Faculty profile

Brenda Andrews

ResearcherMolecular GeneticsUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Brenda Andrews

Researcher

Molecular Genetics

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
18 publications in the last five years, latest in 2026.
Senior (last) author on 3 recent papers, a sign of leading a research group.
Principal investigator on 10 research grants (10 CIHR), most recently in 2023.
Supervisor on 5 trainee awards (5 CIHR), most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

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Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Functional Genomics Genetic Networks Yeast Genetics Network Biology Complex Genetics Genetic Interactions Automated Imaging Phenomics

Latest papers

The 2025 Westlake Autumn Symposium for AI Proteomics and Virtual Cell.
Genomics, proteomics & bioinformatics · 2026
Role of Pbr1, a putative oxidoreductase, in the ER quality control and folding of yeast Fks1 glucan synthase.
Proceedings of the National Academy of Sciences of the United States of America · 2026
The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation.
bioRxiv : the preprint server for biology · 2026

All 62 publications

Latest funding

Mapping genetic suppression interaction networks in yeast and human cells
CIHR · 2023 · Nominated PI
$1,178,100
Exploring genetic network dynamics in the context of diverse genetic backgrounds
CIHR · 2022 · Nominated PI
$1,231,650
Decoding the molecular basis of natural aging using deep learning
CIHR · 2022 · Supervisor
$45,000

All 18 grants and awards

62 publications.

The 2025 Westlake Autumn Symposium for AI Proteomics and Virtual Cell.

Sun 孙瑞 R, Aebersold R, Xiao 肖琦 Q, Mann M, Zhou 周岩 Y, Heck AJR, Wang 王瑛睿 Y, Völker U, Cai 蔡雪 X, Boone C, Zhou 周梓卓 Z, Li 李明 M, Dong 董振 Z, Andrews B, Wang 王帅尧 S, Schacherer J, Jimenez CR, Wollscheid B, Yue 岳靓 L, Collins BC, Jiang 蒋恒 H, Wang 王栋 D, Qian 钱鎏佳 L, Yue 岳家兴 JX, Sun 孙莹莹 Y, Nice E, Zhang 张晓帆 X, Perez-Riverol Y, A 阿俊 J, Sander C, Hermjakob H, Bittremieux W, Goh WWB, Gao 高歌 G, Zhou 周沛劼 P, Sun 孙思琦 S, Wen 温翰 H, Xu 许梓妍 Z, Guo 郭天南 T

Genomics, proteomics & bioinformatics2026

DOI: 10.1093/gpbjnl/qzag022 PMID: 41795813

Role of Pbr1, a putative oxidoreductase, in the ER quality control and folding of yeast Fks1 glucan synthase.

Obara K, Okada H, Tan G, Ohnuki S, Suzuki G, Ohtake H, Kubo K, Ghanegolmohammadi F, Ishizaka S, Yashiroda Y, Okita A, Mishiro-Sato E, Suzuki K, Tamura Y, Ashine R, Ikeda Y, Kamura T, van Leeuwen J, Andrews B, Bi E, Noda NN, Boone C, Ohya Y

Proceedings of the National Academy of Sciences of the United States of America2026

DOI: 10.1073/pnas.2612792123 PMID: 42441850

The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation.

Chen L, Thompson K, Kamal M, Sihuta K, Topalidou I, Burns AR, Farshour NH, Cooke B, Knox J, Jiang Y, Qasser MA, Shuteriqi E, Usaj M, Ching J, Flaget A, Costanzo M, Tan G, Lacoste J, Lautens M, Andrews B, Boone C, Taipale M, Lehrbach NJ, Roy PJ

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.07.10.737828 PMID: 42523351

Towards the construction of a virtual yeast.

Qian L, Zhou Z, Zhou P, Dong Z, Zhang X, Dai Z, Gao Z, Sun S, Roy KR, Wang S, Zamboni N, Boone C, Costanzo M, Li J, Liti G, Yue JX, Ralser M, Williams E, Zampieri M, Jiang H, Wu T, Wang Y, Li F, Schacherer J, Sun R, Li Z, Deng Y, Chen Y, Xie Z, Lou H, Wang X, Xie L, Wen H, Chen L, Lei K, Rosenberger G, Cai X, Wang Y, Xiao Q, Shen H, Liu G, Ma L, Andrews B, Lu H, Piatkevich K, Zhu Y, Bai L, Cai Y, Chen Y, E W, Gao G, He F, Chen L, Li SZ, Ma H, Qiao L, Steinmetz LM, Tang L, Tang T, Zhang X, Yang J, Yang Y, Yu K, Zeng J, Zheng Y, Zhou B, Guo T

Nature2026

DOI: 10.1038/s41586-026-10574-9 PMID: 42387167

Orobas: A computational approach for scoring and analysis of quantitative chemical-genetic interactions from CRISPR-Cas9 screens.

Hassan AZ, Zhang X, Ward HN, Billmann M, Bajjali S, Brown KR, Bhojoo U, Chan K, Lin K, Costanzo M, Andrews B, Boone C, Moffat J, Myers CL

STAR protocols2026

DOI: 10.1016/j.xpro.2026.104594 PMID: 42213768

Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.

Billmann M, Costanzo M, Zhang X, Hassan AZ, Rahman M, Brown KR, Chan KS, Tong AHY, Pons C, Ward HN, Ross C, van Leeuwen J, Aregger M, Lawson KA, Mair B, Roth AF, Sen NE, Forster DT, Tan G, Mero P, Masud SN, Lee Y, Aguilera-Uribe M, Ušaj M, Almeida SMT, Aulakh K, Bhojoo U, Birkadze S, Budijono N, Cai X, Caumanns JJ, Chalmers JJ, Chandrashekhar M, Chang D, Climie R, Dasgupta K, Drazic A, Echenique JIR, Gacesa R, Farias AG, Habsid A, Horecka I, Kantautas K, Ji F, Kim DK, Lee SY, Liang W, Lim HJ, Lin K, Lu X, Maier M, Nami B, Nixon A, Mikolajewicz N, Mokhtaridoost M, Nedyalkova L, Rohde T, Rodrigues MS, Soste M, Schultz E, Wang W, Seetharaman A, Shuteriqi E, Sizova O, Taylor DT, Tereshchenko M, Tieu D, Turowec J, Ubhi T, Varland S, Wang KE, Wang ZY, Wei J, Xiao YX, Maass PG, Reversade B, Brown GW, Cravatt BF, Dixon SJ, Wyatt HDM, Röst HL, Roth FP, Xia T, Bader GD, Loewith R, Davis NG, Andrews B, Myers CL, Moffat J, Boone C

Cell2026

DOI: 10.1016/j.cell.2026.03.044 PMID: 42049019

Expanding TheCellMap.org to visualize a genome-scale genetic interaction network for a human cell line.

Horecka I, Ušaj M, Masinas MPD, Ward HN, Zhang X, Hassan AZ, Billmann M, Röst HL, Myers CL, Costanzo M, Andrews B, Boone C

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.03.16.712129 PMID: 41890115

Domestication drives repeated evolution of sexual-asexual life cycle trade-offs in yeast.

Becerra-Rodríguez C, Thiele P, Brach G, Dutta A, Garin M, Tan G, Loegler V, Friedrich A, Andrews B, Boone C, Schacherer J, Hou J

Proceedings of the National Academy of Sciences of the United States of America2026

DOI: 10.1073/pnas.2526682123 PMID: 41505518

Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens.

Billmann M, Costanzo M, Rahman M, Chan K, Yan Tong AH, Ward HN, Hassan AZ, Zhang X, Brown KR, Rohde T, Shaw AH, Ross C, van Leeuwen J, Aregger M, Lawson K, Mair B, Mero P, Usaj M, Andrews B, Boone C, Moffat J, Myers CL

bioRxiv : the preprint server for biology2026

DOI: 10.1101/2025.06.30.662330 PMID: 41542642

Harmonizing the Generation and Pre-publication Stewardship of FAIR bioimage data.

Bialy N, Alber F, Andrews B, Angelo M, Beliveau B, Bintu L, Boettiger A, Boehm U, Brown CM, Maina MB, Chambers JJ, Cimini BA, Eliceiri K, Errington R, Faklaris O, Gaudreault N, Germain RN, Goscinski W, Grunwald D, Halter M, Hanein D, Hickey JW, Lacoste J, Laude A, Lundberg E, Ma J, Malacrida L, Moore J, Nelson G, Neumann EK, Nitschke R, Onami S, Pimentel JA, Plant AL, Radtke AJ, Sabata B, Schapiro D, Schöneberg J, Spraggins JM, Sudar D, Vierdag WAM, Volkmann N, Wählby C, Wang SS, Yaniv Z, Strambio-De-Castillia C

ArXiv2025

DOI: 10.1007/s00418-023-02209-1 PMID: 38351940

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Brenda Andrews

Research

Latest papers

Latest funding

The 2025 Westlake Autumn Symposium for AI Proteomics and Virtual Cell.

Role of Pbr1, a putative oxidoreductase, in the ER quality control and folding of yeast Fks1 glucan synthase.

The Nematicide Tioxazafen Disrupts Proteasome Function via Cytochrome P450 Bioactivation.

Towards the construction of a virtual yeast.

Orobas: A computational approach for scoring and analysis of quantitative chemical-genetic interactions from CRISPR-Cas9 screens.

Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.

Expanding TheCellMap.org to visualize a genome-scale genetic interaction network for a human cell line.

Domestication drives repeated evolution of sexual-asexual life cycle trade-offs in yeast.

Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens.

Harmonizing the Generation and Pre-publication Stewardship of FAIR bioimage data.

Mapping genetic suppression interaction networks in yeast and human cells

Exploring genetic network dynamics in the context of diverse genetic backgrounds

Decoding the molecular basis of natural aging using deep learning

Mapping Biological Pathways using Systematic Genetics and Single Cell Imaging

Canada Reserch Chair - Tier 1

Mapping the Human Apoptosis Genetic Interaction Network

Systems Genetics & Cell Biology: Mapping Biological Pathways in the Eukaryotic Cell

Large-scale analysis of complex genetic suppression networks

Exploration of conditional genetic interaction reveals unforeseen link between DNA damage repair and cell polarization

Gene duplication and functional divergence: using systematic genetics to link genotype to phenotype

Frequent collaborators

Charles Boone

Jason Moffat

Anne-Claude Gingras

Philip Hieter

Ji-Young Youn

Zhaolei Zhang

Elena Kuzmin

Andrew Emili

Brian Raught

Igor Stagljar

David Hess

Mikko Taipale

Laurence Pelletier

Robert Rottapel