Ma Y, Tse K, Zeng T, Shumansky K, Roth AJ, Shah S, Farooq H, Kijima N, Holgado BL, Lee JJ, Matan-Lithwick S, Liu J, Mack SC, Manno A, Michealraj KA, Nor C, Peacock J, Qin L, Reimand J, Rolider A, Thompson YY, Wu X, Pugh T, Ally A, Bilenky M, Butterfield YS, Carlsen R, Cheng Y, Chuah E, Corbett RD, Dhalla N, He A, Lee D, Li HI, Long W, Mayo M, Plettner P, Qian JQ, Schein JE, Tam A, Wong T, Birol I, Zhao Y, Faria CC, Pimentel J, Nunes S, Shalaby T, Grotzer M, Pollack IF, Hamilton RL, Li XN, Bendel AE, Fults DW, Walter AW, Kumabe T, Tominaga T, Collins VP, Cho YJ, Hoffman C, Lyden D, Wisoff JH, Garvin JH, Stearns DS, Massimi L, Schüller U, Sterba J, Zitterbart K, Puget S, Ayrault O, Dunn SE, Tirapelli DP, Carlotti CG, Wheeler H, Hallahan AR, Ingram W, MacDonald TJ, Olson JJ, Van Meir EG, Lee JY, Wang KC, Kim SK, Cho BK, Pietsch T, Fleischhack G, Tippelt S, Ra YS, Bailey S, Lindsey JC, Clifford SC, Eberhart CG, Cooper MK, Packer RJ, Massimino M, Garre ML, Bartels U, Tabori U, Hawkins CE, Dirks P, Bouffet E, Rutka JT, Wechsler-Reya RJ, Weiss WA, Collier LS, Dupuy AJ, Korshunov A, Jones DT, Kool M, Northcott PA, Pfister SM, Largaespada DA, Mungall AJ, Moore RA, Jabado N, Bader GD, Jones SJ, Malkin D, Marra MA, Taylor MD

Nature2016

DOI: 10.1038/nature16478 PMID: 26760213

A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.

Vollan HK, Rueda OM, Chin SF, Curtis C, Turashvili G, Shah S, Lingjærde OC, Yuan Y, Ng CK, Dunning MJ, Dicks E, Provenzano E, Sammut S, McKinney S, Ellis IO, Pinder S, Purushotham A, Murphy LC, Kristensen VN, METABRIC Group, Brenton JD, Pharoah PD, Børresen-Dale AL, Aparicio S, Caldas C

Molecular oncology2015

DOI: 10.1016/j.molonc.2014.07.019 PMID: 25169931

DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts.

Nguyen LV, Cox CL, Eirew P, Knapp DJ, Pellacani D, Kannan N, Carles A, Moksa M, Balani S, Shah S, Hirst M, Aparicio S, Eaves CJ

Nature communications2014

DOI: 10.1038/ncomms6871 PMID: 25532760

Canada Research Chair - Tier 2

Nominated PICIHR2017Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Shah, Sohrab P

Keywords: Crc

$500,000

Targeting the dynamics and genomics of clonal evolution in cancer patients

Co-investigatorCIHR2015Foundation Grant

Principal investigators: Aparicio, Samuel J

Keywords: Breast Cancer; Cancer; Clonal Evolution; Clonal Genomes; Genomics; Oncology; Patient-Derived Xenografts; Single Cell; Therapeutics; Translational Medicine

$2,833,460

Chromosome instability and synthetic lethality in yeast and cancer

Co-investigatorCIHR2015Foundation Grant

Principal investigators: Hieter, Philip A

Keywords: C. Elegans Genetics; Cancer Therapeutics; Chromosome Biology; Chromosome Instability Genes; Dna Repair; Genome Stability; Mechanisms Of Aneuploidy; Model Organisms And Human Disease; Synthetic Lethality; Yeast Genetics

$2,526,307

The biology and clinical significance of the tumour microenvironment in B cell lymphomas

Co-investigatorCIHR2015Foundation Grant

Principal investigators: Steidl, Christian

Keywords: Biomarker; Cancer; Genomics; Immune Biology; Lymphoma; Microenvironment; Molecular Genetics; Pathogenesis; Treatment Outcome

$1,534,008

The clonal dynamics of ovarian cancers: phylogenetic models of chemosensitivity and resistance

Nominated PICIHR2014Foundation Grant

Principal investigators: Shah, Sohrab P

Keywords: Clonal Dynamics; Computational Biology; Dna Repair; Genomic Instability; Genomic Signatures; Homologous Recombination; Next-Generation Sequencing; Ovarian Cancer; Response Prediction; Tumour Evolution

$910,631

Targeting the tumour cell stress response in high-risk childhood cancers

Co-investigatorCIHR2014Foundation Grant

Principal investigators: Sorensen, Poul H

Keywords: Animal Models; Cell Signalling; Cell Stress Including Hypoxia; Childhood Sarcoma; Ewing Tumour; Mechanisms Of Metastasis; Metastasis; Molecular Pathology; Osteosarcoma; Pediatric Brain Tumours

$2,301,116

The Role of Tumor Microenvironment in Cancer Progression: Identification and Therapeutic Intervention of Novel Targets

Co-investigatorCIHR2014Foundation Grant

Principal investigators: Dedhar, Shoukat R

Keywords: Cancer Progression And Metastasis; Cancer Therapeutics; Carbonic Anhydrase Ix/Xii; Epithelial-Mesenchymal Transition (Emt); Invasion And Invadopodia; Metabolism And Angiogenesis; Synthetic Lethal Screen; Therapeutic Antibodies; Tumor Hypoxia; Tumor Microenvironment; Tumor Recurrence And Drug Resistance

$4,164,493

Clonal evolution and acquired drug resistance in breast cancer patient xenografts profiled at single cell resolution

SupervisorCIHR2014Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Steif, Adi

Keywords: Breast Cancer; Clonal Evolution; Computational Models; Drug Resistance; Single Cell Sequencing; Tumour Heterogeneity

$105,000

Integrating Quantitative Imaging Methods and Genomic Biomarkers to Assess the Therapeutic Response of Cancers

Co-investigatorCIHR2014Operating Grant: Quantitative Imaging for Responses to Cancer Therapies

Principal investigators: Benard, Francois

Keywords: Quantitative Imaging

$1,548,954

The cancer genome collaboratory

Co-investigatorCIHR2013Operating Grant: Discovery Frontiers - LOI

Principal investigators: Stein, Lincoln

Keywords: Bioethics; Biostatistics; Cancer; Cloud Computing; Computational Biology; Computer Science; Genomics; Machine Learning

$24,991

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Sohrab Shah

Research

Latest papers

Latest funding

Dhaka: variational autoencoder for unmasking tumor heterogeneity from single cell genomic data.

Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation.

Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma.

The driver landscape of sporadic chordoma.

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.

densityCut: an efficient and versatile topological approach for automatic clustering of biological data.

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.

Divergent clonal selection dominates medulloblastoma at recurrence.

A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.

DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts.

Frequent collaborators

Samuel Aparicio

Jiarui Ding

Inanc Birol

Martin Hirst

Ali Bashashati

Steven Jones

Christian Steidl

David Huntsman

Vijay Ramaswamy

Adam Shlien

Eric Bouffet

Jüri Reimand

Peter Unrau

Ute Bartels

Colin Collins

Livia Garzia

Leigh Murphy

Trevor Pugh

Xi Huang

Colin Collins

Nada Jabado

Uri Tabori

David Malkin