Faculty profile

Brian Wilson

ResearcherMedical BiophysicsUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Brian Wilson

Researcher

Medical Biophysics

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
6 publications in the last five years, latest in 2026.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 7 research grants (6 CIHR, 1 NSERC), most recently in 2018.
Supervisor on 2 trainee awards (2 CIHR), most recently in 2010.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Cancer Medical Physics Nanotechnology Pancreatic Cancer Photodynamic Therapy X-Ray Nuclear-Targeted X-Ray

Latest papers

Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors.
Bioorganic & medicinal chemistry letters · 2026
OICR-41103 as a chemical probe for the DCAF1 WD40 domain.
Communications biology · 2025
Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.
Nature communications · 2024

All 11 publications

Latest funding

Rapid high sensitivity and specificity diagnosis of melanoma with Picosecond infrared laser mass spectrometry
CIHR · 2023 · Co-investigator
$619,650
Protection of Metallic Surfaces from Bulk to Nano Through Molecular-level Innovation.
SSHRC · 2020 · Co-investigator
$8,000,000
Protection of Metallic Surfaces from Bulk to Nano Through Molecular-level Innovation.
SSHRC · 2020 · Co-investigator
$8,000,000

All 34 grants and awards

11 publications.

Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors.

Mamai A, Morshed MM, Prakesch M, Poda G, Subramanian P, Chau AM, Watson IDG, Joseph B, Wilson B, Morin JA, Marcellus R, Theriault B, Mohammed M, Abibi A, Chan M, Kiyota T, Aman A, Subramaniam R, Strathdee C, Winston J, O'Meara J, Kuntz D, Pomroy NC, Uehling D, Isaac M, Privé GG, Al-Awar R

Bioorganic & medicinal chemistry letters2026

DOI: 10.1016/j.bmcl.2025.130471 PMID: 41241078

OICR-41103 as a chemical probe for the DCAF1 WD40 domain.

Kimani SW, Noureldin M, Wilson B, Hoffer L, Green SR, Szewczyk MM, González-Álvarez H, Mohammed M, Chan M, Krausser C, Li ASM, Hajian T, Tucker S, Joshi D, Saraon P, Thériault B, Kim JS, Santhakumar V, Loppnau P, Li Y, Seitova A, Dong A, Kiyota T, Hammann T, Gehrtz P, Patel B, Rathod V, Vala A, Rout B, Jagodra P, Brown PJ, Aman A, Ramnauth J, Poda G, Uehling D, Arrowsmith CH, Barsyte-Lovejoy D, Marcellus R, Ackloo S, Mamai A, Al-Awar R, Halabelian L

Communications biology2025

DOI: 10.1038/s42003-025-08491-0 PMID: 40683980

Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.

Mabanglo MF, Wilson B, Noureldin M, Kimani SW, Mamai A, Krausser C, González-Álvarez H, Srivastava S, Mohammed M, Hoffer L, Chan M, Avrumutsoae J, Li ASM, Hajian T, Tucker S, Green S, Szewczyk M, Barsyte-Lovejoy D, Santhakumar V, Ackloo S, Loppnau P, Li Y, Seitova A, Kiyota T, Wang JG, Privé GG, Kuntz DA, Patel B, Rathod V, Vala A, Rout B, Aman A, Poda G, Uehling D, Ramnauth J, Halabelian L, Marcellus R, Al-Awar R, Vedadi M

Nature communications2024

DOI: 10.1038/s41467-024-54500-x PMID: 39580491

Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle.

Mann MK, Wolf E, Silva M, Kwak HA, Wilson B, Bolotokova A, Wilson DJ, Harding RJ, Schapira M

ACS omega2024

DOI: 10.1021/acsomega.3c07070 PMID: 38222562

Preclinical evaluation of Raman spectroscopy for pedicular screw insertion surgical guidance in a porcine spine model.

Kosik I, Dallaire F, Pires L, Tran T, Leblond F, Wilson B

Journal of biomedical optics2023Senior author

DOI: 10.1117/1.jbo.28.5.057003 PMID: 37265877

Discovery of Nanomolar DCAF1 Small Molecule Ligands.

Li ASM, Kimani S, Wilson B, Noureldin M, González-Álvarez H, Mamai A, Hoffer L, Guilinger JP, Zhang Y, von Rechenberg M, Disch JS, Mulhern CJ, Slakman BL, Cuozzo JW, Dong A, Poda G, Mohammed M, Saraon P, Mittal M, Modh P, Rathod V, Patel B, Ackloo S, Santhakumar V, Szewczyk MM, Barsyte-Lovejoy D, Arrowsmith CH, Marcellus R, Guié MA, Keefe AD, Brown PJ, Halabelian L, Al-Awar R, Vedadi M

Journal of medicinal chemistry2023

DOI: 10.1021/acs.jmedchem.2c02132 PMID: 36948210

Structure-Activity Relationship of USP5 Inhibitors.

Mann MK, Zepeda-Velázquez CA, González-Álvarez H, Dong A, Kiyota T, Aman AM, Loppnau P, Li Y, Wilson B, Arrowsmith CH, Al-Awar R, Harding RJ, Schapira M

Journal of medicinal chemistry2021

DOI: 10.1021/acs.jmedchem.1c00889 PMID: 34648286

Interstitial imaging with multiple diffusive reflectance spectroscopy projections for in vivo blood vessels detection during brain needle biopsy procedures.

Picot F, Goyette A, Obaid S, Desroches J, Lessard S, Tremblay MA, Strupler M, Wilson B, Petrecca K, Soulez G, Leblond F

Neurophotonics2019

DOI: 10.1117/1.nph.6.2.025003 PMID: 31037243

Topical MMP beacon enabled fluorescence-guided resection of oral carcinoma.

Burgess L, Chen J, Wolter NE, Wilson B, Zheng G

Biomedical optics express2016

DOI: 10.1364/boe.7.001089 PMID: 27231609

Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.

Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-awar R, Poda G, Prakesch M, Wilson B, Tam V, Schweitzer C, Toro A, Lucas JL, Vuga D, Lehmann L, Durocher D, Zeng Q, Patterson JB, Sicheri F

Nature communications2014

DOI: 10.1038/ncomms5202 PMID: 25164867

Rapid high sensitivity and specificity diagnosis of melanoma with Picosecond infrared laser mass spectrometry

Co-investigatorCIHR2023Project Grant

Principal investigators: Zarrine-Afsar, Arash

Keywords: Melanoma

$619,650

Protection of Metallic Surfaces from Bulk to Nano Through Molecular-level Innovation.

Co-investigatorSSHRC2020New Frontiers in Research Fund - Transformation

Principal investigators: Crudden, Cathleen

Keywords: Surface Science Nanomedicine Corrosion protection Nanomaterials Self Assembled Monolayers N-heterocyclic Carbenes Bio-Imaging

$8,000,000

Protection of Metallic Surfaces from Bulk to Nano Through Molecular-level Innovation.

Co-investigatorSSHRC2020New Frontiers in Research Fund - Transformation

Principal investigators: Crudden, Cathleen

Keywords: Surface Science; Nanomedicine; Corrosion protection; Nanomaterials; Self Assembled Monolayers; N-heterocyclic Carbenes; Bio-Imaging

$8,000,000

Nuclear-targeted X-ray activated photodynamic therapy of pancreatic cancer

Nominated PICIHR2018Project Grant

Principal investigators: Wilson, Brian C; Allen, Christine J

Keywords: Cancer; Medical Physics; Nanotechnology; Pancreatic Cancer; Photodynamic; Therapy; X-Ray

$371,024

Nuclear-targeted x-ray activated photodynamic therapy of metastic cancer.

Nominated PICIHR2018CIHR - ICR / Cancer Research Society Partnership - Research Grants

Principal investigators: Wilson, Brian C

Keywords: Nuclear-Targeted X-Ray

$60,000

A new treatment platform for glioblastoma: Ultrasound-mediated in situ conversion of porpyrin microbubbles to theranostic nanoparticles

Co-investigatorCIHR2016Project Grant

Principal investigators: Zheng, Gang

Keywords: Blood-Brain Barriers; Glioblastoma; Microbubbles; Multimodal Imaging; Nanoparticles; Photodynamic Therapy; Porphyrin; Sonodynamic Therapy; Ultrasound

$707,164

Development and clinical translation of a Raman spectroscopy imaging technique to increase the extent of tumor resection in glioma surgery

Co-investigatorNSERC2016Collaborative Health Research Projects

Principal investigators: Leblond, Frederic

$264,929

Real-time intraoperative spectroscopic tumor margin detection in robotic-assisted radical prostatectomy on prostate cancer patients

Co-investigatorNSERC2016Collaborative Research and Development Grants

Principal investigators: Lesage, Frederic

$86,200

Porphyrin Nanomedicine for Cancer Imaging and Therapy

Co-investigatorCIHR2016Foundation Grant

Principal investigators: Zheng, Gang

Keywords: Blood Brain Barrier; Cancer Imaging; Image-Guided Therapy; Immunotherapy; Lipoprotein; Microbubbles; Nanoparticle; Photodynamic Therapy; Photothermal Therapy; Radiotherapy

$3,300,088

Nonlinear Optical Imaging for Digital Pathology

Co-investigatorNSERC2014Collaborative Health Research Projects

Principal investigators: Barzda, Virginijus

$425,394

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Brian Wilson

Research

Latest papers

Latest funding

Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors.

OICR-41103 as a chemical probe for the DCAF1 WD40 domain.

Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.

Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle.

Preclinical evaluation of Raman spectroscopy for pedicular screw insertion surgical guidance in a porcine spine model.

Discovery of Nanomolar DCAF1 Small Molecule Ligands.

Structure-Activity Relationship of USP5 Inhibitors.

Interstitial imaging with multiple diffusive reflectance spectroscopy projections for in vivo blood vessels detection during brain needle biopsy procedures.

Topical MMP beacon enabled fluorescence-guided resection of oral carcinoma.

Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.

Rapid high sensitivity and specificity diagnosis of melanoma with Picosecond infrared laser mass spectrometry

Protection of Metallic Surfaces from Bulk to Nano Through Molecular-level Innovation.

Protection of Metallic Surfaces from Bulk to Nano Through Molecular-level Innovation.

Nuclear-targeted X-ray activated photodynamic therapy of pancreatic cancer

Nuclear-targeted x-ray activated photodynamic therapy of metastic cancer.

A new treatment platform for glioblastoma: Ultrasound-mediated in situ conversion of porpyrin microbubbles to theranostic nanoparticles

Development and clinical translation of a Raman spectroscopy imaging technique to increase the extent of tumor resection in glioma surgery

Real-time intraoperative spectroscopic tumor margin detection in robotic-assisted radical prostatectomy on prostate cancer patients

Porphyrin Nanomedicine for Cancer Imaging and Therapy

Nonlinear Optical Imaging for Digital Pathology

Frequent collaborators

David Uehling

Dalia Barsyte-Lovejoy

Ahmed Aman

Matthieu Schapira

Gilles Soulez

Kevin Petrecca

Frank Sicheri

Gilles Soulez

Gilles Soulez

Daniel Durocher

Ren-Ke Li

Gang Zheng

Kevin Petrecca