Faculty profile

Peter ST GEORGE-HYSLOP

ResearcherMedicineUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Peter ST GEORGE-HYSLOP

Researcher

Medicine

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
16 publications in the last five years, latest in 2026.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Principal investigator on 5 research grants (5 CIHR), most recently in 2019.
Supervisor on 1 trainee award (1 CIHR), most recently in 2008.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

1,094

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Alzheimer Disease Dementia Diagnosis Prevention Quality Of Life Sex Treatment Biomarkers

Latest papers

Microglial phagocytosis in Alzheimer disease.
Nature reviews. Neurology · 2026
Quantifying collective interactions in biomolecular phase separation.
Nature communications · 2025
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
Nature communications · 2025 · senior author

All 90 publications

Latest funding

Phase Two of the Canadian Consortium on Neurodegeneration in Aging
CIHR · 2019 · Principal investigator
$31,625,000
Functional Genomics of Neurodegenerative Diseases: Defining Molecular Pathogenesis and Targets for Biomarkers and Personalised Therapies
CIHR · 2018 · Nominated PI
$3,062,890
In Vivo Brain Mapping in the Dementias: A Longitudinal Brain-Behaviour Study with a Focus on Cerebrovascular Disease and Heterogeneity
CIHR · 2013 · Co-investigator
$100,000

All 8 grants and awards

90 publications.

Microglial phagocytosis in Alzheimer disease.

Brown GC, St George-Hyslop P, Paolicelli RC, Lemke G

Nature reviews. Neurology2026

DOI: 10.1038/s41582-025-01162-y PMID: 41315858

Quantifying collective interactions in biomolecular phase separation.

Ausserwöger H, de Csilléry E, Qian D, Krainer G, Welsh TJ, Sneideris T, Franzmann TM, Qamar S, Erkamp NA, Nixon-Abell J, Kar M, St George-Hyslop P, Hyman AA, Alberti S, Pappu RV, Knowles TPJ

Nature communications2025

DOI: 10.1038/s41467-025-62437-y PMID: 40830100

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.

Nixon-Abell J, Ruggeri FS, Qamar S, Herling TW, Czekalska MA, Shen Y, Wang G, King C, Fernandopulle MS, Sneideris T, Watson JL, Pillai VVS, Meadows W, Henderson JW, Chambers JE, Wagstaff JL, Williams SH, Coyle H, Šneiderienė G, Lu Y, Zhang S, Marciniak SJ, Freund SMV, Derivery E, Ward ME, Vendruscolo M, Knowles TPJ, St George-Hyslop P

Nature communications2025Senior author

DOI: 10.1038/s41467-025-58142-5 PMID: 40118863

Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates.

Miller A, Toprakcioglu Z, Qamar S, St George-Hyslop P, Ruggeri FS, Knowles TPJ, Vendruscolo M

Communications chemistry2025

DOI: 10.1038/s42004-025-01659-z PMID: 41023446

Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity.

Resnick SJ, Qamar S, Krishna P, Korben VA, Ausserwoger H, Miller A, Esposito P, Varela JA, Sheng J, Huang LH, Nixon-Abell J, Melore S, Chung CW, Läubli NF, Kapsiani S, Li X, Wang J, Zhang N, Alam MM, Burguete AS, Swayne TC, Chen Y, Liao YC, Shneider NA, Vendruscolo M, Knowles TPJ, Kaminski CF, Ruggeri FS, Kaminski Schierle GS, St George-Hyslop P, Chavez A

Nature communications2025

DOI: 10.1038/s41467-025-65178-0 PMID: 41271702

Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)

Chertkow H, Phillips N, Rockwood K, Anderson N, Andrew MK, Bartha R, Beaudoin C, Bélanger N, Bellec P, Belleville S

Journal of Alzheimer's Disease20249 citations

DOI: 10.1177/13872877241290990

Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians.

Ho PC, Yu WH, Tee BL, Lee WP, Li C, Gu Y, Yokoyama JS, Reyes-Dumeyer D, Choi YB, Yang HS, Vardarajan BN, Tzuang M, Lieu K, Lu A, Faber KM, Potter ZD, Revta C, Kirsch M, McCallum J, Mei D, Booth B, Cantwell LB, Chen F, Chou S, Clark D, Deng M, Hong TH, Hwang LJ, Jiang L, Joo Y, Kang Y, Kim ES, Kim H, Kim K, Kuzma AB, Lam E, Lanata SC, Lee K, Li D, Li M, Li X, Liu CL, Liu C, Liu L, Lupo JL, Nguyen K, Pfleuger SE, Qian J, Qian W, Ramirez V, Russ KA, Seo EH, Song YE, Tartaglia MC, Tian L, Torres M, Vo N, Wong EC, Xie Y, Yau EB, Yi I, Yu V, Zeng X, St George-Hyslop P, Au R, Schellenberg GD, Dage JL, Varma R, Hsiung GR, Rosen H, Henderson VW, Foroud T, Kukull WA, Peavy GM, Lee H, Feldman HH, Mayeux R, Chui H, Jun GR, Ta Park VM, Chow TW, Wang LS

Alzheimer's & dementia : the journal of the Alzheimer's Association2024

DOI: 10.1002/alz.13611 PMID: 38215053

Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia.

Manzoni C, Kia DA, Ferrari R, Leonenko G, Costa B, Saba V, Jabbari E, Tan MM, Albani D, Alvarez V, Alvarez I, Andreassen OA, Angiolillo A, Arighi A, Baker M, Benussi L, Bessi V, Binetti G, Blackburn DJ, Boada M, Boeve BF, Borrego-Ecija S, Borroni B, Bråthen G, Brooks WS, Bruni AC, Caroppo P, Bandres-Ciga S, Clarimon J, Colao R, Cruchaga C, Danek A, de Boer SC, de Rojas I, di Costanzo A, Dickson DW, Diehl-Schmid J, Dobson-Stone C, Dols-Icardo O, Donizetti A, Dopper E, Durante E, Ferrari C, Forloni G, Frangipane F, Fratiglioni L, Kramberger MG, Galimberti D, Gallucci M, García-González P, Ghidoni R, Giaccone G, Graff C, Graff-Radford NR, Grafman J, Halliday GM, Hernandez DG, Hjermind LE, Hodges JR, Holloway G, Huey ED, Illán-Gala I, Josephs KA, Knopman DS, Kristiansen M, Kwok JB, Leber I, Leonard HL, Libri I, Lleo A, Mackenzie IR, Madhan GK, Maletta R, Marquié M, Maver A, Menendez-Gonzalez M, Milan G, Miller BL, Morris CM, Morris HR, Nacmias B, Newton J, Nielsen JE, Nilsson C, Novelli V, Padovani A, Pal S, Pasquier F, Pastor P, Perneczky R, Peterlin B, Petersen RC, Piguet O, Pijnenburg YA, Puca AA, Rademakers R, Rainero I, Reus LM, Richardson AM, Riemenschneider M, Rogaeva E, Rogelj B, Rollinson S, Rosen H, Rossi G, Rowe JB, Rubino E, Ruiz A, Salvi E, Sanchez-Valle R, Sando SB, Santillo AF, Saxon JA, Schlachetzki JC, Scholz SW, Seelaar H, Seeley WW, Serpente M, Sorbi S, Sordon S, St George-Hyslop P, Thompson JC, Van Broeckhoven C, Van Deerlin VM, Van der Lee SJ, Van Swieten J, Tagliavini F, van der Zee J, Veronesi A, Vitale E, Waldo ML, Yokoyama JS, Nalls MA, Momeni P, Singleton AB, Hardy J, Escott-Price V

American journal of human genetics2024

DOI: 10.1016/j.ajhg.2024.05.017 PMID: 38889728

Understanding the endo-lysosomal network in neurodegeneration.

Cullen PJ, Holstege H, Small SA, St George-Hyslop P

Philosophical transactions of the Royal Society of London. Series B, Biological sciences2024Senior author

DOI: 10.1098/rstb.2022.0372 PMID: 38368931

Mimicking hypomethylation of FUS requires liquid-liquid phase separation to induce synaptic dysfunctions.

Kim SC, Mitchell SJ, Qamar S, Whitcomb DJ, Ruepp MD, St George-Hyslop P, Cho K

Acta neuropathologica communications2023

DOI: 10.1186/s40478-023-01703-w PMID: 38105257

Phase Two of the Canadian Consortium on Neurodegeneration in Aging

Principal investigatorCIHR2019Canadian Consortium on Neurodegeneration in Aging

Principal investigators: Chertkow, Howard M; Anderson, Nicole D; Andrew, Melissa K; Bartha, Robert; Bellec, Pierre; Belleville, Sylvie N; Bergman, Howard; Bherer, Louis; Black, Sandra E; Borrie, Michael J; Camicioli, J. Richard M; Carrier, Julie; Cashman, Neil R; Collins, Donald L; Cuello, A. Claudio G; Dixon, Roger A; Ducharme, Simon; Duchesne, Simon; Einstein, Gillian; Eintracht, Shaun; Evans, Alan C; Fahnestock, Margaret; Feldman, Howard; Ferland, Guylaine; Fisk, John D; Gan-Or, Ziv; Giguère, Anik; Herrmann, Nathan; Hsiung, Ging-Yuek R; Lanctôt, Krista L; Lim, Andrew S; Mackenzie, Ian R; Masellis, Mario; Maxwell, Colleen J; McGilton, Katherine S; Mclaurin, Joanne; Montero Odasso, Manuel M; Morgan, Debra G; Naglie, Gary; Nygaard, Haakon B; O'Connell, Megan E; Phillips, Natalie A; Poirier, Judes; Rapoport, Mark J; Robillard, Julie; Rockwood, Kenneth; Rogaeva, Ekaterina; Rosa-Neto, Pedro; Rylett, Jane R; Seitz, Dallas P; Siminovitch, Katherine A; Smith, Eric E; ST GEORGE-HYSLOP, Peter H; Vedel, Isabelle; Walker, Jennifer; Wittich, Walter

Keywords: Alzheimer Disease; Dementia; Diagnosis; Prevention; Quality Of Life; Sex; Treatment

$31,625,000

Functional Genomics of Neurodegenerative Diseases: Defining Molecular Pathogenesis and Targets for Biomarkers and Personalised Therapies

Nominated PICIHR2018Foundation Grant

Principal investigators: ST GEORGE-HYSLOP, Peter H

Keywords: Alzheimer Disease; Biomarkers; Frontotemporal Lobar Degeneration; Functional Genetics Of Risk Genes; Intrinsically Disordered Phase Separating Proteins; Neurological Disorders; Therapeutic Targets

$3,062,890

In Vivo Brain Mapping in the Dementias: A Longitudinal Brain-Behaviour Study with a Focus on Cerebrovascular Disease and Heterogeneity

Co-investigatorCIHR2013Operating Grant

Principal investigators: Black, Sandra E; Masellis, Mario

Keywords: Dementia (Alzheimer'S; Frontotemporal; Imaging-Genetics; Lewy Body); Longitudinal Cohort; Mri (Structural/Functional); Neurodegenerative Gait Disorders; Neuropathology; Neuropsychology; Single Photon Emission Computerized Tomography; Vascular Cognitive Disorders

$100,000

Investigation of the roles of GSK-3 isoforms in mediating Abeta, tau and insulin related Alzheimer-like synaptic, cholinergic impairments

Principal investigatorCIHR2012Team Grant: China-Canada: Alzheimer's Disease and Related Disorders

Principal investigators: Woodgett, James (Jim) R; ST GEORGE-HYSLOP, Peter H; Zhang, Wandong

Keywords: Cell Culture; Electrophysiology; Mouse Model; Neuroanatomy; Neurobehaviour; Signal Transduction; Transgenic/Knockout

$1,000,000

The role in Abeta synaptotoxicity of kinases identified through functional and genetic studies in Alzheimer Disease

Nominated PICIHR2011Team Grant: China-Canada: Alzheimer's Disease and Related Disorders

Principal investigators: ST GEORGE-HYSLOP, Peter H; Wang, Yun

Keywords: Abeta Tpxicity; Alzheimer Disease; Animal Models; Disease Genes

$998,589

Mutational and Functional Analysis of Genes Identified by GWAS Studies of Alzheimer's Disease

Nominated PICIHR2011Operating Grant

Principal investigators: ST GEORGE-HYSLOP, Peter H

Keywords: Aging; Genetics; Neurodegeneration; Neuroscience

$1,473,232

Synaptic loss in neurodegenerative diseases: Identification of structural and molecular events leading to the collapse of the synapse

SupervisorCIHR2008CIHR Clinician Scientist - Phase 1

Principal investigators: Hazrati, Lili-Naz

Keywords: Dendritic Spine; In Vivo Imaging; Neurodegeneration; Synapse

$172,500

Canadian Genetic Diseases Network (CGDN) / Réseau Canadien de maladies génétiques

Co-investigatorNSERC2005Research Management Funds - Group

Principal investigators: Hayden, Michael

$250,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Peter ST GEORGE-HYSLOP

Research

Latest papers

Latest funding

Microglial phagocytosis in Alzheimer disease.

Quantifying collective interactions in biomolecular phase separation.

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.

Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates.

Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity.

Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)

Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians.

Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia.

Understanding the endo-lysosomal network in neurodegeneration.

Mimicking hypomethylation of FUS requires liquid-liquid phase separation to induce synaptic dysfunctions.

Phase Two of the Canadian Consortium on Neurodegeneration in Aging

Functional Genomics of Neurodegenerative Diseases: Defining Molecular Pathogenesis and Targets for Biomarkers and Personalised Therapies

In Vivo Brain Mapping in the Dementias: A Longitudinal Brain-Behaviour Study with a Focus on Cerebrovascular Disease and Heterogeneity

Investigation of the roles of GSK-3 isoforms in mediating Abeta, tau and insulin related Alzheimer-like synaptic, cholinergic impairments

The role in Abeta synaptotoxicity of kinases identified through functional and genetic studies in Alzheimer Disease

Mutational and Functional Analysis of Genes Identified by GWAS Studies of Alzheimer's Disease

Synaptic loss in neurodegenerative diseases: Identification of structural and molecular events leading to the collapse of the synapse

Canadian Genetic Diseases Network (CGDN) / Réseau Canadien de maladies génétiques

Frequent collaborators

Ekaterina Rogaeva

Gerold Schmitt-Ulms

Paul Fraser

Mario Masellis

Anurag Tandon

Janice Robertson

York Pei

Daniel Cattran

Joanne McLaurin

Sandra Black

Walter Swardfager

James Raymond Gilbert

Mei Zhen

Nathan Herrmann

Kenneth Rockwood

Paul Arnold

Gustavo Turecki

Robert Bartha

Michael Borrie

Louis Bherer

Isabelle Vedel

Joel Watts

Louis Bherer

Katherine McGilton

Edward Fon

Margaret Fahnestock

Cynthia Hawkins

Alex Mihailidis

Neil Cashman

Martin Alda

Debra Morgan

Howard Bergman

Bojana Stefanovic

Cheryl Wellington

Nicole Anderson

Thomas Kislinger