Clinton Robbins, University of Toronto

Research

Atherosclerosis Monocyte Abdominal Aortic Aneurysm Macrophage Inflammation Parabiosis Plaque Animal Models

Latest papers

Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity.
eLife · 2022
Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux.
Communications biology · 2022
Interrupting reactivation of immunologic memory diverts the allergic response and prevents anaphylaxis
Journal of Allergy and Clinical Immunology · 2021

All 5 publications

Latest funding

Mutations in pancreatic cancer cause increased sterol efflux and immune dysfunction in pancreatic cancer.
CIHR · 2025 · Co-investigator
$1,170,450
Notch Signaling Determines Regulatory Plasmocyte (PCreg) Maintenance and Expansion Across Species
CIHR · 2025 · Nominated PI
$1,093,950
Unveiling the Mechanisms of Cigarette Smoking-Induced Abdominal Aortic Aneurysms: A Focus on Atherosclerosis and Macrophage Subtypes
CIHR · 2023 · Nominated PI
$967,725

All 15 grants and awards

5 publications.

01

Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity.

Boroumand P, Prescott DC, Mukherjee T, Bilan PJ, Wong M, Shen J, Tattoli I, Zhou Y, Li A, Sivasubramaniyam T, Shi N, Zhu LY, Liu Z, Robbins C, Philpott DJ, Girardin SE, Klip A

eLife2022

DOI: 10.7554/elife.65553 PMID: 36125130

02

Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux.

Dotan I, Yang J, Ikeda J, Roth Z, Pollock-Tahiri E, Desai H, Sivasubramaniyam T, Rehal S, Rapps J, Li YZ, Le H, Farber G, Alchami E, Xiao C, Karim S, Gronda M, Saikali MF, Tirosh A, Wagner KU, Genest J, Schimmer AD, Gupta V, Minden MD, Cummins CL, Lewis GF, Robbins C, Jongstra-Bilen J, Cybulsky M, Woo M

Communications biology2022

DOI: 10.1038/s42003-022-03078-5 PMID: 35169231

03

Interrupting reactivation of immunologic memory diverts the allergic response and prevents anaphylaxis

Bruton K, Spill P, Vohra S, Baribeau O, Manzoor S, Gadkar S, Davidson M, Walker TD, Koenig JFE, Ellenbogen Y

Journal of Allergy and Clinical Immunology202139 citations

DOI: 10.1016/j.jaci.2020.11.042

04

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.

Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, Burrows K, Robinson HG, Allanach JR, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne LC, Robbins C, Baranzini SE, Gommerman JL

Cell2019

DOI: 10.1016/j.cell.2018.11.035 PMID: 30612739

05

Effect of removing Kupffer cells on nanoparticle tumor delivery.

Tavares AJ, Poon W, Zhang YN, Dai Q, Besla R, Ding D, Ouyang B, Li A, Chen J, Zheng G, Robbins C, Chan WCW

Proceedings of the National Academy of Sciences of the United States of America2017

DOI: 10.1073/pnas.1713390114 PMID: 29208719

Mutations in pancreatic cancer cause increased sterol efflux and immune dysfunction in pancreatic cancer.

Co-investigatorCIHR2025Project Grant

Principal investigators: McGaha, Tracy

Keywords: Macrophages; Neutrophils; Pancreatic Cancer; Tumor Immunology

$1,170,450

Notch Signaling Determines Regulatory Plasmocyte (PCreg) Maintenance and Expansion Across Species

Nominated PICIHR2025Project Grant

Principal investigators: Robbins, Clinton S

Keywords: B Cells; Notch Signaling; Plasma Cells; Plasmablasts; Plasmocytes; Regulatory Cells

$1,093,950

Unveiling the Mechanisms of Cigarette Smoking-Induced Abdominal Aortic Aneurysms: A Focus on Atherosclerosis and Macrophage Subtypes

Nominated PICIHR2023Project Grant

Principal investigators: Robbins, Clinton S

Keywords: Abdominal Aortic Aneurysm; Atherosclerosis; Macrophage

$967,725

Atherosclerosis drives arterial damage and abdominal aortic aneurysm formation and rupture

Nominated PICIHR2023Project Grant - PA: Circulatory and Respiratory Health

Principal investigators: Robbins, Clinton S

Keywords: Abdominal Aortic Aneurysm; Atherosclerosis; Monocyte; Plaque

$100,000

Synthetic nucleic acid nanoparticles that leverage the bone marrow as an unprecedented therapeutic target for the on-demand control of chronic inflammation

Co-investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Khan, Omar

Keywords: RNA; Nanotechnology; Drug delivery; Monocyte; Therapy

$125,000

Atherosclerotic process drives arterial damage, abdominal aortic aneurysm formation, and rupture

Nominated PICIHR2022Project Grant

Principal investigators: Robbins, Clinton S

Keywords: Abdominal Aortic Aneurysm; Atherosclerosis; Monocyte; Plaque

$100,000

Canada Research Chair - Tier 1

Nominated PICIHR2022Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Robbins, Clinton S

Keywords: Crc

$1,400,000

Defining the role of cardiovascular co-morbidity in COVID-19 disease pathogenesis

Nominated PICIHR2021Project Grant

Principal investigators: Robbins, Clinton S; Epelman, Slava

Keywords: Cardiac Injury; Coronary Artery Disease; Covid-19; Hypertension; Inflammation; Sars-Cov-2; Vascular Disease

$1,063,350

Investigation of CSF1 hematopoietic niches in atherosclerosis

Nominated PICIHR2019Project Grant

Principal investigators: Robbins, Clinton S

Keywords: Animal Models; Atherosclerosis; Immune Mechanisms; Macrophages; Monocytes; Niche

$803,250

Contribution of circulating microRNAs to the etiology of vascular disease

Co-investigatorCIHR2016Project Grant

Principal investigators: Fish, Jason E

Keywords: Atherosclerosis; Biomarker; Blood Vessel; Endothelial Cell; Extracellular Vesicle; Gene Regulation; Inflammation; Microrna; Monocyte; Signaling

$684,229

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Cardiology
Cell Biology
Department of Immunology
Toronto General Research Institute
Other

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Atherosclerosis Dear Professor Robbins, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity." (2022), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Notch Signaling Determines Regulatory Plasmocyte (PCreg) Maintenance and Expansion Across Species" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]