Faculty profile

Sylvain Lother

ResearcherInternal MedicineUniversity of Manitoba

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Manitoba directory, so their courses and email address may be missing. Find their university profile.

Sylvain Lother

Researcher

Internal Medicine

Health Sciences

University of Manitoba

Winnipeg, Manitoba, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
8 publications in the last five years, latest in 2026.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 3 research grants (3 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

1,065

Citations

117

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Bayesian Adaptive Trial Community Acquired Pneumonia (Cap)Corticosteroids Dexamethasone Phase Iii Trial Randomized Trial Antibiotic Pneumonia

Latest papers

Association of anti-anaerobic antibiotics with mortality and the gut microbiome: a sub-study of the BALANCE randomized clinical trial
Clinical Infectious Diseases · 2026
Evaluating possible treatment effect heterogeneity in a randomized trial of milrinone versus dobutamine in cardiogenic shock.
Critical care (London, England) · 2026
Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections
New England Journal of Medicine · 2025

All 16 publications

Latest funding

From Local to Global: Expanding Canadian One Health Leadership Through International Partnerships to fight AMR
CIHR · 2025 · Co-investigator
$50,000
IMPACT-CC: Increasing Meaningful Participation and Access to Critical Care Trials in Community Intensive Care Units
CIHR · 2025 · Co-investigator
$20,000
Best Effective Antibiotic Treatment for Community Acquired Pneumonia (BEAT-CAP): A pilot feasibility domain of the GUARD-Resp platform trial
CIHR · 2025 · Nominated PI
$180,000

All 15 grants and awards

16 publications.

Association of anti-anaerobic antibiotics with mortality and the gut microbiome: a sub-study of the BALANCE randomized clinical trial

Armstrong E, Pinto R, Kulikova M, Yee NR, Rishu A, Muscedere J, Sibley S, Maslove DM, Boyd JG, Evans GA

Clinical Infectious Diseases2026

DOI: 10.1093/cid/ciag460

Evaluating possible treatment effect heterogeneity in a randomized trial of milrinone versus dobutamine in cardiogenic shock.

Marinho LL, Lileikyte G, Boileau P, Lu Y, Churpek M, Spicer A, Harhay M, Chen Z, Luk A, Zampieri FG, Tavares CAM, Proudfoot A, Pop C, Deschênes PJF, Zarychanzki R, Lother S, Abrahão Hajjar L, Jentzer JC, van Diepen S, di Santo P, Mathew R, Lawler PR

Critical care (London, England)2026

DOI: 10.1186/s13054-026-05938-6 PMID: 42298588

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections

Daneman N, Rishu A, Pinto R, Rogers BA, Shehabi Y, Parke R, Cook D, Arabi Y, Muscedere J, Reynolds S

New England Journal of Medicine2025167 citations

DOI: 10.1056/nejmoa2404991

Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomised controlled adaptive platform trial of treatments for acute SARS-CoV-2 infection in community settings

Hosseini B, Condon A, da Costa BR, Daley P, Greiver M, Jüni P, Lee TC, McBrien K, McDonald EG, Murthy S

BMJ Open20256 citations

DOI: 10.1136/bmjopen-2024-097134

Disparities in access to and timing of interventional therapies for pulmonary embolism across the United States.

Rush B, Ziegler J, Dyck S, Dhaliwal S, Mooney O, Lother S, Celi LA, Mendelson AA

Journal of thrombosis and haemostasis : JTH2024

DOI: 10.1016/j.jtha.2024.03.013 PMID: 38554934

AMMI Canada Practice Point: Updated recommendations for treatment of adults with symptomatic COVID-19 in 2023–2024

Grant JM, Lam J, Goyal SV, Lother S, Kassim SS, Lee SB, Chan J, Girouard G, Barrett L, Takaya S

JAMMI20233 citations

DOI: 10.3138/jammi-2023-12-07

Outcomes with severe pulmonary coccidioidomycosis and respiratory failure in the United States.

Rush B, Zeigler J, Cheng MP, Hrymak C, Lother S

Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada2023Senior author

DOI: 10.3138/jammi-2022-0028 PMID: 37008578

Low-dose trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia (LOW-TMP): protocol for a phase III randomised, placebo-controlled, dose-comparison trial.

Sohani ZN, Butler-Laporte G, Aw A, Belga S, Benedetti A, Carignan A, Cheng MP, Coburn B, Costiniuk CT, Ezer N, Gregson D, Johnson A, Khwaja K, Lawandi A, Leung V, Lother S, MacFadden D, McGuinty M, Parkes L, Qureshi S, Roy V, Rush B, Schwartz I, So M, Somayaji R, Tan D, Trinh E, Lee TC, McDonald EG

BMJ open2022

DOI: 10.1136/bmjopen-2021-053039 PMID: 35863836

Perioperative Coronavirus Vaccination-Timing and Implications: A Guidance Document.

Merritt-Genore H, Moosdorf R, Gillaspie E, Lother S, Engelman D, Ahmed S, Baciewicz FA, Grant MC, Milewski R, Cawcutt K, Hayanga JA, Chatterjee S, Arora RC, Society of Thoracic Surgeons Workforce on Critical Care

The Annals of thoracic surgery2021

DOI: 10.1016/j.athoracsur.2021.07.016 PMID: 34370980

Outcomes With Severe Blastomycosis and Respiratory Failure in the United States.

Rush B, Lother S, Paunovic B, Mooney O, Kumar A

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America2021

DOI: 10.1093/cid/ciaa294 PMID: 32227089

From Local to Global: Expanding Canadian One Health Leadership Through International Partnerships to fight AMR

Co-investigatorCIHR2025Planning and Dissemination Grant - Institute Community Support

Principal investigators: Herrera Diaz, Mariana D; Bharat, Amrita K; Cienfuegos-Gallet, Astrid V; Jiménez, Judy N; Keynan, Yoav; Vanegas, Johanna M

Keywords: Antimicrobial Resistance; Environmental Surveillance; Global Health; International Collaborations; Microbiome; Omics; One Health; Provincial Collaborations; Resistone; Workshop

$50,000

IMPACT-CC: Increasing Meaningful Participation and Access to Critical Care Trials in Community Intensive Care Units

Co-investigatorCIHR2025Planning and Dissemination Grants - Institute/Initiative Community Support

Principal investigators: Tsang, Jennifer L; Orlando, Elaina; Binnie, Alexandra; O'Grady, Heather

Keywords: Clinical Trials; Community Icu; Critical Care; Equity; Platform Trials; Research Capacity Building

$20,000

Best Effective Antibiotic Treatment for Community Acquired Pneumonia (BEAT-CAP): A pilot feasibility domain of the GUARD-Resp platform trial

Nominated PICIHR2025Project Grant

Principal investigators: Lother, Sylvain

Keywords: Antibiotic; Pneumonia

$180,000

BALANCE+: A Platform Trial for Gram Negative Bloodstream Infections

Co-investigatorCIHR2025Project Grant

Principal investigators: Daneman, Nick; Fowler, Robert A; Johnstone, Jennie; Lee, Todd C; MacFadden, Derek R; McDonald, Emily G; Ong, Sean W; Pinto, Ruxandra; Rogers, Benjamin A

Keywords: Adaptive Platform Trial; Antibiotic De-Escalation; Antibiotic Duration; Antibiotic Oral Switch; Antimicrobial Resistance; Bloodstream Infection; Central Venous Catheter Infection; Gram Negative Bacteremia; Randomized Clinical Trial

$1,908,674

Strengthened Prairies Integrated Knowledge Exchange (SPIKE) Hub: Enhancing Community Responsive and Peer Integrated Clinical Trials

Co-investigatorCIHR2025HIV/AIDS & STBBI Clinical Trials Research Network - Phase 2

Principal investigators: Keynan, Yoav; Haworth-Brockman, Margaret J; Illsley, Shohan; Singh, Ameeta E; Sutherland, Dessie Jo; Kelly, Lauren; Rueda, Zulma V; Spence, Cara J

Keywords: Diverse And Inclusive Training; Hiv; Key Populations; Mentoring Platforms; People With Lived And Living Experience; Sexually Transmitted Infections

$800,000

An international platform for finding the optimal therapies for Pneumocystis jirovecii pneumonia: The PCP Platform

Co-investigatorCIHR2024Project Grant

Principal investigators: Lee, Todd C; Benedetti, Andrea; Bhagani, Sanjay; Boyles, Tom; Butler-Laporte, Guillaume; Cheng, Matthew P; McDonald, Emily G; McGuinty, Michaeline; Nakashima, Kei; Schwartz, Ilan S; Slavin, Monica; So, Miranda; Tan, Darrell H; Yong, Michelle

Keywords: Immunomodulation; Platform Trial; Pneumocystis; Pneumonia; Randomized Controlled Trial; Secondary Prophylaxis; Treatment

$1,683,000

A Randomized Controlled Trial of Oral Antimicrobial Therapy for Patients with Staphylococcus aureus Bacteremia: The Early Oral Switch Domain in the Staphylococcus aureus Network Adaptive Trial (EOS-SNAP)

Co-investigatorCIHR2024Project Grant

Principal investigators: Cheng, Matthew P; Bai, Anthony D; Daley, Peter; Daneman, Nick; Grant, Jennifer; Lawandi, Alexander; Lee, Todd C; MacFadden, Derek R; McDonald, Emily G; Somayaji, Ranjani; Wuerz, Terence

Keywords: Bacteremia; Bloodstream Infection; Clinical Trial; Oral Antibiotics; Staphylococcus Aureus

$1,705,952

Dexamethasone For Preventing Deterioration In Community Acquired Pneumonia (DEFEND-CAP)

Principal investigatorCIHR2023Operating Grant: Clinical Trials Projects - Indirect Costs

Principal investigators: Zarychanski, Ryan; Lawler, Patrick R; Lother, Sylvain; McDonald, Emily G

Keywords: Bayesian Adaptive Trial; Community Acquired Pneumonia (Cap); Corticosteroids; Dexamethasone; Phase Iii Trial; Randomized Trial

$1,375,000

CLEAR-HORIZONS Post-Sepsis Platform Trial: Statin Pilot RCT

Co-investigatorCIHR2023Operating Grant: Clinical Trials Projects - Indirect Costs

Principal investigators: Lawler, Patrick R

Keywords: Atorvastatin; Long-Term Outcomes; Pandemic Preparedness; Pilot; Post-Infection Syndrome; Randomized Controlled Trial; Sepsis

$112,231

CLEAR-HORIZONS Post-Sepsis Platform Trial: Statin Pilot RCT

Co-investigatorCIHR2023Operating Grant: Clinical Trials Projects

Principal investigators: Lawler, Patrick R

Keywords: Atorvastatin; Long-Term Outcomes; Pandemic Preparedness; Pilot; Post-Infection Syndrome; Randomized Controlled Trial; Sepsis

$448,925

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Bayesian Adaptive Trial Dear Professor Lother, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Association of anti-anaerobic antibiotics with mortality and the gut microbiome: a sub-study of the BALANCE randomized clinical trial" (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Best Effective Antibiotic Treatment for Community Acquired Pneumonia (BEAT-CAP): A pilot feasibility domain of the GUARD-Resp platform trial" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Sylvain Lother

Research

Latest papers

Latest funding

Association of anti-anaerobic antibiotics with mortality and the gut microbiome: a sub-study of the BALANCE randomized clinical trial

Evaluating possible treatment effect heterogeneity in a randomized trial of milrinone versus dobutamine in cardiogenic shock.

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections

Canadian Adaptive Platform Trial of Treatments for COVID in Community Settings (CanTreatCOVID): protocol for a randomised controlled adaptive platform trial of treatments for acute SARS-CoV-2 infection in community settings

Disparities in access to and timing of interventional therapies for pulmonary embolism across the United States.

AMMI Canada Practice Point: Updated recommendations for treatment of adults with symptomatic COVID-19 in 2023–2024

Outcomes with severe pulmonary coccidioidomycosis and respiratory failure in the United States.

Low-dose trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia (LOW-TMP): protocol for a phase III randomised, placebo-controlled, dose-comparison trial.

Perioperative Coronavirus Vaccination-Timing and Implications: A Guidance Document.

Outcomes With Severe Blastomycosis and Respiratory Failure in the United States.

Frequent collaborators

Ryan Zarychanski

Anand Kumar

Peter Daley

Francois Lamontagne

Nick Daneman

Bryan Coburn

Jennifer Tsang

Ruxandra Pinto

John Marshall

Michael Detsky

Aidan Findlater

John Muscedere

Srinivas Murthy

Gloria Vazquez-Grande

Robert Fowler

Erick Duan

Jennifer Hulme

Guillaume Butler-Laporte

Donald Arnold

Robert Fowler

Jennifer Tsang

Emilie Trinh

Andrew Nicholson

Carolyn Calfee

Danny McAuley

Jennifer Grant

Marc Carrier

Daniel Warshafsky

Bram Rochwerg

Jennifer Rayner

Rahim Moineddin

Miranda So

Richard Gould

Derek MacFadden

Andrew Morris

Darrell Tan

Dean Fergusson

Catherine Hudon

Andrea Benedetti

John Laffey