David Hess, University of Toronto

Research

Angiogenesis Hematopoietic Progenitor Cells Oxidative Stress Blood Vessel Regeneration Cariovascular Disease South Asian Type 2 Diabetes Vascular Regenerative Progenitor Cell Depletion

Latest papers

Cardiometabolic risk management: insights from a European Society of Cardiology Cardiovascular Round Table.
European heart journal · 2023
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale.
Nature methods · 2010

All 2 publications

Latest funding

Functional implications of vascular regenerative cell exhaustion in South Asian individuals with elevated cardiovascular disease risk
CIHR · 2024 · Principal investigator
$1,027,780
Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion in Type 2 Diabetes
CIHR · 2024 · Supervisor
$120,000
Semaglutide and Vascular Regeneration (SEMA-VR)
CIHR · 2023 · Supervisor
$105,000

All 4 grants and awards

2 publications.

01

Cardiometabolic risk management: insights from a European Society of Cardiology Cardiovascular Round Table.

Cosentino F, Verma S, Ambery P, Treppendahl MB, van Eickels M, Anker SD, Cecchini M, Fioretto P, Groop PH, Hess D, Khunti K, Lam CSP, Richard-Lordereau I, Lund LH, McGreavy P, Newsome PN, Sattar N, Solomon S, Weidinger F, Zannad F, Zeiher A

European heart journal2023

DOI: 10.1093/eurheartj/ehad445 PMID: 37448181

02

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale.

Baryshnikova A, Costanzo M, Kim Y, Ding H, Koh J, Toufighi K, Youn JY, Ou J, San Luis BJ, Bandyopadhyay S, Hibbs M, Hess D, Gingras AC, Bader GD, Troyanskaya OG, Brown GW, Andrews B, Boone C, Myers CL

Nature methods2010

DOI: 10.1038/nmeth.1534 PMID: 21076421

Functional implications of vascular regenerative cell exhaustion in South Asian individuals with elevated cardiovascular disease risk

Principal investigatorCIHR2024Project Grant

Principal investigators: Verma, Subodh S; Hess, David A

Keywords: Angiogenesis; Blood Vessel Regeneration; Cariovascular Disease; Hematopoietic Progenitor Cells; Oxidative Stress; South Asian; Type 2 Diabetes; Vascular Regenerative Progenitor Cell Depletion; Vascular Regenerative Progenitor Cell Dysfunction; White European

$1,027,780

Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion in Type 2 Diabetes

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Dennis, Fallon

Keywords: Blood Health; Blood Vessels; Cardiovascular Disease; Colony Formation Assay; Functionality; Hematopoietic Progenitor Cells; Stem Cell; Type 2 Diabetes; Vascular Regeneration

$120,000

Semaglutide and Vascular Regeneration (SEMA-VR)

SupervisorCIHR2023Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Park, Brady

Keywords: Aldehyde Dehydrogenase; Atherosclerosis; Endothelial Progenitor Cells; Glp-1 Receptor Agonist; Hematopoietic Progenitor Cells; Inflammation; Oxidative Stress; Semaglutide; Type 2 Diabetes; Vascular Regeneration

$105,000

Combination SGLT2i - GLP-1RA treatment for the reversal of pro-vascular regenerative cell exhaustion.

Principal investigatorCIHR2022Project Grant

Principal investigators: Verma, Subodh S; Hess, David A

Keywords: Aldehyde Dehydrogenase Activity; Angiogenesis; Circulating Progenitor Cells; Endothelial Precursor Cells; Granulocyte Precursor Cells; Hematopoietic Progenitor Cells; Inflammation; M1 / M2 Macrophage Polarfization; Oxidative Stress; Regenerative Cell Exhaustion

$929,475

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Cardiac Surgery
Department of Molecular Genetics
Molecular Genetics
Donnelly Centre
Department of Physiology and Pharmacology
Molecular Medicine
Anesthesiology

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Anne-Claude Gingras

Department of Molecular Genetics

1 shared papers, latest 2010

Brenda Andrews

Molecular Genetics

1 shared papers, latest 2010

Charles Boone

Donnelly Centre

1 shared papers, latest 2010

Subodh Verma

Anesthesiology

1 shared papers, latest 2023

David Hess

Department of Physiology and Pharmacology

1 shared papers, latest 2023

Ji-Young Youn

Molecular Medicine

1 shared papers, latest 2010

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Angiogenesis Dear Professor Hess, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Cardiometabolic risk management: insights from a European Society of Cardiology Cardiovascular Round Table." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Functional implications of vascular regenerative cell exhaustion in South Asian individuals with elevated cardiovascular disease risk" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]