Faculty profile

Mario Masellis

ResearcherMedicineUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Mario Masellis

Researcher

Medicine

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
163 publications in the last five years, latest in 2026.
Senior (last) author on 10 recent papers, a sign of leading a research group.
Principal investigator on 12 research grants (12 CIHR), most recently in 2023.
Supervised 2 trainees who won CIHR awards, most recently in 2024.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

312

Publications

1,002

Citations

h-index

191

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Genomics Biomarkers Dementia Prevention C9orf72 Frontotemporal Dementia Mapt Mri

Latest papers

Neurodevelopmental effects of genetic frontotemporal dementia mutations revealed by total intracranial volume differences.
Journal of Alzheimer's disease : JAD · 2026
Survival estimates and their predictors in genetic frontotemporal dementia: an international, retrospective, cohort study.
The Lancet. Neurology · 2026
Educational attainment and sex modulate clinical outcomes in genetic frontotemporal dementia.
Brain communications · 2026

All 312 publications

Latest funding

Understanding Clinicopathological Heterogeneity and Mixed Pathologies across the Neurodegenerative Dementia Spectrums: A Multimodal Integrative Investigation
CIHR · 2024 · Supervisor
$120,000
Canadian Consortium on Neurodegeneration in Aging: Application for Phase III CCNA Operations Centre
CIHR · 2023 · Principal investigator
$20,555,200
NMR spectroscopy in brain organoids: identifying neurochemical and gene regulatory network signatures of the healthy and Alzheimer's Disease brain
CIHR · 2022 · Co-investigator
$940,950

All 21 grants and awards

From the 150 most recent of 312 publications.

Neurodevelopmental effects of genetic frontotemporal dementia mutations revealed by total intracranial volume differences.

So I, Bouzigues A, Russell LL, Foster PH, Ferry-Bolder E, van Swieten JC, Jiskoot LC, Seelaar H, Sanchez-Valle R, Laforce R, Graff C, Galimberti D, Vandenberghe R, de Mendonça A, Tiraboschi P, Santana I, Gerhard A, Levin J, Sorbi S, Otto M, Pasquier F, Ducharme S, Butler CR, Le Ber I, Tartaglia MC, Masellis M, Rowe JB, Synofzik M, Moreno F, Borroni B, Kolander T, Mester C, Brushaber D, Kantarci K, Heuer HW, Forsberg LK, Rohrer JD, Boeve BF, Boxer AL, Rosen HJ, Finger EC, Frontotemporal Dementia Prevention Initiative (FPI) Investigators

Journal of Alzheimer's disease : JAD2026

DOI: 10.1177/13872877251393414 PMID: 41259271

Survival estimates and their predictors in genetic frontotemporal dementia: an international, retrospective, cohort study.

Bouzigues A, Grassi M, Cantoni V, Premi E, Bellini S, Binetti G, Logroscino G, Russell LL, Ferry-Bolder E, Foster PH, van Swieten JC, Jiskoot LC, Seelaar H, Sanchez-Valle R, Laforce R, Graff C, Galimberti D, Vandenberghe R, de Mendonça A, Di Fede G, Santana I, Gerhard A, Langheinrich T, Levin J, Nacmias B, Otto M, Bertoux M, Lebouvier T, Ducharme S, Butler C, le Ber I, Bruffaerts R, Solje E, Kinnunen M, Krüger J, Finger E, Tartaglia MC, Masellis M, Rowe JB, Synofzik M, Moreno F, Ghidoni R, Migliaccio R, Rohrer JD, Borroni B, GENFI consortium

The Lancet. Neurology2026

DOI: 10.1016/s1474-4422(26)00197-3 PMID: 42456683

Educational attainment and sex modulate clinical outcomes in genetic frontotemporal dementia.

Premi E, Archetti D, Redolfi A, Bracca V, Cantoni V, Iraji A, Calhoun VD, Bellini S, Ghidoni R, Gasparotti R, Bouzigues A, Russell LL, Foster PH, Ferry-Bolder E, van Swieten JC, Jiskoot LC, Seelaar H, Sanchez-Valle R, Laforce R, Graff C, Galimberti D, Vandenberghe R, de Mendonça A, Di Fede G, Santana I, Gerhard A, Levin J, Nacmias B, Otto M, Bertoux M, Lebouvier T, Ducharme S, Butler CR, Le Ber I, Finger E, Tartaglia MC, Masellis M, Rowe JB, Synofzik M, Moreno F, Zetterberg H, Rohrer JD, Borroni B, GENetic Frontotemporal dementia Initiative (GENFI), GENetic Frontotemporal dementia Initiative (GENFI)

Brain communications2026

DOI: 10.1093/braincomms/fcag262 PMID: 42553777

Age at menopause, APOE-ε4, and Alzheimer's disease risk.

Wood Alexander M, Nyman AJ, Casaletto KB, Saloner R, Vandeloo KL, Splinter TFL, Swardfager W, Ottoy J, Masellis M, Galea LAM, Black SE, Einstein G, Denkinger MN, Ashton NJ, Caldwell JZK, Johnson SC, Arvanitakis Z, Rabin JS

Research square2026

DOI: 10.21203/rs.3.rs-10121551/v1 PMID: 42539099

Distinct proteomic CSF profiles in genetic frontotemporal lobar degeneration.

De Houwer JFH, Dopper EG, van Buuren R, Stokkel M, de Boer L, Swartenbroekx T, Boesjes PA, Rajicic A, Sogorb-Esteve A, Bouzigues A, Russell LL, Foster PH, Ferry-Bolder E, van Swieten JC, Jiskoot LC, Sanchez-Valle R, Laforce R, Graff C, Galimberti D, Vandenberghe R, de Mendonça A, Tiraboschi P, Santana I, Gerhard A, Levin J, Nacmias B, Otto M, Bertoux M, Lebouvier T, Ducharme S, Butler CR, Le Ber I, Finger E, Tartaglia MC, Masellis M, Rowe JB, Synofzik M, Moreno F, Borroni B, Zetterberg H, Rohrer JD, Tijms BM, Pijnenburg YAL, Teunissen C, Seelaar H, GENFI Consortium Members

Brain : a journal of neurology2026

DOI: 10.1093/brain/awaf457 PMID: 41343108

Reviewer Comment on Martineau et al. "Barriers to Clinical Care in Frontotemporal Dementia and Related Disorders: A Cross-Sectional Survey of Patients and Caregivers' Journey in the Canadian Healthcare System".

Garcia-Cifuentes E, Masellis M

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques2026Senior author

DOI: 10.1017/cjn.2026.10610 PMID: 42312460

Composite grey matter fingerprints for genetic frontotemporal dementia.

Bouzigues A, Campana G, Joulot M, Gensollen N, Russell LL, Foster PH, Ferry-Bolder E, Van Swieten JC, Jiskoot LC, Seelaar H, Sánchez-Valle R, Laforce R, Graff C, Galimberti D, Vandenberghe R, de Mendonca A, Tiraboschi P, Santana I, Gerhard A, Levin J, Sorbi S, Otto M, Bertoux M, Lebouvier T, Ducharme S, Butler C, Finger E, Tartaglia MC, Masellis M, Rowe JB, Synofzik M, Moreno F, Borroni B, Leber I, Zanusso G, Rohrer JD, Migliaccio R, GENetic Frontotemporal dementia Initiative (GENFI)

Journal of neurology, neurosurgery, and psychiatry2026

DOI: 10.1136/jnnp-2025-337186 PMID: 41679970

Examining the effects of alcohol use on verbal memory processes in older adults with mild cognitive impairment.

Cuperfain AB, Pishdadian S, Binns MA, Black SE, Chertkow H, Freedman M, Louis J, Ma C, Masellis M, Mclaughlin PM, Ramirez J, Tang-Wai DF, Tartaglia MC, Kumar S, CCNA COMPASS-ND Group, and on behalf of the ONDRI Group

Journal of Alzheimer's disease : JAD2026

DOI: 10.1177/13872877261444995 PMID: 42033405

Substantia Innominata : Atrophy, Gait Variability and Dual-Task Gait Across the Lewy Body Disease Spectrum.

Yeung AK, Gee M, Ba F, Almeida Q, Smith E, Nelles K, Sharma B, Masellis M, Black S, Pieruccini-Faria F, Montero-Odasso M, Camicioli R

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques2026

DOI: 10.1017/cjn.2026.10623 PMID: 42165216

Blood-based biomarkers for Alzheimer's disease. 'Treat the test, not the patient?'; are we ready to defy Osler?

Connon P, McKenna MC, Black SE, Masellis M

Expert review of molecular diagnostics2026Senior author

DOI: 10.1080/14737159.2026.2669646 PMID: 42107929

Understanding Clinicopathological Heterogeneity and Mixed Pathologies across the Neurodegenerative Dementia Spectrums: A Multimodal Integrative Investigation

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Saeed, Usman

Keywords: Alzheimer'S Disease Spectrum; Cerebrovascular Disease; Cognitive Neuropsychology; Frontotemporal Dementia Spectrum; Genomics; Lewy Body Dementia Spectrum; Magnetic Resonance Imaging (Mri); Mixed Neuropathology; Neurodegenerative Dementia

$120,000

Canadian Consortium on Neurodegeneration in Aging: Application for Phase III CCNA Operations Centre

Principal investigatorCIHR2023Canadian Consortium on Neurodegeneration in Aging

Principal investigators: Chertkow, Howard M; Anderson, Nicole D; Andrew, Melissa K; Badhwar, Amanpreet; Belleville, Sylvie N; Bethell, Jennifer M; Bhangu, Jaspreet S; Black, Sandra E; Borrie, Michael J; Brewster, Paul W; Camicioli, J. Richard M; Crowshoe, Lynden L; Darvesh, Sultan; DeMarco, Mari; Dixon, Roger A; Duchesne, Simon; Einstein, Gillian; Evans, Alan C; Feldman, Howard; Fisk, John D; Geddes, Maiya R; Lim, Andrew S; Masellis, Mario; McAiney, Carrie A; Mclaurin, Joanne; Montero Odasso, Manuel M; Nygaard, Haakon B; O'Connell, Megan E; Phillips, Natalie A; Rajah, Maria N; Roach, Pamela Marie; Robillard, Julie; Rockwood, Kenneth; Smith, Eric E; Villeneuve, Sylvia C; Waldron, Ingrid R; Walker, Jennifer

Keywords: Biomarkers; Brain Imaging; Cognition; Dementia; Diagnosis; Edi; Indigenous Cognitive Health; Knowledge Mobilization; Prevention; Risk Factors

$20,555,200

NMR spectroscopy in brain organoids: identifying neurochemical and gene regulatory network signatures of the healthy and Alzheimer's Disease brain

Co-investigatorCIHR2022Project Grant

Principal investigators: Near, Jamie; Schuurmans, Carol J

Keywords: Aging; Alzheimer'S Disease; Brain Metabolism; Cerebral Organoids; Epigenetics; Gene Regulatory Networks; Magnetic Resonance Imaging; Neurochemistry; Nuclear Magnetic Resonance Spectroscopy

$940,950

TACKLing the challenges of PREsymptomatic sporadic Dementia (TACKL-PRED)

Nominated PICIHR2021Operating Grant: Joint Programme on Neurodegenerative Disease Research (JPND)

Principal investigators: Masellis, Mario

Keywords: Alzheimer'S Disease; Biomarkers; Biostatisics And Neuroinformatics; Cardiovascular Risk Factors; Cerebrovascular Disease; Cognitive Impairment/Dementia; Frontotemporal Dementia-Amyotrophic Lateral Sclersosis; Genomics; Neuroimaging; Parkinson-Lewy Body Disease

NeuroCovid: European Solution for the Global Problem of dementia and Neurodegeneration following COVID-19 (EU-Connect)

Nominated PICIHR2021Team Grant: JPND Call for Expert Working Groups

Principal investigators: Masellis, Mario

Keywords: Alzheimer'S Disease; Covid-19; Dementia; Multidomain Intervention Trials; Neurodegeneration; Prevention; Sars-Cov-2

Methylphenidate-primed rTMS for apathy in neurocognitive disorders

Co-investigatorCIHR2021Project Grant - Priority Announcement: Aging

Principal investigators: Lanctôt, Krista L; Hamani, Clement

Keywords: Apathy; Dorsofrontal Prefrontal Cortex; Methylphenidate; Neurocognitive Disorder; Randomized Controlled Trial; Repetitive Transcranial Magnetic Stimulation

$100,000

Longitudinal brain networks integrity in genetic frontotemporal dementia: A GENFI study.

SupervisorCIHR2021CIHR Fellowship

Principal investigators: Sanchez-Gonzalez, Erlan

Keywords: Fluid Biomarkers; Frontotemporal Dementia; Genomics; Longitudinal Cohort; Mri

$135,000

Mid Career Investigator Prize in Research in Aging: Genetic Frontotemporal Dementia Initiative (GENFI) in Canada: Combined Investigation of Clinical, MRI, Genomic, and Epigenomic Biomarkers

Nominated PICIHR2020PRIZE - Project Grant - PA: Mid Career Investigator Prize in Research in Aging

Principal investigators: Masellis, Mario

Keywords: C9orf72; Dna Methylation; Epigenomics; Frontotemporal Dementia; Genomics; Grn; Mapt; Mri; Quantitative Traits; Single Nucleotide Polymorphisms

$50,000

Genetic Frontotemporal Dementia Initiative (GENFI) in Canada: Combined Investigation of Clinical, MRI, Genomic, and Epigenomic Biomarkers

Nominated PICIHR2020Project Grant

Principal investigators: Masellis, Mario; Finger, Elizabeth

Keywords: C9orf72; Dna Methylation; Epigenomics; Frontotemporal Dementia; Genomics; Grn; Mapt; Mri; Quantitative Traits; Single Nucleotide Polymorphisms

$1,128,375

Phase Two of the Canadian Consortium on Neurodegeneration in Aging

Principal investigatorCIHR2019Canadian Consortium on Neurodegeneration in Aging

Principal investigators: Chertkow, Howard M; Anderson, Nicole D; Andrew, Melissa K; Bartha, Robert; Bellec, Pierre; Belleville, Sylvie N; Bergman, Howard; Bherer, Louis; Black, Sandra E; Borrie, Michael J; Camicioli, J. Richard M; Carrier, Julie; Cashman, Neil R; Collins, Donald L; Cuello, A. Claudio G; Dixon, Roger A; Ducharme, Simon; Duchesne, Simon; Einstein, Gillian; Eintracht, Shaun; Evans, Alan C; Fahnestock, Margaret; Feldman, Howard; Ferland, Guylaine; Fisk, John D; Gan-Or, Ziv; Giguère, Anik; Herrmann, Nathan; Hsiung, Ging-Yuek R; Lanctôt, Krista L; Lim, Andrew S; Mackenzie, Ian R; Masellis, Mario; Maxwell, Colleen J; McGilton, Katherine S; Mclaurin, Joanne; Montero Odasso, Manuel M; Morgan, Debra G; Naglie, Gary; Nygaard, Haakon B; O'Connell, Megan E; Phillips, Natalie A; Poirier, Judes; Rapoport, Mark J; Robillard, Julie; Rockwood, Kenneth; Rogaeva, Ekaterina; Rosa-Neto, Pedro; Rylett, Jane R; Seitz, Dallas P; Siminovitch, Katherine A; Smith, Eric E; ST GEORGE-HYSLOP, Peter H; Vedel, Isabelle; Walker, Jennifer; Wittich, Walter

Keywords: Alzheimer Disease; Dementia; Diagnosis; Prevention; Quality Of Life; Sex; Treatment

$31,625,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Mario Masellis

Research

Latest papers

Latest funding

Neurodevelopmental effects of genetic frontotemporal dementia mutations revealed by total intracranial volume differences.

Survival estimates and their predictors in genetic frontotemporal dementia: an international, retrospective, cohort study.

Educational attainment and sex modulate clinical outcomes in genetic frontotemporal dementia.

Age at menopause, APOE-&#x3b5;4, and Alzheimer's disease risk.

Distinct proteomic CSF profiles in genetic frontotemporal lobar degeneration.

Reviewer Comment on Martineau et al. "Barriers to Clinical Care in Frontotemporal Dementia and Related Disorders: A Cross-Sectional Survey of Patients and Caregivers' Journey in the Canadian Healthcare System".

Composite grey matter fingerprints for genetic frontotemporal dementia.

Examining the effects of alcohol use on verbal memory processes in older adults with mild cognitive impairment.

Substantia Innominata : Atrophy, Gait Variability and Dual-Task Gait Across the Lewy Body Disease Spectrum.

Blood-based biomarkers for Alzheimer's disease. 'Treat the test, not the patient?'; are we ready to defy Osler?

Frequent collaborators

Elizabeth Finger

Robert Laforce

Simon Ducharme

Ekaterina Rogaeva

Robert Bartha

Connie Marras

Sanjeev Kumar

Demetrios Sahlas

Walter Swardfager

Nathan Herrmann

Dar Dowlatshahi

Andrew Frank

Gustavo Saposnik

David Grimes

Maged Goubran

Manuel Montero Odasso

Michael Borrie

Serge Gauthier

John Turnbull

Dallas Seitz

Serge Gauthier

Mario Masellis

Elizabeth Finger

Robert Laforce

Anthony Lang

Stephen Strother

Simon Ducharme

Simon Ducharme

Ivy Cheng

Peter ST GEORGE-HYSLOP

Allison Sekuler

Mario Masellis

Simon Duchesne

Allison Sekuler

Wendy Lou

Marvin Chum

Brian Levine

Gillian Einstein

Bojana Stefanovic

Sandra Black

Age at menopause, APOE-ε4, and Alzheimer's disease risk.