Faculty profile

David Natale

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ProfessorDepartment of Biomedical and Molecular SciencesQueen's University

David Natale

Professor

Department of Biomedical and Molecular Sciences

Queen's University

Kingston, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
14 publications in the last five years, latest in 2025.
Senior (last) author on 10 recent papers, a sign of leading a research group.
Principal investigator on 4 research grants (2 CIHR, 1 ONTARIO, 1 CFI), most recently in 2022.
Supervisor on 1 trainee award (1 CIHR), most recently in 2020.

These signals come from public records, including federal and provincial funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

2,714

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Read how they describe their research on their Queen's University profile.

Currently funded:

Latest papers

Maternal dietary DHA and EPA supplementation ameliorates adverse cardiac outcomes in THC-exposed rat offspring
Scientific Reports · 2025
The regulation of placental pericyte function through transforming growth factor β-1 signalling
Scientific Reports · 2025 · senior author
Identifying established human placental markers of schizophrenia in rodents after gestational ∆9-tetrahydrocannabinol exposure
Biology of Reproduction · 2025

All 73 publications

Latest funding

The adverse impact of prenatal cannabinoid exposure on placental and postnatal cardiovascular function: can we intervene?
CIHR · 2022 · Principal investigator
$799,426
The impact of opioid and cannabis use during pregnancy on placental and fetal development
CIHR · 2021 · Co-investigator
$1,216,351
The role of trophoblast stem cells in placental insufficiency: adaptation or pathology?
CIHR · 2020 · Supervisor
$135,000

All 6 grants and awards

73 publications.

Maternal dietary DHA and EPA supplementation ameliorates adverse cardiac outcomes in THC-exposed rat offspring

Kendrick Lee, Mohammed Halit Sarikahya, Samantha L. Cousineau, Ken K.‐C. Yeung, Amanda H. Lucas, K W Loudon, Thane Tomy, Gregg T. Tomy, David R.C. Natale, Steven R. Laviolette, Daniel Barry Hardy

Scientific Reports20256 citationsOpen Access

DOI: 10.1038/s41598-025-92844-6 PMID: 40064971

The regulation of placental pericyte function through transforming growth factor β-1 signalling

Caelan A. MacPhee, Bryony V. Natale, Curtis Noordhof, SOPHIA S WANG, Patricia D.A. Lima, David R.C. Natale

Scientific Reports20253 citationsSenior authorOpen Access

DOI: 10.1038/s41598-025-20432-9 PMID: 41120412

Identifying established human placental markers of schizophrenia in rodents after gestational ∆9-tetrahydrocannabinol exposure

Andrea Kocsis, Enzo Pérez-Valenzuela, Mar Rodríguez-Ruiz, Mohammed Halit Sarikahya, Anubha Dembla, David R.C. Natale, Steven R. Laviolette, Daniel Barry Hardy

Biology of Reproduction20252 citationsOpen Access

DOI: 10.1093/biolre/ioaf191 PMID: 40827685

Exploring the differentiation potential of EomesPOS mouse trophoblast cells in mid-gestation

Avery J. McGinnis, Megan E Cull, Nichole T. Peterson, Minqiang Tang, Bryony V. Natale, David R.C. Natale

Developmental Biology20251 citationsSenior authorOpen Access

DOI: 10.1016/j.ydbio.2025.02.002 PMID: 39922418

Investigating Stem Cell Antigen-1 Expression and Effects in Mouse Trophoblast Stem Cells

Matthew Y. H. Tang, Bryony V. Natale, Curtis Noordhof, Patrícia Lima, David R.C. Natale

Placenta2025Senior author

DOI: 10.1016/j.placenta.2025.08.292

Delta 9-Tetrahydrocannabinol Signaling Through Cannabinoid Receptor 1 Alters Trophoblast Differentiation

Jessica L. Koven, Bryony V. Natale, Daniel Barry Hardy, David R.C. Natale

Stem Cells and Development2025Senior authorOpen Access

DOI: 10.1177/15473287251392544 PMID: 41203261

Cannabidiol Exposure During Rat Pregnancy Leads to Labyrinth-Specific Vascular Defects in the Placenta and Reduced Fetal Growth

S D Allen, Bryony V. Natale, Alexis O. Ejeckam, Kendrick Lee, Daniel Barry Hardy, David R.C. Natale

Cannabis and Cannabinoid Research202419 citationsSenior authorOpen Access

DOI: 10.1089/can.2023.0166 PMID: 38364116

Cannabidiol Exposure During Gestation Leads to Adverse Cardiac Outcomes Early in Postnatal Life in Male Rat Offspring

Kendrick Lee, Sebastian Vanin, Mina G. Nashed, Mohammed Halit Sarikahya, Steven R. Laviolette, David R.C. Natale, Daniel Barry Hardy

Cannabis and Cannabinoid Research202414 citationsOpen Access

DOI: 10.1089/can.2023.0213 PMID: 38358335

Investigating the effects of valproic acid on placental epigenetic modifications and development in the CD-1 mouse model

Brianna L. Jackson, Sidra Shafique, Bryony V. Natale, David R.C. Natale, Louise M. Winn

Reproductive Toxicology20247 citationsOpen Access

DOI: 10.1016/j.reprotox.2024.108551 PMID: 38280688

Characterizing placental pericytes: Hypoxia and proangiogenic signalling

Megan J. Morrison, Bryony V. Natale, S D Allen, Nichole T. Peterson, David R.C. Natale

Placenta20244 citationsSenior authorOpen Access

DOI: 10.1016/j.placenta.2024.07.314 PMID: 39106637

The adverse impact of prenatal cannabinoid exposure on placental and postnatal cardiovascular function: can we intervene?

Principal investigatorCIHR2022Project Grant

Principal investigators: Hardy, Daniel B; Natale, David R

Keywords: 9-Tetrahydrocannabidiol; Cannabidiol; Cannabinoids; Cardiac Dysfunction; Eachocardiogram; Fetal Growth Restriction; Omega-3 Diet; Peroxisome Proliferator-Activated Receptors; Placenta; Pregnancy

$799,426

The impact of opioid and cannabis use during pregnancy on placental and fetal development

Co-investigatorCIHR2021Project Grant

Principal investigators: Bainbridge, Shannon A; Gaudet, Laura M

Keywords: Cannabis; Drug Use; Fetal Growth; Opioid Use Disorder; Opioids; Pathology; Placenta; Pregnancy; Thc

$1,216,351

The role of trophoblast stem cells in placental insufficiency: adaptation or pathology?

SupervisorCIHR2020CIHR Fellowship

Principal investigators: Droste, Samantha J

Keywords: Animal Models; Fetal Growth Restriction; Lenitviral Ablation; Obstetrical Complications; Placenta; Pregnancy; Transgenic Mice; Translational Biology; Trophoblast Stem Cells

$135,000

Stress-mediated trophoblast proliferation: adaptation or pathology?

Principal investigatorONTARIO2020Ontario Research Fund - Research Infrastructure: Small Infrastructure Fund - Round 047 - 2019 - October

Principal investigators: Natale, David

$100,000

Stress-mediated trophoblast proliferation: adaptation or pathology?

Principal investigatorCFI2019John R. Evans Leaders Fund: John R. Evans Leaders Fund – Funding for research infrastructure

Principal investigators: Natale, David

Keywords: placenta, trophoblast stem cell, pregnancy, adaptation, pathology, development gene expression, histology, cell culture, stem cell, hypoxia

$100,000

Characterization of placental adaptations to stress during pregnancy in the mouse

Nominated PICIHR2012Operating Grant

Principal investigators: Natale, David R

Keywords: Adaptation; Mouse; Placenta; Pregnancy; Stem Cell; Trophoblast

$618,087

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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David Natale

Research

Latest papers

Latest funding

Maternal dietary DHA and EPA supplementation ameliorates adverse cardiac outcomes in THC-exposed rat offspring

The regulation of placental pericyte function through transforming growth factor β-1 signalling

Identifying established human placental markers of schizophrenia in rodents after gestational ∆9-tetrahydrocannabinol exposure

Exploring the differentiation potential of EomesPOS mouse trophoblast cells in mid-gestation

Investigating Stem Cell Antigen-1 Expression and Effects in Mouse Trophoblast Stem Cells

Delta 9-Tetrahydrocannabinol Signaling Through Cannabinoid Receptor 1 Alters Trophoblast Differentiation

Cannabidiol Exposure During Rat Pregnancy Leads to Labyrinth-Specific Vascular Defects in the Placenta and Reduced Fetal Growth

Cannabidiol Exposure During Gestation Leads to Adverse Cardiac Outcomes Early in Postnatal Life in Male Rat Offspring

Investigating the effects of valproic acid on placental epigenetic modifications and development in the CD-1 mouse model

Characterizing placental pericytes: Hypoxia and proangiogenic signalling

The adverse impact of prenatal cannabinoid exposure on placental and postnatal cardiovascular function: can we intervene?

The impact of opioid and cannabis use during pregnancy on placental and fetal development

The role of trophoblast stem cells in placental insufficiency: adaptation or pathology?

Stress-mediated trophoblast proliferation: adaptation or pathology?

Stress-mediated trophoblast proliferation: adaptation or pathology?

Characterization of placental adaptations to stress during pregnancy in the mouse

Frequent collaborators

Andrew Watson

James Cross

Daniel Hardy

Dan Hardy

Steven Laviolette

Josef Penninger

Myriam Hemberger

Lina Dagnino

Gregg Tomy

Alison Holloway

Pedro Santamaria

Frank Beier

Pere Santamaria

John Matyas

Louise Winn

Benedikt Hallgrimsson

Carol Huang

Ken Yeung