Argel Aguilar Valles, Carleton University

Research

Chronic Stress Dendritogenesis Enantiomers Interneurons Mrna Translation Nmda Receptor Opioid Receptors Ribotag

Latest papers

Sex differences in placebo and antidepressant response to intranasal esketamine for treatment-resistant depression.
Molecular psychiatry · 2026 · senior author
DCC and the Architecture of Stress Vulnerability: A Guidance Cue for Depression.
Biological psychiatry global open science · 2026 · first author
Using, misusing, and improving online machine learning-based meta-analysis of neuroimaging published data: A perspective on NeuroQuery.
Neuroimage. Reports · 2026

All 23 publications

Latest funding

Implantable wireless telemetry system
NSERC · 2024 · Co-investigator
$150,000
Identifying the molecular determinants of ketamine's antidepressant action
CIHR · 2023 · Nominated PI
$929,476
Molecular control of social memory in mice
NSERC · 2022 · Principal investigator
$93,000

All 5 grants and awards

23 publications.

01

Sex differences in placebo and antidepressant response to intranasal esketamine for treatment-resistant depression.

Huc M, Siddiqi S, Myers M, Colman I, Salmaso N, Jaworska N, Aguilar-Valles A

Molecular psychiatry2026Senior author

DOI: 10.1038/s41380-026-03493-8 PMID: 41708888

02

DCC and the Architecture of Stress Vulnerability: A Guidance Cue for Depression.

Aguilar-Valles A

Biological psychiatry global open science2026First author

DOI: 10.1016/j.bpsgos.2025.100684 PMID: 41659277

03

Using, misusing, and improving online machine learning-based meta-analysis of neuroimaging published data: A perspective on NeuroQuery.

Mahafza Y, Mason I, Telfer A, Aguilar-Valles A, D'Angiulli A

Neuroimage. Reports2026

DOI: 10.1016/j.ynirp.2025.100306 PMID: 41467210

04

Early postsynaptic potentiation in hippocampal somatostatin interneurons is mTORC1-dependent and disrupted in Fmr1-/y mice.

Eslamizade MJ, Saffarzadeh F, Aguilar-Valles A

Neuroscience2026Senior author

DOI: 10.1016/j.neuroscience.2025.12.033 PMID: 41401891

05

Genetic Reduction of the Translational Repressors FMRP and 4E-BP2 Preserves Memory in Mouse Models of Alzheimer's Disease.

Ribeiro FC, Cozachenco D, Parkhill M, Rodrigue B, Borges C, Lacaille JC, Nader K, De Felice FG, Lourenco MV, Aguilar-Valles A, Sonenberg N, Ferreira ST

Aging cell2026

DOI: 10.1111/acel.70315 PMID: 41334801

06

Orchestrating Neural Development Through mRNA Translation Regulation.

Rodrigue B, Sajish M, Salmaso N, Aguilar-Valles A

Journal of neurochemistry2025Senior author

DOI: 10.1111/jnc.70128 PMID: 40509688

07

Emerging autism and Fragile X syndrome treatments.

Parkhill M, Salmaso N, D'Angiulli A, Lee V, Aguilar-Valles A

Trends in pharmacological sciences2025Senior author

DOI: 10.1016/j.tips.2025.02.004 PMID: 40102109

08

The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease.

Ribeiro FC, Cozachenco D, Argyrousi EK, Staniszewski A, Wiebe S, Calixtro JD, Soares-Neto R, Al-Chami A, Sayegh FE, Bermudez S, Arsenault E, Cossenza M, Lacaille JC, Nader K, Sun H, De Felice FG, Lourenco MV, Arancio O, Aguilar-Valles A, Sonenberg N, Ferreira ST

Alzheimer's & dementia : the journal of the Alzheimer's Association2024

DOI: 10.1002/alz.14034 PMID: 38934107

09

Testing PET-[ 11 C]ABP688 as a tool to quantify glutamate release in vivo.

Bdair H, Sato-Fitoussi M, Planche S, Moquin L, Kang MS, Aliaga A, Nagano-Saito A, Smart K, Cox SML, Near J, Aguilar-Valles A, Massarweh G, Rosa-Neto P, Benkelfat C, Soucy JP, Kostikov A, Gratton A, Leyton M

Imaging neuroscience (Cambridge, Mass.)2024

DOI: 10.1162/imag_a_00126 PMID: 40800322

10

An integrative view on the cell-type-specific mechanisms of ketamine's antidepressant actions.

Lewis V, Rurak G, Salmaso N, Aguilar-Valles A

Trends in neurosciences2024Senior author

DOI: 10.1016/j.tins.2023.12.004 PMID: 38220554

Implantable wireless telemetry system

Co-investigatorNSERC2024Research Tools and Instruments

Principal investigators: Chee, Melissa

Keywords: brain; EEG; glucose; inflammation; metabolism; pain; physiology; sleep; spinal cord; stress

$150,000

Identifying the molecular determinants of ketamine's antidepressant action

Nominated PICIHR2023Project Grant

Principal investigators: Aguilar Valles, Argel

Keywords: Chronic Stress; Dendritogenesis; Enantiomers; Interneurons; Mrna Translation; Nmda Receptor; Opioid Receptors; Ribotag; Synaptic Plasticity; Synaptogenesis

$929,476

Molecular control of social memory in mice

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Aguilar Valles, Argel

$93,000

Molecular control of social memory in mice

Principal investigatorNSERC2022Discovery Launch Supplement

Principal investigators: Aguilar Valles, Argel

$12,500

Astroglial estrogen receptor alpha as a mediator of neuroplasticity and stress-induced depressive behaviours

Co-investigatorCIHR2021Project Grant

Principal investigators: Salmaso, Natalina

Keywords: Brain; Estrogen; Glia; Mood Disorder; Plasticity; Stress

$875,926

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Pedro Rosa-Neto and Jean-Paul Soucy: 95 shared papers
Marco Leyton and Marco Leyton: 83 shared papers
Jamie Near and Jamie Near: 50 shared papers
Pedro Rosa-Neto and Alexey Kostikov: 17 shared papers
Jean-Paul Soucy and Alexey Kostikov: 16 shared papers
Nahum Sonenberg and Jean-Claude Lacaille: 15 shared papers
Karim Nader and Nahum Sonenberg: 11 shared papers
Marco Leyton and Natalia Jaworska: 10 shared papers
Marco Leyton and Natalia Jaworska: 10 shared papers
Marco Leyton and Pedro Rosa-Neto: 7 shared papers
Karim Nader and Jean-Claude Lacaille: 6 shared papers
Nahum Sonenberg and Argel Aguilar Valles: 6 shared papers
Natalina Salmaso and Argel Aguilar Valles: 6 shared papers
Nahum Sonenberg and Gabriella Gobbi: 5 shared papers
Jean-Claude Lacaille and Argel Aguilar Valles: 5 shared papers
Pedro Rosa-Neto and Marco Leyton: 5 shared papers
Nahum Sonenberg and Argel Aguilar Valles: 4 shared papers
Jean-Claude Lacaille and Argel Aguilar Valles: 4 shared papers
Gabriella Gobbi and Marco Leyton: 4 shared papers
Marco Leyton and Jean-Paul Soucy: 4 shared papers
Marco Leyton and Alexey Kostikov: 4 shared papers
Gabriella Gobbi and Marco Leyton: 3 shared papers
Gabriella Gobbi and Argel Aguilar Valles: 3 shared papers
Julio Martinez-Trujillo and Argel Aguilar Valles: 3 shared papers
Karim Nader and Argel Aguilar Valles: 2 shared papers
Karim Nader and Argel Aguilar Valles: 2 shared papers
Jamie Near and Pedro Rosa-Neto: 2 shared papers
Pedro Rosa-Neto and Jamie Near: 2 shared papers
Karim Nader and Hongyu Sun: 1 shared paper
Nahum Sonenberg and Natalina Salmaso: 1 shared paper
Nahum Sonenberg and Hongyu Sun: 1 shared paper
Jean-Claude Lacaille and Natalina Salmaso: 1 shared paper
Jean-Claude Lacaille and Hongyu Sun: 1 shared paper
Ian Colman and Natalina Salmaso: 1 shared paper
Ian Colman and Natalia Jaworska: 1 shared paper
Ian Colman and Argel Aguilar Valles: 1 shared paper
Marco Leyton and Jamie Near: 1 shared paper
Marco Leyton and Jamie Near: 1 shared paper
Marco Leyton and Argel Aguilar Valles: 1 shared paper
Natalina Salmaso and Vivian Lee: 1 shared paper
Alfonso Abizaid and Hongyu Sun: 1 shared paper
Alfonso Abizaid and Argel Aguilar Valles: 1 shared paper
Jamie Near and Argel Aguilar Valles: 1 shared paper
Pedro Rosa-Neto and Argel Aguilar Valles: 1 shared paper
Jean-Paul Soucy and Argel Aguilar Valles: 1 shared paper
Hongyu Sun and Argel Aguilar Valles: 1 shared paper
Jamie Near and Argel Aguilar Valles: 1 shared paper
Argel Aguilar Valles and Argel Aguilar Valles: 1 shared paper
Marco Leyton and Argel Aguilar Valles: 1 shared paper
Natalia Jaworska and Argel Aguilar Valles: 1 shared paper
Argel Aguilar Valles and Alexey Kostikov: 1 shared paper
Argel Aguilar Valles and Vivian Lee: 1 shared paper

Neurosciences
Psychiatry
Biochemistry
Psychology
Neurology and Neurosurgery
Physiology and Pharmacology
School of Epidemiology and Public Health
Other

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Chronic Stress Dear Professor Aguilar Valles, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Sex differences in placebo and antidepressant response to intranasal esketamine for treatment-resistant depression." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Identifying the molecular determinants of ketamine's antidepressant action" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]